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. 2000 Mar;84(3):332–336. doi: 10.1136/bjo.84.3.332

Role of cytokines in the pathogenesis of posterior capsule opacification

W MEACOCK 1, D SPALTON 1, M STANFORD 1
PMCID: PMC1723397  PMID: 10684849

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Figure 1  .

Figure 1  

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Role of TGF-β in the turnover of extracellular matrix.

Figure 2  .

Figure 2  

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Concentration and actions of TGF-β and b-FGF following cataract surgery in rabbits.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Apple D. J., Solomon K. D., Tetz M. R., Assia E. I., Holland E. Y., Legler U. F., Tsai J. C., Castaneda V. E., Hoggatt J. P., Kostick A. M. Posterior capsule opacification. Surv Ophthalmol. 1992 Sep-Oct;37(2):73–116. doi: 10.1016/0039-6257(92)90073-3. [DOI] [PubMed] [Google Scholar]
  2. Attisano L., Wrana J. L., López-Casillas F., Massagué J. TGF-beta receptors and actions. Biochim Biophys Acta. 1994 May 26;1222(1):71–80. doi: 10.1016/0167-4889(94)90026-4. [DOI] [PubMed] [Google Scholar]
  3. Bassols A., Massagué J. Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans. J Biol Chem. 1988 Feb 25;263(6):3039–3045. [PubMed] [Google Scholar]
  4. Bito L. Z. Species differences in the responses of the eye to irritation and trauma: a hypothesis of divergence in ocular defense mechanisms, and the choice of experimental animals for eye research. Exp Eye Res. 1984 Dec;39(6):807–829. doi: 10.1016/0014-4835(84)90079-4. [DOI] [PubMed] [Google Scholar]
  5. Burgess W. H., Maciag T. The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem. 1989;58:575–606. doi: 10.1146/annurev.bi.58.070189.003043. [DOI] [PubMed] [Google Scholar]
  6. Cousins S. W., McCabe M. M., Danielpour D., Streilein J. W. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci. 1991 Jul;32(8):2201–2211. [PubMed] [Google Scholar]
  7. Dennis P. A., Rifkin D. B. Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):580–584. doi: 10.1073/pnas.88.2.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Desmoulière A., Geinoz A., Gabbiani F., Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993 Jul;122(1):103–111. doi: 10.1083/jcb.122.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Duncan G., Wormstone I. M., Liu C. S., Marcantonio J. M., Davies P. D. Thapsigargin-coated intraocular lenses inhibit human lens cell growth. Nat Med. 1997 Sep;3(9):1026–1028. doi: 10.1038/nm0997-1026. [DOI] [PubMed] [Google Scholar]
  10. Ellingsworth L. R., Brennan J. E., Fok K., Rosen D. M., Bentz H., Piez K. A., Seyedin S. M. Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells. J Biol Chem. 1986 Sep 15;261(26):12362–12367. [PubMed] [Google Scholar]
  11. Eshaghian J., Streeten B. W. Human posterior subcapsular cataract. An ultrastructural study of the posteriorly migrating cells. Arch Ophthalmol. 1980 Jan;98(1):134–143. doi: 10.1001/archopht.1980.01020030136016. [DOI] [PubMed] [Google Scholar]
  12. Farrar W. L., Humes J. L. The role of arachidonic acid metabolism in the activities of interleukin 1 and 2. J Immunol. 1985 Aug;135(2):1153–1159. [PubMed] [Google Scholar]
