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. 2001 Jun;35(3):170–173. doi: 10.1136/bjsm.35.3.170

The acute phase response and exercise: court and field sports

K Fallon 1, S Fallon 1, T Boston 1
PMCID: PMC1724337  PMID: 11375875

Abstract

Objective—To determine the presence or absence of an acute phase response after training for court and field sports.

Participants—All members of the Australian women's soccer team (n = 18) and all members of the Australian Institute of Sport netball team (n = 14).

Methods—Twelve acute phase reactants (white blood cell count, neutrophil count, platelet count, serum iron, ferritin, and transferrin, percentage transferrin saturation, α1 antitrypsin, caeruloplasmin, α2 acid glycoprotein, C reactive protein, and erythrocyte sedimentation rate) were measured during a rest period and after moderate and heavy training weeks in members of elite netball and women's soccer teams.

Results—Responses consistent with an acute phase response were found in five of 24 tests in the soccer players, and in three of 24 tests in the netball players. Responses in the opposite direction were found in seven of 24 tests in the soccer players and two of 24 tests in the netballers. The most sensitive reactant measured, C reactive protein, did not respond in a manner typical of an acute phase response.

Conclusion—An acute phase response does not seem to occur as a consequence of the levels of training typical of elite female netball and soccer teams. This has implications for the interpretation of biochemical variables in these groups.

Key Words: acute phase response; iron; plasma proteins; inflammation

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Selected References

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  1. Ali M. A., Luxton A. W., Walker W. H. Serum ferritin concentration and bone marrow iron stores: a prospective study. Can Med Assoc J. 1978 Apr 22;118(8):945–946. [PMC free article] [PubMed] [Google Scholar]
  2. Baynes R., Bezwoda W., Bothwell T., Khan Q., Mansoor N. The non-immune inflammatory response: serial changes in plasma iron, iron-binding capacity, lactoferrin, ferritin and C-reactive protein. Scand J Clin Lab Invest. 1986 Nov;46(7):695–704. doi: 10.3109/00365518609083733. [DOI] [PubMed] [Google Scholar]
  3. Chatard J. C., Mujika I., Guy C., Lacour J. R. Anaemia and iron deficiency in athletes. Practical recommendations for treatment. Sports Med. 1999 Apr;27(4):229–240. doi: 10.2165/00007256-199927040-00003. [DOI] [PubMed] [Google Scholar]
  4. Dickson D. N., Wilkinson R. L., Noakes T. D. Effects of ultra-marathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes. Int J Sports Med. 1982 May;3(2):111–117. doi: 10.1055/s-2008-1026073. [DOI] [PubMed] [Google Scholar]
  5. Fallon K. E., Sivyer G., Sivyer K., Dare A. Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon. Br J Sports Med. 1999 Feb;33(1):27–32. doi: 10.1136/bjsm.33.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jupe D. The acute phase response and laboratory testing. Aust Fam Physician. 1996 Mar;25(3):324–329. [PubMed] [Google Scholar]
  7. Konijn A. M. Iron metabolism in inflammation. Baillieres Clin Haematol. 1994 Dec;7(4):829–849. doi: 10.1016/s0950-3536(05)80127-1. [DOI] [PubMed] [Google Scholar]
  8. Kushner I., Rzewnicki D. L. The acute phase response: general aspects. Baillieres Clin Rheumatol. 1994 Aug;8(3):513–530. doi: 10.1016/s0950-3579(05)80113-x. [DOI] [PubMed] [Google Scholar]
  9. Kushner I. The phenomenon of the acute phase response. Ann N Y Acad Sci. 1982;389:39–48. doi: 10.1111/j.1749-6632.1982.tb22124.x. [DOI] [PubMed] [Google Scholar]
  10. Malczewska J., Błach W., Stupnicki R. The effects of physical exercise on the concentrations of ferritin and transferrin receptor in plasma of female judoists. Int J Sports Med. 2000 Apr;21(3):175–179. doi: 10.1055/s-2000-299. [DOI] [PubMed] [Google Scholar]
  11. Mast A. E., Blinder M. A., Gronowski A. M., Chumley C., Scott M. G. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem. 1998 Jan;44(1):45–51. [PubMed] [Google Scholar]
  12. Mattusch F., Dufaux B., Heine O., Mertens I., Rost R. Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med. 2000 Jan;21(1):21–24. doi: 10.1055/s-2000-8852. [DOI] [PubMed] [Google Scholar]
  13. Nielsen P., Nachtigall D. Iron supplementation in athletes. Current recommendations. Sports Med. 1998 Oct;26(4):207–216. doi: 10.2165/00007256-199826040-00001. [DOI] [PubMed] [Google Scholar]
  14. Poortmans J. R., Haralambie G. Biochemical changes in a 100 km run: proteins in serum and urine. Eur J Appl Physiol Occup Physiol. 1979 Mar 1;40(4):245–254. doi: 10.1007/BF00421516. [DOI] [PubMed] [Google Scholar]
  15. Seiler D., Nagel D., Franz H., Hellstern P., Leitzmann C., Jung K. Effects of long-distance running on iron metabolism and hematological parameters. Int J Sports Med. 1989 Oct;10(5):357–362. doi: 10.1055/s-2007-1024928. [DOI] [PubMed] [Google Scholar]
  16. Strachan A. F., Noakes T. D., Kotzenberg G., Nel A. E., de Beer F. C. C reactive protein concentrations during long distance running. Br Med J (Clin Res Ed) 1984 Nov 10;289(6454):1249–1251. doi: 10.1136/bmj.289.6454.1249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Taylor C., Rogers G., Goodman C., Baynes R. D., Bothwell T. H., Bezwoda W. R., Kramer F., Hattingh J. Hematologic, iron-related, and acute-phase protein responses to sustained strenuous exercise. J Appl Physiol (1985) 1987 Feb;62(2):464–469. doi: 10.1152/jappl.1987.62.2.464. [DOI] [PubMed] [Google Scholar]
  18. Weight L. M., Alexander D., Jacobs P. Strenuous exercise: analogous to the acute-phase response? Clin Sci (Lond) 1991 Nov;81(5):677–683. doi: 10.1042/cs0810677. [DOI] [PubMed] [Google Scholar]
  19. Witte D. L. Can serum ferritin be effectively interpreted in the presence of the acute-phase response? Clin Chem. 1991 Apr;37(4):484–485. [PubMed] [Google Scholar]

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