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British Journal of Sports Medicine logoLink to British Journal of Sports Medicine
. 2005 Sep;39(9):665–670. doi: 10.1136/bjsm.2004.017194

Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses

A McKune 1, L Smith 1, S Semple 1, A Wadee 1
PMCID: PMC1725321  PMID: 16118307

Abstract

Background: Strenuous exercise is associated with tissue damage. This activates the innate immune system and local inflammation. Interaction between innate and adaptive immunity is essential for maintaining health, suggesting that the adaptive immune system may also be altered by exercise.

Objectives: To determine exercise induced changes in the adaptive immune system by measuring the immunoglobulin isotype and subclass response to an ultra-marathon.

Methods: Venepuncture was performed on 11 experienced volunteers (six men, five women; mean (SD) age 43 (9.8) years) 24 hours before the projected finishing time and immediately after and 3, 24, and 72 hours after an ultra-marathon (90 km). Serum was stored at –80°C. IgM, IgD, IgA, IgG, IgG1, 2, 3, and 4, and total IgE were measured.

Results: The following immunoglobulins were significantly (p⩽0.05) altered after the race: IgD, immediately (–51%) and 24 hours (–41%) after; IgM 24 hours after (–23%); total IgG immediately after (+12%). There were no reports of symptoms of upper respiratory tract infections after the ultra-marathon.