  13. Ferrick M. R., Thurau S. R., Oppenheim M. H., Herbort C. P., Ni M., Zachariae C. O., Matsushima K., Chan C. C. Ocular inflammation stimulated by intravitreal interleukin-8 and interleukin-1. Invest Ophthalmol Vis Sci. 1991 Apr;32(5):1534–1539. [PubMed] [Google Scholar]
  14. Gajdusek C. M., Luo Z., Mayberg M. R. Basic fibroblast growth factor and transforming growth factor beta-1: synergistic mediators of angiogenesis in vitro. J Cell Physiol. 1993 Oct;157(1):133–144. doi: 10.1002/jcp.1041570118. [DOI] [PubMed] [Google Scholar]
  15. Gordon-Thomson C., de Iongh R. U., Hales A. M., Chamberlain C. G., McAvoy J. W. Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci. 1998 Jul;39(8):1399–1409. [PubMed] [Google Scholar]
  16. Gordon-Thomson C., de Iongh R. U., Hales A. M., Chamberlain C. G., McAvoy J. W. Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci. 1998 Jul;39(8):1399–1409. [PubMed] [Google Scholar]
  17. Gospodarowicz D., Neufeld G., Schweigerer L. Fibroblast growth factor: structural and biological properties. J Cell Physiol Suppl. 1987;Suppl 5:15–26. doi: 10.1002/jcp.1041330405. [DOI] [PubMed] [Google Scholar]
  18. Hirano T., Akira S., Taga T., Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today. 1990 Dec;11(12):443–449. doi: 10.1016/0167-5699(90)90173-7. [DOI] [PubMed] [Google Scholar]
  19. Hynes R. O. Integrins: a family of cell surface receptors. Cell. 1987 Feb 27;48(4):549–554. doi: 10.1016/0092-8674(87)90233-9. [DOI] [PubMed] [Google Scholar]
  20. Jampel H. D., Roche N., Stark W. J., Roberts A. B. Transforming growth factor-beta in human aqueous humor. Curr Eye Res. 1990 Oct;9(10):963–969. doi: 10.3109/02713689009069932. [DOI] [PubMed] [Google Scholar]
  21. Kaji Y., Mita T., Obata H., Tsuru T., Soya K., Shirasawa E., Sakai H., Hanyu A., Kato M., Yamashita H. Expression of transforming growth factor beta superfamily and their receptors in the corneal stromal wound healing process after excimer laser keratectomy. Br J Ophthalmol. 1998 Apr;82(4):462–463. doi: 10.1136/bjo.82.4.456g. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Kappelhof J. P., Vrensen G. F. The pathology of after-cataract. A minireview. Acta Ophthalmol Suppl. 1992;(205):13–24. doi: 10.1111/j.1755-3768.1992.tb02176.x. [DOI] [PubMed] [Google Scholar]
  23. Kato K., Kurosaka D., Nagamoto T. Apoptotic cell death in rabbit lens after lens extraction. Invest Ophthalmol Vis Sci. 1997 Oct;38(11):2322–2330. [PubMed] [Google Scholar]
  24. Kurosaka D., Kato K., Nagamoto T., Negishi K. Growth factors influence contractility and alpha-smooth muscle actin expression in bovine lens epithelial cells. Invest Ophthalmol Vis Sci. 1995 Jul;36(8):1701–1708. [PubMed] [Google Scholar]
  25. Kurosaka D., Kato K., Nagamoto T. Presence of alpha smooth muscle actin in lens epithelial cells of aphakic rabbit eyes. Br J Ophthalmol. 1996 Oct;80(10):906–910. doi: 10.1136/bjo.80.10.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Kurosaka D., Nagamoto T. Inhibitory effect of TGF-beta 2 in human aqueous humor on bovine lens epithelial cell proliferation. Invest Ophthalmol Vis Sci. 1994 Aug;35(9):3408–3412. [PubMed] [Google Scholar]
  27. Liu J., Hales A. M., Chamberlain C. G., McAvoy J. W. Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta. Invest Ophthalmol Vis Sci. 1994 Feb;35(2):388–401. [PubMed] [Google Scholar]
