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. 1995 Jan;8(1):87–112. doi: 10.1128/cmr.8.1.87

Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.

M Bendinelli 1, M Pistello 1, S Lombardi 1, A Poli 1, C Garzelli 1, D Matteucci 1, L Ceccherini-Nelli 1, G Malvaldi 1, F Tozzini 1
PMCID: PMC172850  PMID: 7704896

Abstract

The lentivirus feline immunodeficiency virus (FIV) is a widespread pathogen of the domestic cat that is mainly transmitted through bites, although other means of transmission are also possible. Its prevalence ranges from 1 to 10% in different cat populations throughout the world, thus representing a large reservoir of naturally infected animals. FIV resembles the human immunodeficiency virus (HIV) in many respects. Similarities include the structural features of the virion, the general organization and great variability of the genome, the life cycle in the infected host, and most importantly, the pathogenic potential. Infection is associated with laboratory signs of immunosuppression as well as with a large variety of superinfections, tumors, and neurological manifestations. Our understanding of FIV is steadily improving and is providing important clues to the pathogenesis of immunodeficiency-inducing lentiviruses. The cellular receptor for FIV is different from the feline equivalent of the human CD4 molecule used by HIV; nevertheless, the major hallmark of infection is a progressive loss of CD4+ T lymphocytes as in HIV infection. The mechanisms by which FIV escapes the host's immune responses are being actively investigated. FIV causes lysis of infected T cells and also appears to predispose these cells to apoptosis. Infection of macrophages and other cell types has also been documented. For reasons yet to be understood, antibody-mediated neutralization of fresh FIV isolates is very inefficient both in vitro and in vivo. Vaccination studies have provided some encouraging results, but the difficulties encountered appear to match those met in HIV vaccine development. FIV susceptibility to antiviral agents is similar to that of HIV, thus providing a valuable system for in vivo preclinical evaluation of therapies. It is concluded that in many respects FIV is an ideal model for AIDS studies.

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Selected References

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  1. Ackley C. D., Yamamoto J. K., Levy N., Pedersen N. C., Cooper M. D. Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus. J Virol. 1990 Nov;64(11):5652–5655. doi: 10.1128/jvi.64.11.5652-5655.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arthur L. O., Bess J. W., Jr, Sowder R. C., 2nd, Benveniste R. E., Mann D. L., Chermann J. C., Henderson L. E. Cellular proteins bound to immunodeficiency viruses: implications for pathogenesis and vaccines. Science. 1992 Dec 18;258(5090):1935–1938. doi: 10.1126/science.1470916. [DOI] [PubMed] [Google Scholar]
  3. Astrin S. M., Schattner E., Laurence J., Lebman R. I., Rodriguez-Alfageme C. Does HIV infection of B lymphocytes initiate AIDS lymphoma? Detection by PCR of viral sequences in lymphoma tissue. Curr Top Microbiol Immunol. 1992;182:399–407. doi: 10.1007/978-3-642-77633-5_51. [DOI] [PubMed] [Google Scholar]
  4. Atwood W. J., Berger J. R., Kaderman R., Tornatore C. S., Major E. O. Human immunodeficiency virus type 1 infection of the brain. Clin Microbiol Rev. 1993 Oct;6(4):339–366. doi: 10.1128/cmr.6.4.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Avrameas A., Guillet J. G., Chouchane L., Moraillon A., Sonigo P., Strosberg A. D. Localisation of three epitopes of the env protein of feline immunodeficiency virus. Mol Immunol. 1992 May;29(5):565–572. doi: 10.1016/0161-5890(92)90192-z. [DOI] [PubMed] [Google Scholar]
  6. Avrameas A., Strosberg A. D., Moraillon A., Sonigo P., Pancino G. Serological diagnosis of feline immunodeficiency virus infection based on synthetic peptides from Env glycoproteins. Res Virol. 1993 May-Jun;144(3):209–218. doi: 10.1016/s0923-2516(06)80031-2. [DOI] [PubMed] [Google Scholar]
  7. Baldinotti F., Matteucci D., Mazzetti P., Giannelli C., Bandecchi P., Tozzini F., Bendinelli M. Serum neutralization of feline immunodeficiency virus is markedly dependent on passage history of the virus and host system. J Virol. 1994 Jul;68(7):4572–4579. doi: 10.1128/jvi.68.7.4572-4579.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ball J. M., Rushlow K. E., Issel C. J., Montelaro R. C. Detailed mapping of the antigenicity of the surface unit glycoprotein of equine infectious anemia virus by using synthetic peptide strategies. J Virol. 1992 Feb;66(2):732–742. doi: 10.1128/jvi.66.2.732-742.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bandecchi P., Matteucci D., Baldinotti F., Guidi G., Abramo F., Tozzini F., Bendinelli M. Prevalence of feline immunodeficiency virus and other retroviral infections in sick cats in Italy. Vet Immunol Immunopathol. 1992 Mar;31(3-4):337–345. doi: 10.1016/0165-2427(92)90020-q. [DOI] [PubMed] [Google Scholar]
  10. Barlough J. E., Ackley C. D., George J. W., Levy N., Acevedo R., Moore P. F., Rideout B. A., Cooper M. D., Pedersen N. C. Acquired immune dysfunction in cats with experimentally induced feline immunodeficiency virus infection: comparison of short-term and long-term infections. J Acquir Immune Defic Syndr. 1991;4(3):219–227. [PubMed] [Google Scholar]
  11. Barlough J. E., North T. W., Oxford C. L., Remington K. M., Dandekar S., Ellis M. N., Pedersen N. C. Feline immunodeficiency virus infection of cats as a model to test the effect of certain in vitro selection pressures on the infectivity and virulence of resultant lentivirus variants. Antiviral Res. 1993 Dec;22(4):259–272. doi: 10.1016/0166-3542(93)90036-i. [DOI] [PubMed] [Google Scholar]
  12. Barr M. C., Butt M. T., Anderson K. L., Lin D. S., Kelleher T. F., Scott F. W. Spinal lymphosarcoma and disseminated mastocytoma associated with feline immunodeficiency virus infection in a cat. J Am Vet Med Assoc. 1993 Jun 15;202(12):1978–1980. [PubMed] [Google Scholar]
  13. Beatty J. A., Reid G., Rigby M. A., Neil J. C., Jarrett O., Browning M. J. A recombinant feline immunodeficiency virus envelope fusion protein stimulates peripheral blood lymphocytes from naive cats to proliferate in vitro. Vet Immunol Immunopathol. 1992 Dec;35(1-2):143–153. doi: 10.1016/0165-2427(92)90127-c. [DOI] [PubMed] [Google Scholar]
  14. Beebe A. M., Dua N., Faith T. G., Moore P. F., Pedersen N. C., Dandekar S. Primary stage of feline immunodeficiency virus infection: viral dissemination and cellular targets. J Virol. 1994 May;68(5):3080–3091. doi: 10.1128/jvi.68.5.3080-3091.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Beebe A. M., Gluckstern T. G., George J., Pedersen N. C., Dandekar S. Detection of feline immunodeficiency virus infection in bone marrow of cats. Vet Immunol Immunopathol. 1992 Dec;35(1-2):37–49. doi: 10.1016/0165-2427(92)90119-b. [DOI] [PubMed] [Google Scholar]
  16. Bendinelli M., Pistello M., Matteucci D., Lombardi S., Baldinotti F., Bandecchi P., Ghilarducci R., Ceccherini-Nelli L., Garzelli C., Poli A. Small animal model of AIDS and the feline immunodeficiency virus. Adv Exp Med Biol. 1993;335:189–202. doi: 10.1007/978-1-4615-2980-4_27. [DOI] [PubMed] [Google Scholar]
  17. Bishop S. A., Gruffydd-Jones T. J., Harbour D. A., Stokes C. R. Programmed cell death (apoptosis) as a mechanism of cell death in peripheral blood mononuclear cells from cats infected with feline immunodeficiency virus (FIV). Clin Exp Immunol. 1993 Jul;93(1):65–71. doi: 10.1111/j.1365-2249.1993.tb06498.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Bishop S. A., Williams N. A., Gruffydd-Jones T. J., Harbour D. A., Stokes C. R. An early defect in primary and secondary T cell responses in asymptomatic cats during acute feline immunodeficiency virus (FIV) infection. Clin Exp Immunol. 1992 Dec;90(3):491–496. doi: 10.1111/j.1365-2249.1992.tb05872.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Bishop S. A., Williams N. A., Gruffydd-Jones T. J., Harbour D. A., Stokes C. R. Impaired T-cell priming and proliferation in cats infected with feline immunodeficiency virus. AIDS. 1992 Mar;6(3):287–293. doi: 10.1097/00002030-199203000-00005. [DOI] [PubMed] [Google Scholar]
  20. Brown A., Bennett M., Gaskell C. J. Fatal poxvirus infection in association with FIV infection. Vet Rec. 1989 Jan 7;124(1):19–20. doi: 10.1136/vr.124.1.19. [DOI] [PubMed] [Google Scholar]
