Skip to main content
Heart logoLink to Heart
. 1998 May;79(5):429–431. doi: 10.1136/hrt.79.5.429

Cell adhesion molecules in cardiovascular disease: a clinical perspective

G Hillis 1, A Flapan 1
PMCID: PMC1728696  PMID: 9659186

Full Text

The Full Text of this article is available as a PDF (92.3 KB).

Figure 1  .

Figure 1  

Schematic representations of integrin (left), immunoglobulin superfamily (centre), and selectin (right) adhesion molecule structures.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams D. H., Shaw S. Leucocyte-endothelial interactions and regulation of leucocyte migration. Lancet. 1994 Apr 2;343(8901):831–836. doi: 10.1016/s0140-6736(94)92029-x. [DOI] [PubMed] [Google Scholar]
  2. Belch J. J., Shaw J. W., Kirk G., McLaren M., Robb R., Maple C., Morse P. The white blood cell adhesion molecule E-selectin predicts restenosis in patients with intermittent claudication undergoing percutaneous transluminal angioplasty. Circulation. 1997 Apr 15;95(8):2027–2031. doi: 10.1161/01.cir.95.8.2027. [DOI] [PubMed] [Google Scholar]
  3. Bevilacqua M. P., Nelson R. M. Selectins. J Clin Invest. 1993 Feb;91(2):379–387. doi: 10.1172/JCI116210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blann A. D., McCollum C. N. Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb Haemost. 1994 Jul;72(1):151–154. [PubMed] [Google Scholar]
  5. Hillis G. S., MacLeod A. M. Integrins and disease. Clin Sci (Lond) 1996 Dec;91(6):639–650. doi: 10.1042/cs0910639. [DOI] [PubMed] [Google Scholar]
  6. Hoshiga M., Alpers C. E., Smith L. L., Giachelli C. M., Schwartz S. M. Alpha-v beta-3 integrin expression in normal and atherosclerotic artery. Circ Res. 1995 Dec;77(6):1129–1135. doi: 10.1161/01.res.77.6.1129. [DOI] [PubMed] [Google Scholar]
  7. Hynes R. O. Integrins: a family of cell surface receptors. Cell. 1987 Feb 27;48(4):549–554. doi: 10.1016/0092-8674(87)90233-9. [DOI] [PubMed] [Google Scholar]
  8. Hynes R. O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 1992 Apr 3;69(1):11–25. doi: 10.1016/0092-8674(92)90115-s. [DOI] [PubMed] [Google Scholar]
  9. Ikeda H., Takajo Y., Ichiki K., Ueno T., Maki S., Noda T., Sugi K., Imaizumi T. Increased soluble form of P-selectin in patients with unstable angina. Circulation. 1995 Oct 1;92(7):1693–1696. doi: 10.1161/01.cir.92.7.1693. [DOI] [PubMed] [Google Scholar]
  10. Jang Y., Lincoff A. M., Plow E. F., Topol E. J. Cell adhesion molecules in coronary artery disease. J Am Coll Cardiol. 1994 Dec;24(7):1591–1601. doi: 10.1016/0735-1097(94)90162-7. [DOI] [PubMed] [Google Scholar]
  11. Lefkovits J., Plow E. F., Topol E. J. Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. N Engl J Med. 1995 Jun 8;332(23):1553–1559. doi: 10.1056/NEJM199506083322306. [DOI] [PubMed] [Google Scholar]
  12. Libby P., Li H. Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis. J Clin Invest. 1993 Aug;92(2):538–539. doi: 10.1172/JCI116620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ma X. L., Lefer D. J., Lefer A. M., Rothlein R. Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation. 1992 Sep;86(3):937–946. doi: 10.1161/01.cir.86.3.937. [DOI] [PubMed] [Google Scholar]
  14. Mazzone A., De Servi S., Ricevuti G., Mazzucchelli I., Fossati G., Pasotti D., Bramucci E., Angoli L., Marsico F., Specchia G. Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease. Circulation. 1993 Aug;88(2):358–363. doi: 10.1161/01.cir.88.2.358. [DOI] [PubMed] [Google Scholar]
  15. Mickelson J. K., Lakkis N. M., Villarreal-Levy G., Hughes B. J., Smith C. W. Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease? J Am Coll Cardiol. 1996 Aug;28(2):345–353. doi: 10.1016/0735-1097(96)00164-7. [DOI] [PubMed] [Google Scholar]
  16. Ross R. Cell biology of atherosclerosis. Annu Rev Physiol. 1995;57:791–804. doi: 10.1146/annurev.ph.57.030195.004043. [DOI] [PubMed] [Google Scholar]
  17. Ruoslahti E., Engvall E. Integrins and vascular extracellular matrix assembly. J Clin Invest. 1997 Mar 15;99(6):1149–1152. doi: 10.1172/JCI119269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Springer T. A. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425–434. doi: 10.1038/346425a0. [DOI] [PubMed] [Google Scholar]
  19. Yasukawa H., Imaizumi T., Matsuoka H., Nakashima A., Morimatsu M. Inhibition of intimal hyperplasia after balloon injury by antibodies to intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1. Circulation. 1997 Mar 18;95(6):1515–1522. doi: 10.1161/01.cir.95.6.1515. [DOI] [PubMed] [Google Scholar]

Articles from Heart are provided here courtesy of BMJ Publishing Group

RESOURCES