Skip to main content
Gut logoLink to Gut
. 1999 Aug;45(2):159–163. doi: 10.1136/gut.45.2.159

Hepatitis C and liver transplantation

M BERENGUER 1, T WRIGHT 1
PMCID: PMC1727595  PMID: 10403720

Full Text

The Full Text of this article is available as a PDF (73.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berenguer M., Prieto M., Córdoba J., Rayón J. M., Carrasco D., Olaso V., San-Juan F., Gobernado M., Mir J., Berenguer J. Early development of chronic active hepatitis in recurrent hepatitis C virus infection after liver transplantation: association with treatment of rejection. J Hepatol. 1998 May;28(5):756–763. doi: 10.1016/s0168-8278(98)80224-9. [DOI] [PubMed] [Google Scholar]
  2. Berenguer M., Terrault N. A., Piatak M., Yun A., Kim J. P., Lau J. Y., Lake J. R., Roberts J. R., Ascher N. L., Ferrell L. Hepatitis G virus infection in patients with hepatitis C virus infection undergoing liver transplantation. Gastroenterology. 1996 Dec;111(6):1569–1575. doi: 10.1016/s0016-5085(96)70019-7. [DOI] [PubMed] [Google Scholar]
  3. Bizollon T., Palazzo U., Ducerf C., Chevallier M., Elliott M., Baulieux J., Pouyet M., Trepo C. Pilot study of the combination of interferon alfa and ribavirin as therapy of recurrent hepatitis C after liver transplantation. Hepatology. 1997 Aug;26(2):500–504. doi: 10.1002/hep.510260236. [DOI] [PubMed] [Google Scholar]
  4. Böker K. H., Dalley G., Bahr M. J., Maschek H., Tillmann H. L., Trautwein C., Oldhaver K., Bode U., Pichlmayr R., Manns M. P. Long-term outcome of hepatitis C virus infection after liver transplantation. Hepatology. 1997 Jan;25(1):203–210. doi: 10.1002/hep.510250137. [DOI] [PubMed] [Google Scholar]
  5. Casavilla F. A., Rakela J., Kapur S., Irish W., McMichael J., Demetris A. J., Starzl T. E., Fung J. J. Clinical outcome of patients infected with hepatitis C virus infection on survival after primary liver transplantation under tacrolimus. Liver Transpl Surg. 1998 Nov;4(6):448–454. doi: 10.1002/lt.500040605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cattral M. S., Krajden M., Wanless I. R., Rezig M., Cameron R., Greig P. D., Chung S. W., Levy G. A. A pilot study of ribavirin therapy for recurrent hepatitis C virus infection after liver transplantation. Transplantation. 1996 May 27;61(10):1483–1488. doi: 10.1097/00007890-199605270-00013. [DOI] [PubMed] [Google Scholar]
  7. Charlton M., Seaberg E., Wiesner R., Everhart J., Zetterman R., Lake J., Detre K., Hoofnagle J. Predictors of patient and graft survival following liver transplantation for hepatitis C. Hepatology. 1998 Sep;28(3):823–830. doi: 10.1002/hep.510280333. [DOI] [PubMed] [Google Scholar]
  8. Chazouilleres O., Kim M., Combs C., Ferrell L., Bacchetti P., Roberts J., Ascher N. L., Neuwald P., Wilber J., Urdea M. Quantitation of hepatitis C virus RNA in liver transplant recipients. Gastroenterology. 1994 Apr;106(4):994–999. doi: 10.1016/0016-5085(94)90759-5. [DOI] [PubMed] [Google Scholar]
  9. Di Martino V., Saurini F., Samuel D., Gigou M., Dussaix E., Reynès M., Bismuth H., Féray C. Long-term longitudinal study of intrahepatic hepatitis C virus replication after liver transplantation. Hepatology. 1997 Nov;26(5):1343–1350. doi: 10.1053/jhep.1997.v26.pm0009362382. [DOI] [PubMed] [Google Scholar]
  10. Donegan E., Wright T. L., Roberts J., Ascher N. L., Lake J. R., Neuwald P., Wilber J., Quan S., Kuramoto I. K., Dinello R. K. Detection of hepatitis C after liver transplantation. Four serologic tests compared. Am J Clin Pathol. 1995 Dec;104(6):673–679. doi: 10.1093/ajcp/104.6.673. [DOI] [PubMed] [Google Scholar]
