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. 1998 Aug;80(2):170–173. doi: 10.1136/hrt.80.2.170

Outcomes of transposition of the great arteries in the era of atrial inflow correction

D Birnie 1, A Tometzki 1, J Curzio 1, A Houston 1, S Hood 1, L Swan 1, W Doig 1, N Wilson 1, M Jamieson 1, J Pollock 1, W Hillis 1
PMCID: PMC1728792  PMID: 9813565

Abstract

Objective—To examine long term morbidity and mortality following atrial inflow corrective procedures for transposition of the great arteries (TGA) and to investigate factors that influence morbidity and mortality.
Design—Retrospective cohort study from a single centre.
Setting—Cardiology and cardiothoracic surgical unit in a large tertiary referral centre.
Patients—All 130 patients who had TGA diagnosed between August 1972 and May 1988 and were considered suitable for atrial inflow correction; 109 of these underwent surgery (operative cohort: 84 Mustard operations and 25 Senning operations); 95 survived to hospital discharge (hospital surviving cohort).
Main outcome measures—Death and cardiac events.
Results—There were relatively good long term results from atrial inflow correction for TGA with 5, 10, and 15 year survivals of 77.3%, 75.9%, and 71.3%. However, there was an appreciable incidence of late cardiac death and events, with 5, 10, and 15 year cardiac event-free survivals of 74.5%, 67.1%, and 39.6%. Supraventricular tachycardia was the only significant risk factor for late cardiac death (relative risk 8.72, 95% confidence interval, 2.86 to 26.64). Senning patients had better event-free survival (p = 0.04).
Conclusions—Atrial inflow correction for TGA has a reasonably good 15 year survival (71.3%), but there is an appreciable incidence of late cardiac deaths and events (15 year event-free survival 39.6%). The Senning procedure is preferable to the Mustard procedure for cases unsuitable for arterial switching.

 Keywords: transposition of the great arteries;  congenital heart disease;  Mustard operation;  Senning operation

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Figure 1  .

Figure 1  

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Kaplan-Meier survival curve of operative cohort (n = 109).

Figure 2  .

Figure 2  

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Event-free survival: comparison of Mustard and Senning cohorts (after adjustment for date of operation).

Figure 3  .

Figure 3  

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Kaplan-Meier curve of long term survival in sinus rhythm (hospital surviving cohort, n = 95).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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