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. 2000 Dec;47(6):801–803. doi: 10.1136/gut.47.6.801

Measles, month of birth, and Crohn's disease

N Haslam 1, J Mayberry 1, A Hawthorne 1, R Newcombe 1, G Holmes 1, C Probert 1
PMCID: PMC1728130  PMID: 11076878

Abstract

BACKGROUND—The rise in the incidence of Crohn's disease (CD) suggests the role of an environmental factor in the development of the disease in susceptible individuals. Perinatal exposure to infection has been proposed as such an environmental factor.
AIM—To investigate the influence of birth date on the development of CD in later life.
PATIENTS AND METHOD—Four registers of patients with CD, diagnosed from 1972 to 1989, were combined, and data from 1624 patients were examined. The birth dates of CD patients were compared with national birth figures for three decades (1941-50, 1951-60, and 1961-70) to avoid temporal changes in birth trends, and year of birth was compared with epidemic measles years between 1951 and 1967. Risk ratios with 95% confidence intervals (CI) and χ2 tests were performed.
RESULTS—There were marginal differences between the birth dates of the CD patients and those predicted from the general population. Further analysis of both season of birth and year halves revealed a very weak association with the first half of the year (relative risk 1.14 (95% CI 1.01-1.30)). There was no association between developing CD and birth during measles epidemics between 1951 and 1967.
CONCLUSIONS—In utero or perinatal exposure to seasonal environmental factors are unlikely potential aetiological agents in the later development of CD.


Keywords: measles; birth date; Crohn's disease; epidemiology

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Figure 1  .

Figure 1  

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Measles notifications versus adjusted Crohn's disease (CD) birth rate by year.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ekbom A., Helmick C., Zack M., Adami H. O. The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden. Gastroenterology. 1991 Feb;100(2):350–358. doi: 10.1016/0016-5085(91)90202-v. [DOI] [PubMed] [Google Scholar]
  2. Ekbom A., Wakefield A. J., Zack M., Adami H. O. Perinatal measles infection and subsequent Crohn's disease. Lancet. 1994 Aug 20;344(8921):508–510. doi: 10.1016/s0140-6736(94)91898-8. [DOI] [PubMed] [Google Scholar]
  3. Fellows I. W., Freeman J. G., Holmes G. K. Crohn's disease in the city of Derby, 1951-85. Gut. 1990 Nov;31(11):1262–1265. doi: 10.1136/gut.31.11.1262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jayanthi V., Probert C. S., Pollock D. J., Baithun S. I., Rampton D. S., Mayberry J. F. Low incidence of ulcerative colitis and proctitis in Bangladeshi migrants in Britain. Digestion. 1992;52(1):34–42. doi: 10.1159/000200936. [DOI] [PubMed] [Google Scholar]
  5. Lennard-Jones J. E. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 1989;170:2–19. doi: 10.3109/00365528909091339. [DOI] [PubMed] [Google Scholar]
  6. Newcombe R. G. Interval estimation for the difference between independent proportions: comparison of eleven methods. Stat Med. 1998 Apr 30;17(8):873–890. doi: 10.1002/(sici)1097-0258(19980430)17:8<873::aid-sim779>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  7. Probert C. S., Jayanthi V., Hughes A. O., Thompson J. R., Wicks A. C., Mayberry J. F. Prevalence and family risk of ulcerative colitis and Crohn's disease: an epidemiological study among Europeans and south Asians in Leicestershire. Gut. 1993 Nov;34(11):1547–1551. doi: 10.1136/gut.34.11.1547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Probert C. S., Jayanthi V., Pollock D. J., Baithun S. I., Mayberry J. F., Rampton D. S. Crohn's disease in Bangladeshis and Europeans in Britain: an epidemiological comparison in Tower Hamlets. Postgrad Med J. 1992 Nov;68(805):914–920. doi: 10.1136/pgmj.68.805.914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rose J. D., Roberts G. M., Williams G., Mayberry J. F., Rhodes J. Cardiff Crohn's disease jubilee: the incidence over 50 years. Gut. 1988 Mar;29(3):346–351. doi: 10.1136/gut.29.3.346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Srivastava E. D., Mayberry J. F., Morris T. J., Smith P. M., Williams G. T., Roberts G. M., Newcombe R. G., Rhodes J. Incidence of ulcerative colitis in Cardiff over 20 years: 1968-87. Gut. 1992 Feb;33(2):256–258. doi: 10.1136/gut.33.2.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Thomas G. A., Millar-Jones D., Rhodes J., Roberts G. M., Williams G. T., Mayberry J. F. Incidence of Crohn's disease in Cardiff over 60 years: 1986-1990 an update. Eur J Gastroenterol Hepatol. 1995 May;7(5):401–405. [PubMed] [Google Scholar]
  12. Thomas G. A., Millar-Jones D., Rhodes J., Roberts G. M., Williams G. T., Mayberry J. F. Incidence of Crohn's disease in Cardiff over 60 years: 1986-1990 an update. Eur J Gastroenterol Hepatol. 1995 May;7(5):401–405. [PubMed] [Google Scholar]
  13. Thompson N. P., Montgomery S. M., Pounder R. E., Wakefield A. J. Is measles vaccination a risk factor for inflammatory bowel disease? Lancet. 1995 Apr 29;345(8957):1071–1074. doi: 10.1016/s0140-6736(95)90816-1. [DOI] [PubMed] [Google Scholar]
  14. Zareparsi S., Kaye J., Camicioli R., Kramer P., Nutt J., Bird T., Litt M., Payami H., Kay J. Analysis of the alpha-synuclein G209A mutation in familial Parkinson's disease. Lancet. 1998 Jan 3;351(9095):37–38. doi: 10.1016/s0140-6736(05)78089-2. [DOI] [PubMed] [Google Scholar]

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