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. 2000 Sep;84(9):1061–1063. doi: 10.1136/bjo.84.9.1061

Subretinal fluid levels of topical, oral, and combined administered ciprofloxacin in humans

O Cekic 1, C Batman 1, U Yasar 1, N Basci 1, O Zilelioglu 1, A Bozkurt 1
PMCID: PMC1723621  PMID: 10966968

Abstract

AIMS—To investigate the subretinal fluid (SRF) penetration of ciprofloxacin following topical, oral, and combined administration.
METHODS—34 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Twelve patients received topical ciprofloxacin, 11 patients received oral ciprofloxacin, and the other 11 patients received combined drug administration. SRF drug level was measured by using high performance liquid chromatography method.
RESULTS—The highest drug concentrations of all tested modes were attained following combined administration and lowest following topical administration (p <0.001). The SRF drug concentration following oral administration was also significantly higher than that of topical administration (p <0.001). Concentrations after oral and combined administration did not differ significantly (p = 0.217).
CONCLUSIONS—Topical ciprofloxacin can penetrate SRF. Ocular bioavailability of ciprofloxacin in SRF after oral and combined administration is equivalent.



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Selected References

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  1. Akkan A. G., Mutlu I., Ozyazgan S., Gok A., Yigit U., Ozuner Z., Senses V., Pekel H. Penetration of topically applied ciprofloxacin, norfloxacin and ofloxacin into the aqueous humor of the uninflamed human eye. J Chemother. 1997 Aug;9(4):257–262. doi: 10.1179/joc.1997.9.4.257. [DOI] [PubMed] [Google Scholar]
  2. Alfaro D. V., Davis J., Kim S., Bia F., Bogard J. F., Briggs J. W., Liggett P. E. Experimental Bacillus cereus post-traumatic endophthalmitis and treatment with ciprofloxacin. Br J Ophthalmol. 1996 Aug;80(8):755–758. doi: 10.1136/bjo.80.8.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Alfaro D. V., Hudson S. J., Rafanan M. M., Moss S. T., Levy S. D. The effect of trauma on the ocular penetration of intravenous ciprofloxacin. Am J Ophthalmol. 1996 Nov;122(5):678–683. doi: 10.1016/s0002-9394(14)70486-6. [DOI] [PubMed] [Google Scholar]
  4. Barza M. Antibacterial agents in the treatment of ocular infections. Infect Dis Clin North Am. 1989 Sep;3(3):533–551. [PubMed] [Google Scholar]
  5. Basci N. E., Bozkurt A., Kalayci D., Kayaalp S. O. Rapid liquid chromatographic assay of ciprofloxacin in human aqueous humor. J Pharm Biomed Anal. 1996 Jan;14(3):353–356. doi: 10.1016/0731-7085(95)01614-7. [DOI] [PubMed] [Google Scholar]
  6. Cekic O., Batman C., Yasar U., Basci N. E., Bozkurt A., Kayaalp S. O. Penetration of ofloxacin in human aqueous and vitreous humors following oral and topical administration. Retina. 1998;18(6):521–525. doi: 10.1097/00006982-199806000-00005. [DOI] [PubMed] [Google Scholar]
  7. Cekiç O., Batman C., Totan Y., Yasar U., Basci N. E., Bozkurt A., Kayaalp S. O. Penetration of ofloxacin and ciprofloxacin in aqueous humor after topical administration. Ophthalmic Surg Lasers. 1999 Jun;30(6):465–468. [PubMed] [Google Scholar]
  8. Cekiç O., Batman C., Totan Y., Yasar U., Basci N. E., Bozkurt A., Kayaalp S. O., Zilelioglu O. Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects. Eye (Lond) 1999 Oct;13(Pt 5):656–659. doi: 10.1038/eye.1999.178. [DOI] [PubMed] [Google Scholar]
  9. Cekiç O., Batman C., Yasar U., Basci N. E., Bozkurt A., Kayaalp S. O. Comparison of aqueous humour and vitreous humour levels of two 0.3% ciprofloxacin eyedrops. Can J Ophthalmol. 1998 Dec;33(7):373–376. [PubMed] [Google Scholar]
  10. Cekiç O., Batman C., Yasar U., Başci N. E., Bozkurt A., Kayaalp S. O. Human aqueous and vitreous humour levels of ciprofloxacin following oral and topical administration. Eye (Lond) 1999 Aug;13(Pt 4):555–558. doi: 10.1038/eye.1999.137. [DOI] [PubMed] [Google Scholar]
