Abstract
AIMS—To quantitatively evaluate the changes in corneal irregular astigmatism after laser in situ keratomileusis (LASIK) in relation to the amount of laser ablation. METHODS—In 189 eyes of 116 patients undergoing LASIK for myopia, corneal topography was obtained before and 1 month after surgery. Using Fourier harmonic analysis of the topography data, corneal irregular astigmatism (asymmetry and higher order irregularity) was calculated. RESULTS—By surgery, asymmetry component significantly increased (p <0.0001, Wilcoxon signed rank test), while higher order irregularity did not (p = 0.767). The increases in the asymmetry component significantly correlated with ablation depth (Spearman rank correlation coefficient rs=0.440, p <0.0001). No significant correlation was found between changes in higher order irregularity and ablation depth (rs=0.137, p = 0.074). CONCLUSION—LASIK significantly increases the asymmetry component of the cornea which is dependent on the amount of laser ablation.
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Figure 1 .
Significant correlation between the amount of laser ablation and changes in asymmetry component. (Spearman rank correlation coefficient rs=0.440, p<0.0001).
Figure 2 .
Relation between the amount of laser ablation and changes in higher order irregularity. There was no significant correlation (Spearman rank correlation coefficient rs=0.137, p=0.074).
Selected References
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- Applegate R. A., Hilmantel G., Howland H. C. Corneal aberrations increase with the magnitude of radial keratotomy refractive correction. Optom Vis Sci. 1996 Sep;73(9):585–589. doi: 10.1097/00006324-199609000-00004. [DOI] [PubMed] [Google Scholar]
- Barker N. H., Couper T. A., Taylor H. R. Changes in corneal topography after laser in situ keratomileusis for myopia. J Refract Surg. 1999 Jan-Feb;15(1):46–52. doi: 10.3928/1081-597X-19990101-08. [DOI] [PubMed] [Google Scholar]
- Butuner Z., Elliott D. B., Gimbel H. V., Slimmon S. Visual function one year after excimer laser photorefractive keratectomy. J Refract Corneal Surg. 1994 Nov-Dec;10(6):625–630. [PubMed] [Google Scholar]
- Coorpender S. J., Klyce S. D., McDonald M. B., Doubrava M. W., Kim C. K., Tan A. L., Srivannaboon S. Corneal topography of small-beam tracking excimer laser photorefractive keratectomy. J Cataract Refract Surg. 1999 May;25(5):674–684. doi: 10.1016/s0886-3350(99)00015-2. [DOI] [PubMed] [Google Scholar]
- Ghaith A. A., Daniel J., Stulting R. D., Thompson K. P., Lynn M. Contrast sensitivity and glare disability after radial keratotomy and photorefractive keratectomy. Arch Ophthalmol. 1998 Jan;116(1):12–18. doi: 10.1001/archopht.116.1.12. [DOI] [PubMed] [Google Scholar]
- Halliday B. L. Refractive and visual results and patient satisfaction after excimer laser photorefractive keratectomy for myopia. Br J Ophthalmol. 1995 Oct;79(10):881–887. doi: 10.1136/bjo.79.10.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hersh P. S., Scher K. S., Irani R. Corneal topography of photorefractive keratectomy versus laser in situ keratomileusis. Summit PRK-LASIK Study Group. Ophthalmology. 1998 Apr;105(4):612–619. doi: 10.1016/s0161-6420(98)94013-1. [DOI] [PubMed] [Google Scholar]
- Hjortdal J. O., Erdmann L., Bek T. Fourier analysis of video-keratographic data. A tool for separation of spherical, regular astigmatic and irregular astigmatic corneal power components. Ophthalmic Physiol Opt. 1995 May;15(3):171–185. [PubMed] [Google Scholar]
- Holladay J. T., Dudeja D. R., Chang J. Functional vision and corneal changes after laser in situ keratomileusis determined by contrast sensitivity, glare testing, and corneal topography. J Cataract Refract Surg. 1999 May;25(5):663–669. doi: 10.1016/s0886-3350(99)00011-5. [DOI] [PubMed] [Google Scholar]
- Keller P. R., McGhee C. N., Weed K. H. Fourier analysis of corneal topography data after photorefractive keratectomy. J Cataract Refract Surg. 1998 Nov;24(11):1447–1455. doi: 10.1016/s0886-3350(98)80165-x. [DOI] [PubMed] [Google Scholar]