  21. Brown P. J., Hopper C. D., Harbour D. A. Pathological features of lymphoid tissues in cats with natural feline immunodeficiency virus infection. J Comp Pathol. 1991 May;104(4):345–355. doi: 10.1016/S0021-9975(08)80145-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Brown W. C., Bissey L., Logan K. S., Pedersen N. C., Elder J. H., Collisson E. W. Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes. J Virol. 1991 Jun;65(6):3359–3364. doi: 10.1128/jvi.65.6.3359-3364.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Brunner D., Pedersen N. C. Infection of peritoneal macrophages in vitro and in vivo with feline immunodeficiency virus. J Virol. 1989 Dec;63(12):5483–5488. doi: 10.1128/jvi.63.12.5483-5488.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Callanan J. J., Hosie M. J., Jarrett O. Transmission of feline immunodeficiency virus from mother to kitten. Vet Rec. 1991 Apr 6;128(14):332–333. doi: 10.1136/vr.128.14.332. [DOI] [PubMed] [Google Scholar]
  25. Callanan J. J., McCandlish I. A., O'Neil B., Lawrence C. E., Rigby M., Pacitti A. M., Jarrett O. Lymphosarcoma in experimentally induced feline immunodeficiency virus infection [corrected]. Vet Rec. 1992 Apr 4;130(14):293–295. doi: 10.1136/vr.130.14.293. [DOI] [PubMed] [Google Scholar]
  26. Callanan J. J., Thompson H., Toth S. R., O'Neil B., Lawrence C. E., Willett B., Jarrett O. Clinical and pathological findings in feline immunodeficiency virus experimental infection. Vet Immunol Immunopathol. 1992 Dec;35(1-2):3–13. doi: 10.1016/0165-2427(92)90116-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Chalmers S., Schick R. O., Jeffers J. Demodicosis in two cats seropositive for feline immunodeficiency virus. J Am Vet Med Assoc. 1989 Jan 15;194(2):256–257. [PubMed] [Google Scholar]
  28. Cheng-Mayer C., Shioda T., Levy J. A. Host range, replicative, and cytopathic properties of human immunodeficiency virus type 1 are determined by very few amino acid changes in tat and gp120. J Virol. 1991 Dec;65(12):6931–6941. doi: 10.1128/jvi.65.12.6931-6941.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Cohen J. Jitters jeopardize AIDS vaccine trials. Science. 1993 Nov 12;262(5136):980–981. doi: 10.1126/science.8235635. [DOI] [PubMed] [Google Scholar]
  30. Cohen N. D., Carter C. N., Thomas M. A., Lester T. L., Eugster A. K. Epizootiologic association between feline immunodeficiency virus infection and feline leukemia virus seropositivity. J Am Vet Med Assoc. 1990 Jul 15;197(2):220–225. [PubMed] [Google Scholar]
  31. Cranage M. P., Polyanskaya N., McBride B., Cook N., Ashworth L. A., Dennis M., Baskerville A., Greenaway P. J., Corcoran T., Kitchin P. Studies on the specificity of the vaccine effect elicited by inactivated simian immunodeficiency virus. AIDS Res Hum Retroviruses. 1993 Jan;9(1):13–22. doi: 10.1089/aid.1993.9.13. [DOI] [PubMed] [Google Scholar]
  32. Cronn R. C., Remington K. M., Preston B. D., North T. W. Inhibition of reverse transcriptase from feline immunodeficiency virus by analogs of 2'-deoxyadenosine-5'-triphosphate. Biochem Pharmacol. 1992 Oct 6;44(7):1375–1381. doi: 10.1016/0006-2952(92)90539-u. [DOI] [PubMed] [Google Scholar]
  33. Cronn R. C., Whitmer J. D., North T. W. RNase H activity associated with reverse transcriptase from feline immunodeficiency virus. J Virol. 1992 Feb;66(2):1215–1218. doi: 10.1128/jvi.66.2.1215-1218.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Dandekar S., Beebe A. M., Barlough J., Phillips T., Elder J., Torten M., Pedersen N. Detection of feline immunodeficiency virus (FIV) nucleic acids in FIV-seronegative cats. J Virol. 1992 Jul;66(7):4040–4049. doi: 10.1128/jvi.66.7.4040-4049.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Davidson M. G., Rottman J. B., English R. V., Lappin M. R., Tompkins M. B. Feline immunodeficiency virus predisposes cats to acute generalized toxoplasmosis. Am J Pathol. 1993 Nov;143(5):1486–1497. [PMC free article] [PubMed] [Google Scholar]
  36. Dawson S., Smyth N. R., Bennett M., Gaskell R. M., McCracken C. M., Brown A., Gaskell C. J. Effect of primary-stage feline immunodeficiency virus infection on subsequent feline calicivirus vaccination and challenge in cats. AIDS. 1991 Jun;5(6):747–750. doi: 10.1097/00002030-199106000-00016. [DOI] [PubMed] [Google Scholar]
  37. Desrosiers R. C. The simian immunodeficiency viruses. Annu Rev Immunol. 1990;8:557–578. doi: 10.1146/annurev.iy.08.040190.003013. [DOI] [PubMed] [Google Scholar]
  38. Dieth V., Lutz H., Hauser B., Ossent P. Pathologische Befunde bei mit Lentiviren infizierten Katzen. Schweiz Arch Tierheilkd. 1989;131(1):19–25. [PubMed] [Google Scholar]
  39. Dow S. W., Dreitz M. J., Hoover E. A. Feline immunodeficiency virus neurotropism: evidence that astrocytes and microglia are the primary target cells. Vet Immunol Immunopathol. 1992 Dec;35(1-2):23–35. doi: 10.1016/0165-2427(92)90118-a. [DOI] [PubMed] [Google Scholar]
  40. Dow S. W., Poss M. L., Hoover E. A. Feline immunodeficiency virus: a neurotropic lentivirus. J Acquir Immune Defic Syndr. 1990;3(7):658–668. [PubMed] [Google Scholar]
  41. Egberink H. F., Berrocal A., Bax H. A., van den Ingh T. S., Walter J. H., Horzinek M. C. Papillomavirus associated skin lesions in a cat seropositive for feline immunodeficiency virus. Vet Microbiol. 1992 Jun 1;31(2-3):117–125. doi: 10.1016/0378-1135(92)90070-a. [DOI] [PubMed] [Google Scholar]
  42. Egberink H. F., Ederveen J., Montelaro R. C., Pedersen N. C., Horzinek M. C., Koolen M. J. Intracellular proteins of feline immunodeficiency virus and their antigenic relationship with equine infectious anaemia virus proteins. J Gen Virol. 1990 Mar;71(Pt 3):739–743. doi: 10.1099/0022-1317-71-3-739. [DOI] [PubMed] [Google Scholar]
  43. Egberink H. F., Keldermans C. E., Koolen M. J., Horzinek M. C. Humoral immune response to feline immunodeficiency virus in cats with experimentally induced and naturally acquired infections. Am J Vet Res. 1992 Jul;53(7):1133–1138. [PubMed] [Google Scholar]
  44. Egberink H. F., Lutz H., Horzinek M. C. Use of western blot and radioimmunoprecipitation for diagnosis of feline leukemia and feline immunodeficiency virus infections. J Am Vet Med Assoc. 1991 Nov 15;199(10):1339–1342. [PubMed] [Google Scholar]
  45. Egberink H., Borst M., Niphuis H., Balzarini J., Neu H., Schellekens H., De Clercq E., Horzinek M., Koolen M. Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3087–3091. doi: 10.1073/pnas.87.8.3087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Egberink H., Keldermans L., Schuurman N., Stam J., Hesselink W., van Vliet A., Verschoor E., Horzinek M., de Ronde A. Monoclonal antibodies to immunodominant and neutralizing domains of the envelope surface protein of feline immunodeficiency virus. J Gen Virol. 1994 Apr;75(Pt 4):889–893. doi: 10.1099/0022-1317-75-4-889. [DOI] [PubMed] [Google Scholar]
  47. Elder J. H., Lerner D. L., Hasselkus-Light C. S., Fontenot D. J., Hunter E., Luciw P. A., Montelaro R. C., Phillips T. R. Distinct subsets of retroviruses encode dUTPase. J Virol. 1992 Mar;66(3):1791–1794. doi: 10.1128/jvi.66.3.1791-1794.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Elder J. H., Schnölzer M., Hasselkus-Light C. S., Henson M., Lerner D. A., Phillips T. R., Wagaman P. C., Kent S. B. Identification of proteolytic processing sites within the Gag and Pol polyproteins of feline immunodeficiency virus. J Virol. 1993 Apr;67(4):1869–1876. doi: 10.1128/jvi.67.4.1869-1876.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. English R. V., Johnson C. M., Gebhard D. H., Tompkins M. B. In vivo lymphocyte tropism of feline immunodeficiency virus. J Virol. 1993 Sep;67(9):5175–5186. doi: 10.1128/jvi.67.9.5175-5186.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Fauci A. S. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science. 1993 Nov 12;262(5136):1011–1018. doi: 10.1126/science.8235617. [DOI] [PubMed] [Google Scholar]
  51. Fevereiro M., Roneker C., Laufs A., Tavares L., de Noronha F. Characterization of two monoclonal antibodies against feline immunodeficiency virus gag gene products and their application in an assay to evaluate neutralizing antibody activity. J Gen Virol. 1991 Mar;72(Pt 3):617–622. doi: 10.1099/0022-1317-72-3-617. [DOI] [PubMed] [Google Scholar]
