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. 1996 Jul;9(3):423–434. doi: 10.1128/cmr.9.3.423

Rotavirus vaccines: an overview.

K Midthun 1, A Z Kapikian 1
PMCID: PMC172902  PMID: 8809469

Abstract

Rotavirus vaccine development has focused on the delivery of live attenuated rotavirus strains by the oral route. The initial "Jennerian" approach involving bovine (RIT4237, WC3) or rhesus (RRV) rotavirus vaccine candidates showed that these vaccines were safe, well tolerated, and immunogenic but induced highly variable rates of protection against rotavirus diarrhea. The goal of a rotavirus vaccine is to prevent severe illness that can lead to dehydration in infants and young children in both developed and developing countries. These studies led to the concept that a multivalent vaccine that represented each of the four epidemiologically important VP7 serotypes might be necessary to induce protection in young infants, the target population for vaccination. Human-animal rotavirus reassortants whose gene encoding VP7 was derived from their human rotavirus parent but whose remaining genes were derived from the animal rotavirus parent were developed as vaccine candidates. The greatest experience with a multivalent vaccine to date has been gained with the quadrivalent preparation containing RRV (VP7 serotype 3) and human-RRV reassortants of VP7 serotype 1, 2, and 4 specificity. Preliminary efficacy trial results in the United States have been promising, whereas a study in Peru has shown only limited protection. Human-bovine reassortant vaccines, including a candidate that contains the VP4 gene of a human rotavirus (VP4 serotype 1A), are also being studied.

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Selected References

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  1. Anderson E. L., Belshe R. B., Bartram J., Crookshanks-Newman F., Chanock R. M., Kapikian A. Z. Evaluation of rhesus rotavirus vaccine (MMU 18006) in infants and young children. J Infect Dis. 1986 May;153(5):823–831. doi: 10.1093/infdis/153.5.823. [DOI] [PubMed] [Google Scholar]
  2. Andrew M. E., Boyle D. B., Coupar B. E., Reddy D., Bellamy A. R., Both G. W. Vaccinia-rotavirus VP7 recombinants protect mice against rotavirus-induced diarrhoea. Vaccine. 1992;10(3):185–191. doi: 10.1016/0264-410x(92)90010-h. [DOI] [PubMed] [Google Scholar]
  3. Andrew M. E., Boyle D. B., Coupar B. E., Whitfeld P. L., Both G. W., Bellamy A. R. Vaccinia virus recombinants expressing the SA11 rotavirus VP7 glycoprotein gene induce serotype-specific neutralizing antibodies. J Virol. 1987 Apr;61(4):1054–1060. doi: 10.1128/jvi.61.4.1054-1060.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Arias C. F., Lizano M., López S. Synthesis in Escherichia coli and immunological characterization of a polypeptide containing the cleavage sites associated with trypsin enhancement of rotavirus SA11 infectivity. J Gen Virol. 1987 Mar;68(Pt 3):633–642. doi: 10.1099/0022-1317-68-3-633. [DOI] [PubMed] [Google Scholar]
  5. Barnes G. L., Doyle L. W., Hewson P. H., Knoches A. M., McLellan J. A., Kitchen W. H., Bishop R. F. A randomised trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus. Lancet. 1982 Jun 19;1(8286):1371–1373. doi: 10.1016/s0140-6736(82)92496-5. [DOI] [PubMed] [Google Scholar]
  6. Bellamy A. R., Both G. W. Molecular biology of rotaviruses. Adv Virus Res. 1990;38:1–43. doi: 10.1016/s0065-3527(08)60858-1. [DOI] [PubMed] [Google Scholar]
  7. Bernstein D. I., Sander D. S., Smith V. E., Schiff G. M., Ward R. L. Protection from rotavirus reinfection: 2-year prospective study. J Infect Dis. 1991 Aug;164(2):277–283. doi: 10.1093/infdis/164.2.277. [DOI] [PubMed] [Google Scholar]
  8. Bernstein D. I., Smith V. E., Sander D. S., Pax K. A., Schiff G. M., Ward R. L. Evaluation of WC3 rotavirus vaccine and correlates of protection in healthy infants. J Infect Dis. 1990 Nov;162(5):1055–1062. doi: 10.1093/infdis/162.5.1055. [DOI] [PubMed] [Google Scholar]
  9. Birch C. J., Lewis F. A., Kennett M. L., Homola M., Pritchard H., Gust I. D. A study of the prevalence of rotavirus infection in children with gastroenteritis admitted to an infectious diseases hospital. J Med Virol. 1977;1(1):69–77. doi: 10.1002/jmv.1890010109. [DOI] [PubMed] [Google Scholar]
  10. Bishop R. F., Barnes G. L., Cipriani E., Lund J. S. Clinical immunity after neonatal rotavirus infection. A prospective longitudinal study in young children. N Engl J Med. 1983 Jul 14;309(2):72–76. doi: 10.1056/NEJM198307143090203. [DOI] [PubMed] [Google Scholar]
  11. Bishop R. F., Tzipori S. R., Coulson B. S., Unicomb L. E., Albert M. J., Barnes G. L. Heterologous protection against rotavirus-induced disease in gnotobiotic piglets. J Clin Microbiol. 1986 Dec;24(6):1023–1028. doi: 10.1128/jcm.24.6.1023-1028.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Black R. E., Greenberg H. B., Kapikian A. Z., Brown K. H., Becker S. Acquisition of serum antibody to Norwalk Virus and rotavirus and relation to diarrhea in a longitudinal study of young children in rural Bangladesh. J Infect Dis. 1982 Apr;145(4):483–489. doi: 10.1093/infdis/145.4.483. [DOI] [PubMed] [Google Scholar]
