Genetics of inflammatory bowel disease: a puzzle with contradictions?

Full Text

The Full Text of this article is available as a PDF (96.1 KB).

Figure 1  .

Variations in linkage results in repeated studies are dependent on the genetic impact of a locus and sample size. A population was simulated with a six locus disease, with three contributing loci of high frequency but low impact (scenario F) and three contributing loci with high impact but low frequency (scenario R). LOD score as a function of the number of analysed sib pairs is shown, as calculated by the SIPPAIR program in 60 replicate studies, which were conducted in sib pairs randomly drawn from the population. The analysis of locus 1 under both disease model scenarios (F=frequent, locus specific heritability h2=0.37; R=rare, h2=0.25) is shown. Boxes denote median (interquartile range), and whiskers indicate minimum and maximum values (reprinted from Hampe and colleagues²¹).