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. 2001 Jun;48(6):790–791. doi: 10.1136/gut.48.6.790

Methotrexate in Crohn's disease

D Rampton 1
PMCID: PMC1728338  PMID: 11358896

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arora S., Katkov W., Cooley J., Kemp J. A., Johnston D. E., Schapiro R. H., Podolsky D. Methotrexate in Crohn's disease: results of a randomized, double-blind, placebo-controlled trial. Hepatogastroenterology. 1999 May-Jun;46(27):1724–1729. [PubMed] [Google Scholar]
  2. Egan L. J., Sandborn W. J. Methotrexate for inflammatory bowel disease: pharmacology and preliminary results. Mayo Clin Proc. 1996 Jan;71(1):69–80. doi: 10.4065/71.1.69. [DOI] [PubMed] [Google Scholar]
  3. Egan L. J., Sandborn W. J., Tremaine W. J., Leighton J. A., Mays D. C., Pike M. G., Zinsmeister A. R., Lipsky J. J. A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn's disease and ulcerative colitis. Aliment Pharmacol Ther. 1999 Dec;13(12):1597–1604. doi: 10.1046/j.1365-2036.1999.00667.x. [DOI] [PubMed] [Google Scholar]
  4. Feagan B. G., Fedorak R. N., Irvine E. J., Wild G., Sutherland L., Steinhart A. H., Greenberg G. R., Koval J., Wong C. J., Hopkins M. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. N Engl J Med. 2000 Jun 1;342(22):1627–1632. doi: 10.1056/NEJM200006013422202. [DOI] [PubMed] [Google Scholar]
  5. Feagan B. G., Rochon J., Fedorak R. N., Irvine E. J., Wild G., Sutherland L., Steinhart A. H., Greenberg G. R., Gillies R., Hopkins M. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. N Engl J Med. 1995 Feb 2;332(5):292–297. doi: 10.1056/NEJM199502023320503. [DOI] [PubMed] [Google Scholar]
  6. Kanik K. S., Cash J. M. Does methotrexate increase the risk of infection or malignancy? Rheum Dis Clin North Am. 1997 Nov;23(4):955–967. doi: 10.1016/s0889-857x(05)70368-9. [DOI] [PubMed] [Google Scholar]
  7. Kozarek R. A., Patterson D. J., Gelfand M. D., Botoman V. A., Ball T. J., Wilske K. R. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989 Mar 1;110(5):353–356. doi: 10.7326/0003-4819-110-5-353. [DOI] [PubMed] [Google Scholar]
  8. Kremer J. M., Alarcón G. S., Lightfoot R. W., Jr, Willkens R. F., Furst D. E., Williams H. J., Dent P. B., Weinblatt M. E. Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology. Arthritis Rheum. 1994 Mar;37(3):316–328. doi: 10.1002/art.1780370304. [DOI] [PubMed] [Google Scholar]
  9. Maini R., St Clair E. W., Breedveld F., Furst D., Kalden J., Weisman M., Smolen J., Emery P., Harriman G., Feldmann M. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group. Lancet. 1999 Dec 4;354(9194):1932–1939. doi: 10.1016/s0140-6736(99)05246-0. [DOI] [PubMed] [Google Scholar]
  10. Moshkowitz M., Oren R., Tishler M., Konikoff F. M., Graff E., Brill S., Yaron M., Gilat T. The absorption of low-dose methotrexate in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 1997 Jun;11(3):569–573. doi: 10.1046/j.1365-2036.1997.00175.x. [DOI] [PubMed] [Google Scholar]
  11. Oren R., Moshkowitz M., Odes S., Becker S., Keter D., Pomeranz I., Shirin H., Shirin C., Reisfeld I., Broide E. Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial. Am J Gastroenterol. 1997 Dec;92(12):2203–2209. [PubMed] [Google Scholar]
  12. Weinblatt M. E., Coblyn J. S., Fox D. A., Fraser P. A., Holdsworth D. E., Glass D. N., Trentham D. E. Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med. 1985 Mar 28;312(13):818–822. doi: 10.1056/NEJM198503283121303. [DOI] [PubMed] [Google Scholar]
  13. Willkens R. F., Williams H. J., Ward J. R., Egger M. J., Reading J. C., Clements P. J., Cathcart E. S., Samuelson C. O., Jr, Solsky M. A., Kaplan S. B. Randomized, double-blind, placebo controlled trial of low-dose pulse methotrexate in psoriatic arthritis. Arthritis Rheum. 1984 Apr;27(4):376–381. doi: 10.1002/art.1780270403. [DOI] [PubMed] [Google Scholar]

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