  13. Black R. E., Merson M. H., Rahman A. S., Yunus M., Alim A. R., Huq I., Yolken R. H., Curlin G. T. A two-year study of bacterial, viral, and parasitic agents associated with diarrhea in rural Bangladesh. J Infect Dis. 1980 Nov;142(5):660–664. doi: 10.1093/infdis/142.5.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Brandt C. D., Kim H. W., Rodriguez W. J., Arrobio J. O., Jeffries B. C., Stallings E. P., Lewis C., Miles A. J., Chanock R. M., Kapikian A. Z. Pediatric viral gastroenteritis during eight years of study. J Clin Microbiol. 1983 Jul;18(1):71–78. doi: 10.1128/jcm.18.1.71-78.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Bridger J. C., Woode G. N. Neonatal calf diarrhoea: identification of a reovirus-like (rotavirus) agent in faeces by immunofluorescence and immune electron microscopy. Br Vet J. 1975 Sep-Oct;131(5):528–535. [PubMed] [Google Scholar]
  16. Brüssow H., Werchau H., Lerner L., Mietens C., Liedtke W., Sidoti J., Sotek J. Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis. J Infect Dis. 1988 Sep;158(3):588–595. doi: 10.1093/infdis/158.3.588. [DOI] [PubMed] [Google Scholar]
  17. Chiba S., Yokoyama T., Nakata S., Morita Y., Urasawa T., Taniguchi K., Urasawa S., Nakao T. Protective effect of naturally acquired homotypic and heterotypic rotavirus antibodies. Lancet. 1986 Aug 23;2(8504):417–421. doi: 10.1016/s0140-6736(86)92133-1. [DOI] [PubMed] [Google Scholar]
  18. Christy C., Madore H. P., Pichichero M. E., Gala C., Pincus P., Vosefski D., Hoshino Y., Kapikian A., Dolin R. Field trial of rhesus rotavirus vaccine in infants. Pediatr Infect Dis J. 1988 Sep;7(9):645–650. doi: 10.1097/00006454-198809000-00009. [DOI] [PubMed] [Google Scholar]
  19. Christy C., Madore H. P., Treaner J. J., Pray K., Kapikian A. Z., Chanock R. M., Dolin R. Safety and immunogenicity of live attenuated rhesus monkey rotavirus vaccine. J Infect Dis. 1986 Dec;154(6):1045–1047. doi: 10.1093/infdis/154.6.1045. [DOI] [PubMed] [Google Scholar]
  20. Chrystie I. L., Totterdell B. M., Banatvala J. E. Asymptomatic endemic rotavirus infections in the newborn. Lancet. 1978 Jun 3;1(8075):1176–1178. doi: 10.1016/S0140-6736(78)90967-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Clark H. F., Borian F. E., Bell L. M., Modesto K., Gouvea V., Plotkin S. A. Protective effect of WC3 vaccine against rotavirus diarrhea in infants during a predominantly serotype 1 rotavirus season. J Infect Dis. 1988 Sep;158(3):570–587. doi: 10.1093/infdis/158.3.570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Clark H. F., Borian F. E., Plotkin S. A. Immune protection of infants against rotavirus gastroenteritis by a serotype 1 reassortant of bovine rotavirus WC3. J Infect Dis. 1990 Jun;161(6):1099–1104. doi: 10.1093/infdis/161.6.1099. [DOI] [PubMed] [Google Scholar]
  23. Clark H. F., Dolan K. T., Horton-Slight P., Palmer J., Plotkin S. A. Diverse serologic response to rotavirus infection of infants in a single epidemic. Pediatr Infect Dis. 1985 Nov-Dec;4(6):626–631. doi: 10.1097/00006454-198511000-00006. [DOI] [PubMed] [Google Scholar]
  24. Clark H. F., Furukawa T., Bell L. M., Offit P. A., Perrella P. A., Plotkin S. A. Immune response of infants and children to low-passage bovine rotavirus (strain WC3). Am J Dis Child. 1986 Apr;140(4):350–356. doi: 10.1001/archpedi.1986.02140180084030. [DOI] [PubMed] [Google Scholar]
  25. Clemens J. D., Ward R. L., Rao M. R., Sack D. A., Knowlton D. R., van Loon F. P., Huda S., McNeal M., Ahmed F., Schiff G. Seroepidemiologic evaluation of antibodies to rotavirus as correlates of the risk of clinically significant rotavirus diarrhea in rural Bangladesh. J Infect Dis. 1992 Jan;165(1):161–165. doi: 10.1093/infdis/165.1.161. [DOI] [PubMed] [Google Scholar]
  26. Cook S. M., Glass R. I., LeBaron C. W., Ho M. S. Global seasonality of rotavirus infections. Bull World Health Organ. 1990;68(2):171–177. [PMC free article] [PubMed] [Google Scholar]
  27. Davidson G. P., Bishop R. F., Townley R. R., Holmes I. H. Importance of a new virus in acute sporadic enteritis in children. Lancet. 1975 Feb 1;1(7901):242–246. doi: 10.1016/s0140-6736(75)91140-x. [DOI] [PubMed] [Google Scholar]
  28. Davidson G. P., Whyte P. B., Daniels E., Franklin K., Nunan H., McCloud P. I., Moore A. G., Moore D. J. Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. Lancet. 1989 Sep 23;2(8665):709–712. doi: 10.1016/s0140-6736(89)90771-x. [DOI] [PubMed] [Google Scholar]
  29. De Mol P., Zissis G., Butzler J. P., Mutwewingabo A., André F. E. Failure of live, attenuated oral rotavirus vaccine. Lancet. 1986 Jul 12;2(8498):108–108. doi: 10.1016/s0140-6736(86)91643-0. [DOI] [PubMed] [Google Scholar]
  30. Delem A., Lobmann M., Zygraich N. A bovine rotavirus developed as a candidate vaccine for use in humans. J Biol Stand. 1984 Oct;12(4):443–445. doi: 10.1016/s0092-1157(84)80068-2. [DOI] [PubMed] [Google Scholar]
