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. 2000 Nov;84(11):1312–1317. doi: 10.1136/bjo.84.11.1312

Fibrillin and the eye

J ASHWORTH 1, C KIELTY 1, D McLEOD 1
PMCID: PMC1723284  PMID: 11049961

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Figure 1  .

Figure 1  

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Schematic diagram of multidomain structure of fibrillin-1 and fibrillin-2.

Figure 2  .

Figure 2  

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Environmental scanning electron microscopy of normal hydrated human zonules. (A) Zonular fibres arising from ciliary processes. (B) Branching of a zonular fibre.

Figure 3  .

Figure 3  

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Transmission electron microscopy (TEM) of human zonular microfibrils, and effects of matrix metalloproteinase treatment. Normal human zonular specimens from a 54 year old were incubated for 3 hours at 37°C in the presence of 10 mM calcium chloride and hyaluronidase to remove adherent vitreous, with and without MMP-13, before fixation and TEM with uranyl acetate and lead citrate stain. (A) and (B) are untreated zonules which consist of dense and regular, parallel striated microfibrils. (C) and (D) are MMP-13 treated zonules. The zonular microfibrils are fragmented and irregularly and loosely arranged. Magnification: (A) and (C) ×20 000; (B) and (D) ×68 000.

Figure 4  .

Figure 4  

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Scanning transmission electron microscopy of an isolated human zonular microfibril. Bar = 100 nm. Zonular microfibrils were biochemically isolated using an established method29 30 by incubation with collagenase and hyaluronidase in the presence of protease inhibitors, followed by size fractionation. The excluded volume (Vo) contained fibrillin-rich microfibrils.

Selected References

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