  11. Cekiç O., Batman C., Yasar U., Totan Y., Basci N. E., Bozkurt A., Zilelioglu O., Kayaalp S. O. Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid. Br J Ophthalmol. 1999 Oct;83(10):1183–1185. doi: 10.1136/bjo.83.10.1183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Celebi S., Ay S., Aykan U., Bulut V., Alagöz G., Celiker U. O. Penetration of oral and topical ciprofloxacin into human aqueous humor. Acta Ophthalmol Scand. 1998 Dec;76(6):683–685. doi: 10.1034/j.1600-0420.1998.760610.x. [DOI] [PubMed] [Google Scholar]
  13. Diamond J. P., White L., Leeming J. P., Bing Hoh H., Easty D. L. Topical 0.3% ciprofloxacin, norfloxacin, and ofloxacin in treatment of bacterial keratitis: a new method for comparative evaluation of ocular drug penetration. Br J Ophthalmol. 1995 Jun;79(6):606–609. doi: 10.1136/bjo.79.6.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Durmaz B., Marol S., Durmaz R., Oram O., Hepsen I. F., Günal S. Aqueous humor penetration of topically applied ciprofloxacin, ofloxacin and tobramycin. Arzneimittelforschung. 1997 Apr;47(4):413–415. [PubMed] [Google Scholar]
  15. Hobden J. A., O'Callaghan R. J., Insler M. S., Hill J. M. Ciprofloxacin ointment versus ciprofloxacin drops for therapy of experimental Pseudomonas keratitis. Cornea. 1993 Mar;12(2):138–141. doi: 10.1097/00003226-199303000-00008. [DOI] [PubMed] [Google Scholar]
  16. Kalayci D., Basci N., Akpek E., Hasiripi H., Bozkurt A. Penetration of topical 0.3% ciprofloxacin into human aqueous humor. Ophthalmic Surg Lasers. 1996 Jan;27(1):21–24. [PubMed] [Google Scholar]
  17. Keren G., Alhalel A., Bartov E., Kitzes-Cohen R., Rubinstein E., Segev S., Treister G. The intravitreal penetration of orally administered ciprofloxacin in humans. Invest Ophthalmol Vis Sci. 1991 Jul;32(8):2388–2392. [PubMed] [Google Scholar]
  18. Leeming J. P., Diamond J. P., Trigg R., White L., Hoh H. B., Easty D. L. Ocular penetration of topical ciprofloxacin and norfloxacin drops and their effect upon eyelid flora. Br J Ophthalmol. 1994 Jul;78(7):546–548. doi: 10.1136/bjo.78.7.546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lesk M. R., Ammann H., Marcil G., Vinet B., Lamer L., Sebag M. The penetration of oral ciprofloxacin into the aqueous humor, vitreous, and subretinal fluid of humans. Am J Ophthalmol. 1993 May 15;115(5):623–628. doi: 10.1016/s0002-9394(14)71460-6. [DOI] [PubMed] [Google Scholar]
  20. Madu A. A., Mayers M., Perkins R., Liu W., Drusano G. L., Aswani R., Madu C. N., Miller M. H. Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration. Exp Eye Res. 1996 Aug;63(2):129–136. doi: 10.1006/exer.1996.0101. [DOI] [PubMed] [Google Scholar]
  21. Mounier M., Adenis J. P., Denis F. Pénétration intraoculaire de la ciprofloxacine après perfusion et prise orale. Pathol Biol (Paris) 1988 Jun;36(5 Pt 2):724–727. [PubMed] [Google Scholar]
  22. Oztürk F., Kortunay S., Kurt E., Ilker S. S., Basci N. E., Bozkurt A. Penetration of topical and oral ciprofloxacin into the aqueous and vitreous humor in inflamed eyes. Retina. 1999;19(3):218–222. doi: 10.1097/00006982-199903000-00007. [DOI] [PubMed] [Google Scholar]
  23. Oztürk F., Kortunay S., Kurt E., Ilker S. S., Inan U. U., Basci N. E., Bozkurt A., Kayaalp O. Effects of trauma and infection on ciprofloxacin levels in the vitreous cavity. Retina. 1999;19(2):127–130. doi: 10.1097/00006982-199902000-00007. [DOI] [PubMed] [Google Scholar]
  24. Pearson P. A., Hainsworth D. P., Ashton P. Clearance and distribution of ciprofloxacin after intravitreal injection. Retina. 1993;13(4):326–330. doi: 10.1097/00006982-199313040-00010. [DOI] [PubMed] [Google Scholar]
  25. Takeuchi A., Kricorian G., Wolfensberger T. J., Marmor M. F. The source of fluid and protein in serous retinal detachments. Curr Eye Res. 1996 Jul;15(7):764–767. doi: 10.3109/02713689609003460. [DOI] [PubMed] [Google Scholar]
  26. el Baba F. Z., Trousdale M. D., Gauderman W. J., Wagner D. G., Liggett P. E. Intravitreal penetration of oral ciprofloxacin in humans. Ophthalmology. 1992 Apr;99(4):483–486. doi: 10.1016/s0161-6420(92)31943-8. [DOI] [PubMed] [Google Scholar]

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