  31. Dharakul T., Rott L., Greenberg H. B. Recovery from chronic rotavirus infection in mice with severe combined immunodeficiency: virus clearance mediated by adoptive transfer of immune CD8+ T lymphocytes. J Virol. 1990 Sep;64(9):4375–4382. doi: 10.1128/jvi.64.9.4375-4382.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Ebina T., Sato A., Umezu K., Ishida N., Ohyama S., Oizumi A., Aikawa K., Katagiri S., Katsushima N., Imai A. Prevention of rotavirus infection by oral administration of cow colostrum containing antihumanrotavirus antibody. Med Microbiol Immunol. 1985;174(4):177–185. doi: 10.1007/BF02123694. [DOI] [PubMed] [Google Scholar]
  33. Estes M. K., Cohen J. Rotavirus gene structure and function. Microbiol Rev. 1989 Dec;53(4):410–449. doi: 10.1128/mr.53.4.410-449.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Flores J., Midthun K., Hoshino Y., Green K., Gorziglia M., Kapikian A. Z., Chanock R. M. Conservation of the fourth gene among rotaviruses recovered from asymptomatic newborn infants and its possible role in attenuation. J Virol. 1986 Dec;60(3):972–979. doi: 10.1128/jvi.60.3.972-979.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Flores J., Perez-Schael I., Blanco M., Rojas A. M., Alfonzo E., Crespo I., Cunto W., Pittman A. L., Kapikian A. Z. Reactogenicity and immunogenicity of a high-titer rhesus rotavirus-based quadrivalent rotavirus vaccine. J Clin Microbiol. 1993 Sep;31(9):2439–2445. doi: 10.1128/jcm.31.9.2439-2445.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Flores J., Perez-Schael I., Blanco M., Vilar M., Garcia D., Perez M., Daoud N., Midthun K., Kapikian A. Z. Reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in Venezuelan infants. J Clin Microbiol. 1989 Mar;27(3):512–518. doi: 10.1128/jcm.27.3.512-518.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Flores J., Perez-Schael I., Blanco M., White L., Garcia D., Vilar M., Cunto W., Gonzalez R., Urbina C., Boher J. Comparison of reactogenicity and antigenicity of M37 rotavirus vaccine and rhesus-rotavirus-based quadrivalent vaccine. Lancet. 1990 Aug 11;336(8711):330–334. doi: 10.1016/0140-6736(90)91876-c. [DOI] [PubMed] [Google Scholar]
  38. Flores J., Perez-Schael I., Gonzalez M., Garcia D., Perez M., Daoud N., Cunto W., Chanock R. M., Kapikian A. Z. Protection against severe rotavirus diarrhoea by rhesus rotavirus vaccine in Venezuelan infants. Lancet. 1987 Apr 18;1(8538):882–884. doi: 10.1016/s0140-6736(87)92858-3. [DOI] [PubMed] [Google Scholar]
  39. Foster S. O., Palmer E. L., Gary G. W., Jr, Martin M. L., Herrmann K. L., Beasley P., Sampson J. Gastroenteritis due to rotavirus in an isolated Pacific island group: an epidemic of 3,439 cases. J Infect Dis. 1980 Jan;141(1):32–39. doi: 10.1093/infdis/141.1.32. [DOI] [PubMed] [Google Scholar]
  40. Fun B. N., Unicomb L., Rahim Z., Banu N. N., Podder G., Clemens J., Van Loon F. P., Rao M. R., Malek A., Tzipori S. Rotavirus-associated diarrhea in rural Bangladesh: two-year study of incidence and serotype distribution. J Clin Microbiol. 1991 Jul;29(7):1359–1363. doi: 10.1128/jcm.29.7.1359-1363.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Gallois Y., Vol S., Cacès E., Balkau B. Distribution of fasting serum insulin measured by enzyme immunoassay in an unselected population of 4,032 individuals. Reference values according to age and sex. D.E.S.I.R. Study Group. Données Epidémiologiques sur le Syndrome d'Insulino-Résistance. Diabetes Metab. 1996 Dec;22(6):427–431. [PubMed] [Google Scholar]
  42. Georges-Courbot M. C., Monges J., Siopathis M. R., Roungou J. B., Gresenguet G., Bellec L., Bouquety J. C., Lanckriet C., Cadoz M., Hessel L. Evaluation of the efficacy of a low-passage bovine rotavirus (strain WC3) vaccine in children in Central Africa. Res Virol. 1991 Sep-Oct;142(5):405–411. doi: 10.1016/0923-2516(91)90008-q. [DOI] [PubMed] [Google Scholar]
  43. Gerna G., Sarasini A., Parea M., Arista S., Miranda P., Brüssow H., Hoshino Y., Flores J. Isolation and characterization of two distinct human rotavirus strains with G6 specificity. J Clin Microbiol. 1992 Jan;30(1):9–16. doi: 10.1128/jcm.30.1.9-16.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Gerna G., Sarasini A., Torsellini M., Torre D., Parea M., Battaglia M. Group- and type-specific serologic response in infants and children with primary rotavirus infections and gastroenteritis caused by a strain of known serotype. J Infect Dis. 1990 Jun;161(6):1105–1111. doi: 10.1093/infdis/161.6.1105. [DOI] [PubMed] [Google Scholar]
  45. Giammanco G., De Grandi V., Lupo L., Mistretta A., Pignato S., Teuween D., Bogaerts H., Andre F. E. Interference of oral poliovirus vaccine on RIT 4237 oral rotavirus vaccine. Eur J Epidemiol. 1988 Mar;4(1):121–123. doi: 10.1007/BF00152704. [DOI] [PubMed] [Google Scholar]