  52. Fevereiro M., Roneker C., de Noronha F. Antibody response to reverse transcriptase in cats infected with feline immunodeficiency virus. Viral Immunol. 1991 Winter;4(4):225–235. doi: 10.1089/vim.1991.4.225. [DOI] [PubMed] [Google Scholar]
  53. Fevereiro M., Roneker C., de Noronha F. Enhanced neutralization of feline immunodeficiency virus by complement viral lysis. Vet Immunol Immunopathol. 1993 Apr;36(3):191–206. doi: 10.1016/0165-2427(93)90019-z. [DOI] [PubMed] [Google Scholar]
  54. Fleming E. J., McCaw D. L., Smith J. A., Buening G. M., Johnson C. Clinical, hematologic, and survival data from cats infected with feline immunodeficiency virus: 42 cases (1983-1988). J Am Vet Med Assoc. 1991 Oct 1;199(7):913–916. [PubMed] [Google Scholar]
  55. Flynn J. N., Cannon C. A., Lawrence C. E., Jarrett O. Polyclonal B-cell activation in cats infected with feline immunodeficiency virus. Immunology. 1994 Apr;81(4):626–630. [PMC free article] [PubMed] [Google Scholar]
  56. Fontenot J. D., Hoover E. A., Elder J. H., Montelaro R. C. Evaluation of feline immunodeficiency virus and feline leukemia virus transmembrane peptides for serological diagnosis. J Clin Microbiol. 1992 Jul;30(7):1885–1890. doi: 10.1128/jcm.30.7.1885-1890.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Fujimoto S., Masuda M., Ono E., Kida H., Shimizu Y. Establishment of a feline T-lymphoblastoid cell line susceptible to feline immunodeficiency viruses. Microbiol Immunol. 1993;37(5):415–418. doi: 10.1111/j.1348-0421.1993.tb03231.x. [DOI] [PubMed] [Google Scholar]
  58. Furuya T., Hasegawa A., Miyazawa T., Miki K., Mikami T. Detection of anti-gag antibodies of feline immunodeficiency virus in cat sera by enzyme-linked immunosorbent assay. Arch Virol. 1992;124(3-4):355–361. doi: 10.1007/BF01309815. [DOI] [PubMed] [Google Scholar]
  59. Gardner M. B. Simian and feline immunodeficiency viruses: animal lentivirus models for evaluation of AIDS vaccines and antiviral agents. Antiviral Res. 1991 May;15(4):267–286. doi: 10.1016/0166-3542(91)90009-g. [DOI] [PubMed] [Google Scholar]
  60. George J. W., Pedersen N. C., Higgins J. The effect of age on the course of experimental feline immunodeficiency virus infection in cats. AIDS Res Hum Retroviruses. 1993 Sep;9(9):897–905. doi: 10.1089/aid.1993.9.897. [DOI] [PubMed] [Google Scholar]
  61. Greene W. K., Meers J., Chadwick B., Carnegie P. R., Robinson W. F. Nucleotide sequences of Australian isolates of the feline immunodeficiency virus: comparison with other feline lentiviruses. Arch Virol. 1993;132(3-4):369–379. doi: 10.1007/BF01309546. [DOI] [PubMed] [Google Scholar]
  62. Greene W. K., Meers J., del Fierro G., Carnegie P. R., Robinson W. F. Extensive sequence variation of feline immunodeficiency virus env genes in isolates from naturally infected cats. Arch Virol. 1993;133(1-2):51–62. doi: 10.1007/BF01309743. [DOI] [PubMed] [Google Scholar]
  63. Grindem C. B., Corbett W. T., Ammerman B. E., Tomkins M. T. Seroepidemiologic survey of feline immunodeficiency virus infection in cats of Wake County, North Carolina. J Am Vet Med Assoc. 1989 Jan 15;194(2):226–228. [PubMed] [Google Scholar]
  64. Gruffydd-Jones T. J., Hopper C. D., Harbour D. A., Lutz H. Serological evidence of feline immunodeficiency virus infection in UK cats from 1975-76. Vet Rec. 1988 Nov 26;123(22):569–570. doi: 10.1136/vr.123.22.569. [DOI] [PubMed] [Google Scholar]
  65. Hafkemeyer P., Neftel K., Hobi R., Pfaltz A., Lutz H., Lüthi K., Focher F., Spadari S., Hübscher U. HP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNAses H. Nucleic Acids Res. 1991 Aug 11;19(15):4059–4065. doi: 10.1093/nar/19.15.4059. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Hanlon M. A., Marr J. M., Hayes K. A., Mathes L. E., Stromberg P. C., Ringler S., Krakowka S., Lafrado L. J. Loss of neutrophil and natural killer cell function following feline immunodeficiency virus infection. Viral Immunol. 1993 Summer;6(2):119–124. doi: 10.1089/vim.1993.6.119. [DOI] [PubMed] [Google Scholar]
  67. Hara Y., Ishida T., Ejima H., Tagawa M., Motoyoshi S., Tomoda I., Shimizu M., Shichinohe K. Decrease in mitogen-induced lymphocyte proliferative responses in cats infected with feline immunodeficiency virus. Nihon Juigaku Zasshi. 1990 Jun;52(3):573–579. doi: 10.1292/jvms1939.52.573. [DOI] [PubMed] [Google Scholar]
  68. Harbour D. A., Williams P. D., Gruffydd-Jones T. J., Burbridge J., Pearson G. R. Isolation of a T-lymphotropic lentivirus from a persistently leucopenic domestic cat. Vet Rec. 1988 Jan 23;122(4):84–86. doi: 10.1136/vr.122.4.84. [DOI] [PubMed] [Google Scholar]
  69. Hartmann K., Donath A., Beer B., Egberink H. F., Horzinek M. C., Lutz H., Hoffmann-Fezer G., Thum I., Thefeld S. Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms. Vet Immunol Immunopathol. 1992 Dec;35(1-2):167–175. doi: 10.1016/0165-2427(92)90129-e. [DOI] [PubMed] [Google Scholar]
  70. Haynes B. F. Scientific and social issues of human immunodeficiency virus vaccine development. Science. 1993 May 28;260(5112):1279–1286. doi: 10.1126/science.8493572. [DOI] [PubMed] [Google Scholar]
  71. Heidel J. R., Dubey J. P., Blythe L. L., Walker L. L., Duimstra J. R., Jordan J. S. Myelitis in a cat infected with Toxoplasma gondii and feline immunodeficiency virus. J Am Vet Med Assoc. 1990 Jan 15;196(2):316–318. [PubMed] [Google Scholar]
  72. Hoffmann-Fezer G., Thum J., Ackley C., Herbold M., Mysliwietz J., Thefeld S., Hartmann K., Kraft W. Decline in CD4+ cell numbers in cats with naturally acquired feline immunodeficiency virus infection. J Virol. 1992 Mar;66(3):1484–1488. doi: 10.1128/jvi.66.3.1484-1488.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Hohdatsu T., Pu R., Torres B. A., Trujillo S., Gardner M. B., Yamamoto J. K. Passive antibody protection of cats against feline immunodeficiency virus infection. J Virol. 1993 Apr;67(4):2344–2348. doi: 10.1128/jvi.67.4.2344-2348.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Hohdatsu T., Yamada M., Okada M., Fukasawa M., Watanabe K., Ogasawara T., Takagi M., Aizawa C., Hayami M., Koyama H. Detection of feline immunodeficiency proviral DNA in peripheral blood lymphocytes by the polymerase chain reaction. Vet Microbiol. 1992 Feb;30(2-3):113–123. doi: 10.1016/0378-1135(92)90107-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Hopper C. D., Sparkes A. H., Gruffydd-Jones T. J., Crispin S. M., Muir P., Harbour D. A., Stokes C. R. Clinical and laboratory findings in cats infected with feline immunodeficiency virus. Vet Rec. 1989 Sep 23;125(13):341–346. doi: 10.1136/vr.125.13.341. [DOI] [PubMed] [Google Scholar]
  76. Hosie M. J., Jarrett O. Serological responses of cats to feline immunodeficiency virus. AIDS. 1990 Mar;4(3):215–220. doi: 10.1097/00002030-199003000-00006. [DOI] [PubMed] [Google Scholar]
  77. Hosie M. J., Osborne R., Reid G., Neil J. C., Jarrett O. Enhancement after feline immunodeficiency virus vaccination. Vet Immunol Immunopathol. 1992 Dec;35(1-2):191–197. doi: 10.1016/0165-2427(93)90149-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Hosie M. J., Robertson C., Jarrett O. Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. Vet Rec. 1989 Sep 9;125(11):293–297. doi: 10.1136/vr.125.11.293. [DOI] [PubMed] [Google Scholar]
  79. Hosie M. J. The development of a vaccine against feline immunodeficiency virus. Br Vet J. 1994 Jan-Feb;150(1):25–39. doi: 10.1016/S0007-1935(05)80094-6. [DOI] [PubMed] [Google Scholar]
  80. Hosie M. J., Willett B. J., Dunsford T. H., Jarrett O., Neil J. C. A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor. J Virol. 1993 Mar;67(3):1667–1671. doi: 10.1128/jvi.67.3.1667-1671.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Hu S. L., Abrams K., Barber G. N., Moran P., Zarling J. M., Langlois A. J., Kuller L., Morton W. R., Benveniste R. E. Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160. Science. 1992 Jan 24;255(5043):456–459. doi: 10.1126/science.1531159. [DOI] [PubMed] [Google Scholar]
  82. Hurtrel M., Ganière J. P., Guelfi J. F., Chakrabarti L., Maire M. A., Gray F., Montagnier L., Hurtrel B. Comparison of early and late feline immunodeficiency virus encephalopathies. AIDS. 1992 Apr;6(4):399–406. doi: 10.1097/00002030-199204000-00007. [DOI] [PubMed] [Google Scholar]
  83. Hutson C. A., Rideout B. A., Pedersen N. C. Neoplasia associated with feline immunodeficiency virus infection in cats of southern California. J Am Vet Med Assoc. 1991 Nov 15;199(10):1357–1362. [PubMed] [Google Scholar]