  28. Lovicu F. J., McAvoy J. W. Localization of acidic fibroblast growth factor, basic fibroblast growth factor, and heparan sulphate proteoglycan in rat lens: implications for lens polarity and growth patterns. Invest Ophthalmol Vis Sci. 1993 Nov;34(12):3355–3365. [PubMed] [Google Scholar]
  29. Malecaze F., Chollet P., Cavrois E., Vita N., Arné J. L., Ferrara P. Role of interleukin 6 in the inflammatory response after cataract surgery. An experimental and clinical study. Arch Ophthalmol. 1991 Dec;109(12):1681–1683. doi: 10.1001/archopht.1991.01080120065027. [DOI] [PubMed] [Google Scholar]
  30. Massagué J. The transforming growth factor-beta family. Annu Rev Cell Biol. 1990;6:597–641. doi: 10.1146/annurev.cb.06.110190.003121. [DOI] [PubMed] [Google Scholar]
  31. May L. T., Torcia G., Cozzolino F., Ray A., Tatter S. B., Santhanam U., Sehgal P. B., Stern D. Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins and inhibition of proliferation. Biochem Biophys Res Commun. 1989 Mar 31;159(3):991–998. doi: 10.1016/0006-291x(89)92206-7. [DOI] [PubMed] [Google Scholar]
  32. McAvoy J. W., Chamberlain C. G. Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development. 1989 Oct;107(2):221–228. doi: 10.1242/dev.107.2.221. [DOI] [PubMed] [Google Scholar]
  33. McAvoy J. W., Chamberlain C. G. Growth factors in the eye. Prog Growth Factor Res. 1990;2(1):29–43. doi: 10.1016/0955-2235(90)90008-8. [DOI] [PubMed] [Google Scholar]
  34. McDonnell P. J., Rowen S. L., Glaser B. M., Sato M. Posterior capsule opacification. An in vitro model. Arch Ophthalmol. 1985 Sep;103(9):1378–1381. doi: 10.1001/archopht.1985.01050090130047. [DOI] [PubMed] [Google Scholar]
  35. McDonnell P. J., Zarbin M. A., Green W. R. Posterior capsule opacification in pseudophakic eyes. Ophthalmology. 1983 Dec;90(12):1548–1553. doi: 10.1016/s0161-6420(83)34350-5. [DOI] [PubMed] [Google Scholar]
  36. Nishi O., Nishi K., Akaishi T., Shirasawa E. Detection of cell adhesion molecules in lens epithelial cells of human cataracts. Invest Ophthalmol Vis Sci. 1997 Mar;38(3):579–585. [PubMed] [Google Scholar]
  37. Nishi O., Nishi K., Fujiwara T., Shirasawa E. Effects of diclofenac sodium and indomethacin on proliferation and collagen synthesis of lens epithelial cells in vitro. J Cataract Refract Surg. 1995 Jul;21(4):461–465. doi: 10.1016/s0886-3350(13)80541-x. [DOI] [PubMed] [Google Scholar]
  38. Nishi O., Nishi K., Fujiwara T., Shirasawa E., Ohmoto Y. Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells. Br J Ophthalmol. 1996 Jan;80(1):63–68. doi: 10.1136/bjo.80.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Nishi O., Nishi K., Fujiwara T., Shirasawa E. Types of collagen synthesised by the lens epithelial cells of human cataracts. Br J Ophthalmol. 1995 Oct;79(10):939–943. doi: 10.1136/bjo.79.10.939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Nishi O., Nishi K., Imanishi M. Synthesis of interleukin-1 and prostaglandin E2 by lens epithelial cells of human cataracts. Br J Ophthalmol. 1992 Jun;76(6):338–341. doi: 10.1136/bjo.76.6.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Nishi O., Nishi K., Mano C., Ichihara M., Honda T., Saitoh I. Inhibition of migrating lens epithelial cells by blocking the adhesion molecule integrin: a preliminary report. J Cataract Refract Surg. 1997 Jul-Aug;23(6):860–865. doi: 10.1016/s0886-3350(97)80244-1. [DOI] [PubMed] [Google Scholar]