  46. Gorziglia M., Green K., Nishikawa K., Taniguchi K., Jones R., Kapikian A. Z., Chanock R. M. Sequence of the fourth gene of human rotaviruses recovered from asymptomatic or symptomatic infections. J Virol. 1988 Aug;62(8):2978–2984. doi: 10.1128/jvi.62.8.2978-2984.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Gorziglia M., Larralde G., Kapikian A. Z., Chanock R. M. Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4. Proc Natl Acad Sci U S A. 1990 Sep;87(18):7155–7159. doi: 10.1073/pnas.87.18.7155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Gothefors L., Wadell G., Juto P., Taniguchi K., Kapikian A. Z., Glass R. I. Prolonged efficacy of rhesus rotavirus vaccine in Swedish children. J Infect Dis. 1989 Apr;159(4):753–757. doi: 10.1093/infdis/159.4.753. [DOI] [PubMed] [Google Scholar]
  49. Gouvea V., Santos N., Timenetsky M. do C. VP4 typing of bovine and porcine group A rotaviruses by PCR. J Clin Microbiol. 1994 May;32(5):1333–1337. doi: 10.1128/jcm.32.5.1333-1337.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Green K. Y., Kapikian A. Z. Identification of VP7 epitopes associated with protection against human rotavirus illness or shedding in volunteers. J Virol. 1992 Jan;66(1):548–553. doi: 10.1128/jvi.66.1.548-553.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Guarino A., Canani R. B., Russo S., Albano F., Canani M. B., Ruggeri F. M., Donelli G., Rubino A. Oral immunoglobulins for treatment of acute rotaviral gastroenteritis. Pediatrics. 1994 Jan;93(1):12–16. [PubMed] [Google Scholar]
  52. Halsey N. A., Anderson E. L., Sears S. D., Steinhoff M., Wilson M., Belshe R. B., Midthun K., Kapikian A. Z., Chanock R. M., Samorodin R. Human-rhesus reassortant rotavirus vaccines: safety and immunogenicity in adults, infants, and children. J Infect Dis. 1988 Dec;158(6):1261–1267. doi: 10.1093/infdis/158.6.1261. [DOI] [PubMed] [Google Scholar]
  53. Hanlon P., Hanlon L., Marsh V., Byass P., Shenton F., Hassan-King M., Jobe O., Sillah H., Hayes R., M'Boge B. H. Trial of an attenuated bovine rotavirus vaccine (RIT 4237) in Gambian infants. Lancet. 1987 Jun 13;1(8546):1342–1345. doi: 10.1016/s0140-6736(87)90649-0. [DOI] [PubMed] [Google Scholar]
  54. Hilpert H., Brüssow H., Mietens C., Sidoti J., Lerner L., Werchau H. Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. J Infect Dis. 1987 Jul;156(1):158–166. doi: 10.1093/infdis/156.1.158. [DOI] [PubMed] [Google Scholar]
  55. Ho M. S., Floyd R. L., Glass R. I., Pallansch M. A., Jones B., Hamby B., Woods P., Penaranda M. E., Kapikian A. Z., Bohan G. Simultaneous administration of rhesus rotavirus vaccine and oral poliovirus vaccine: immunogenicity and reactogenicity. Pediatr Infect Dis J. 1989 Oct;8(10):692–696. doi: 10.1097/00006454-198910000-00006. [DOI] [PubMed] [Google Scholar]
  56. Ho M. S., Glass R. I., Pinsky P. F., Anderson L. J. Rotavirus as a cause of diarrheal morbidity and mortality in the United States. J Infect Dis. 1988 Nov;158(5):1112–1116. doi: 10.1093/infdis/158.5.1112. [DOI] [PubMed] [Google Scholar]
  57. Hoshino Y., Kapikian A. Z., Chanock R. M. Selection of cold-adapted mutants of human rotaviruses that exhibit various degrees of growth restriction in vitro. J Virol. 1994 Nov;68(11):7598–7602. doi: 10.1128/jvi.68.11.7598-7602.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Hoshino Y., Kapikian A. Z. Rotavirus antigens. Curr Top Microbiol Immunol. 1994;185:179–227. doi: 10.1007/978-3-642-78256-5_7. [DOI] [PubMed] [Google Scholar]
  59. Hoshino Y., Kapikian A. Z. Rotavirus vaccine development for the prevention of severe diarrhea in infants and young children. Trends Microbiol. 1994 Jul;2(7):242–249. doi: 10.1016/0966-842x(94)90629-7. [DOI] [PubMed] [Google Scholar]
  60. Hoshino Y., Saif L. J., Sereno M. M., Chanock R. M., Kapikian A. Z. Infection immunity of piglets to either VP3 or VP7 outer capsid protein confers resistance to challenge with a virulent rotavirus bearing the corresponding antigen. J Virol. 1988 Mar;62(3):744–748. doi: 10.1128/jvi.62.3.744-748.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Hoshino Y., Sereno M. M., Midthun K., Flores J., Kapikian A. Z., Chanock R. M. Independent segregation of two antigenic specificities (VP3 and VP7) involved in neutralization of rotavirus infectivity. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8701–8704. doi: 10.1073/pnas.82.24.8701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Ing D. J., Glass R. I., Woods P. A., Simonetti M., Pallansch M. A., Wilcox W. D., Davidson B. L., Sievert A. J. Immunogenicity of tetravalent rhesus rotavirus vaccine administered with buffer and oral polio vaccine. Am J Dis Child. 1991 Aug;145(8):892–897. doi: 10.1001/archpedi.1991.02160080070023. [DOI] [PubMed] [Google Scholar]
  63. Jalil F., Zaman S., Carlsson B., Glass R. I., Kapikian A. Z., Mellander L., Hanson L. A. Immunogenicity and reactogenicity of rhesus rotavirus vaccine given in combination with oral or inactivated poliovirus vaccines and diphtheria-tetanus-pertussis vaccine. Trans R Soc Trop Med Hyg. 1991 Mar-Apr;85(2):292–296. doi: 10.1016/0035-9203(91)90061-3. [DOI] [PubMed] [Google Scholar]
  64. Kapikian A. Z., Flores J., Hoshino Y., Glass R. I., Midthun K., Gorziglia M., Chanock R. M. Rotavirus: the major etiologic agent of severe infantile diarrhea may be controllable by a "Jennerian" approach to vaccination. J Infect Dis. 1986 May;153(5):815–822. doi: 10.1093/infdis/153.5.815. [DOI] [PubMed] [Google Scholar]
