Abstract
Thirty-four isolates of Pseudomonas pseudomallei were tested by a broth microdilution technique for susceptibility to amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin. Ciprofloxacin was the most active agent tested, with an MIC for 90% of the strains tested of 8 micrograms/ml. These in vitro results suggest that the fluoroquinolones tested would not be optimal for therapy of melioidosis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chau P. Y., Ng W. S., Leung Y. K., Lolekha S. In vitro susceptibility of strains of Pseudomonas pseudomallei isolated in Thailand and Hong Kong to some newer beta-lactam antibiotics and quinolone derivatives. J Infect Dis. 1986 Jan;153(1):167–170. doi: 10.1093/infdis/153.1.167. [DOI] [PubMed] [Google Scholar]
- Desplaces N., Gutmann L., Carlet J., Guibert J., Acar J. F. The new quinolones and their combinations with other agents for therapy of severe infections. J Antimicrob Chemother. 1986 Mar;17 (Suppl A):25–39. doi: 10.1093/jac/17.suppl_a.25. [DOI] [PubMed] [Google Scholar]
- Everett E. D., Nelson R. A. Pulmonary melioidosis. Observations in thirty-nine cases. Am Rev Respir Dis. 1975 Sep;112(3):331–340. doi: 10.1164/arrd.1975.112.3.331. [DOI] [PubMed] [Google Scholar]
- Hooper D. C., Wolfson J. S. The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans. Antimicrob Agents Chemother. 1985 Nov;28(5):716–721. doi: 10.1128/aac.28.5.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCormick J. B., Sexton D. J., McMurray J. G., Carey E., Hayes P., Feldman R. A. Human-to-human transmission of Pseudomonas pseudomallei. Ann Intern Med. 1975 Oct;83(4):512–513. doi: 10.7326/0003-4819-83-4-512. [DOI] [PubMed] [Google Scholar]