Skip to main content
NCBI home page
Gut logoLink to Gut
. 1998 Oct;43(4):456–457. doi: 10.1136/gut.43.4.456

The medium is the messenger

A PHILLIPS 1
PMCID: PMC1727282  PMID: 9824568

Full Text

The Full Text of this article is available as a PDF (73.2 KB).

Figure 1 .

Figure 1

Open in a new tab

Diagram of the EPEC attaching-effacing lesion showing the proteins involved. EspA delivery of Tir and EspB, and pedestal formation. 


Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Collazo C. M., Galán J. E. The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell. Mol Microbiol. 1997 May;24(4):747–756. doi: 10.1046/j.1365-2958.1997.3781740.x. [DOI] [PubMed] [Google Scholar]
  2. Cornelis G. R., Wolf-Watz H. The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells. Mol Microbiol. 1997 Mar;23(5):861–867. doi: 10.1046/j.1365-2958.1997.2731623.x. [DOI] [PubMed] [Google Scholar]
  3. Deibel C., Krämer S., Chakraborty T., Ebel F. EspE, a novel secreted protein of attaching and effacing bacteria, is directly translocated into infected host cells, where it appears as a tyrosine-phosphorylated 90 kDa protein. Mol Microbiol. 1998 May;28(3):463–474. doi: 10.1046/j.1365-2958.1998.00798.x. [DOI] [PubMed] [Google Scholar]
  4. Donnenberg M. S., Kaper J. B. Enteropathogenic Escherichia coli. Infect Immun. 1992 Oct;60(10):3953–3961. doi: 10.1128/iai.60.10.3953-3961.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Donnenberg M. S., Kaper J. B., Finlay B. B. Interactions between enteropathogenic Escherichia coli and host epithelial cells. Trends Microbiol. 1997 Mar;5(3):109–114. doi: 10.1016/S0966-842X(97)01000-7. [DOI] [PubMed] [Google Scholar]
  6. Elliott S. J., Wainwright L. A., McDaniel T. K., Jarvis K. G., Deng Y. K., Lai L. C., McNamara B. P., Donnenberg M. S., Kaper J. B. The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69. Mol Microbiol. 1998 Apr;28(1):1–4. doi: 10.1046/j.1365-2958.1998.00783.x. [DOI] [PubMed] [Google Scholar]
  7. Ginocchio C. C., Olmsted S. B., Wells C. L., Galán J. E. Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium. Cell. 1994 Feb 25;76(4):717–724. doi: 10.1016/0092-8674(94)90510-x. [DOI] [PubMed] [Google Scholar]
  8. Hicks S., Frankel G., Kaper J. B., Dougan G., Phillips A. D. Role of intimin and bundle-forming pili in enteropathogenic Escherichia coli adhesion to pediatric intestinal tissue in vitro. Infect Immun. 1998 Apr;66(4):1570–1578. doi: 10.1128/iai.66.4.1570-1578.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kaper J. B. EPEC delivers the goods. Trends Microbiol. 1998 May;6(5):169–173. doi: 10.1016/s0966-842x(98)01266-9. [DOI] [PubMed] [Google Scholar]
  10. Kenny B., DeVinney R., Stein M., Reinscheid D. J., Frey E. A., Finlay B. B. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell. 1997 Nov 14;91(4):511–520. doi: 10.1016/s0092-8674(00)80437-7. [DOI] [PubMed] [Google Scholar]
  11. Knutton S., Baldwin T., Williams P. H., McNeish A. S. Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli. Infect Immun. 1989 Apr;57(4):1290–1298. doi: 10.1128/iai.57.4.1290-1298.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McDaniel T. K., Kaper J. B. A cloned pathogenicity island from enteropathogenic Escherichia coli confers the attaching and effacing phenotype on E. coli K-12. Mol Microbiol. 1997 Jan;23(2):399–407. doi: 10.1046/j.1365-2958.1997.2311591.x. [DOI] [PubMed] [Google Scholar]
  13. Moon H. W., Whipp S. C., Argenzio R. A., Levine M. M., Giannella R. A. Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines. Infect Immun. 1983 Sep;41(3):1340–1351. doi: 10.1128/iai.41.3.1340-1351.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ménard R., Prévost M. C., Gounon P., Sansonetti P., Dehio C. The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1254–1258. doi: 10.1073/pnas.93.3.1254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Nataro J. P., Kaper J. B. Diarrheagenic Escherichia coli. Clin Microbiol Rev. 1998 Jan;11(1):142–201. doi: 10.1128/cmr.11.1.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rosqvist R., Håkansson S., Forsberg A., Wolf-Watz H. Functional conservation of the secretion and translocation machinery for virulence proteins of yersiniae, salmonellae and shigellae. EMBO J. 1995 Sep 1;14(17):4187–4195. doi: 10.1002/j.1460-2075.1995.tb00092.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ulshen M. H., Rollo J. L. Pathogenesis of escherichia coli gastroenteritis in man--another mechanism. N Engl J Med. 1980 Jan 10;302(2):99–101. doi: 10.1056/NEJM198001103020207. [DOI] [PubMed] [Google Scholar]
  18. Wolff C., Nisan I., Hanski E., Frankel G., Rosenshine I. Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli. Mol Microbiol. 1998 Apr;28(1):143–155. doi: 10.1046/j.1365-2958.1998.00782.x. [DOI] [PubMed] [Google Scholar]
  19. Wood M. W., Rosqvist R., Mullan P. B., Edwards M. H., Galyov E. E. SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry. Mol Microbiol. 1996 Oct;22(2):327–338. doi: 10.1046/j.1365-2958.1996.00116.x. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES