Abstract
OBJECTIVE—To determine whether there are seasonal variations in survival following out of hospital cardiopulmonary arrest. DESIGN—Prospective cohort study using the Heartstart (Scotland) database. SETTING—All of Scotland. PATIENTS—10 890 people who suffered out of hospital cardiopulmonary arrest in the summer or winter between December 1988 and August 1997 inclusive. INTERVENTION—Univariate comparisons of 5406 arrests occurring in summer with 5484 in winter, in terms of patient characteristics, management, and survival using χ2 and Mann-Whitney U tests. Multivariate analysis of the association between season and survival following adjustment for case mix. MAIN OUTCOMES MEASURES—Survival to discharge from hospital, survival pre-admission, in-hospital survival. RESULTS—Only 6% of people who arrested in winter survived to discharge, compared to 8% of those who arrested in summer (odds ratio 0.77, p < 0.001). People who arrested in winter had a poorer risk profile in that they were older, more likely to arrest at home, less likely to have a witness, and less likely to receive defibrillation. However, after adjustment for case mix, people who arrested in winter were still 19% less likely to survive compared to those who arrested in summer. Deaths pre-admission were significantly higher in winter (odds ratio 1.18, p < 0.05) but in-hospital deaths were not. CONCLUSIONS—People who suffer cardiopulmonary arrest in winter have a significantly lower likelihood of surviving. This is, in part, caused by the higher frequency of a number of recognised risk factors. However, their prognosis remains poorer even after adjustment for these factors. Keywords: cardiopulmonary arrest; cardiopulmonary resuscitation; seasonal variations; ischaemic heart disease
Full Text
The Full Text of this article is available as a PDF (82.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson T. W., Rochard C. Cold snaps, snowfall and sudden death from ischemic heart disease. Can Med Assoc J. 1979 Dec 22;121(12):1580–1583. [PMC free article] [PubMed] [Google Scholar]
- Beard C. M., Fuster V., Elveback L. R. Daily and seasonal variation in sudden cardiac death, Rochester, Minnesota, 1950-1975. Mayo Clin Proc. 1982 Nov;57(11):704–706. [PubMed] [Google Scholar]
- Biemond B. J., Levi M., Ten Cate H., Van der Poll T., Büller H. R., Hack C. E., Ten Cate J. W. Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: effect of interventions in the cytokine and coagulation cascades. Clin Sci (Lond) 1995 May;88(5):587–594. doi: 10.1042/cs0880587. [DOI] [PubMed] [Google Scholar]
- Cech I., Smolensky M., Lane R., Halevy B., Samueloff S. Meteorologic factors and temporal variations of cardiac mortality in an urban setting in a desert climatic zone. Isr J Med Sci. 1977 May;13(5):451–459. [PubMed] [Google Scholar]
- Danesh J., Collins R., Peto R. Chronic infections and coronary heart disease: is there a link? Lancet. 1997 Aug 9;350(9075):430–436. doi: 10.1016/S0140-6736(97)03079-1. [DOI] [PubMed] [Google Scholar]
- Dannenberg A. L., Keller J. B., Wilson P. W., Castelli W. P. Leisure time physical activity in the Framingham Offspring Study. Description, seasonal variation, and risk factor correlates. Am J Epidemiol. 1989 Jan;129(1):76–88. doi: 10.1093/oxfordjournals.aje.a115126. [DOI] [PubMed] [Google Scholar]
- Douglas A. S., Allan T. M., Rawles J. M. Composition of seasonality of disease. Scott Med J. 1991 Jun;36(3):76–82. doi: 10.1177/003693309103600304. [DOI] [PubMed] [Google Scholar]
- Douglas A. S., Dunnigan M. G., Allan T. M., Rawles J. M. Seasonal variation in coronary heart disease in Scotland. J Epidemiol Community Health. 1995 Dec;49(6):575–582. doi: 10.1136/jech.49.6.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Douglas A. S., Russell D., Allan T. M. Seasonal, regional and secular variations of cardiovascular and cerebrovascular mortality in New Zealand. Aust N Z J Med. 1990 Oct;20(5):669–676. doi: 10.1111/j.1445-5994.1990.tb00397.x. [DOI] [PubMed] [Google Scholar]
- Ellis R. W. Infection and coronary heart disease. J Med Microbiol. 1997 Jul;46(7):535–539. doi: 10.1099/00222615-46-7-535. [DOI] [PubMed] [Google Scholar]
- Enquselassie F., Dobson A. J., Alexander H. M., Steele P. L. Seasons, temperature and coronary disease. Int J Epidemiol. 1993 Aug;22(4):632–636. doi: 10.1093/ije/22.4.632. [DOI] [PubMed] [Google Scholar]
- Folsom A. R., Nieto F. J., Sorlie P., Chambless L. E., Graham D. Y. Helicobacter pylori seropositivity and coronary heart disease incidence. Atherosclerosis Risk In Communities (ARIC) Study Investigators. Circulation. 1998 Sep 1;98(9):845–850. doi: 10.1161/01.cir.98.9.845. [DOI] [PubMed] [Google Scholar]
- Gordon D. J., Trost D. C., Hyde J., Whaley F. S., Hannan P. J., Jacobs D. R., Jr, Ekelund L. G. Seasonal cholesterol cycles: the Lipid Research Clinics Coronary Primary Prevention Trial placebo group. Circulation. 1987 Dec;76(6):1224–1231. doi: 10.1161/01.cir.76.6.1224. [DOI] [PubMed] [Google Scholar]
- