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. 2001 May;85(5):531–533. doi: 10.1136/bjo.85.5.531

Pulsatile ocular blood flow study: decreases in exudative age related macular degeneration

F Mori 1, S Konno 1, T Hikichi 1, Y Yamaguchi 1, S Ishiko 1, A Yoshida 1
PMCID: PMC1723978  PMID: 11316708

Abstract

BACKGROUND—Pulsatile ocular blood flow (POBF) is a parameter for evaluating choroidal blood flow. POBF in the patients with non-exudative and exudative age related macular degeneration (AMD) was investigated.
METHODS—POBF, pulse amplitude (PA), systolic and diastolic blood pressures, intraocular pressure (IOP), refractive error, and axial length were compared among 10 patients with non-exudative AMD, 11 patients with exudative AMD, and 69 age matched controls. A Langham OBF computerised tonometer was used with the participants in the sitting position to measure POBF and PA.
RESULTS—No significant differences were found in age, systolic and diastolic blood pressures, IOP, or refractive error between patients with exudative and non-exudative AMD and the control subjects. In the patients with exudative AMD the POBF (median, 372.7 µl/min) and PA (median, 1.2 mm Hg) were significantly lower than in the patients with non-exudative AMD (median, 607.0 µl/min (p = 0.02) and 2.2 mm Hg (p = 0.04), respectively) and control subjects (median, 547.4 µl/min (p = 0.01) and 2.0 mm Hg (p = 0.01), respectively).
CONCLUSIONS—These data show that the POBF and PA in the patients with exudative AMD are lower than in the patients with non-exudative AMD and normal subjects. Decreased choroidal blood flow may have a role in the development of choroidal neovascularisation in AMD.



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Figure 1  .

Figure 1  

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Pulse amplitude in patients with exudative age related macular degeneration (AMD) (n=11), patients with non-exudative AMD (n=10), and age matched controls (n=69).    

Figure 2  .

Figure 2  

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Pulsatile ocular blood flow in patients with exudative age related macular degeneration (AMD) (n=11), patients with non-exudative AMD (n=10), and age matched controls (n=69).

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