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. 1989 Aug;33(8):1395–1399. doi: 10.1128/aac.33.8.1395

Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.

D M Coen 1, D J Goldstein 1, S K Weller 1
PMCID: PMC172665  PMID: 2552912

Abstract

Two mutants defective in herpes simplex virus-encoded ribonucleotide reductase activity exhibited the novel phenotype of hypersensitivity to acyclovir, aphidicolin, and to a lesser extent, phosphonoacetic acid. These results have implications for acyclovir resistance and the development of drugs that potentiate acyclovir action by inhibition of viral ribonucleotide reductase.

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Selected References

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