Abstract
beta-Lactamase production in biological fluids was evaluated by using an antibiotic-resistant Pseudomonas aeruginosa strain. Enzyme production was low in plasma or ascitic fluid and high in urine. Induction of beta-lactamase by imipenem was studied by using an inducible P. aeruginosa strain. Induction was lower in biological fluids than in Mueller-Hinton broth.
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Selected References
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- Aronoff S. C., Shlaes D. M. Factors that influence the evolution of beta-lactam resistance in beta-lactamase-inducible strains of Enterobacter cloacae and Pseudomonas aeruginosa. J Infect Dis. 1987 May;155(5):936–941. doi: 10.1093/infdis/155.5.936. [DOI] [PubMed] [Google Scholar]
- Dalhoff A., Cullmann W. Specificity of beta-lactamase induction in Pseudomonas aeruginosa. J Antimicrob Chemother. 1984 Oct;14(4):349–357. doi: 10.1093/jac/14.4.349. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Letendre E. D., Mantha R., Turgeon P. L. Selection of resistance by piperacillin during Pseudomonas aeruginosa endocarditis. J Antimicrob Chemother. 1988 Oct;22(4):557–562. doi: 10.1093/jac/22.4.557. [DOI] [PubMed] [Google Scholar]
- O'Callaghan C. H., Morris A., Kirby S. M., Shingler A. H. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother. 1972 Apr;1(4):283–288. doi: 10.1128/aac.1.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanders C. C., Sanders W. E., Jr Emergence of resistance during therapy with the newer beta-lactam antibiotics: role of inducible beta-lactamases and implications for the future. Rev Infect Dis. 1983 Jul-Aug;5(4):639–648. doi: 10.1093/clinids/5.4.639. [DOI] [PubMed] [Google Scholar]