  84. Ishida T., Taniguchi A., Matsumura S., Washizu T., Tomoda I. Long-term clinical observations on feline immunodeficiency virus infected asymptomatic carriers. Vet Immunol Immunopathol. 1992 Dec;35(1-2):15–22. doi: 10.1016/0165-2427(92)90117-9. [DOI] [PubMed] [Google Scholar]
  85. Ishida T., Tomoda I. Clinical staging of feline immunodeficiency virus infection. Nihon Juigaku Zasshi. 1990 Jun;52(3):645–648. doi: 10.1292/jvms1939.52.645. [DOI] [PubMed] [Google Scholar]
  86. Ishida T., Washizu T., Toriyabe K., Motoyoshi S. Detection of feline T-lymphotropic lentivirus (FTLV) infection in Japanese domestic cats. Nihon Juigaku Zasshi. 1988 Feb;50(1):39–44. doi: 10.1292/jvms1939.50.39. [DOI] [PubMed] [Google Scholar]
  87. Ishida T., Washizu T., Toriyabe K., Motoyoshi S., Tomoda I., Pedersen N. C. Feline immunodeficiency virus infection in cats of Japan. J Am Vet Med Assoc. 1989 Jan 15;194(2):221–225. [PubMed] [Google Scholar]
  88. Johnston M. I., Hoth D. F. Present status and future prospects for HIV therapies. Science. 1993 May 28;260(5112):1286–1293. doi: 10.1126/science.7684163. [DOI] [PubMed] [Google Scholar]
  89. Kawaguchi Y., Maeda K., Tohya Y., Furuya T., Miyazawa T., Horimoto T., Norimine J., Kai C., Mikami T. Replicative difference in early-passage feline brain cells among feline immunodeficiency virus isolates. Arch Virol. 1992;125(1-4):347–354. doi: 10.1007/BF01309653. [DOI] [PubMed] [Google Scholar]
  90. Kawaguchi Y., Miyazawa T., Horimoto T., Itagaki S., Fukasawa M., Takahashi E., Mikami T. Activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1. Virology. 1991 Sep;184(1):449–454. doi: 10.1016/0042-6822(91)90868-c. [DOI] [PubMed] [Google Scholar]
  91. Kawaguchi Y., Norimine J., Miyazawa T., Kai C., Mikami T. Sequences within the feline immunodeficiency virus long terminal repeat that regulate gene expression and respond to activation by feline herpesvirus type 1. Virology. 1992 Sep;190(1):465–468. doi: 10.1016/0042-6822(92)91235-m. [DOI] [PubMed] [Google Scholar]
  92. Kindt T. J., Hirsch V. M., Johnson P. R., Sawasdikosol S. Animal models for acquired immunodeficiency syndrome. Adv Immunol. 1992;52:425–474. doi: 10.1016/s0065-2776(08)60880-9. [DOI] [PubMed] [Google Scholar]
  93. Kiyomasu T., Miyazawa T., Furuya T., Shibata R., Sakai H., Sakuragi J., Fukasawa M., Maki N., Hasegawa A., Mikami T. Identification of feline immunodeficiency virus rev gene activity. J Virol. 1991 Aug;65(8):4539–4542. doi: 10.1128/jvi.65.8.4539-4542.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Knowles J. O., Gaskell R. M., Gaskell C. J., Harvey C. E., Lutz H. Prevalence of feline calicivirus, feline leukaemia virus and antibodies to FIV in cats with chronic stomatitis. Vet Rec. 1989 Apr 1;124(13):336–338. doi: 10.1136/vr.124.13.336. [DOI] [PubMed] [Google Scholar]
  95. Lackner A. A., Dandekar S., Gardner M. B. Neurobiology of simian and feline immunodeficiency virus infections. Brain Pathol. 1991 Apr;1(3):201–212. doi: 10.1111/j.1750-3639.1991.tb00660.x. [DOI] [PubMed] [Google Scholar]
  96. Lappin M. R., Gasper P. W., Rose B. J., Powell C. C. Effect of primary phase feline immunodeficiency virus infection on cats with chronic toxoplasmosis. Vet Immunol Immunopathol. 1992 Dec;35(1-2):121–131. doi: 10.1016/0165-2427(92)90125-a. [DOI] [PubMed] [Google Scholar]
  97. Lawrence C. E., Callanan J. J., Jarrett O. Decreased mitogen responsiveness and elevated tumor necrosis factor production in cats shortly after feline immunodeficiency virus infection. Vet Immunol Immunopathol. 1992 Dec;35(1-2):51–59. doi: 10.1016/0165-2427(92)90120-f. [DOI] [PubMed] [Google Scholar]
  98. Lehmann R., Franchini M., Aubert A., Wolfensberger C., Cronier J., Lutz H. Vaccination of cats experimentally infected with feline immunodeficiency virus, using a recombinant feline leukemia virus vaccine. J Am Vet Med Assoc. 1991 Nov 15;199(10):1446–1452. [PubMed] [Google Scholar]
  99. Lehmann R., Joller H., Haagmans B. L., Lutz H. Tumor necrosis factor alpha levels in cats experimentally infected with feline immunodeficiency virus: effects of immunization and feline leukemia virus infection. Vet Immunol Immunopathol. 1992 Dec;35(1-2):61–69. doi: 10.1016/0165-2427(92)90121-6. [DOI] [PubMed] [Google Scholar]
  100. Lehmann R., von Beust B., Niederer E., Condrau M. A., Fierz W., Aubert A., Ackley C. D., Cooper M. D., Tompkins M. B., Lutz H. Immunization-induced decrease of the CD4+:CD8+ ratio in cats experimentally infected with feline immunodeficiency virus. Vet Immunol Immunopathol. 1992 Dec;35(1-2):199–214. doi: 10.1016/0165-2427(92)90132-a. [DOI] [PubMed] [Google Scholar]
  101. Levy J. A. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 1993 Mar;57(1):183–289. doi: 10.1128/mr.57.1.183-289.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Lin D. S., Bowman D. D., Jacobson R. H., Barr M. C., Fevereiro M., Williams J. R., Noronha F. M., Scott F. W., Avery R. J. Suppression of lymphocyte blastogenesis to mitogens in cats experimentally infected with feline immunodeficiency virus. Vet Immunol Immunopathol. 1990 Oct;26(2):183–189. doi: 10.1016/0165-2427(90)90066-2. [DOI] [PubMed] [Google Scholar]
  103. Lin D. S., Bowman D. D., Jacobson R. H. Immunological changes in cats with concurrent Toxoplasma gondii and feline immunodeficiency virus infections. J Clin Microbiol. 1992 Jan;30(1):17–24. doi: 10.1128/jcm.30.1.17-24.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Lin D. S., Bowman D. D. Macrophage functions in cats experimentally infected with feline immunodeficiency virus and Toxoplasma gondii. Vet Immunol Immunopathol. 1992 Jun;33(1-2):69–78. doi: 10.1016/0165-2427(92)90035-o. [DOI] [PubMed] [Google Scholar]
  105. Lin D. S. Feline immune system. Comp Immunol Microbiol Infect Dis. 1992 Jan;15(1):1–11. doi: 10.1016/0147-9571(92)90097-B. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Lombardi S., Bendinelli M., Garzelli C. Detection of B epitopes on the p24 gag protein of feline immunodeficiency virus by monoclonal antibodies. AIDS Res Hum Retroviruses. 1993 Feb;9(2):141–146. doi: 10.1089/aid.1993.9.141. [DOI] [PubMed] [Google Scholar]
  107. Lombardi S., Garzelli C., La Rosa C., Zaccaro L., Specter S., Malvaldi G., Tozzini F., Esposito F., Bendinelli M. Identification of a linear neutralization site within the third variable region of the feline immunodeficiency virus envelope. J Virol. 1993 Aug;67(8):4742–4749. doi: 10.1128/jvi.67.8.4742-4749.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Lombardi S., Poli A., Massi C., Abramo F., Zaccaro L., Bazzichi A., Malvaldi G., Bendinelli M., Garzelli C. Detection of feline immunodeficiency virus p24 antigen and p24-specific antibodies by monoclonal antibody-based assays. J Virol Methods. 1994 Mar;46(3):287–301. doi: 10.1016/0166-0934(94)90001-9. [DOI] [PubMed] [Google Scholar]
  109. Lutz H. Feline retroviruses: a brief review. Vet Microbiol. 1990 Jun;23(1-4):131–146. doi: 10.1016/0378-1135(90)90143-j. [DOI] [PubMed] [Google Scholar]
  110. Lutz H., Isenbügel E., Lehmann R., Sabapara R. H., Wolfensberger C. Retrovirus infections in non-domestic felids: serological studies and attempts to isolate a lentivirus. Vet Immunol Immunopathol. 1992 Dec;35(1-2):215–224. doi: 10.1016/0165-2427(92)90133-b. [DOI] [PubMed] [Google Scholar]
  111. Lutz H., Lehmann R., Winkler G., Kottwitz B., Dittmer A., Wolfensberger C., Arnold P. Das Feline Immunschwächevirus in der Schweiz: Klinik und Epidemiologie im Vergleich mit dem leukämie- und dem Coronavirus. Schweiz Arch Tierheilkd. 1990;132(5):217–225. [PubMed] [Google Scholar]
  112. Magnani M., Rossi L., Fraternale A., Silvotti L., Quintavalla F., Piedimonte G., Matteucci D., Baldinotti F., Bendinelli M. Feline immunodeficiency virus infection of macrophages: in vitro and in vivo inhibition by dideoxycytidine-5'-triphosphate-loaded erythrocytes. AIDS Res Hum Retroviruses. 1994 Sep;10(9):1179–1186. doi: 10.1089/aid.1994.10.1179. [DOI] [PubMed] [Google Scholar]
  113. Maki N., Miyazawa T., Fukasawa M., Hasegawa A., Hayami M., Miki K., Mikami T. Molecular characterization and heterogeneity of feline immunodeficiency virus isolates. Arch Virol. 1992;123(1-2):29–45. doi: 10.1007/BF01317136. [DOI] [PubMed] [Google Scholar]
  114. Mancianti F., Giannelli C., Bendinelli M., Poli A. Mycological findings in feline immunodeficiency virus-infected cats. J Med Vet Mycol. 1992;30(3):257–259. doi: 10.1080/02681219280000321. [DOI] [PubMed] [Google Scholar]
