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. 2005 Jan;39(1):15–19. doi: 10.1136/bjsm.2003.009886

Does oral contraceptive use affect maximum force production in women?

K Elliott 1, N Cable 1, T Reilly 1
PMCID: PMC1725011  PMID: 15618333

Abstract

Objective: To examine the effects of oral contraceptive use on maximum force production in young women.

Methods: In the study, 21 female subjects (14 pill users and seven eumenorrheic controls) took part. All pill using subjects had been taking a combined, monophasic oral contraceptive pill for at least 6 months. Maximum dynamic and isometric leg strength, maximum isometric strength of the first dorsal interosseus (FDI) muscle, and plasma concentrations of oestradiol and progesterone were measured on days 7 and 14 of pill consumption and day 5 of pill withdrawal. The eumenorrheic group was tested (FDI strength and hormone concentrations) on days 2 and 21 of the menstrual cycle.

Results: There were no significant changes in the concentration of endogenous oestradiol or progesterone or any measure of muscle strength between pill phases (p<0.05). The pill group did not significantly differ from the eumenorrheic group (p<0.05), despite a significant increase in the concentration of progesterone and oestradiol on day 21 of the menstrual cycle compared with day 2 of the menstrual cycle and pill consumption and withdrawal (p<0.05).

Conclusions: These data suggest that oral contraceptive use does not significantly affect muscle strength. Moreover, oral contraceptive users were not stronger or weaker than their eumenorrheic counterparts.