Conclusions: In experienced ultra-endurance runners, alterations in immunoglobulin concentrations after a race suggest an enhanced immune response, including isotype switching, interactions with the innate immune system, and a secondary antibody response. These alterations may have a role in the maintenance of subject health after an ultra-marathon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boes M. Role of natural and immune IgM antibodies in immune responses. Mol Immunol. 2000 Dec;37(18):1141–1149. doi: 10.1016/s0161-5890(01)00025-6. [DOI] [PubMed] [Google Scholar]
  2. Ceddia M. A., Woods J. A. Exercise suppresses macrophage antigen presentation. J Appl Physiol (1985) 1999 Dec;87(6):2253–2258. doi: 10.1152/jappl.1999.87.6.2253. [DOI] [PubMed] [Google Scholar]
  3. Coffman R. L., Lebman D. A., Rothman P. Mechanism and regulation of immunoglobulin isotype switching. Adv Immunol. 1993;54:229–270. doi: 10.1016/s0065-2776(08)60536-2. [DOI] [PubMed] [Google Scholar]
  4. Crotty Shane, Ahmed Rafi. Immunological memory in humans. Semin Immunol. 2004 Jun;16(3):197–203. doi: 10.1016/j.smim.2004.02.008. [DOI] [PubMed] [Google Scholar]
  5. Dill D. B., Costill D. L. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 1974 Aug;37(2):247–248. doi: 10.1152/jappl.1974.37.2.247. [DOI] [PubMed] [Google Scholar]
  6. Elenkov I. J., Wilder R. L., Chrousos G. P., Vizi E. S. The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev. 2000 Dec;52(4):595–638. [PubMed] [Google Scholar]
  7. Gleeson M. Mucosal immunity and respiratory illness in elite athletes. Int J Sports Med. 2000 May;21 (Suppl 1):S33–S43. doi: 10.1055/s-2000-1450. [DOI] [PubMed] [Google Scholar]
  8. Gmünder F. K., Joller P. W., Joller-Jemelka H. I., Bechler B., Cogoli M., Ziegler W. H., Müller J., Aeppli R. E., Cogoli A. Effect of a herbal yeast food supplement and long-distance running on immunological parameters. Br J Sports Med. 1990 Jun;24(2):103–112. doi: 10.1136/bjsm.24.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hanson P. G., Flaherty D. K. Immunological responses to training in conditioned runners. Clin Sci (Lond) 1981 Feb;60(2):225–228. doi: 10.1042/cs0600225. [DOI] [PubMed] [Google Scholar]
  10. Kendall A., Hoffman-Goetz L., Houston M., MacNeil B., Arumugam Y. Exercise and blood lymphocyte subset responses: intensity, duration, and subject fitness effects. J Appl Physiol (1985) 1990 Jul;69(1):251–260. doi: 10.1152/jappl.1990.69.1.251. [DOI] [PubMed] [Google Scholar]
  11. Lakier Smith Lucille. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med. 2003;33(5):347–364. doi: 10.2165/00007256-200333050-00002. [DOI] [PubMed] [Google Scholar]
  12. Mackinnon L. T., Hooper S. Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining. Int J Sports Med. 1994 Oct;15 (Suppl 3):S179–S183. doi: 10.1055/s-2007-1021134. [DOI] [PubMed] [Google Scholar]
  13. Mars M., Govender S., Weston A., Naicker V., Chuturgoon A. High intensity exercise: a cause of lymphocyte apoptosis? Biochem Biophys Res Commun. 1998 Aug 19;249(2):366–370. doi: 10.1006/bbrc.1998.9156. [DOI] [PubMed] [Google Scholar]
  14. Mashiko T., Umeda T., Nakaji S., Sugawara K. Effects of exercise on the physical condition of college rugby players during summer training camp. Br J Sports Med. 2004 Apr;38(2):186–190. doi: 10.1136/bjsm.2002.004333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Nehlsen-Cannarella S. L., Nieman D. C., Jessen J., Chang L., Gusewitch G., Blix G. G., Ashley E. The effects of acute moderate exercise on lymphocyte function and serum immunoglobulin levels. Int J Sports Med. 1991 Aug;12(4):391–398. doi: 10.1055/s-2007-1024700. [DOI] [PubMed] [Google Scholar]
  16. Nieman D. C., Johanssen L. M., Lee J. W., Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness. 1990 Sep;30(3):316–328. [PubMed] [Google Scholar]
  17. Nieman D. C., Nehlsen-Cannarella S. L. The effects of acute and chronic exercise of immunoglobulins. Sports Med. 1991 Mar;11(3):183–201. doi: 10.2165/00007256-199111030-00003. [DOI] [PubMed] [Google Scholar]
  18. Nieman D. C., Tan S. A., Lee J. W., Berk L. S. Complement and immunoglobulin levels in athletes and sedentary controls. Int J Sports Med. 1989 Apr;10(2):124–128. doi: 10.1055/s-2007-1024887. [DOI] [PubMed] [Google Scholar]
  19. Ohlin Mats, Zouali Moncef. The human antibody repertoire to infectious agents: implications for disease pathogenesis. Mol Immunol. 2003 Sep;40(1):1–11. doi: 10.1016/s0161-5890(03)00099-3. [DOI] [PubMed] [Google Scholar]
  20. Pedersen B. K., Ullum H. NK cell response to physical activity: possible mechanisms of action. Med Sci Sports Exerc. 1994 Feb;26(2):140–146. doi: 10.1249/00005768-199402000-00003. [DOI] [PubMed] [Google Scholar]
  21. Peters E. M., Bateman E. D. Ultramarathon running and upper respiratory tract infections. An epidemiological survey. S Afr Med J. 1983 Oct 1;64(15):582–584. [PubMed] [Google Scholar]
  22. Peters E. M., Goetzsche J. M., Grobbelaar B., Noakes T. D. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993 Feb;57(2):170–174. doi: 10.1093/ajcn/57.2.170. [DOI] [PubMed] [Google Scholar]
  23. Petibois C., Cazorla G., Déléris G. The biological and metabolic adaptations to 12 months training in elite rowers. Int J Sports Med. 2003 Jan;24(1):36–42. doi: 10.1055/s-2003-37194. [DOI] [PubMed] [Google Scholar]
  24. Poortmans J. R., Haralambie G. Biochemical changes in a 100 km run: proteins in serum and urine. Eur J Appl Physiol Occup Physiol. 1979 Mar 1;40(4):245–254. doi: 10.1007/BF00421516. [DOI] [PubMed] [Google Scholar]
  25. Poortmans J. R. Serum protein determination during short exhaustive physical activity. J Appl Physiol. 1971 Feb;30(2):190–192. doi: 10.1152/jappl.1971.30.2.190. [DOI] [PubMed] [Google Scholar]
  26. Romagnani S. The Th1/Th2 paradigm and allergic disorders. Allergy. 1998;53(46 Suppl):12–15. doi: 10.1111/j.1398-9995.1998.tb04951.x. [DOI] [PubMed] [Google Scholar]
  27. Ross W. D., Wilson N. C. A strategem for proportional growth assessment. Acta Paediatr Belg. 1974;28 Suppl:169–182. [PubMed] [Google Scholar]
  28. Smith Taro P., Kennedy Sarah L., Fleshner Monika. Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men. J Appl Physiol (1985) 2004 Aug;97(2):491–498. doi: 10.1152/japplphysiol.01404.2003. [DOI] [PubMed] [Google Scholar]
  29. Stavnezer J. Immunoglobulin class switching. Curr Opin Immunol. 1996 Apr;8(2):199–205. doi: 10.1016/s0952-7915(96)80058-6. [DOI] [PubMed] [Google Scholar]
  30. Whitham M., Blannin A. K. The effect of exercise training on the kinetics of the antibody response to influenza vaccination. J Sports Sci. 2003 Dec;21(12):991–1000. doi: 10.1080/0264041031000140464. [DOI] [PubMed] [Google Scholar]

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