  115. Matsumura S., Ishida T., Washizu T., Tomoda I., Nagata S., Chiba J., Kurata T. Pathologic features of acquired immunodeficiency-like syndrome in cats experimentally infected with feline immunodeficiency virus. J Vet Med Sci. 1993 Jun;55(3):387–394. doi: 10.1292/jvms.55.387. [DOI] [PubMed] [Google Scholar]
  116. Matsuo K., Nishino Y., Kimura T., Yamaguchi R., Yamazaki A., Mikami T., Ikuta K. Highly conserved epitope domain in major core protein p24 is structurally similar among human, simian and feline immunodeficiency viruses. J Gen Virol. 1992 Sep;73(Pt 9):2445–2450. doi: 10.1099/0022-1317-73-9-2445. [DOI] [PubMed] [Google Scholar]
  117. Matteucci D., Baldinotti F., Mazzetti P., Pistello M., Bandecchi P., Ghilarducci R., Poli A., Tozzini F., Bendinelli M. Detection of feline immunodeficiency virus in saliva and plasma by cultivation and polymerase chain reaction. J Clin Microbiol. 1993 Mar;31(3):494–501. doi: 10.1128/jcm.31.3.494-501.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  118. Meers J., Robinson W. F., del Fierro G. M., Scoones M. A., Lawson M. A. Feline immunodeficiency virus: quantification in peripheral blood mononuclear cells and isolation from plasma of infected cats. Arch Virol. 1992;127(1-4):233–243. doi: 10.1007/BF01309587. [DOI] [PubMed] [Google Scholar]
  119. Meers J., del Fierro G. M., Cope R. B., Park H. S., Greene W. K., Robinson W. F. Feline immunodeficiency virus infection: plasma, but not peripheral blood mononuclear cell virus titer is influenced by zidovudine and cyclosporine. Arch Virol. 1993;132(1-2):67–81. doi: 10.1007/BF01309844. [DOI] [PubMed] [Google Scholar]
  120. Mermer B., Hillman P., Harris R., Krogmann T., Tonelli Q., Palin W., Andersen P. A recombinant-based feline immunodeficiency virus antibody enzyme-linked immunosorbent assay. Vet Immunol Immunopathol. 1992 Dec;35(1-2):133–141. doi: 10.1016/0165-2427(92)90126-b. [DOI] [PubMed] [Google Scholar]
  121. Miyazawa T., Fukasawa M., Hasegawa A., Maki N., Ikuta K., Takahashi E., Hayami M., Mikami T. Molecular cloning of a novel isolate of feline immunodeficiency virus biologically and genetically different from the original U.S. isolate. J Virol. 1991 Mar;65(3):1572–1577. doi: 10.1128/jvi.65.3.1572-1577.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Miyazawa T., Furuya T., Itagaki S., Tohya Y., Nakano K., Takahashi E., Mikami T. Preliminary comparisons of the biological properties of two strains of feline immunodeficiency virus (FIV) isolated in Japan with FIV Petaluma strain isolated in the United States. Arch Virol. 1989;108(1-2):59–68. doi: 10.1007/BF01313743. [DOI] [PubMed] [Google Scholar]
  123. Miyazawa T., Kawaguchi Y., Kohmoto M., Sakuragi J., Adachi A., Fukasawa M., Mikami T. Production of feline immunodeficiency virus in feline and non-feline non-lymphoid cell lines by transfection of an infectious molecular clone. J Gen Virol. 1992 Jun;73(Pt 6):1543–1546. doi: 10.1099/0022-1317-73-6-1543. [DOI] [PubMed] [Google Scholar]
  124. Miyazawa T., Kohmoto M., Kawaguchi Y., Tomonaga K., Toyosaki T., Ikuta K., Adachi A., Mikami T. The AP-1 binding site in the feline immunodeficiency virus long terminal repeat is not required for virus replication in feline T lymphocytes. J Gen Virol. 1993 Aug;74(Pt 8):1573–1580. doi: 10.1099/0022-1317-74-8-1573. [DOI] [PubMed] [Google Scholar]
  125. Mochizuki M., Akuzawa M., Nagatomo H. Serological survey of the Iriomote cat (Felis iriomotensis) in Japan. J Wildl Dis. 1990 Apr;26(2):236–245. doi: 10.7589/0090-3558-26.2.236. [DOI] [PubMed] [Google Scholar]
  126. Moench T. R., Whaley K. J., Mandrell T. D., Bishop B. D., Witt C. J., Cone R. A. The cat/feline immunodeficiency virus model for transmucosal transmission of AIDS: nonoxynol-9 contraceptive jelly blocks transmission by an infected cell inoculum. AIDS. 1993 Jun;7(6):797–802. doi: 10.1097/00002030-199306000-00006. [DOI] [PubMed] [Google Scholar]
  127. Moraillon A., Barré-Sinoussi F., Parodi A., Moraillon R., Dauguet C. In vitro properties and experimental pathogenic effect of three strains of feline immunodeficiency viruses (FIV) isolated from cats with terminal disease. Vet Microbiol. 1992 Apr;31(1):41–54. doi: 10.1016/0378-1135(92)90140-O. [DOI] [PMC free article] [PubMed] [Google Scholar]
  128. Moraillon A. Feline immunodepressive retrovirus infections in France. Vet Rec. 1990 Jan 20;126(3):68–69. [PubMed] [Google Scholar]
  129. Morikawa S., Bishop D. H. Identification and analysis of the gag-pol ribosomal frameshift site of feline immunodeficiency virus. Virology. 1992 Feb;186(2):389–397. doi: 10.1016/0042-6822(92)90004-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Morikawa S., Booth T. F., Bishop D. H. Analyses of the requirements for the synthesis of virus-like particles by feline immunodeficiency virus gag using baculovirus vectors. Virology. 1991 Jul;183(1):288–297. doi: 10.1016/0042-6822(91)90141-w. [DOI] [PubMed] [Google Scholar]
  131. Morikawa S., Lutz H., Aubert A., Bishop D. H. Identification of conserved and variable regions in the envelope glycoprotein sequences of two feline immunodeficiency viruses isolated in Zurich, Switzerland. Virus Res. 1991 Sep;21(1):53–63. doi: 10.1016/0168-1702(91)90071-3. [DOI] [PubMed] [Google Scholar]
  132. Mtambo M. M., Nash A. S., Blewett D. A., Smith H. V., Wright S. Cryptosporidium infection in cats: prevalence of infection in domestic and feral cats in the Glasgow area. Vet Rec. 1991 Dec 7;129(23):502–504. [PubMed] [Google Scholar]
  133. Nara P. L., Garrity R. R., Goudsmit J. Neutralization of HIV-1: a paradox of humoral proportions. FASEB J. 1991 Jul;5(10):2437–2455. doi: 10.1096/fasebj.5.10.1712328. [DOI] [PubMed] [Google Scholar]
  134. Nishino Y., Ohki K., Kimura T., Morikawa S., Mikami T., Ikuta K. Major core proteins, p24s, of human, simian, and feline immunodeficiency viruses are partly expressed on the surface of the virus-infected cells. Vaccine. 1992;10(10):677–683. doi: 10.1016/0264-410x(92)90089-3. [DOI] [PubMed] [Google Scholar]
  135. Norimine J., Miyazawa T., Kawaguchi Y., Tomonaga K., Shin Y. S., Toyosaki T., Kohmoto M., Niikura M., Tohya Y., Mikami T. Feline CD4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates. Arch Virol. 1993;130(1-2):171–178. doi: 10.1007/BF01319005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. North T. W., Cronn R. C., Remington K. M., Tandberg R. T. Direct comparisons of inhibitor sensitivities of reverse transcriptases from feline and human immunodeficiency viruses. Antimicrob Agents Chemother. 1990 Aug;34(8):1505–1507. doi: 10.1128/aac.34.8.1505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. North T. W., Cronn R. C., Remington K. M., Tandberg R. T., Judd R. C. Characterization of reverse transcriptase from feline immunodeficiency virus. J Biol Chem. 1990 Mar 25;265(9):5121–5128. [PubMed] [Google Scholar]
  138. North T. W., North G. L., Pedersen N. C. Feline immunodeficiency virus, a model for reverse transcriptase-targeted chemotherapy for acquired immune deficiency syndrome. Antimicrob Agents Chemother. 1989 Jun;33(6):915–919. doi: 10.1128/aac.33.6.915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Novotney C., English R. V., Housman J., Davidson M. G., Nasisse M. P., Jeng C. R., Davis W. C., Tompkins M. B. Lymphocyte population changes in cats naturally infected with feline immunodeficiency virus. AIDS. 1990 Dec;4(12):1213–1218. doi: 10.1097/00002030-199012000-00005. [DOI] [PubMed] [Google Scholar]
  140. O'Connor T. P., Jr, Tanguay S., Steinman R., Smith R., Barr M. C., Yamamoto J. K., Pedersen N. C., Andersen P. R., Tonelli Q. J. Development and evaluation of immunoassay for detection of antibodies to the feline T-lymphotropic lentivirus (feline immunodeficiency virus). J Clin Microbiol. 1989 Mar;27(3):474–479. doi: 10.1128/jcm.27.3.474-479.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  141. O'Connor T. P., Jr, Tonelli Q. J., Scarlett J. M. Report of the National FeLV/FIV Awareness Project. J Am Vet Med Assoc. 1991 Nov 15;199(10):1348–1353. [PubMed] [Google Scholar]