- Lohmann C. P., Fitzke F. W., O'Brart D., Muir M. K., Marshall J. Halos--a problem for all myopes? A comparison between spectacles, contact lenses, and photorefractive keratectomy. Refract Corneal Surg. 1993 Mar-Apr;9(2 Suppl):S72–S75. [PubMed] [Google Scholar]
- Martínez C. E., Applegate R. A., Klyce S. D., McDonald M. B., Medina J. P., Howland H. C. Effect of pupillary dilation on corneal optical aberrations after photorefractive keratectomy. Arch Ophthalmol. 1998 Aug;116(8):1053–1062. doi: 10.1001/archopht.116.8.1053. [DOI] [PubMed] [Google Scholar]
- Mulhern M. G., Foley-Nolan A., O'Keefe M., Condon P. I. Topographical analysis of ablation centration after excimer laser photorefractive keratectomy and laser in situ keratomileusis for high myopia. J Cataract Refract Surg. 1997 May;23(4):488–494. doi: 10.1016/s0886-3350(97)80204-0. [DOI] [PubMed] [Google Scholar]
- Olsen T., Dam-Johansen M., Bek T., Hjortdal J. O. Evaluating surgically induced astigmatism by Fourier analysis of corneal topography data. J Cataract Refract Surg. 1996 Apr;22(3):318–323. doi: 10.1016/s0886-3350(96)80243-4. [DOI] [PubMed] [Google Scholar]
- Oshika T., Klyce S. D., Applegate R. A., Howland H. C., El Danasoury M. A. Comparison of corneal wavefront aberrations after photorefractive keratectomy and laser in situ keratomileusis. Am J Ophthalmol. 1999 Jan;127(1):1–7. doi: 10.1016/s0002-9394(98)00288-8. [DOI] [PubMed] [Google Scholar]
- Oshika T., Klyce S. D. Corneal topography in LASIK. Semin Ophthalmol. 1998 Jun;13(2):64–70. doi: 10.3109/08820539809059820. [DOI] [PubMed] [Google Scholar]
- Oshika T., Tomidokoro A., Maruo K., Tokunaga T., Miyata N. Quantitative evaluation of irregular astigmatism by fourier series harmonic analysis of videokeratography data. Invest Ophthalmol Vis Sci. 1998 Apr;39(5):705–709. [PubMed] [Google Scholar]
- Pallikaris I. G., Koufala K. I., Siganos D. S., Papadaki T. G., Katsanevaki V. J., Tourtsan V., McDonald M. B. Photorefractive keratectomy with a small spot laser and tracker. J Refract Surg. 1999 Mar-Apr;15(2):137–144. doi: 10.3928/1081-597X-19990301-10. [DOI] [PubMed] [Google Scholar]
- Pallikaris I. G., Siganos D. S. Excimer laser in situ keratomileusis and photorefractive keratectomy for correction of high myopia. J Refract Corneal Surg. 1994 Sep-Oct;10(5):498–510. [PubMed] [Google Scholar]
- Pérez-Santonja J. J., Sakla H. F., Alió J. L. Contrast sensitivity after laser in situ keratomileusis. J Cataract Refract Surg. 1998 Feb;24(2):183–189. doi: 10.1016/s0886-3350(98)80198-3. [DOI] [PubMed] [Google Scholar]
- Pérez-Santonja J. J., Sakla H. F., Alió J. L. Contrast sensitivity after laser in situ keratomileusis. J Cataract Refract Surg. 1998 Feb;24(2):183–189. doi: 10.1016/s0886-3350(98)80198-3. [DOI] [PubMed] [Google Scholar]
- Raasch T. W. Corneal topography and irregular astigmatism. Optom Vis Sci. 1995 Nov;72(11):809–815. doi: 10.1097/00006324-199511000-00006. [DOI] [PubMed] [Google Scholar]
- Seiler T., Reckmann W., Maloney R. K. Effective spherical aberration of the cornea as a quantitative descriptor in corneal topography. J Cataract Refract Surg. 1993;19 (Suppl):155–165. doi: 10.1016/s0886-3350(13)80400-2. [DOI] [PubMed] [Google Scholar]
- Spadea L., Bianco G., Masini M. C., Balestrazzi E. Videokeratographic changes after laser in situ keratomileusis to correct high myopia. J Cataract Refract Surg. 1999 Dec;25(12):1589–1595. doi: 10.1016/s0886-3350(99)00287-4. [DOI] [PubMed] [Google Scholar]
- Tsai Y. Y., Lin J. M. Ablation centration after active eye-tracker-assisted photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg. 2000 Jan;26(1):28–34. doi: 10.1016/s0886-3350(99)00328-4. [DOI] [PubMed] [Google Scholar]
- Wang Z., Chen J., Yang B. Comparison of laser in situ keratomileusis and photorefractive keratectomy to correct myopia from -1.25 to -6.00 diopters. J Refract Surg. 1997 Sep-Oct;13(6):528–534. doi: 10.3928/1081-597X-19970901-09. [DOI] [PubMed] [Google Scholar]
- Wyzinski P. Escalation of keratospeak: regular and irregular astigmatism. Refract Corneal Surg. 1990 May-Jun;6(3):231–231. [PubMed] [Google Scholar]


