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. 2001 Nov;85(11):1313–1315. doi: 10.1136/bjo.85.11.1313

Plasma homocysteine, methylene tetrahydrofolate reductase C677T and factor II G20210A polymorphisms, factor VIII, and VWF in central retinal vein occlusion

S Boyd 1, D Owens 1, T Gin 1, K Bunce 1, H Sherafat 1, D Perry 1, P Hykin 1
PMCID: PMC1723784  PMID: 11673296

Abstract

AIMS—To determine whether plasma homocysteine, methylene tetrahydrofolate reductase (MTHFR) C677T and factor II G20210A polymorphisms, factor VIII, and vWF are risk factors for central retinal vein occlusion (CRVO).
METHOD—Prospective comparison of 63 consecutive patients with central retinal vein occlusion and 63 age matched controls. Plasma homocysteine and vWF were estimated by ELISA, the MTFHR and factor II G20210A polymorphisms determined by polymerase chain reaction with restriction enzyme product digestion and factor VIII by one stage automated clotting assay.
RESULTS—Plasma homocysteine (patients: median 12.4 µmol/l, controls: median 11.6 µmol OR = 1.05, p=0.20), factor VIII (patients: median = 115 U/dl, controls: median = 113 U/dl), and vWF (patients: median = 115 U/dl, controls: median = 108 U/dl) were not statistically higher in patients than in controls. Five CRVO patients and seven controls were homozygous for the MTHFR C677T mutation. One control was heterozygous for the factor II G20210A mutation.
CONCLUSION—This study has not identified new risk factors for CRVO.



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Selected References

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  1. Albisinni R., Coppola A., Loffredo M., Cerbone A. M., Di Minno G., Greco G. M. Retinal vein occlusion and inherited conditions predisposing to thrombophilia. Thromb Haemost. 1998 Oct;80(4):702–703. [PubMed] [Google Scholar]
  2. Cahill M., Karabatzaki M., Meleady R., Refsum H., Ueland P., Shields D., Mooney D., Graham I. Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease. Br J Ophthalmol. 2000 Feb;84(2):154–157. doi: 10.1136/bjo.84.2.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dodson P. M., Westwick J., Marks G., Kakkar V. V., Galton D. J. beta-thromboglobulin and platelet factor 4 levels in retinal vein occlusion. Br J Ophthalmol. 1983 Mar;67(3):143–146. doi: 10.1136/bjo.67.3.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kang S. S., Wong P. W., Zhou J. M., Sora J., Lessick M., Ruggie N., Grcevich G. Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism. 1988 Jul;37(7):611–613. doi: 10.1016/0026-0495(88)90076-5. [DOI] [PubMed] [Google Scholar]
  5. Larsson J., Hultberg B., Hillarp A. Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion. Acta Ophthalmol Scand. 2000 Jun;78(3):340–343. doi: 10.1034/j.1600-0420.2000.078003340.x. [DOI] [PubMed] [Google Scholar]
  6. Larsson J., Olafsdottir E., Bauer B. Activated protein C resistance in young adults with central retinal vein occlusion. Br J Ophthalmol. 1996 Mar;80(3):200–202. doi: 10.1136/bjo.80.3.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Martin S. C., Rauz S., Marr J. E., Martin N., Jones A. F., Dodson P. M. Plasma total homocysteine and retinal vascular disease. Eye (Lond) 2000 Aug;14(Pt 4):590–593. doi: 10.1038/eye.2000.148. [DOI] [PubMed] [Google Scholar]
  8. McCully K. S. Homocysteine and vascular disease. Nat Med. 1996 Apr;2(4):386–389. doi: 10.1038/nm0496-386. [DOI] [PubMed] [Google Scholar]
  9. Pianka P., Almog Y., Man O., Goldstein M., Sela B. A., Loewenstein A. Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Ophthalmology. 2000 Aug;107(8):1588–1592. doi: 10.1016/s0161-6420(00)00181-0. [DOI] [PubMed] [Google Scholar]
  10. Poort S. R., Rosendaal F. R., Reitsma P. H., Bertina R. M. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996 Nov 15;88(10):3698–3703. [PubMed] [Google Scholar]
  11. Salomon O., Moisseiev J., Rosenberg N., Vidne O., Yassur I., Zivelin A., Treister G., Steinberg D. M., Seligsohn U. Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion. Blood Coagul Fibrinolysis. 1998 Oct;9(7):617–622. doi: 10.1097/00001721-199810000-00008. [DOI] [PubMed] [Google Scholar]
  12. Ubbink J. B., van der Merwe A., Vermaak W. J., Delport R. Hyperhomocysteinemia and the response to vitamin supplementation. Clin Investig. 1993 Dec;71(12):993–998. doi: 10.1007/BF00180030. [DOI] [PubMed] [Google Scholar]
  13. Vine A. K. Hyperhomocysteinemia: a risk factor for central retinal vein occlusion. Am J Ophthalmol. 2000 May;129(5):640–644. doi: 10.1016/s0002-9394(99)00476-6. [DOI] [PubMed] [Google Scholar]
  14. Williamson T. H., Rumley A., Lowe G. D. Blood viscosity, coagulation, and activated protein C resistance in central retinal vein occlusion: a population controlled study. Br J Ophthalmol. 1996 Mar;80(3):203–208. doi: 10.1136/bjo.80.3.203. [DOI] [PMC free article] [PubMed] [Google Scholar]

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