  142. Ohno K., Nakano T., Matsumoto Y., Watari T., Goitsuka R., Nakayama H., Tsujimoto H., Hasegawa A. Apoptosis induced by tumor necrosis factor in cells chronically infected with feline immunodeficiency virus. J Virol. 1993 May;67(5):2429–2433. doi: 10.1128/jvi.67.5.2429-2433.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  143. Ohno K., Watari T., Goitsuka R., Tsujimoto H., Hasegawa A. Altered surface antigen expression on peripheral blood mononuclear cells in cats infected with feline immunodeficiency virus. J Vet Med Sci. 1992 Jun;54(3):517–522. doi: 10.1292/jvms.54.517. [DOI] [PubMed] [Google Scholar]
  144. Olmsted R. A., Hirsch V. M., Purcell R. H., Johnson P. R. Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8088–8092. doi: 10.1073/pnas.86.20.8088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. Olmsted R. A., Langley R., Roelke M. E., Goeken R. M., Adger-Johnson D., Goff J. P., Albert J. P., Packer C., Laurenson M. K., Caro T. M. Worldwide prevalence of lentivirus infection in wild feline species: epidemiologic and phylogenetic aspects. J Virol. 1992 Oct;66(10):6008–6018. doi: 10.1128/jvi.66.10.6008-6018.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  146. Orentas R. J., Hildreth J. E. Association of host cell surface adhesion receptors and other membrane proteins with HIV and SIV. AIDS Res Hum Retroviruses. 1993 Nov;9(11):1157–1165. doi: 10.1089/aid.1993.9.1157. [DOI] [PubMed] [Google Scholar]
  147. Pancino G., Chappey C., Saurin W., Sonigo P. B epitopes and selection pressures in feline immunodeficiency virus envelope glycoproteins. J Virol. 1993 Feb;67(2):664–672. doi: 10.1128/jvi.67.2.664-672.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  148. Pancino G., Fossati I., Chappey C., Castelot S., Hurtrel B., Moraillon A., Klatzmann D., Sonigo P. Structure and variations of feline immunodeficiency virus envelope glycoproteins. Virology. 1993 Feb;192(2):659–662. doi: 10.1006/viro.1993.1083. [DOI] [PubMed] [Google Scholar]
  149. Pearson L. D., Poss M. L., Demartini J. C. Animal lentivirus vaccines: problems and prospects. Vet Immunol Immunopathol. 1989 Feb;20(3):183–212. doi: 10.1016/0165-2427(89)90002-0. [DOI] [PubMed] [Google Scholar]
  150. Pedersen N. C., Barlough J. E. Clinical overview of feline immunodeficiency virus. J Am Vet Med Assoc. 1991 Nov 15;199(10):1298–1305. [PubMed] [Google Scholar]
  151. Pedersen N. C., Ho E. W., Brown M. L., Yamamoto J. K. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science. 1987 Feb 13;235(4790):790–793. doi: 10.1126/science.3643650. [DOI] [PubMed] [Google Scholar]
  152. Pedersen N. C., Torten M., Rideout B., Sparger E., Tonachini T., Luciw P. A., Ackley C., Levy N., Yamamoto J. Feline leukemia virus infection as a potentiating cofactor for the primary and secondary stages of experimentally induced feline immunodeficiency virus infection. J Virol. 1990 Feb;64(2):598–606. doi: 10.1128/jvi.64.2.598-606.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  153. Pedersen N. C., Yamamoto J. K., Ishida T., Hansen H. Feline immunodeficiency virus infection. Vet Immunol Immunopathol. 1989 May;21(1):111–129. doi: 10.1016/0165-2427(89)90134-7. [DOI] [PubMed] [Google Scholar]
  154. Phillips T. R., Lamont C., Konings D. A., Shacklett B. L., Hamson C. A., Luciw P. A., Elder J. H. Identification of the Rev transactivation and Rev-responsive elements of feline immunodeficiency virus. J Virol. 1992 Sep;66(9):5464–5471. doi: 10.1128/jvi.66.9.5464-5471.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  155. Phillips T. R., Talbott R. L., Lamont C., Muir S., Lovelace K., Elder J. H. Comparison of two host cell range variants of feline immunodeficiency virus. J Virol. 1990 Oct;64(10):4605–4613. doi: 10.1128/jvi.64.10.4605-4613.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  156. Philpott M. S., Ebner J. P., Hoover E. A. Evaluation of 9-(2-phosphonylmethoxyethyl) adenine therapy for feline immunodeficiency virus using a quantitative polymerase chain reaction. Vet Immunol Immunopathol. 1992 Dec;35(1-2):155–166. doi: 10.1016/0165-2427(92)90128-d. [DOI] [PubMed] [Google Scholar]
  157. Pistello M., Menzo S., Giorgi M., Da Prato L., Cammarota G., Clementi M., Bendinelli M. Competitive polymerase chain reaction for quantitating feline immunodeficiency virus load in infected cat tissues. Mol Cell Probes. 1994 Jun;8(3):229–234. doi: 10.1006/mcpr.1994.1032. [DOI] [PubMed] [Google Scholar]
  158. Podell M., Oglesbee M., Mathes L., Krakowka S., Olmstead R., Lafrado L. AIDS-associated encephalopathy with experimental feline immunodeficiency virus infection. J Acquir Immune Defic Syndr. 1993 Jul;6(7):758–771. [PubMed] [Google Scholar]
  159. Poli A., Abramo F., Baldinotti F., Pistello M., Da Prato L., Bendinelli M. Malignant lymphoma associated with experimentally induced feline immunodeficiency virus infection. J Comp Pathol. 1994 May;110(4):319–328. doi: 10.1016/s0021-9975(08)80309-x. [DOI] [PubMed] [Google Scholar]
  160. Poli A., Abramo F., Taccini E., Guidi G., Barsotti P., Bendinelli M., Malvaldi G. Renal involvement in feline immunodeficiency virus infection: a clinicopathological study. Nephron. 1993;64(2):282–288. doi: 10.1159/000187327. [DOI] [PubMed] [Google Scholar]
  161. Poli A., Giannelli C., Pistello M., Zaccaro L., Pieracci D., Bendinelli M., Malvaldi G. Detection of salivary antibodies in cats infected with feline immunodeficiency virus. J Clin Microbiol. 1992 Aug;30(8):2038–2041. doi: 10.1128/jcm.30.8.2038-2041.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  162. Poss M. L., Dow S. W., Hoover E. A. Cell-specific envelope glycosylation distinguishes FIV glycoproteins produced in cytopathically and noncytopathically infected cells. Virology. 1992 May;188(1):25–32. doi: 10.1016/0042-6822(92)90731-4. [DOI] [PubMed] [Google Scholar]
  163. Reid G., Rigby M. A., McDonald M., Hosie M. J., Neil J. C., Jarrett O. Immunodiagnosis of feline immunodeficiency virus infection using recombinant viral p17 and p24. AIDS. 1991 Dec;5(12):1477–1483. doi: 10.1097/00002030-199112000-00010. [DOI] [PubMed] [Google Scholar]
  164. Remington K. M., Chesebro B., Wehrly K., Pedersen N. C., North T. W. Mutants of feline immunodeficiency virus resistant to 3'-azido-3'-deoxythymidine. J Virol. 1991 Jan;65(1):308–312. doi: 10.1128/jvi.65.1.308-312.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  165. Remington K. M., Zhu Y. Q., Phillips T. R., North T. W. Rapid phenotypic reversion of zidovudine-resistant feline immunodeficiency virus without loss of drug-resistant reverse transcriptase. J Virol. 1994 Feb;68(2):632–637. doi: 10.1128/jvi.68.2.632-637.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  166. Reubel G. H., George J. W., Barlough J. E., Higgins J., Grant C. K., Pedersen N. C. Interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats. Vet Immunol Immunopathol. 1992 Dec;35(1-2):95–119. doi: 10.1016/0165-2427(92)90124-9. [DOI] [PubMed] [Google Scholar]
  167. Rideout B. A., Lowensteine L. J., Hutson C. A., Moore P. F., Pedersen N. C. Characterization of morphologic changes and lymphocyte subset distribution in lymph nodes from cats with naturally acquired feline immunodeficiency virus infection. Vet Pathol. 1992 Sep;29(5):391–399. doi: 10.1177/030098589202900504. [DOI] [PubMed] [Google Scholar]
  168. Rideout B. A., Moore P. F., Pedersen N. C. Persistent upregulation of MHC class II antigen expression on T-lymphocytes from cats experimentally infected with feline immunodeficiency virus. Vet Immunol Immunopathol. 1992 Dec;35(1-2):71–81. doi: 10.1016/0165-2427(92)90122-7. [DOI] [PubMed] [Google Scholar]
  169. Rideout D., Schinazi R., Pauza C. D., Lovelace K., Chiang L. C., Calogeropoulou T., McCarthy M., Elder J. H. Derivatives of 4-amino-3,6-disulfonato-1,8-naphthalimide inhibit reverse transcriptase and suppress human and feline immunodeficiency virus expression in cultured cells. J Cell Biochem. 1993 Apr;51(4):446–457. doi: 10.1002/jcb.2400510410. [DOI] [PubMed] [Google Scholar]
  170. Rigby M. A., Holmes E. C., Pistello M., Mackay A., Brown A. J., Neil J. C. Evolution of structural proteins of feline immunodeficiency virus: molecular epidemiology and evidence of selection for change. J Gen Virol. 1993 Mar;74(Pt 3):425–436. doi: 10.1099/0022-1317-74-3-425. [DOI] [PubMed] [Google Scholar]
  171. Rimstad E., Ueland K. Detection of feline immunodeficiency virus by a nested polymerase chain reaction. J Virol Methods. 1992 Mar;36(3):239–248. doi: 10.1016/0166-0934(92)90055-i. [DOI] [PubMed] [Google Scholar]