  65. Kapikian A. Z., Flores J., Midthun K., Hoshino Y., Green K. Y., Gorziglia M., Nishikawa K., Chanock R. M., Potash L., Perez-Schael I. Strategies for the development of a rotavirus vaccine against infantile diarrhea with an update on clinical trials of rotavirus vaccines. Adv Exp Med Biol. 1989;257:67–89. doi: 10.1007/978-1-4684-5712-4_9. [DOI] [PubMed] [Google Scholar]
  66. Kapikian A. Z., Greenberg H. B., Cline W. L., Kalica A. R., Wyatt R. G., James H. D., Jr, Lloyd N. L., Chanock R. M., Ryder R. W., Kim H. W. Prevalence of antibody to the Norwalk agent by a newly developed immune adherence hemagglutination assay. J Med Virol. 1978;2(4):281–294. doi: 10.1002/jmv.1890020402. [DOI] [PubMed] [Google Scholar]
  67. Kapikian A. Z., Kim H. W., Wyatt R. G., Cline W. L., Arrobio J. O., Brandt C. D., Rodriguez W. J., Sack D. A., Chanock R. M., Parrott R. H. Human reovirus-like agent as the major pathogen associated with "winter" gastroenteritis in hospitalized infants and young children. N Engl J Med. 1976 Apr 29;294(18):965–972. doi: 10.1056/NEJM197604292941801. [DOI] [PubMed] [Google Scholar]
  68. Kapikian A. Z., Vesikari T., Ruuska T., Madore H. P., Christy C., Dolin R., Flores J., Green K. Y., Davidson B. L., Gorziglia M. An update on the "Jennerian" and modified "Jennerian" approach to vaccination of infants and young children against rotavirus diarrhea. Adv Exp Med Biol. 1992;327:59–69. doi: 10.1007/978-1-4615-3410-5_8. [DOI] [PubMed] [Google Scholar]
  69. Kapikian A. Z. Viral gastroenteritis. JAMA. 1993 Feb 3;269(5):627–630. [PubMed] [Google Scholar]
  70. Kapikian A. Z., Wyatt R. G., Levine M. M., Yolken R. H., VanKirk D. H., Dolin R., Greenberg H. B., Chanock R. M. Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance. J Infect Dis. 1983 Jan;147(1):95–106. doi: 10.1093/infdis/147.1.95. [DOI] [PubMed] [Google Scholar]
  71. Kim H. W., Brandt C. D., Kapikian A. Z., Wyatt R. G., Arrobio J. O., Rodriguez W. J., Chanock R. M., Parrott R. H. Human reovirus-like agent infection. Occurrence in adult contacts of pediatric patients with gastroenteritis. JAMA. 1977 Aug 1;238(5):404–407. doi: 10.1001/jama.238.5.404. [DOI] [PubMed] [Google Scholar]
  72. Konno T., Suzuki H., Katsushima N., Imai A., Tazawa F., Kutsuzawa T., Kitaoka S., Sakamoto M., Yazaki N., Ishida N. Influence of temperature and relative humidity on human rotavirus infection in Japan. J Infect Dis. 1983 Jan;147(1):125–128. doi: 10.1093/infdis/147.1.125. [DOI] [PubMed] [Google Scholar]
  73. Lanata C. F., Black R. E., del Aguila R., Gil A., Verastegui H., Gerna G., Flores J., Kapikian A. Z., Andre F. E. Protection of Peruvian children against rotavirus diarrhea of specific serotypes by one, two, or three doses of the RIT 4237 attenuated bovine rotavirus vaccine. J Infect Dis. 1989 Mar;159(3):452–459. doi: 10.1093/infdis/159.3.452. [DOI] [PubMed] [Google Scholar]
  74. Losonsky G. A., Johnson J. P., Winkelstein J. A., Yolken R. H. Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis. J Clin Invest. 1985 Dec;76(6):2362–2367. doi: 10.1172/JCI112248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Losonsky G. A., Rennels M. B., Kapikian A. Z., Midthun K., Ferra P. J., Fortier D. N., Hoffman K. M., Baig A., Levine M. M. Safety, infectivity, transmissibility and immunogenicity of rhesus rotavirus vaccine (MMU 18006) in infants. Pediatr Infect Dis. 1986 Jan-Feb;5(1):25–29. doi: 10.1097/00006454-198601000-00005. [DOI] [PubMed] [Google Scholar]
  76. Losonsky G. A., Rennels M. B., Lim Y., Krall G., Kapikian A. Z., Levine M. M. Systemic and mucosal immune responses to rhesus rotavirus vaccine MMU 18006. Pediatr Infect Dis J. 1988 Jun;7(6):388–393. doi: 10.1097/00006454-198806000-00004. [DOI] [PubMed] [Google Scholar]
  77. Mackow E. R., Barnett J. W., Chan H., Greenberg H. B. The rhesus rotavirus outer capsid protein VP4 functions as a hemagglutinin and is antigenically conserved when expressed by a baculovirus recombinant. J Virol. 1989 Apr;63(4):1661–1668. doi: 10.1128/jvi.63.4.1661-1668.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Mackow E. R., Vo P. T., Broome R., Bass D., Greenberg H. B. Immunization with baculovirus-expressed VP4 protein passively protects against simian and murine rotavirus challenge. J Virol. 1990 Apr;64(4):1698–1703. doi: 10.1128/jvi.64.4.1698-1703.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Madore H. P., Christy C., Pichichero M., Long C., Pincus P., Vosefsky D., Kapikian A. Z., Dolin R. Field trial of rhesus rotavirus or human-rhesus rotavirus reassortant vaccine of VP7 serotype 3 or 1 specificity in infants. The Elmwood, Panorama, and Westfall Pediatric Groups. J Infect Dis. 1992 Aug;166(2):235–243. doi: 10.1093/infdis/166.2.235. [DOI] [PubMed] [Google Scholar]