  11. Doughty A. L., Spencer J. D., Cossart Y. E., McCaughan G. W. Cholestatic hepatitis after liver transplantation is associated with persistently high serum hepatitis C virus RNA levels. Liver Transpl Surg. 1998 Jan;4(1):15–21. doi: 10.1002/lt.500040102. [DOI] [PubMed] [Google Scholar]
  12. Ferrell L. D., Wright T. L., Roberts J., Ascher N., Lake J. Hepatitis C viral infection in liver transplant recipients. Hepatology. 1992 Oct;16(4):865–876. doi: 10.1002/hep.1840160403. [DOI] [PubMed] [Google Scholar]
  13. Féray C., Gigou M., Samuel D., Ducot B., Maisonneuve P., Reynès M., Bismuth A., Bismuth H. Incidence of hepatitis C in patients receiving different preparations of hepatitis B immunoglobulins after liver transplantation. Ann Intern Med. 1998 May 15;128(10):810–816. doi: 10.7326/0003-4819-128-10-199805150-00003. [DOI] [PubMed] [Google Scholar]
  14. Féray C., Gigou M., Samuel D., Paradis V., Mishiro S., Maertens G., Reynés M., Okamoto H., Bismuth H., Bréchot C. Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation. Gastroenterology. 1995 Apr;108(4):1088–1096. doi: 10.1016/0016-5085(95)90207-4. [DOI] [PubMed] [Google Scholar]
  15. Féray C., Gigou M., Samuel D., Paradis V., Wilber J., David M. F., Urdea M., Reynes M., Bréchot C., Bismuth H. The course of hepatitis C virus infection after liver transplantation. Hepatology. 1994 Nov;20(5):1137–1143. doi: 10.1002/hep.1840200506. [DOI] [PubMed] [Google Scholar]
  16. Féray C., Samuel D., Gigou M., Paradis V., David M. F., Lemonnier C., Reynès M., Bismuth H. An open trial of interferon alfa recombinant for hepatitis C after liver transplantation: antiviral effects and risk of rejection. Hepatology. 1995 Oct;22(4 Pt 1):1084–1089. [PubMed] [Google Scholar]
  17. Gane E. J., Lo S. K., Riordan S. M., Portmann B. C., Lau J. Y., Naoumov N. V., Williams R. A randomized study comparing ribavirin and interferon alfa monotherapy for hepatitis C recurrence after liver transplantation. Hepatology. 1998 May;27(5):1403–1407. doi: 10.1002/hep.510270530. [DOI] [PubMed] [Google Scholar]
  18. Gane E. J., Portmann B. C., Naoumov N. V., Smith H. M., Underhill J. A., Donaldson P. T., Maertens G., Williams R. Long-term outcome of hepatitis C infection after liver transplantation. N Engl J Med. 1996 Mar 28;334(13):815–820. doi: 10.1056/NEJM199603283341302. [DOI] [PubMed] [Google Scholar]
  19. Gane E. J., Tibbs C. J., Ramage J. K., Portmann B. C., Williams R. Ribavirin therapy for hepatitis C infection following liver transplantation. Transpl Int. 1995;8(1):61–64. doi: 10.1007/BF00366714. [DOI] [PubMed] [Google Scholar]
  20. Gayowski T., Singh N., Marino I. R., Vargas H., Wagener M., Wannstedt C., Morelli F., Laskus T., Fung J. J., Rakela J. Hepatitis C virus genotypes in liver transplant recipients: impact on posttransplant recurrence, infections, response to interferon-alpha therapy and outcome. Transplantation. 1997 Aug 15;64(3):422–426. doi: 10.1097/00007890-199708150-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Gretch D. R., Bacchi C. E., Corey L., dela Rosa C., Lesniewski R. R., Kowdley K., Gown A., Frank I., Perkins J. D., Carithers R. L., Jr Persistent hepatitis C virus infection after liver transplantation: clinical and virological features. Hepatology. 1995 Jul;22(1):1–9. [PubMed] [Google Scholar]
  22. Huang E. J., Wright T. L., Lake J. R., Combs C., Ferrell L. D. Hepatitis B and C coinfections and persistent hepatitis B infections: clinical outcome and liver pathology after transplantation. Hepatology. 1996 Mar;23(3):396–404. doi: 10.1002/hep.510230302. [DOI] [PubMed] [Google Scholar]