  172. Salk J., Bretscher P. A., Salk P. L., Clerici M., Shearer G. M. A strategy for prophylactic vaccination against HIV. Science. 1993 May 28;260(5112):1270–1272. doi: 10.1126/science.8098553. [DOI] [PubMed] [Google Scholar]
  173. Saxinger W. C., Levine P. H., Dean A. G., de Thé G., Lange-Wantzin G., Moghissi J., Laurent F., Hoh M., Sarngadharan M. G., Gallo R. C. Evidence for exposure to HTLV-III in Uganda before 1973. Science. 1985 Mar 1;227(4690):1036–1038. doi: 10.1126/science.2983417. [DOI] [PubMed] [Google Scholar]
  174. Shelton G. H., Abkowitz J. L., Linenberger M. L., Russell R. G., Grant C. K. Chronic leukopenia associated with feline immunodeficiency virus infection in a cat. J Am Vet Med Assoc. 1989 Jan 15;194(2):253–255. [PubMed] [Google Scholar]
  175. Shelton G. H., Grant C. K., Cotter S. M., Gardner M. B., Hardy W. D., Jr, DiGiacomo R. F. Feline immunodeficiency virus and feline leukemia virus infections and their relationships to lymphoid malignancies in cats: a retrospective study (1968-1988). J Acquir Immune Defic Syndr. 1990;3(6):623–630. [PubMed] [Google Scholar]
  176. Shelton G. H., Linenberger M. L., Abkowitz J. L. Hematologic abnormalities in cats seropositive for feline immunodeficiency virus. J Am Vet Med Assoc. 1991 Nov 15;199(10):1353–1357. [PubMed] [Google Scholar]
  177. Shelton G. H., Linenberger M. L., Grant C. K., Abkowitz J. L. Hematologic manifestations of feline immunodeficiency virus infection. Blood. 1990 Sep 15;76(6):1104–1109. [PubMed] [Google Scholar]
  178. Siebelink C. H., Windrich R. W., Chu I., Groen J., Weijer K., UytdeHaag F. G., Osterhaus A. D. An enzyme linked immunosorbent assay (ELISA) for the detection of feline immunodeficiency virus (FIV) antigen in cell culture and FIV specific antibodies in feline serum. Dev Biol Stand. 1990;72:189–196. [PubMed] [Google Scholar]
  179. Siebelink K. H., Chu I. H., Rimmelzwaan G. F., Weijer K., Osterhaus A. D., Bosch M. L. Isolation and partial characterization of infectious molecular clones of feline immunodeficiency virus obtained directly from bone marrow DNA of a naturally infected cat. J Virol. 1992 Feb;66(2):1091–1097. doi: 10.1128/jvi.66.2.1091-1097.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  180. Siebelink K. H., Chu I. H., Rimmelzwaan G. F., Weijer K., van Herwijnen R., Knell P., Egberink H. F., Bosch M. L., Osterhaus A. D. Feline immunodeficiency virus (FIV) infection in the cat as a model for HIV infection in man: FIV-induced impairment of immune function. AIDS Res Hum Retroviruses. 1990 Dec;6(12):1373–1378. doi: 10.1089/aid.1990.6.1373. [DOI] [PubMed] [Google Scholar]
  181. Siebelink K. H., Rimmelzwaan G. F., Bosch M. L., Meloen R. H., Osterhaus A. D. A single amino acid substitution in hypervariable region 5 of the envelope protein of feline immunodeficiency virus allows escape from virus neutralization. J Virol. 1993 Apr;67(4):2202–2208. doi: 10.1128/jvi.67.4.2202-2208.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  182. Sodora D. L., Shpaer E. G., Kitchell B. E., Dow S. W., Hoover E. A., Mullins J. I. Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns. J Virol. 1994 Apr;68(4):2230–2238. doi: 10.1128/jvi.68.4.2230-2238.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  183. Song W., Collisson E. W., Billingsley P. M., Brown W. C. Induction of feline immunodeficiency virus-specific cytolytic T-cell responses from experimentally infected cats. J Virol. 1992 Sep;66(9):5409–5417. doi: 10.1128/jvi.66.9.5409-5417.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  184. Sparger E. E., Luciw P. A., Elder J. H., Yamamoto J. K., Lowenstine L. J., Pedersen N. C. Feline immunodeficiency virus is a lentivirus associated with an AIDS-like disease in cats. AIDS. 1989;3 (Suppl 1):S43–S49. doi: 10.1097/00002030-198901001-00006. [DOI] [PubMed] [Google Scholar]
  185. Sparger E. E., Shacklett B. L., Renshaw-Gegg L., Barry P. A., Pedersen N. C., Elder J. H., Luciw P. A. Regulation of gene expression directed by the long terminal repeat of the feline immunodeficiency virus. Virology. 1992 Mar;187(1):165–177. doi: 10.1016/0042-6822(92)90305-9. [DOI] [PubMed] [Google Scholar]
  186. Steinman R., Dombrowski J., O'Connor T., Montelaro R. C., Tonelli Q., Lawrence K., Seymour C., Goodness J., Pedersen N. C., Andersen P. R. Biochemical and immunological characterization of the major structural proteins of feline immunodeficiency virus. J Gen Virol. 1990 Mar;71(Pt 3):701–706. doi: 10.1099/0022-1317-71-3-701. [DOI] [PubMed] [Google Scholar]
  187. Stephens E. B., Butfiloski E. J., Monck E. Analysis of the amino terminal presequence of the feline immunodeficiency virus glycoprotein: effect of deletions on the intracellular transport of gp95. Virology. 1992 Oct;190(2):569–578. doi: 10.1016/0042-6822(92)90894-u. [DOI] [PubMed] [Google Scholar]
  188. Stephens E. B., Monck E., Reppas K., Butfiloski E. J. Processing of the glycoprotein of feline immunodeficiency virus: effect of inhibitors of glycosylation. J Virol. 1991 Mar;65(3):1114–1123. doi: 10.1128/jvi.65.3.1114-1123.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  189. Sutjipto S., Pedersen N. C., Miller C. J., Gardner M. B., Hanson C. V., Gettie A., Jennings M., Higgins J., Marx P. A. Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals. J Virol. 1990 May;64(5):2290–2297. doi: 10.1128/jvi.64.5.2290-2297.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  190. Swinney G. R., Pauli J. V., Jones B. R., Wilks C. R. Feline t-lymphotropic virus (FTLV) (feline immunodeficiency virus infection) in cats in New Zealand. N Z Vet J. 1989 Mar;37(1):41–43. doi: 10.1080/00480169.1989.35552. [DOI] [PubMed] [Google Scholar]
  191. Talbott R. L., Sparger E. E., Lovelace K. M., Fitch W. M., Pedersen N. C., Luciw P. A., Elder J. H. Nucleotide sequence and genomic organization of feline immunodeficiency virus. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5743–5747. doi: 10.1073/pnas.86.15.5743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  192. Tanabe-Tochikura A., Tochikura T. S., Blakeslee J. R., Jr, Olsen R. G., Mathes L. E. Anti-human immunodeficiency virus (HIV) agents are also potent and selective inhibitors of feline immunodeficiency virus (FIV)-induced cytopathic effect: development of a new method for screening of anti-FIV substances in vitro. Antiviral Res. 1992 Aug;19(2):161–172. doi: 10.1016/0166-3542(92)90075-g. [DOI] [PubMed] [Google Scholar]
  193. Taniguchi A., Ishida T., Konno A., Washizu T., Tomoda I. Altered mitogen response of peripheral blood lymphocytes in different stages of feline immunodeficiency virus infection. Nihon Juigaku Zasshi. 1990 Jun;52(3):513–518. doi: 10.1292/jvms1939.52.513. [DOI] [PubMed] [Google Scholar]
  194. Taniguchi A., Ishida T., Washizu T., Tomoda I. Humoral immune response to T cell dependent and independent antigens in cats infected with feline immunodeficiency virus. J Vet Med Sci. 1991 Apr;53(2):333–335. doi: 10.1292/jvms.53.333. [DOI] [PubMed] [Google Scholar]
  195. Tenorio A. P., Franti C. E., Madewell B. R., Pedersen N. C. Chronic oral infections of cats and their relationship to persistent oral carriage of feline calici-, immunodeficiency, or leukemia viruses. Vet Immunol Immunopathol. 1991 Aug;29(1-2):1–14. doi: 10.1016/0165-2427(91)90048-h. [DOI] [PubMed] [Google Scholar]
  196. Tilton G. K., O'Connor T. P., Jr, Seymour C. L., Lawrence K. L., Cohen N. D., Andersen P. R., Tonelli Q. J. Immunoassay for detection of feline immunodeficiency virus core antigen. J Clin Microbiol. 1990 May;28(5):898–904. doi: 10.1128/jcm.28.5.898-904.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  197. Tochikura T. S., Hayes K. A., Cheney C. M., Tanabe-Tochikura A., Rojko J. L., Mathes L. E., Olsen R. G. In vitro replication and cytopathogenicity of the feline immunodeficiency virus for feline T4 thymic lymphoma 3201 cells. Virology. 1990 Nov;179(1):492–497. doi: 10.1016/0042-6822(90)90323-j. [DOI] [PubMed] [Google Scholar]
  198. Tochikura T. S., Tanabe-Tochikura A., Hayes K. A., Lazo A., Bailer R. T., Blakeslee J. R., Jr, Lafrado L. J., Roy-Burman P., Pandey R., Olsen R. G. Fusion activity dissociated from replication ability in feline immunodeficiency virus (FIV) in human cells. J Acquir Immune Defic Syndr. 1993 Dec;6(12):1301–1310. [PubMed] [Google Scholar]
