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. 2001 Jan;85(1):80–84. doi: 10.1136/bjo.85.1.80

Effect of ADCON-L on adjustable strabismus surgery in rabbits

M Y Choi 1, S Auh 1, D G Choi 1, B L Chang 1
PMCID: PMC1723701  PMID: 11133717

Abstract

BACKGROUND/AIMS—In search of a way to prevent postoperative adhesion after strabismus surgery, an animal study was performed to assess the effect of a gel consisting of a polyglycan ester in a gelatin matrix (ADCON-L).
METHODS—Bilateral recessions of superior rectus muscle (SR) were performed on 16 rabbits. ADCON-L was applied beneath and over the SR in the right eyes of all rabbits, while the operative fields in the left eyes were irrigated with a balanced salt solution (BSS). The adjustment was performed on each SR at 4 and 7 days postoperatively on the same eye. The length and force of the adjustment and the degree of adhesion were recorded. At 3 weeks postoperatively, disinsertional force was measured in several of the eyes, and the other eyes were enucleated.
RESULTS—The length of the adjustment was longer and the force of the adjustment was less in the ADCON-L group than in the BSS treated group at 4 and 7 days postoperatively (p=0.00). A significant reduction (p=0.00) in the degree of adhesion was noted in eyes treated with ADCON-L. There was no significant difference in disinsertional force between the two groups. Histopathological evaluation of the muscle revealed decreased fibrosis of perimuscular connective tissue in eyes treated with ADCON-L at 3 weeks postoperatively.
CONCLUSION—This study suggests that ADCON-L helps to prevent postoperative adhesion in rabbits and enables adjustment twice within 7 days postoperatively without complications.



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Figure 1  .

Figure 1  

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Photograph shows the procedure by which ADCON-L is injected after recession of superior rectus.

Figure 2  .

Figure 2  

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Scatter plot of measurements of force for adjustment at postoperative 4 and 7 days. The circles represent ADCON-L treated eyes and the triangles represent BSS treated eyes. (Mean (SD): 48.0 (11.3) in ADCON-L group, 70.3 (9.9) in BSS treated group at 4 days postoperatively; 79.1 (27.8) in ADCON-L group, 145.0 (31.8) in BSS treated group at 7 days postoperatively)

Figure 3  .

Figure 3  

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Scatter plot of disinsertional force at 3 weeks postoperatively in BSS treated and ADCON-L treated group (mean (SD): 431 (198) in ADCON-L group, 373 (174) in BSS treated group).

Figure 4  .

Figure 4  

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At 3 weeks postoperatively, marked fibrosis was observed surrounding the extraocular muscle (A) in an eye treated with balanced salt solution while fibrosis was comparatively less in an eye treated with ADCON-L (B).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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