  80. Matson D. O., O'Ryan M. L., Herrera I., Pickering L. K., Estes M. K. Fecal antibody responses to symptomatic and asymptomatic rotavirus infections. J Infect Dis. 1993 Mar;167(3):577–583. doi: 10.1093/infdis/167.3.577. [DOI] [PubMed] [Google Scholar]
  81. Matsui S. M., Mackow E. R., Greenberg H. B. Molecular determinant of rotavirus neutralization and protection. Adv Virus Res. 1989;36:181–214. doi: 10.1016/s0065-3527(08)60585-0. [DOI] [PubMed] [Google Scholar]
  82. Matsuno S., Murakami S., Takagi M., Hayashi M., Inouye S., Hasegawa A., Fukai K. Cold-adaptation of human rotavirus. Virus Res. 1987 May;7(3):273–280. doi: 10.1016/0168-1702(87)90033-5. [DOI] [PubMed] [Google Scholar]
  83. McCrae M. A., McCorquodale J. G. Expression of a major bovine rotavirus neutralisation antigen (VP7c) in Escherichia coli. Gene. 1987;55(1):9–18. doi: 10.1016/0378-1119(87)90243-5. [DOI] [PubMed] [Google Scholar]
  84. Mebus C. A., Kono M., Underdahl N. R., Twiehaus M. J. Cell culture propagation of neonatal calf diarrhea (scours) virus. Can Vet J. 1971 Mar;12(3):69–72. [PMC free article] [PubMed] [Google Scholar]
  85. Midthun K., Greenberg H. B., Hoshino Y., Kapikian A. Z., Wyatt R. G., Chanock R. M. Reassortant rotaviruses as potential live rotavirus vaccine candidates. J Virol. 1985 Mar;53(3):949–954. doi: 10.1128/jvi.53.3.949-954.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  86. Midthun K., Halsey N. A., Jett-Goheen M., Clements M. L., Steinhoff M., King J. C., Karron R., Wilson M., Burns B., Perkis V. Safety and immunogenicity of human rotavirus vaccine strain M37 in adults, children, and infants. J Infect Dis. 1991 Oct;164(4):792–796. doi: 10.1093/infdis/164.4.792. [DOI] [PubMed] [Google Scholar]
  87. Midthun K., Hoshino Y., Kapikian A. Z., Chanock R. M. Single gene substitution rotavirus reassortants containing the major neutralization protein (VP7) of human rotavirus serotype 4. J Clin Microbiol. 1986 Nov;24(5):822–826. doi: 10.1128/jcm.24.5.822-826.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Nakagomi O., Mochizuki M., Aboudy Y., Shif I., Silberstein I., Nakagomi T. Hemagglutination by a human rotavirus isolate as evidence for transmission of animal rotaviruses to humans. J Clin Microbiol. 1992 Apr;30(4):1011–1013. doi: 10.1128/jcm.30.4.1011-1013.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Nakagomi O., Nakagomi T. Interspecies transmission of rotaviruses studied from the perspective of genogroup. Microbiol Immunol. 1993;37(5):337–348. doi: 10.1111/j.1348-0421.1993.tb03220.x. [DOI] [PubMed] [Google Scholar]
  90. Nishikawa K., Fukuhara N., Liprandi F., Green K., Kapikian A. Z., Chanock R. M., Gorziglia M. VP4 protein of porcine rotavirus strain OSU expressed by a baculovirus recombinant induces neutralizing antibodies. Virology. 1989 Dec;173(2):631–637. doi: 10.1016/0042-6822(89)90575-8. [DOI] [PubMed] [Google Scholar]
  91. Offit P. A., Clark H. F., Blavat G., Greenberg H. B. Reassortant rotaviruses containing structural proteins vp3 and vp7 from different parents induce antibodies protective against each parental serotype. J Virol. 1986 Nov;60(2):491–496. doi: 10.1128/jvi.60.2.491-496.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Offit P. A., Clark H. F. Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies. J Virol. 1985 Apr;54(1):58–64. doi: 10.1128/jvi.54.1.58-64.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Offit P. A., Dudzik K. I. Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice. J Virol. 1990 Dec;64(12):6325–6328. doi: 10.1128/jvi.64.12.6325-6328.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Perez-Schael I., Blanco M., Garcia D., White L., Alfonzo E., Crespo I., Cunto W., Pittman A. L., Kapikian A. Z., Flores J. Evaluation of the antigenicity and reactogenicity of varying formulations of the rhesus rotavirus-based quadrivalent and the M37 rotavirus vaccine candidates. J Med Virol. 1994 Apr;42(4):330–337. doi: 10.1002/jmv.1890420403. [DOI] [PubMed] [Google Scholar]
  95. Perez-Schael I., Blanco M., Vilar M., Garcia D., White L., Gonzalez R., Kapikian A. Z., Flores J. Clinical studies of a quadrivalent rotavirus vaccine in Venezuelan infants. J Clin Microbiol. 1990 Mar;28(3):553–558. doi: 10.1128/jcm.28.3.553-558.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Perez-Schael I., Garcia D., Gonzalez M., Gonzalez R., Daoud N., Perez M., Cunto W., Kapikian A. Z., Flores J. Prospective study of diarrheal diseases in Venezuelan children to evaluate the efficacy of rhesus rotavirus vaccine. J Med Virol. 1990 Mar;30(3):219–229. doi: 10.1002/jmv.1890300315. [DOI] [PubMed] [Google Scholar]
  97. Perez-Schael I., Gonzalez M., Daoud N., Perez M., Soto I., Garcia D., Daoud G., Kapikian A. Z., Flores J. Reactogenicity and antigenicity of the rhesus rotavirus vaccine in Venezuelan children. J Infect Dis. 1987 Feb;155(2):334–338. doi: 10.1093/infdis/155.2.334. [DOI] [PubMed] [Google Scholar]
  98. Pichichero M. E. Effect of breast-feeding on oral rhesus rotavirus vaccine seroconversion: a metaanalysis. J Infect Dis. 1990 Sep;162(3):753–755. doi: 10.1093/infdis/162.3.753. [DOI] [PubMed] [Google Scholar]