  199. Tokunaga K., Nishino Y., Oikawa H., Ishihara C., Mikami T., Ikuta K. Altered cell tropism and cytopathicity of feline immunodeficiency viruses in two different feline CD4-positive, CD8-negative cell lines. J Virol. 1992 Jun;66(6):3893–3898. doi: 10.1128/jvi.66.6.3893-3898.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  200. Tomonaga K., Miyazawa T., Sakuragi J., Mori T., Adachi A., Mikami T. The feline immunodeficiency virus ORF-A gene facilitates efficient viral replication in established T-cell lines and peripheral blood lymphocytes. J Virol. 1993 Oct;67(10):5889–5895. doi: 10.1128/jvi.67.10.5889-5895.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  201. Tomonaga K., Norimine J., Shin Y. S., Fukasawa M., Miyazawa T., Adachi A., Toyosaki T., Kawaguchi Y., Kai C., Mikami T. Identification of a feline immunodeficiency virus gene which is essential for cell-free virus infectivity. J Virol. 1992 Oct;66(10):6181–6185. doi: 10.1128/jvi.66.10.6181-6185.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  202. Tomonaga K., Shin Y. S., Fukasawa M., Miyazawa T., Adachi A., Mikami T. Feline immunodeficiency virus gene expression: analysis of the RNA splicing pattern and the monocistronic rev mRNA. J Gen Virol. 1993 Nov;74(Pt 11):2409–2417. doi: 10.1099/0022-1317-74-11-2409. [DOI] [PubMed] [Google Scholar]
  203. Tompkins M. B., Nelson P. D., English R. V., Novotney C. Early events in the immunopathogenesis of feline retrovirus infections. J Am Vet Med Assoc. 1991 Nov 15;199(10):1311–1315. [PubMed] [Google Scholar]
  204. Torten M., Franchini M., Barlough J. E., George J. W., Mozes E., Lutz H., Pedersen N. C. Progressive immune dysfunction in cats experimentally infected with feline immunodeficiency virus. J Virol. 1991 May;65(5):2225–2230. doi: 10.1128/jvi.65.5.2225-2230.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  205. Toyosaki T., Miyazawa T., Furuya T., Tomonaga K., Shin Y. S., Okita M., Kawaguchi Y., Kai C., Mori S., Mikami T. Localization of the viral antigen of feline immunodeficiency virus in the lymph nodes of cats at the early stage of infection. Arch Virol. 1993;131(3-4):335–347. doi: 10.1007/BF01378636. [DOI] [PubMed] [Google Scholar]
  206. Tozzini F., Matteucci D., Bandecchi P., Baldinotti F., Poli A., Pistello M., Siebelink K. H., Ceccherini-Nelli L., Bendinelli M. Simple in vitro methods for titrating feline immunodeficiency virus (FIV) and FIV neutralizing antibodies. J Virol Methods. 1992 Jun;37(3):241–252. doi: 10.1016/0166-0934(92)90026-a. [DOI] [PubMed] [Google Scholar]
  207. Tozzini F., Matteucci D., Bandecchi P., Baldinotti F., Siebelink K., Osterhaus A., Bendinelli M. Neutralizing antibodies in cats infected with feline immunodeficiency virus. J Clin Microbiol. 1993 Jun;31(6):1626–1629. doi: 10.1128/jcm.31.6.1626-1629.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  208. Tsoukas C. M., Bernard N. F. Markers predicting progression of human immunodeficiency virus-related disease. Clin Microbiol Rev. 1994 Jan;7(1):14–28. doi: 10.1128/cmr.7.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  209. Ueland K., Nesse L. L. No evidence of vertical transmission of naturally acquired feline immunodeficiency virus infection. Vet Immunol Immunopathol. 1992 Sep;33(4):301–308. doi: 10.1016/0165-2427(92)90002-8. [DOI] [PubMed] [Google Scholar]
  210. Verschoor E. J., van Vliet A. L., Egberink H. F., Hesselink W., Horzinek M. C., de Ronde A. Expression of feline immunodeficiency virus gag and env precursor proteins in Spodoptera frugiperda cells and their use in immunodiagnosis. J Clin Microbiol. 1993 Sep;31(9):2350–2355. doi: 10.1128/jcm.31.9.2350-2355.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  211. Wagaman P. C., Hasselkus-Light C. S., Henson M., Lerner D. L., Phillips T. R., Elder J. H. Molecular cloning and characterization of deoxyuridine triphosphatase from feline immunodeficiency virus (FIV). Virology. 1993 Oct;196(2):451–457. doi: 10.1006/viro.1993.1501. [DOI] [PubMed] [Google Scholar]
  212. Wasmoen T., Armiger-Luhman S., Egan C., Hall V., Chu H. J., Chavez L., Acree W. Transmission of feline immunodeficiency virus from infected queens to kittens. Vet Immunol Immunopathol. 1992 Dec;35(1-2):83–93. doi: 10.1016/0165-2427(92)90123-8. [DOI] [PubMed] [Google Scholar]
  213. Waters L., Hopper C. D., Gruffydd-Jones T. J., Harbour D. A. Chronic gingivitis in a colony of cats infected with feline immunodeficiency virus and feline calicivirus. Vet Rec. 1993 Apr 3;132(14):340–342. doi: 10.1136/vr.132.14.340. [DOI] [PubMed] [Google Scholar]
  214. Weiss R. A. How does HIV cause AIDS? Science. 1993 May 28;260(5112):1273–1279. doi: 10.1126/science.8493571. [DOI] [PubMed] [Google Scholar]
  215. Willett B. J., Hosie M. J., Callanan J. J., Neil J. C., Jarrett O. Infection with feline immunodeficiency virus is followed by the rapid expansion of a CD8+ lymphocyte subset. Immunology. 1993 Jan;78(1):1–6. [PMC free article] [PubMed] [Google Scholar]
  216. Willett B. J., Hosie M. J., Dunsford T. H., Neil J. C., Jarrett O. Productive infection of T-helper lymphocytes with feline immunodeficiency virus is accompanied by reduced expression of CD4. AIDS. 1991 Dec;5(12):1469–1475. doi: 10.1097/00002030-199112000-00009. [DOI] [PubMed] [Google Scholar]
  217. Willett B. J., Hosie M. J., Jarrett O., Neil J. C. Identification of a putative cellular receptor for feline immunodeficiency virus as the feline homologue of CD9. Immunology. 1994 Feb;81(2):228–233. [PMC free article] [PubMed] [Google Scholar]
  218. Witt C. J., Moench T. R., Gittelsohn A. M., Bishop B. D., Childs J. E. Epidemiologic observations on feline immunodeficiency virus and Toxoplasma gondii coinfection in cats in Baltimore, Md. J Am Vet Med Assoc. 1989 Jan 15;194(2):229–233. [PubMed] [Google Scholar]
  219. Yamamoto J. K., Ackley C. D., Zochlinski H., Louie H., Pembroke E., Torten M., Hansen H., Munn R., Okuda T. Development of IL-2-independent feline lymphoid cell lines chronically infected with feline immunodeficiency virus: importance for diagnostic reagents and vaccines. Intervirology. 1991;32(6):361–375. doi: 10.1159/000150220. [DOI] [PubMed] [Google Scholar]
  220. Yamamoto J. K., Hansen H., Ho E. W., Morishita T. Y., Okuda T., Sawa T. R., Nakamura R. M., Pedersen N. C. Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission. J Am Vet Med Assoc. 1989 Jan 15;194(2):213–220. [PubMed] [Google Scholar]
  221. Yamamoto J. K., Hohdatsu T., Olmsted R. A., Pu R., Louie H., Zochlinski H. A., Acevedo V., Johnson H. M., Soulds G. A., Gardner M. B. Experimental vaccine protection against homologous and heterologous strains of feline immunodeficiency virus. J Virol. 1993 Jan;67(1):601–605. doi: 10.1128/jvi.67.1.601-605.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  222. Yamamoto J. K., Okuda T., Ackley C. D., Louie H., Pembroke E., Zochlinski H., Munn R. J., Gardner M. B. Experimental vaccine protection against feline immunodeficiency virus. AIDS Res Hum Retroviruses. 1991 Nov;7(11):911–922. doi: 10.1089/aid.1991.7.911. [DOI] [PubMed] [Google Scholar]
  223. Yamamoto J. K., Pedersen N. C., Ho E. W., Okuda T., Theilen G. H. Feline immunodeficiency syndrome--a comparison between feline T-lymphotropic lentivirus and feline leukemia virus. Leukemia. 1988 Dec;2(12 Suppl):204S–215S. [PubMed] [Google Scholar]
  224. Yamamoto J. K., Sparger E., Ho E. W., Andersen P. R., O'Connor T. P., Mandell C. P., Lowenstine L., Munn R., Pedersen N. C. Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats. Am J Vet Res. 1988 Aug;49(8):1246–1258. [PubMed] [Google Scholar]
  225. Yates K. M., Rosenberg L. J., Harris C. K., Bronstad D. C., King G. K., Biehle G. A., Walker B., Ford C. R., Hall J. E., Tizard I. R. Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus. Vet Immunol Immunopathol. 1992 Dec;35(1-2):177–189. doi: 10.1016/0165-2427(92)90130-i. [DOI] [PubMed] [Google Scholar]
  226. Zenger E., Brown W. C., Song W., Wolf A. M., Pedersen N. C., Longnecker M., Li J., Collisson E. W. Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection. Am J Vet Res. 1993 May;54(5):713–718. [PubMed] [Google Scholar]
  227. de Ronde A., Stam J. G., Boers P., Langedijk H., Meloen R., Hesselink W., Keldermans L. C., van Vliet A., Verschoor E. J., Horzinek M. C. Antibody response in cats to the envelope proteins of feline immunodeficiency virus: identification of an immunodominant neutralization domain. Virology. 1994 Jan;198(1):257–264. doi: 10.1006/viro.1994.1028. [DOI] [PubMed] [Google Scholar]

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