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. 1989 Sep;33(9):1606–1608. doi: 10.1128/aac.33.9.1606

Antagonism of the cytotoxic but not antiviral effects of ara-sangivamycin by adenosine.

G M Birch 1, S H Krawczyk 1, L B Townsend 1, J C Drach 1
PMCID: PMC172710  PMID: 2554803

Abstract

Inhibition of DNA synthesis by ara-sangivamycin was antagonized by adenosine. The 50% inhibitory concentrations increased 1.6- to 32-fold in the presence of 1.0 to 50 microM adenosine, respectively. In contrast, the inhibition of human cytomegalovirus replication by ara-sangivamycin was not antagonized by as much as 50 microM adenosine. This suggests that different enzymes were responsible for the phosphorylation of ara-sangivamycin in uninfected and infected cells.

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Selected References

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