  99. Prasad B. V., Wang G. J., Clerx J. P., Chiu W. Three-dimensional structure of rotavirus. J Mol Biol. 1988 Jan 20;199(2):269–275. doi: 10.1016/0022-2836(88)90313-0. [DOI] [PubMed] [Google Scholar]
  100. Puerto F. I., Padilla-Noriega L., Zamora-Chávez A., Briceño A., Puerto M., Arias C. F. Prevalent patterns of serotype-specific seroconversion in Mexican children infected with rotavirus. J Clin Microbiol. 1987 May;25(5):960–963. doi: 10.1128/jcm.25.5.960-963.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Reeves P. R., Johnson M. A., Holmes I. H., Dyall-Smith M. L. Expression of rotavirus VP7 antigens in fusions with bacterial proteins. Res Microbiol. 1990 Sep-Oct;141(7-8):1019–1025. doi: 10.1016/0923-2508(90)90144-f. [DOI] [PubMed] [Google Scholar]
  102. Rennels M. B., Losonsky G. A., Levine M. M., Kapikian A. Z. Preliminary evaluation of the efficacy of rhesus rotavirus vaccine strain MMU 18006 in young children. Pediatr Infect Dis. 1986 Sep-Oct;5(5):587–588. doi: 10.1097/00006454-198609000-00019. [DOI] [PubMed] [Google Scholar]
  103. Rennels M. B., Losonsky G. A., Shindledecker C. L., Hughes T. P., Kapikian A. Z., Levine M. M. Immunogenicity and reactogenicity of lowered doses of rhesus rotavirus vaccine strain MMU 18006 in young children. Pediatr Infect Dis J. 1987 Mar;6(3):260–264. doi: 10.1097/00006454-198703000-00010. [DOI] [PubMed] [Google Scholar]
  104. Rennels M. B., Losonsky G. A., Young A. E., Shindledecker C. L., Kapikian A. Z., Levine M. M. An efficacy trial of the rhesus rotavirus vaccine in Maryland. The Clinical Study Group. Am J Dis Child. 1990 May;144(5):601–604. doi: 10.1001/archpedi.1990.02150290095037. [DOI] [PubMed] [Google Scholar]
  105. Ruuska T., Vesikari T., Delem A., André F. E., Beards G. M., Flewett T. H. Evaluation of RIT 4237 bovine rotavirus vaccine in newborn infants: correlation of vaccine efficacy to season of birth in relation to rotavirus epidemic period. Scand J Infect Dis. 1990;22(3):269–278. doi: 10.3109/00365549009027047. [DOI] [PubMed] [Google Scholar]
  106. Ryder R. W., McGowan J. E., Hatch M. H., Palmer E. L. Reovirus-like agent as a cause of nosocomial diarrhea in infants. J Pediatr. 1977 May;90(5):698–702. doi: 10.1016/s0022-3476(77)81230-4. [DOI] [PubMed] [Google Scholar]
  107. Salas-Vidal E., Plebañski M., Castro S., Perales G., Mata E., López S., Arias C. F. Synthesis of the surface glycoprotein of rotavirus SA11 in the aroA strain of Salmonella typhimurium SL3261. Res Microbiol. 1990 Sep-Oct;141(7-8):883–886. doi: 10.1016/0923-2508(90)90125-a. [DOI] [PubMed] [Google Scholar]
  108. Santosham M., Letson G. W., Wolff M., Reid R., Gahagan S., Adams R., Callahan C., Sack R. B., Kapikian A. Z. A field study of the safety and efficacy of two candidate rotavirus vaccines in a Native American population. J Infect Dis. 1991 Mar;163(3):483–487. doi: 10.1093/infdis/163.3.483. [DOI] [PubMed] [Google Scholar]
  109. Saulsbury F. T., Winkelstein J. A., Yolken R. H. Chronic rotavirus infection in immunodeficiency. J Pediatr. 1980 Jul;97(1):61–65. doi: 10.1016/s0022-3476(80)80131-4. [DOI] [PubMed] [Google Scholar]
  110. Schaller J. P., Saif L. J., Cordle C. T., Candler E., Jr, Winship T. R., Smith K. L. Prevention of human rotavirus-induced diarrhea in gnotobiotic piglets using bovine antibody. J Infect Dis. 1992 Apr;165(4):623–630. doi: 10.1093/infdis/165.4.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Snodgrass D. R., Wells P. W. Rotavirus infection in lambs: studies on passive protection. Arch Virol. 1976;52(3):201–205. doi: 10.1007/BF01348017. [DOI] [PubMed] [Google Scholar]
  112. Vesikari T. Clinical trials of live oral rotavirus vaccines: the Finnish experience. Vaccine. 1993;11(2):255–261. doi: 10.1016/0264-410x(93)90026-t. [DOI] [PubMed] [Google Scholar]
  113. Vesikari T., Isolauri E., D'Hondt E., Delem A., André F. E., Zissis G. Protection of infants against rotavirus diarrhoea by RIT 4237 attenuated bovine rotavirus strain vaccine. Lancet. 1984 May 5;1(8384):977–981. doi: 10.1016/s0140-6736(84)92323-7. [DOI] [PubMed] [Google Scholar]
  114. Vesikari T., Isolauri E., Delem A., D'Hondt E., André F. E., Zissis G. Immunogenicity and safety of live oral attenuated bovine rotavirus vaccine strain RIT 4237 in adults and young children. Lancet. 1983 Oct 8;2(8354):807–811. doi: 10.1016/s0140-6736(83)90734-1. [DOI] [PubMed] [Google Scholar]
  115. Vesikari T., Isolauri E., Delem A., d'Hondt E., André F. E., Beards G. M., Flewett T. H. Clinical efficacy of the RIT 4237 live attenuated bovine rotavirus vaccine in infants vaccinated before a rotavirus epidemic. J Pediatr. 1985 Aug;107(2):189–194. doi: 10.1016/s0022-3476(85)80123-2. [DOI] [PubMed] [Google Scholar]
  116. Vesikari T., Kapikian A. Z., Delem A., Zissis G. A comparative trial of rhesus monkey (RRV-1) and bovine (RIT 4237) oral rotavirus vaccines in young children. J Infect Dis. 1986 May;153(5):832–839. doi: 10.1093/infdis/153.5.832. [DOI] [PubMed] [Google Scholar]
