Abstract
Objective: To describe the aetiology and outcome of apparent life threatening events (ALTE) presenting to an emergency department (ED), and to assess the value of an initial investigation protocol.
Design: A 12 month prospective study of infants under 1 year of age who presented to a children's hospital ED after an ALTE. A standardised history sheet and initial investigation protocol were used. All infants were admitted to hospital and followed up at six months.
Results: There were 65 infants recruited, median age 7 weeks. None had died at the time of writing. Diagnoses included gastro-oesophageal reflux n=17 (26%), pertussis, n=6 (9%), seizures, n=6 (9%), urinary tract infection (5), factitious illness (2), brain tumour, atrial tachycardia, persistent ductus arteriosus and opioid related apnoea. No diagnosis was reached in 15 cases (23%). Fifty seven (88%) had only one admission to hospital for ALTE. More serious diagnoses were associated with a presentation age over 2 months, abnormal initial clinical examination, and recurrent ALTE.
Conclusions: ALTEs presenting to the ED may remain as a single, unexplained event or be attributable to numerous causes, ranging from minor to serious. Knowledge of the commoner causes and factors associated with higher risk could result in a more targeted approach, improving the decision making process and benefiting both infants and parents.
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Selected References
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- Arens R., Gozal D., Williams J. C., Ward S. L., Keens T. G. Recurrent apparent life-threatening events during infancy: a manifestation of inborn errors of metabolism. J Pediatr. 1993 Sep;123(3):415–418. doi: 10.1016/s0022-3476(05)81747-0. [DOI] [PubMed] [Google Scholar]
- Ariagno R. L., Guilleminault C., Korobkin R., Owen-Boeddiker M., Baldwin R. 'Near-miss' for sudden infant death syndrome infants: a clinical problem. Pediatrics. 1983 May;71(5):726–730. [PubMed] [Google Scholar]
- Duffty P., Bryan M. H. Home apnea monitoring in 'near-miss' sudden infant death syndrome (SIDS) and in siblings of SIDS victims. Pediatrics. 1982 Jul;70(1):69–74. [PubMed] [Google Scholar]
- Dunne K., Matthews T. Near-miss sudden infant death syndrome: clinical findings and management. Pediatrics. 1987 Jun;79(6):889–893. [PubMed] [Google Scholar]
- Gray C., Davies F., Molyneux E. Apparent life-threatening events presenting to a pediatric emergency department. Pediatr Emerg Care. 1999 Jun;15(3):195–199. doi: 10.1097/00006565-199906000-00009. [DOI] [PubMed] [Google Scholar]
- Guilleminault C. SIDS, near-miss SIDS and cardiac arrhythmia. Ann N Y Acad Sci. 1988;533:358–367. doi: 10.1111/j.1749-6632.1988.tb37264.x. [DOI] [PubMed] [Google Scholar]
- Harpey J. P., Charpentier C., Paturneau-Jouas M. Sudden infant death syndrome and inherited disorders of fatty acid beta-oxidation. Biol Neonate. 1990;58 (Suppl 1):70–80. doi: 10.1159/000243301. [DOI] [PubMed] [Google Scholar]
- Hartmann H., Seidenberg J., Noyes J. P., O'Brien L., Poets C. F., Samuels M. P., Southall D. P. Small airway patency in infants with apparent life-threatening events. Eur J Pediatr. 1998 Jan;157(1):71–74. doi: 10.1007/s004310050770. [DOI] [PubMed] [Google Scholar]
- Hickson G. B., Altemeier W. A., Martin E. D., Campbell P. W. Parental administration of chemical agents: a cause of apparent life-threatening events. Pediatrics. 1989 May;83(5):772–776. [PubMed] [Google Scholar]
- Kahn A., Riazi J., Blum D. Oculocardiac reflex in near miss for sudden infant death syndrome infants. Pediatrics. 1983 Jan;71(1):49–52. [PubMed] [Google Scholar]
- Keeton B. R., Southall E., Rutter N., Anderson R. H., Shinebourne E. A., Southall D. P. Cardiac conduction disorders in six infants with "near-miss" sudden infant deaths. Br Med J. 1977 Sep 3;2(6087):600–601. doi: 10.1136/bmj.2.6087.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis J. M., Ganick D. J. Initial laboratory evaluation of infants with 'presumed near-miss' sudden infant death syndrome. Am J Dis Child. 1986 May;140(5):484–486. doi: 10.1001/archpedi.1986.02140190094035. [DOI] [PubMed] [Google Scholar]
