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. 1989 May;33(5):767–770. doi: 10.1128/aac.33.5.767

Ceftriaxone-netilmicin combination in single-daily-dose treatment of experimental Escherichia coli endocarditis.

B Fantin 1, B Pangon 1, G Potel 1, J M Vallois 1, F Caron 1, A Bure 1, C Carbon 1
PMCID: PMC172530  PMID: 2665645

Abstract

We evaluated the activities of ceftriaxone (15 mg/kg), netilmicin (6 mg/kg), and their combination given intramuscularly once daily for 4 days for the treatment of experimental Escherichia coli endocarditis in rabbits. In vitro, a greater rate of killing and an increased trough serum bactericidal titer (P less than 0.01) were achieved with the combination. In vivo, the combination had a greater bactericidal effect (P less than 0.01) and resulted in a greater number of sterile vegetations (P less than 0.05) than single-drug therapy. Thus, in vivo, an increased effect can be obtained despite a single daily dose of a long-acting cephalosporin and an aminoglycoside.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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