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British Journal of Sports Medicine logoLink to British Journal of Sports Medicine
. 2003 Aug;37(4):284–286. doi: 10.1136/bjsm.37.4.284

The inflammatory response: friend or enemy for muscle injury?

H Toumi 1, T Best 1
PMCID: PMC1724680  PMID: 12893707

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Selected References

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  1. Almekinders L. C., Gilbert J. A. Healing of experimental muscle strains and the effects of nonsteroidal antiinflammatory medication. Am J Sports Med. 1986 Jul-Aug;14(4):303–308. doi: 10.1177/036354658601400411. [DOI] [PubMed] [Google Scholar]
  2. Armstrong R. B., Warren G. L., Warren J. A. Mechanisms of exercise-induced muscle fibre injury. Sports Med. 1991 Sep;12(3):184–207. doi: 10.2165/00007256-199112030-00004. [DOI] [PubMed] [Google Scholar]
  3. Best T. M., Fiebig R., Corr D. T., Brickson S., Ji L. Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits. J Appl Physiol (1985) 1999 Jul;87(1):74–82. doi: 10.1152/jappl.1999.87.1.74. [DOI] [PubMed] [Google Scholar]
  4. Brickson S., Hollander J., Corr D. T., Ji L. L., Best T. M. Oxidant production and immune response after stretch injury in skeletal muscle. Med Sci Sports Exerc. 2001 Dec;33(12):2010–2015. doi: 10.1097/00005768-200112000-00006. [DOI] [PubMed] [Google Scholar]
  5. Cambria R. A., Anderson R. J., Dikdan G., Teehan E. P., Hernandez-Maldonado J. J., Hobson R. W., 2nd Leukocyte activation in ischemia-reperfusion injury of skeletal muscle. J Surg Res. 1991 Jul;51(1):13–17. doi: 10.1016/0022-4804(91)90063-r. [DOI] [PubMed] [Google Scholar]
  6. Carlson B. M., Faulkner J. A. The regeneration of skeletal muscle fibers following injury: a review. Med Sci Sports Exerc. 1983;15(3):187–198. [PubMed] [Google Scholar]
  7. Clarkson P. M. Exercise-induced muscle damage--animal and human models. Med Sci Sports Exerc. 1992 May;24(5):510–511. [PubMed] [Google Scholar]
  8. Crinnion J. N., Homer-Vanniasinkam S., Parkin S. M., Gough M. J. Role of neutrophil-endothelial adhesion in skeletal muscle reperfusion injury. Br J Surg. 1996 Feb;83(2):251–254. [PubMed] [Google Scholar]
  9. Fielding R. A., Manfredi T. J., Ding W., Fiatarone M. A., Evans W. J., Cannon J. G. Acute phase response in exercise. III. Neutrophil and IL-1 beta accumulation in skeletal muscle. Am J Physiol. 1993 Jul;265(1 Pt 2):R166–R172. doi: 10.1152/ajpregu.1993.265.1.R166. [DOI] [PubMed] [Google Scholar]
  10. Fielding R. A., Violan M. A., Svetkey L., Abad L. W., Manfredi T. J., Cosmas A., Bean J. Effects of prior exercise on eccentric exercise-induced neutrophilia and enzyme release. Med Sci Sports Exerc. 2000 Feb;32(2):359–364. doi: 10.1097/00005768-200002000-00015. [DOI] [PubMed] [Google Scholar]
  11. Fridén J., Sjöström M., Ekblom B. Myofibrillar damage following intense eccentric exercise in man. Int J Sports Med. 1983 Aug;4(3):170–176. doi: 10.1055/s-2008-1026030. [DOI] [PubMed] [Google Scholar]
  12. Jolly S. R., Kane W. J., Hook B. G., Abrams G. D., Kunkel S. L., Lucchesi B. R. Reduction of myocardial infarct size by neutrophil depletion: effect of duration of occlusion. Am Heart J. 1986 Oct;112(4):682–690. doi: 10.1016/0002-8703(86)90461-8. [DOI] [PubMed] [Google Scholar]
  13. Kearns S. R., Moneley D., Murray P., Kelly C., Daly A. F. Oral vitamin C attenuates acute ischaemia-reperfusion injury in skeletal muscle. J Bone Joint Surg Br. 2001 Nov;83(8):1202–1206. doi: 10.1302/0301-620x.83b8.11754. [DOI] [PubMed] [Google Scholar]
  14. Korthuis R. J., Grisham M. B., Granger D. N. Leukocyte depletion attenuates vascular injury in postischemic skeletal muscle. Am J Physiol. 1988 May;254(5 Pt 2):H823–H827. doi: 10.1152/ajpheart.1988.254.5.H823. [DOI] [PubMed] [Google Scholar]