  42. Olivero D. K., Furcht L. T. Type IV collagen, laminin, and fibronectin promote the adhesion and migration of rabbit lens epithelial cells in vitro. Invest Ophthalmol Vis Sci. 1993 Sep;34(10):2825–2834. [PubMed] [Google Scholar]
  43. Overall C. M., Wrana J. L., Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem. 1989 Jan 25;264(3):1860–1869. [PubMed] [Google Scholar]
  44. Pasquale L. R., Dorman-Pease M. E., Lutty G. A., Quigley H. A., Jampel H. D. Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1993 Jan;34(1):23–30. [PubMed] [Google Scholar]
  45. Ruoslahti E., Pierschbacher M. D. New perspectives in cell adhesion: RGD and integrins. Science. 1987 Oct 23;238(4826):491–497. doi: 10.1126/science.2821619. [DOI] [PubMed] [Google Scholar]
  46. Schaumberg D. A., Dana M. R., Christen W. G., Glynn R. J. A systematic overview of the incidence of posterior capsule opacification. Ophthalmology. 1998 Jul;105(7):1213–1221. doi: 10.1016/S0161-6420(98)97023-3. [DOI] [PubMed] [Google Scholar]
  47. Schulz M. W., Chamberlain C. G., McAvoy J. W. Inhibition of transforming growth factor-beta-induced cataractous changes in lens explants by ocular media and alpha 2-macroglobulin. Invest Ophthalmol Vis Sci. 1996 Jul;37(8):1509–1519. [PubMed] [Google Scholar]
  48. Steinberg E. P., Javitt J. C., Sharkey P. D., Zuckerman A., Legro M. W., Anderson G. F., Bass E. B., O'Day D. The content and cost of cataract surgery. Arch Ophthalmol. 1993 Aug;111(8):1041–1049. doi: 10.1001/archopht.1993.01090080037016. [DOI] [PubMed] [Google Scholar]
  49. Tetz M. R., Ries M. W., Lucas C., Stricker H., Völcker H. E. Inhibition of posterior capsule opacification by an intraocular-lens-bound sustained drug delivery system: an experimental animal study and literature review. J Cataract Refract Surg. 1996 Oct;22(8):1070–1078. doi: 10.1016/s0886-3350(96)80120-9. [DOI] [PubMed] [Google Scholar]
  50. Tripathi R. C., Borisuth N. S., Tripathi B. J. Detection, quantification, and significance of basic fibroblast growth factor in the aqueous humor of man, cat, dog and pig. Exp Eye Res. 1992 Mar;54(3):447–454. doi: 10.1016/0014-4835(92)90056-x. [DOI] [PubMed] [Google Scholar]
  51. Tripathi R. C., Millard C. B., Tripathi B. J., Reddy V. A molecule resembling fibroblast growth factor in aqueous humor. Am J Ophthalmol. 1988 Aug 15;106(2):230–231. doi: 10.1016/0002-9394(88)90841-0. [DOI] [PubMed] [Google Scholar]
  52. Tucker R. F., Shipley G. D., Moses H. L., Holley R. W. Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor. Science. 1984 Nov 9;226(4675):705–707. doi: 10.1126/science.6093254. [DOI] [PubMed] [Google Scholar]
  53. Wallentin N., Wickström K., Lundberg C. Effect of cataract surgery on aqueous TGF-beta and lens epithelial cell proliferation. Invest Ophthalmol Vis Sci. 1998 Jul;39(8):1410–1418. [PubMed] [Google Scholar]
  54. Wormstone I. M., Liu C. S., Rakic J. M., Marcantonio J. M., Vrensen G. F., Duncan G. Human lens epithelial cell proliferation in a protein-free medium. Invest Ophthalmol Vis Sci. 1997 Feb;38(2):396–404. [PubMed] [Google Scholar]

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