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. 1989 Dec;33(12):2149–2151. doi: 10.1128/aac.33.12.2149

Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.

T S Lin 1, R Schinazi 1, B P Griffith 1, E M August 1, B F Eriksson 1, D K Zheng 1, L A Huang 1, W H Prusoff 1
PMCID: PMC172840  PMID: 2619282

Abstract

The (-) enantiomer of gossypol but not the (+) enantiomer had good antiviral activity in peripheral blood mononuclear cells against human immunodeficiency virus type 1 at a concentration more than 20-fold lower than that required for cytotoxicity; however, in H9 cells the (-) enantiomer, although more potent as an antiviral agent, was more cytotoxic.

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Selected References

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