  15. Lapointe Benoît M., Frenette Jérôme, Côté Claude H. Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion. J Appl Physiol (1985) 2002 May;92(5):1995–2004. doi: 10.1152/japplphysiol.00803.2001. [DOI] [PubMed] [Google Scholar]
  16. Mishra D. K., Fridén J., Schmitz M. C., Lieber R. L. Anti-inflammatory medication after muscle injury. A treatment resulting in short-term improvement but subsequent loss of muscle function. J Bone Joint Surg Am. 1995 Oct;77(10):1510–1519. doi: 10.2106/00004623-199510000-00005. [DOI] [PubMed] [Google Scholar]
  17. Nikolaou P. K., Macdonald B. L., Glisson R. R., Seaber A. V., Garrett W. E., Jr Biomechanical and histological evaluation of muscle after controlled strain injury. Am J Sports Med. 1987 Jan-Feb;15(1):9–14. doi: 10.1177/036354658701500102. [DOI] [PubMed] [Google Scholar]
  18. Obremsky W. T., Seaber A. V., Ribbeck B. M., Garrett W. E., Jr Biomechanical and histologic assessment of a controlled muscle strain injury treated with piroxicam. Am J Sports Med. 1994 Jul-Aug;22(4):558–561. doi: 10.1177/036354659402200420. [DOI] [PubMed] [Google Scholar]
  19. Pizza F. X., McLoughlin T. J., McGregor S. J., Calomeni E. P., Gunning W. T. Neutrophils injure cultured skeletal myotubes. Am J Physiol Cell Physiol. 2001 Jul;281(1):C335–C341. doi: 10.1152/ajpcell.2001.281.1.C335. [DOI] [PubMed] [Google Scholar]
  20. Pizza F. X., Mitchell J. B., Davis B. H., Starling R. D., Holtz R. W., Bigelow N. Exercise-induced muscle damage: effect on circulating leukocyte and lymphocyte subsets. Med Sci Sports Exerc. 1995 Mar;27(3):363–370. [PubMed] [Google Scholar]
  21. Pizza Francis X., Koh Timothy J., McGregor Stephen J., Brooks Susan V. Muscle inflammatory cells after passive stretches, isometric contractions, and lengthening contractions. J Appl Physiol (1985) 2002 May;92(5):1873–1878. doi: 10.1152/japplphysiol.01055.2001. [DOI] [PubMed] [Google Scholar]
  22. Rosen G. M., Pou S., Ramos C. L., Cohen M. S., Britigan B. E. Free radicals and phagocytic cells. FASEB J. 1995 Feb;9(2):200–209. doi: 10.1096/fasebj.9.2.7540156. [DOI] [PubMed] [Google Scholar]
  23. Saxton John M., Claxton David, Winter Edward, Pockley A. Graham. Peripheral blood leucocyte functional responses to acute eccentric exercise in humans are influenced by systemic stress, but not by exercise-induced muscle damage. Clin Sci (Lond) 2003 Jan;104(1):69–77. doi: 10.1042/. [DOI] [PubMed] [Google Scholar]
  24. Schneider Barbara St Pierre, Sannes Heather, Fine Jason, Best Thomas. Desmin characteristics of CD11b-positive fibers after eccentric contractions. Med Sci Sports Exerc. 2002 Feb;34(2):274–281. doi: 10.1097/00005768-200202000-00015. [DOI] [PubMed] [Google Scholar]
  25. Seale P., Rudnicki M. A. A new look at the origin, function, and "stem-cell" status of muscle satellite cells. Dev Biol. 2000 Feb 15;218(2):115–124. doi: 10.1006/dbio.1999.9565. [DOI] [PubMed] [Google Scholar]
  26. Smith L. L. Acute inflammation: the underlying mechanism in delayed onset muscle soreness? Med Sci Sports Exerc. 1991 May;23(5):542–551. [PubMed] [Google Scholar]
  27. Tidball J. G. Inflammatory cell response to acute muscle injury. Med Sci Sports Exerc. 1995 Jul;27(7):1022–1032. doi: 10.1249/00005768-199507000-00011. [DOI] [PubMed] [Google Scholar]
  28. Warren G. L., Ingalls C. P., Shah S. J., Armstrong R. B. Uncoupling of in vivo torque production from EMG in mouse muscles injured by eccentric contractions. J Physiol. 1999 Mar 1;515(Pt 2):609–619. doi: 10.1111/j.1469-7793.1999.609ac.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Welbourn C. R., Goldman G., Paterson I. S., Valeri C. R., Shepro D., Hechtman H. B. Neutrophil elastase and oxygen radicals: synergism in lung injury after hindlimb ischemia. Am J Physiol. 1991 Jun;260(6 Pt 2):H1852–H1856. doi: 10.1152/ajpheart.1991.260.6.H1852. [DOI] [PubMed] [Google Scholar]

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