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. 1989 Apr;33(4):576–579. doi: 10.1128/aac.33.4.576

In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.

T Inoue 1, K Tsushita 1, T Itoh 1, M Ogura 1, T Hotta 1, M Saneyoshi 1, S Yoshida 1, H Saitoh 1, Y Tomoda 1, Y Nagai 1
PMCID: PMC172483  PMID: 2543285

Abstract

3'-Azido-2',3'-dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2',3'-dideoxycytidine, it frequently impairs thrombocytogenesis. These differential myelossuppressive features correlated well with the in vitro toxicities of the drugs for a megakaryoblastic cell line and for colony formation of erythroid and granulocytic cells.

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Selected References

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