  117. Vesikari T., Rautanen T., Isolauri E., Delem A., André F. E. Immunogenicity and safety of a low passage level bovine rotavirus candidate vaccine RIT 4256 in human adults and young infants. Vaccine. 1987 Jun;5(2):105–108. doi: 10.1016/0264-410x(87)90055-7. [DOI] [PubMed] [Google Scholar]
  118. Vesikari T., Rautanen T., Varis T., Beards G. M., Kapikian A. Z. Rhesus Rotavirus candidate vaccine. Clinical trial in children vaccinated between 2 and 5 months of age. Am J Dis Child. 1990 Mar;144(3):285–289. [PubMed] [Google Scholar]
  119. Vesikari T., Ruuska T., Bogaerts H., Delem A., André F. Dose-response study of RIT 4237 oral rotavirus vaccine in breast-fed and formula-fed infants. Pediatr Infect Dis. 1985 Nov-Dec;4(6):622–625. doi: 10.1097/00006454-198511000-00005. [DOI] [PubMed] [Google Scholar]
  120. Vesikari T., Ruuska T., Delem A., André F. E., Beards G. M., Flewett T. H. Efficacy of two doses of RIT 4237 bovine rotavirus vaccine for prevention of rotavirus diarrhoea. Acta Paediatr Scand. 1991 Feb;80(2):173–180. doi: 10.1111/j.1651-2227.1991.tb11830.x. [DOI] [PubMed] [Google Scholar]
  121. Vesikari T., Ruuska T., Delem A., André F. E. Neonatal rotavirus vaccination with RIT 4237 bovine rotavirus vaccine: a preliminary report. Pediatr Infect Dis J. 1987 Feb;6(2):164–169. doi: 10.1097/00006454-198702000-00005. [DOI] [PubMed] [Google Scholar]
  122. Vesikari T., Ruuska T., Green K. Y., Flores J., Kapikian A. Z. Protective efficacy against serotype 1 rotavirus diarrhea by live oral rhesus-human reassortant rotavirus vaccines with human rotavirus VP7 serotype 1 or 2 specificity. Pediatr Infect Dis J. 1992 Jul;11(7):535–542. doi: 10.1097/00006454-199207000-00006. [DOI] [PubMed] [Google Scholar]
  123. Vesikari T., Ruuska T., Koivu H. P., Green K. Y., Flores J., Kapikian A. Z. Evaluation of the M37 human rotavirus vaccine in 2- to 6-month-old infants. Pediatr Infect Dis J. 1991 Dec;10(12):912–917. doi: 10.1097/00006454-199112000-00006. [DOI] [PubMed] [Google Scholar]
  124. Vesikari T., Varis T., Green K., Flores J., Kapikian A. Z. Immunogenicity and safety of rhesus-human rotavirus reassortant vaccines with serotype 1 or 2 VP7 specificity. Vaccine. 1991 May;9(5):334–339. doi: 10.1016/0264-410x(91)90060-j. [DOI] [PubMed] [Google Scholar]
  125. Vodopija I., Baklaic Z., Vlatkovic R., Bogaerts H., Delem A., Andre F. E. Combined vaccination with live oral polio vaccine and the bovine rotavirus RIT 4237 strain. Vaccine. 1986 Dec;4(4):233–236. doi: 10.1016/0264-410x(86)90135-0. [DOI] [PubMed] [Google Scholar]
  126. Wallace R. E., Vasington P. J., Petricciani J. C., Hopps H. E., Lorenz D. E., Kadanka Z. Development of a diploid cell line from fetal rhesus monkey lung for virus vaccine production. In Vitro. 1973 Mar-Apr;8(5):323–332. doi: 10.1007/BF02619056. [DOI] [PubMed] [Google Scholar]
  127. Ward R. L., Bernstein D. I., Shukla R., Young E. C., Sherwood J. R., McNeal M. M., Walker M. C., Schiff G. M. Effects of antibody to rotavirus on protection of adults challenged with a human rotavirus. J Infect Dis. 1989 Jan;159(1):79–88. doi: 10.1093/infdis/159.1.79. [DOI] [PubMed] [Google Scholar]
  128. Wright P. F., Tajima T., Thompson J., Kokubun K., Kapikian A., Karzon D. T. Candidate rotavirus vaccine (rhesus rotavirus strain) in children: an evaluation. Pediatrics. 1987 Oct;80(4):473–480. [PubMed] [Google Scholar]
  129. Wyatt R. G., Mebus C. A., Yolken R. H., Kalica A. R., James H. D., Jr, Kapikian A. Z., Chanock R. M. Rotaviral immunity in gnotobiotic calves: heterologous resistance to human virus induced by bovine virus. Science. 1979 Feb 9;203(4380):548–550. doi: 10.1126/science.216077. [DOI] [PubMed] [Google Scholar]
  130. Zhaori G. T., Fu L. T., Xu Y. H., Guo Y. R., Peng Z. J., Shan W. S. Detection of rotavirus antigen in tracheal aspirates of infants and children with pneumonia. Chin Med J (Engl) 1991 Oct;104(10):830–833. [PubMed] [Google Scholar]
  131. Zheng B. J., Chang R. X., Ma G. Z., Xie J. M., Liu Q., Liang X. R., Ng M. H. Rotavirus infection of the oropharynx and respiratory tract in young children. J Med Virol. 1991 May;34(1):29–37. doi: 10.1002/jmv.1890340106. [DOI] [PubMed] [Google Scholar]
  132. Zheng B. J., Han S. X., Yan Y. K., Liang X. R., Ma G. Z., Yang Y., Ng M. H. Development of neutralizing antibodies and group A common antibodies against natural infections with human rotavirus. J Clin Microbiol. 1988 Aug;26(8):1506–1512. doi: 10.1128/jcm.26.8.1506-1512.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Zissis G., Lambert J. P., Marbehant P., Marissens D., Lobmann M., Charlier P., Delem A., Zygraich N. Protection studies in colostrum-deprived piglets of a bovine rotavirus vaccine candidate using human rotavirus strains for challenge. J Infect Dis. 1983 Dec;148(6):1061–1068. doi: 10.1093/infdis/148.6.1061. [DOI] [PubMed] [Google Scholar]
  134. Zoppi G., Ferrarini G., Rigolin F., Bogaerts H., André F. E. Response to RIT 4237 oral rotavirus vaccine in breast-fed and formula-fed infants. Helv Paediatr Acta. 1986 Aug;41(3):203–208. [PubMed] [Google Scholar]

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