  23. Kasahara A., Hayashi N., Mochizuki K., Takayanagi M., Yoshioka K., Kakumu S., Iijima A., Urushihara A., Kiyosawa K., Okuda M. Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group. Hepatology. 1998 May;27(5):1394–1402. doi: 10.1002/hep.510270529. [DOI] [PubMed] [Google Scholar]
  24. Liang T. J. Combination therapy for hepatitis C infection. N Engl J Med. 1998 Nov 19;339(21):1549–1550. doi: 10.1056/NEJM199811193392112. [DOI] [PubMed] [Google Scholar]
  25. Lok A. S., Chien D., Choo Q. L., Chan T. M., Chiu E. K., Cheng I. K., Houghton M., Kuo G. Antibody response to core, envelope and nonstructural hepatitis C virus antigens: comparison of immunocompetent and immunosuppressed patients. Hepatology. 1993 Sep;18(3):497–502. [PubMed] [Google Scholar]
  26. Mazzaferro V., Regalia E., Pulvirenti A., Tagger A., Andreola S., Pasquali M., Baratti D., Romano F., Palazzo U., Zuin M. Prophylaxis against HCV recurrence after liver transplantation: effect of interferon and ribavirin combination. Transplant Proc. 1997 Feb-Mar;29(1-2):519–521. doi: 10.1016/s0041-1345(96)00248-5. [DOI] [PubMed] [Google Scholar]
  27. Mañez R., Mateo R., Tabasco J., Kusne S., Starzl T. E., Duquesnoy R. J. The influence of HLA donor-recipient compatibility on the recurrence of HBV and HCV hepatitis after liver transplantation. Transplantation. 1995 Feb 27;59(4):640–642. doi: 10.1097/00007890-199502270-00036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Poynard T., Bedossa P., Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet. 1997 Mar 22;349(9055):825–832. doi: 10.1016/s0140-6736(96)07642-8. [DOI] [PubMed] [Google Scholar]
  29. Prieto M., Berenguer M., Rayón J. M., Córdoba J., Argüello L., Carrasco D., García-Herola A., Olaso V., De Juan M., Gobernado M. High incidence of allograft cirrhosis in hepatitis C virus genotype 1b infection following transplantation: relationship with rejection episodes. Hepatology. 1999 Jan;29(1):250–256. doi: 10.1002/hep.510290122. [DOI] [PubMed] [Google Scholar]
  30. Rosen H. R., Chou S., Corless C. L., Gretch D. R., Flora K. D., Boudousquie A., Orloff S. L., Rabkin J. M., Benner K. G. Cytomegalovirus viremia: risk factor for allograft cirrhosis after liver transplantation for hepatitis C. Transplantation. 1997 Sep 15;64(5):721–726. doi: 10.1097/00007890-199709150-00010. [DOI] [PubMed] [Google Scholar]
  31. Rosen H. R., Gretch D. R., Oehlke M., Flora K. D., Benner K. G., Rabkin J. M., Corless C. L. Timing and severity of initial hepatitis C recurrence as predictors of long-term liver allograft injury. Transplantation. 1998 May 15;65(9):1178–1182. doi: 10.1097/00007890-199805150-00006. [DOI] [PubMed] [Google Scholar]
  32. Rosen H. R., O'Reilly P. M., Shackleton C. R., McDiarmid S., Holt C., Busuttil R. W., Martin P. Graft loss following liver transplantation in patients with chronic hepatitis C. Transplantation. 1996 Dec 27;62(12):1773–1776. doi: 10.1097/00007890-199612270-00015. [DOI] [PubMed] [Google Scholar]
  33. Rosen H. R., Shackleton C. R., Higa L., Gralnek I. M., Farmer D. A., McDiarmid S. V., Holt C., Lewin K. J., Busuttil R. W., Martin P. Use of OKT3 is associated with early and severe recurrence of hepatitis C after liver transplantation. Am J Gastroenterol. 1997 Sep;92(9):1453–1457. [PubMed] [Google Scholar]
  34. Schluger L. K., Sheiner P. A., Thung S. N., Lau J. Y., Min A., Wolf D. C., Fiel I., Zhang D., Gerber M. A., Miller C. M. Severe recurrent cholestatic hepatitis C following orthotopic liver transplantation. Hepatology. 1996 May;23(5):971–976. doi: 10.1002/hep.510230505. [DOI] [PubMed] [Google Scholar]