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Selected References

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  1. Armstrong A. L., Oborne J., Coupland C. A., Macpherson M. B., Bassey E. J., Wallace W. A. Effects of hormone replacement therapy on muscle performance and balance in post-menopausal women. Clin Sci (Lond) 1996 Dec;91(6):685–690. doi: 10.1042/cs0910685. [DOI] [PubMed] [Google Scholar]
  2. Bassey E. J., Mockett S. P., Fentem P. H. Lack of variation in muscle strength with menstrual status in healthy women aged 45-54 years: data from a national survey. Eur J Appl Physiol Occup Physiol. 1996;73(3-4):382–386. doi: 10.1007/BF02425503. [DOI] [PubMed] [Google Scholar]
  3. Bonen A., Ling W. Y., MacIntyre K. P., Neil R., McGrail J. C., Belcastro A. N. Effects of exercise on the serum concentrations of FSH, LH, progesterone, and estradiol. Eur J Appl Physiol Occup Physiol. 1979 Sep;42(1):15–23. doi: 10.1007/BF00421100. [DOI] [PubMed] [Google Scholar]
  4. Calmels P., Vico L., Alexandre C., Minaire P. Cross-sectional study of muscle strength and bone mineral density in a population of 106 women between the ages of 44 and 87 years: relationship with age and menopause. Eur J Appl Physiol Occup Physiol. 1995;70(2):180–186. doi: 10.1007/BF00361547. [DOI] [PubMed] [Google Scholar]
  5. Elliott K. J., Cable N. T., Reilly T., Diver M. J. Effect of menstrual cycle phase on the concentration of bioavailable 17-beta oestradiol and testosterone and muscle strength. Clin Sci (Lond) 2003 Dec;105(6):663–669. doi: 10.1042/CS20020360. [DOI] [PubMed] [Google Scholar]
  6. Elliott K. J., Sale C., Cable N. T. Effects of resistance training and detraining on muscle strength and blood lipid profiles in postmenopausal women. Br J Sports Med. 2002 Oct;36(5):340–344. doi: 10.1136/bjsm.36.5.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Greeves J. P., Cable N. T., Luckas M. J., Reilly T., Biljan M. M. Effects of acute changes in oestrogen on muscle function of the first dorsal interosseus muscle in humans. J Physiol. 1997 Apr 1;500(Pt 1):265–270. doi: 10.1113/jphysiol.1997.sp022016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Greeves J. P., Cable N. T., Reilly T., Kingsland C. Changes in muscle strength in women following the menopause: a longitudinal assessment of the efficacy of hormone replacement therapy. Clin Sci (Lond) 1999 Jul;97(1):79–84. [PubMed] [Google Scholar]
  9. Heikkinen J., Kyllönen E., Kurttila-Matero E., Wilén-Rosenqvist G., Lankinen K. S., Rita H., Vänänen H. K. HRT and exercise: effects on bone density, muscle strength and lipid metabolism. A placebo controlled 2-year prospective trial on two estrogen-progestin regimens in healthy postmenopausal women. Maturitas. 1997 Mar;26(2):139–149. doi: 10.1016/s0378-5122(96)01098-5. [DOI] [PubMed] [Google Scholar]
  10. Landgren B. M., Undén A. L., Diczfalusy E. Hormonal profile of the cycle in 68 normally menstruating women. Acta Endocrinol (Copenh) 1980 May;94(1):89–98. doi: 10.1530/acta.0.0940089. [DOI] [PubMed] [Google Scholar]
  11. Lanigan C., Howes T. Q., Borzone G., Vianna L. G., Moxham J. The effects of beta 2-agonists and caffeine on respiratory and limb muscle performance. Eur Respir J. 1993 Sep;6(8):1192–1196. [PubMed] [Google Scholar]
  12. McDonald K. S., Field L. J., Parmacek M. S., Soonpaa M., Leiden J. M., Moss R. L. Length dependence of Ca2+ sensitivity of tension in mouse cardiac myocytes expressing skeletal troponin C. J Physiol. 1995 Feb 15;483(Pt 1):131–139. doi: 10.1113/jphysiol.1995.sp020573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Onambele N. G., Skelton D. A., Bruce S. A., Woledge R. C. Follow-up study of the benefits of hormone replacement therapy on isometric muscle strength of adductor pollicis in postmenopausal women. Clin Sci (Lond) 2001 Apr;100(4):421–422. [PubMed] [Google Scholar]
  14. Phillips S. K., Rook K. M., Siddle N. C., Bruce S. A., Woledge R. C. Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy. Clin Sci (Lond) 1993 Jan;84(1):95–98. doi: 10.1042/cs0840095. [DOI] [PubMed] [Google Scholar]
  15. Phillips S. K., Sanderson A. G., Birch K., Bruce S. A., Woledge R. C. Changes in maximal voluntary force of human adductor pollicis muscle during the menstrual cycle. J Physiol. 1996 Oct 15;496(Pt 2):551–557. doi: 10.1113/jphysiol.1996.sp021706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Reichman M. E., Judd J. T., Longcope C., Schatzkin A., Clevidence B. A., Nair P. P., Campbell W. S., Taylor P. R. Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst. 1993 May 5;85(9):722–727. doi: 10.1093/jnci/85.9.722. [DOI] [PubMed] [Google Scholar]
  17. Reilly T. Human circadian rhythms and exercise. Crit Rev Biomed Eng. 1990;18(3):165–180. [PubMed] [Google Scholar]
  18. Rutherford O. M., Jones D. A. Contractile properties and fatiguability of the human adductor pollicis and first dorsal interosseus: a comparison of the effects of two chronic stimulation patterns. J Neurol Sci. 1988 Jul;85(3):319–331. doi: 10.1016/0022-510x(88)90190-6. [DOI] [PubMed] [Google Scholar]
  19. Rutherford O. M., Jones D. A. The relationship of muscle and bone loss and activity levels with age in women. Age Ageing. 1992 Jul;21(4):286–293. doi: 10.1093/ageing/21.4.286. [DOI] [PubMed] [Google Scholar]
  20. Sarwar R., Niclos B. B., Rutherford O. M. Changes in muscle strength, relaxation rate and fatiguability during the human menstrual cycle. J Physiol. 1996 May 15;493(Pt 1):267–272. doi: 10.1113/jphysiol.1996.sp021381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Seeley D. G., Cauley J. A., Grady D., Browner W. S., Nevitt M. C., Cummings S. R. Is postmenopausal estrogen therapy associated with neuromuscular function or falling in elderly women? Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1995 Feb 13;155(3):293–299. [PubMed] [Google Scholar]
  22. Skelton D. A., Phillips S. K., Bruce S. A., Naylor C. H., Woledge R. C. Hormone replacement therapy increases isometric muscle strength of adductor pollicis in post-menopausal women. Clin Sci (Lond) 1999 Apr;96(4):357–364. [PubMed] [Google Scholar]
  23. Taaffe D. R., Luz Villa M., Delay R., Marcus R. Maximal muscle strength of elderly women is not influenced by oestrogen status. Age Ageing. 1995 Jul;24(4):329–333. doi: 10.1093/ageing/24.4.329. [DOI] [PubMed] [Google Scholar]
  24. Tanaka M., McDonagh M. J., Davies C. T. A comparison of the mechanical properties of the first dorsal interosseous in the dominant and non-dominant hand. Eur J Appl Physiol Occup Physiol. 1984;53(1):17–20. doi: 10.1007/BF00964683. [DOI] [PubMed] [Google Scholar]
  25. Wirth J. C., Lohman T. G. The relationship of static muscle function to use of oral contraceptives. Med Sci Sports Exerc. 1982;14(1):16–20. doi: 10.1249/00005768-198201000-00003. [DOI] [PubMed] [Google Scholar]
  26. York J. L. The drinking day as a unit of exposure in the epidemiology of alcohol-related medical disorders. Alcohol. 1998 Oct;16(3):231–236. doi: 10.1016/s0741-8329(98)00007-x. [DOI] [PubMed] [Google Scholar]
  27. Young A., Stokes M., Crowe M. Size and strength of the quadriceps muscles of old and young women. Eur J Clin Invest. 1984 Aug;14(4):282–287. doi: 10.1111/j.1365-2362.1984.tb01182.x. [DOI] [PubMed] [Google Scholar]
  28. de Valk-de Roo G. W., Netelenbos J. C., Peters-Muller I. R., Voetberg G. A., van de Weijer P. H., Bouman A. A., Popp-Snijders C., Kenemans P. Continuously combined hormone replacement therapy and bone turnover: the influence of dydrogesterone dose, smoking and initial degree of bone turnover. Maturitas. 1997 Dec 15;28(2):153–162. doi: 10.1016/s0378-5122(97)00070-4. [DOI] [PubMed] [Google Scholar]

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