- Masters I. B., Vance J., Hills B. A. Surfactant abnormalities in ALTE and SIDS. Arch Dis Child. 1994 Dec;71(6):501–505. doi: 10.1136/adc.71.6.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMurray J. S., Holinger L. D. Otolaryngic manifestations in children presenting with apparent life-threatening events. Otolaryngol Head Neck Surg. 1997 Jun;116(6 Pt 1):575–579. doi: 10.1016/S0194-59989770230-4. [DOI] [PubMed] [Google Scholar]
- Poets C. F., Samuels M. P., Noyes J. P., Hewertson J., Hartmann H., Holder A., Southall D. P. Home event recordings of oxygenation, breathing movements, and heart rate and rhythm in infants with recurrent life-threatening events. J Pediatr. 1993 Nov;123(5):693–701. doi: 10.1016/s0022-3476(05)80842-x. [DOI] [PubMed] [Google Scholar]
- Poets C. F., Samuels M. P., Wardrop C. A., Picton-Jones E., Southall D. P. Reduced haemoglobin levels in infants presenting with apparent life-threatening events--a retrospective investigation. Acta Paediatr. 1992 Apr;81(4):319–321. doi: 10.1111/j.1651-2227.1992.tb12234.x. [DOI] [PubMed] [Google Scholar]
- Rahilly P. M. The pneumographic and medical investigation of infants suffering apparent life threatening episodes. J Paediatr Child Health. 1991 Dec;27(6):349–353. doi: 10.1111/j.1440-1754.1991.tb00417.x. [DOI] [PubMed] [Google Scholar]
- Samuels M. P., Poets C. F., Noyes J. P., Hartmann H., Hewertson J., Southall D. P. Diagnosis and management after life threatening events in infants and young children who received cardiopulmonary resuscitation. BMJ. 1993 Feb 20;306(6876):489–492. doi: 10.1136/bmj.306.6876.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sivan Y., Ben-Ari J., Schonfeld T. M. Laryngomalacia: a cause for early near miss for SIDS. Int J Pediatr Otorhinolaryngol. 1991 Feb;21(1):59–64. doi: 10.1016/0165-5876(91)90060-o. [DOI] [PubMed] [Google Scholar]
- Southall D. P., Janczynski R. E., Alexander J. R., Taylor V. G., Stebbens V. A. Cardiorespiratory patterns in infants presenting with apparent life-threatening episodes. Biol Neonate. 1990;57(2):77–87. doi: 10.1159/000243167. [DOI] [PubMed] [Google Scholar]
- Southall D. P., Plunkett M. C., Banks M. W., Falkov A. F., Samuels M. P. Covert video recordings of life-threatening child abuse: lessons for child protection. Pediatrics. 1997 Nov;100(5):735–760. doi: 10.1542/peds.100.5.735. [DOI] [PubMed] [Google Scholar]
- Southall D. P., Samuels M. P., Talbert D. G. Recurrent cyanotic episodes with severe arterial hypoxaemia and intrapulmonary shunting: a mechanism for sudden death. Arch Dis Child. 1990 Sep;65(9):953–961. doi: 10.1136/adc.65.9.953. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tirosh E., Colin A. A., Tal Y., Kolikovsky Z., Jaffe M. Practical approach to the diagnosis and treatment of apnea of infancy. Isr J Med Sci. 1990 Aug;26(8):429–433. [PubMed] [Google Scholar]
- Tirosh E., Haddad F., Lanir A., Tal Y., Cohen A. Relationship of sweat electrolytes to apparent life-threatening events (ALTE): a case control study. Acta Paediatr. 1994 Dec;83(12):1268–1271. doi: 10.1111/j.1651-2227.1994.tb13012.x. [DOI] [PubMed] [Google Scholar]
- Veereman-Wauters G., Bochner A., Van Caillie-Bertrand M. Gastroesophageal reflux in infants with a history of near-miss sudden infant death. J Pediatr Gastroenterol Nutr. 1991 Apr;12(3):319–323. doi: 10.1097/00005176-199104000-00005. [DOI] [PubMed] [Google Scholar]
- Wennergren G., Milerad J., Lagercrantz H., Karlberg P., Svenningsen N. W., Sedin G., Andersson D., Grögaard J., Bjure J. The epidemiology of sudden infant death syndrome and attacks of lifelessness in Sweden. Acta Paediatr Scand. 1987 Nov;76(6):898–906. doi: 10.1111/j.1651-2227.1987.tb17261.x. [DOI] [PubMed] [Google Scholar]