  35. Serfaty L., Aumaître H., Chazouillères O., Bonnand A. M., Rosmorduc O., Poupon R. E., Poupon R. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology. 1998 May;27(5):1435–1440. doi: 10.1002/hep.510270535. [DOI] [PubMed] [Google Scholar]
  36. Sheiner P. A., Boros P., Klion F. M., Thung S. N., Schluger L. K., Lau J. Y., Mor E., Bodian C., Guy S. R., Schwartz M. E. The efficacy of prophylactic interferon alfa-2b in preventing recurrent hepatitis C after liver transplantation. Hepatology. 1998 Sep;28(3):831–838. doi: 10.1002/hep.510280334. [DOI] [PubMed] [Google Scholar]
  37. Sheiner P. A., Schluger L. K., Emre S., Thung S. N., Lau J. Y., Guy S. R., Schwartz M. E., Miller C. M. Retransplantation for recurrent hepatitis C. Liver Transpl Surg. 1997 Mar;3(2):130–136. doi: 10.1002/lt.500030205. [DOI] [PubMed] [Google Scholar]
  38. Sheiner P. A., Schwartz M. E., Mor E., Schluger L. K., Theise N., Kishikawa K., Kolesnikov V., Bodenheimer H., Emre S., Miller C. M. Severe or multiple rejection episodes are associated with early recurrence of hepatitis C after orthotopic liver transplantation. Hepatology. 1995 Jan;21(1):30–34. [PubMed] [Google Scholar]
  39. Shiffman M. L., Contos M. J., Luketic V. A., Sanyal A. J., Purdum P. P., 3rd, Mills A. S., Fisher R. A., Posner M. P. Biochemical and histologic evaluation of recurrent hepatitis C following orthotopic liver transplantation. Transplantation. 1994 Feb 27;57(4):526–532. [PubMed] [Google Scholar]
  40. Singh N., Gayowski T., Wannstedt C. F., Marino I. R., Wagener M. M. Interferon-alpha therapy for hepatitis C virus recurrence after liver transplantation: long-term response with maintenance therapy. Clin Transplant. 1996 Aug;10(4):348–351. [PubMed] [Google Scholar]
  41. Singh N., Gayowski T., Wannstedt C. F., Shakil A. O., Wagener M. M., Fung J. J., Marino I. R. Interferon-alpha for prophylaxis of recurrent viral hepatitis C in liver transplant recipients: a prospective, randomized, controlled trial. Transplantation. 1998 Jan 15;65(1):82–86. doi: 10.1097/00007890-199801150-00016. [DOI] [PubMed] [Google Scholar]
  42. Sullivan D. G., Wilson J. J., Carithers R. L., Jr, Perkins J. D., Gretch D. R. Multigene tracking of hepatitis C virus quasispecies after liver transplantation: correlation of genetic diversification in the envelope region with asymptomatic or mild disease patterns. J Virol. 1998 Dec;72(12):10036–10043. doi: 10.1128/jvi.72.12.10036-10043.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Wright T. L., Combs C., Kim M., Ferrell L., Bacchetti P., Ascher N., Roberts J., Wilber J., Sheridan P., Urdea M. Interferon-alpha therapy for hepatitis C virus infection after liver transplantation. Hepatology. 1994 Oct;20(4 Pt 1):773–779. doi: 10.1002/hep.1840200402. [DOI] [PubMed] [Google Scholar]
  44. Wright T. L., Donegan E., Hsu H. H., Ferrell L., Lake J. R., Kim M., Combs C., Fennessy S., Roberts J. P., Ascher N. L. Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology. 1992 Jul;103(1):317–322. doi: 10.1016/0016-5085(92)91129-r. [DOI] [PubMed] [Google Scholar]
  45. Zhou S., Terrault N. A., Ferrell L., Hahn J. A., Lau J. Y., Simmonds P., Roberts J. P., Lake J. R., Ascher N. L., Wright T. L. Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: relationship to genotype and level of viremia. Hepatology. 1996 Nov;24(5):1041–1046. doi: 10.1002/hep.510240510. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES