Skip to main content
NCBI home page
Gut logoLink to Gut
. 2001 Jul;49(1):2–4. doi: 10.1136/gut.49.1.2

Prospects for intervention in gastric carcinogenesis: reversibility of gastric atrophy and intestinal metaplasia

M DIXON 1
PMCID: PMC1728347  PMID: 11413099

Full Text

The Full Text of this article is available as a PDF (76.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asaka M., Kato M., Kudo M., Katagiri M., Nishikawa K., Koshiyama H., Takeda H., Yoshida J., Graham D. Y. Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging: studies in asymptomatic Japanese adults. Helicobacter. 1996 Mar;1(1):52–56. doi: 10.1111/j.1523-5378.1996.tb00008.x. [DOI] [PubMed] [Google Scholar]
  2. Blot W. J. Preventing cancer by disrupting progression of precancerous lesions. J Natl Cancer Inst. 2000 Dec 6;92(23):1868–1869. doi: 10.1093/jnci/92.23.1868. [DOI] [PubMed] [Google Scholar]
  3. Claeys D., Faller G., Appelmelk B. J., Negrini R., Kirchner T. The gastric H+,K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy. Gastroenterology. 1998 Aug;115(2):340–347. doi: 10.1016/s0016-5085(98)70200-8. [DOI] [PubMed] [Google Scholar]
  4. Claeys D., Karapetian O., Saraga E., Schreyer M., Louis J., Acha-Orbea H., Blum A. L., Kraehenbuhl J. P. Mouse mammary tumor virus superantigens and murine autoimmune gastritis. Gastroenterology. 1994 Oct;107(4):924–933. doi: 10.1016/0016-5085(94)90215-1. [DOI] [PubMed] [Google Scholar]
  5. Correa P., Fontham E. T., Bravo J. C., Bravo L. E., Ruiz B., Zarama G., Realpe J. L., Malcom G. T., Li D., Johnson W. D. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J Natl Cancer Inst. 2000 Dec 6;92(23):1881–1888. doi: 10.1093/jnci/92.23.1881. [DOI] [PubMed] [Google Scholar]
  6. Correa P., Haenszel W., Cuello C., Tannenbaum S., Archer M. A model for gastric cancer epidemiology. Lancet. 1975 Jul 12;2(7924):58–60. doi: 10.1016/s0140-6736(75)90498-5. [DOI] [PubMed] [Google Scholar]
  7. Correa P., Haenszel W., Cuello C., Zavala D., Fontham E., Zarama G., Tannenbaum S., Collazos T., Ruiz B. Gastric precancerous process in a high risk population: cohort follow-up. Cancer Res. 1990 Aug 1;50(15):4737–4740. [PubMed] [Google Scholar]
  8. DeLuca V. A., Jr, West A. B., Haque S., Katz D. L., Ciarolla D., Goldenberg S., Fette G. Long-term symptom patterns, endoscopic findings, and gastric histology in Helicobacter pylori-infected and -uninfected patients. J Clin Gastroenterol. 1998 Mar;26(2):106–112. doi: 10.1097/00004836-199803000-00004. [DOI] [PubMed] [Google Scholar]
  9. El-Omar E. M., Oien K., El-Nujumi A., Gillen D., Wirz A., Dahill S., Williams C., Ardill J. E., McColl K. E. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology. 1997 Jul;113(1):15–24. doi: 10.1016/s0016-5085(97)70075-1. [DOI] [PubMed] [Google Scholar]
  10. Farinati F., Cardin R., Degan P., Rugge M., Mario F. D., Bonvicini P., Naccarato R. Oxidative DNA damage accumulation in gastric carcinogenesis. Gut. 1998 Mar;42(3):351–356. doi: 10.1136/gut.42.3.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Goldenring J. R., Ray G. S., Coffey R. J., Meunier P. C., Haley P. J., Barnes T. B., Car B. D. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology. 2000 Jun;118(6):1080–1093. doi: 10.1016/s0016-5085(00)70361-1. [DOI] [PubMed] [Google Scholar]
  12. Hamamoto T., Yokozaki H., Semba S., Yasui W., Yunotani S., Miyazaki K., Tahara E. Altered microsatellites in incomplete-type intestinal metaplasia adjacent to primary gastric cancers. J Clin Pathol. 1997 Oct;50(10):841–846. doi: 10.1136/jcp.50.10.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hanby A. M., Poulsom R., Playford R. J., Wright N. A. The mucous neck cell in the human gastric corpus: a distinctive, functional cell lineage. J Pathol. 1999 Feb;187(3):331–337. doi: 10.1002/(SICI)1096-9896(199902)187:3<331::AID-PATH241>3.0.CO;2-S. [DOI] [PubMed] [Google Scholar]
  14. Hattori T., Fjuita S. Fractographic study on the growth and multiplication of the gastric gland of the hamster. The gland division cycle. Cell Tissue Res. 1974;153(2):145–149. doi: 10.1007/BF00226603. [DOI] [PubMed] [Google Scholar]
  15. Iijima K., Ohara S., Sekine H., Koike T., Kato K., Asaki S., Shimosegawa T., Toyota T. Changes in gastric acid secretion assayed by endoscopic gastrin test before and after Helicobacter pylori eradication. Gut. 2000 Jan;46(1):20–26. doi: 10.1136/gut.46.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ishikawa N., Wakelin D., Mahida Y. R. Role of T helper 2 cells in intestinal goblet cell hyperplasia in mice infected with Trichinella spiralis. Gastroenterology. 1997 Aug;113(2):542–549. doi: 10.1053/gast.1997.v113.pm9247474. [DOI] [PubMed] [Google Scholar]
  17. James R. J. Homeodomain proteins and cell phenotype. Gastroenterology. 1997 Aug;113(2):680–682. [PubMed] [Google Scholar]
  18. Maaroos H. I., Vorobjova T., Sipponen P., Tammur R., Uibo R., Wadström T., Keevallik R., Villako K. An 18-year follow-up study of chronic gastritis and Helicobacter pylori association of CagA positivity with development of atrophy and activity of gastritis. Scand J Gastroenterol. 1999 Sep;34(9):864–869. doi: 10.1080/003655299750025318. [DOI] [PubMed] [Google Scholar]
  19. Oberhuber G., Wuendisch T., Rappel S., Stolte M. Significant improvement of atrophy after eradication therapy in atrophic body gastritis. Pathol Res Pract. 1998;194(9):609–613. doi: 10.1016/S0344-0338(98)80095-2. [DOI] [PubMed] [Google Scholar]
  20. Ochiai A., Yamauchi Y., Hirohashi S. p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia. Int J Cancer. 1996 Feb 20;69(1):28–33. doi: 10.1002/(SICI)1097-0215(19960220)69:1<28::AID-IJC6>3.0.CO;2-Y. [DOI] [PubMed] [Google Scholar]
  21. Sakagami T., Dixon M., O'Rourke J., Howlett R., Alderuccio F., Vella J., Shimoyama T., Lee A. Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis. Gut. 1996 Nov;39(5):639–648. doi: 10.1136/gut.39.5.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Schmidt P. H., Lee J. R., Joshi V., Playford R. J., Poulsom R., Wright N. A., Goldenring J. R. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest. 1999 Jun;79(6):639–646. [PubMed] [Google Scholar]
  23. Silberg D. G., Furth E. E., Taylor J. K., Schuck T., Chiou T., Traber P. G. CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology. 1997 Aug;113(2):478–486. doi: 10.1053/gast.1997.v113.pm9247467. [DOI] [PubMed] [Google Scholar]
  24. Silva S., Filipe M. I., Pinho A. Variants of intestinal metaplasia in the evolution of chronic atrophic gastritis and gastric ulcer. A follow up study. Gut. 1990 Oct;31(10):1097–1104. doi: 10.1136/gut.31.10.1097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Slack J. M. Epithelial metaplasia and the second anatomy. Lancet. 1986 Aug 2;2(8501):268–271. doi: 10.1016/s0140-6736(86)92083-0. [DOI] [PubMed] [Google Scholar]
  26. Slack J. M. Stem cells in epithelial tissues. Science. 2000 Feb 25;287(5457):1431–1433. doi: 10.1126/science.287.5457.1431. [DOI] [PubMed] [Google Scholar]
  27. Stolte M., Baumann K., Bethke B., Ritter M., Lauer E., Eidt H. Active autoimmune gastritis without total atrophy of the glands. Z Gastroenterol. 1992 Oct;30(10):729–735. [PubMed] [Google Scholar]
  28. Sugimura T., Ushijima T. Genetic and epigenetic alterations in carcinogenesis. Mutat Res. 2000 Apr;462(2-3):235–246. doi: 10.1016/s1383-5742(00)00005-3. [DOI] [PubMed] [Google Scholar]
  29. Tahara E. Molecular biology of gastric cancer. World J Surg. 1995 Jul-Aug;19(4):484–490. doi: 10.1007/BF00294705. [DOI] [PubMed] [Google Scholar]
  30. Wu M. S., Shun C. T., Lee W. C., Chen C. J., Wang H. P., Lee W. J., Lin J. T. Gastric cancer risk in relation to Helicobacter pylori infection and subtypes of intestinal metaplasia. Br J Cancer. 1998 Jul;78(1):125–128. doi: 10.1038/bjc.1998.453. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES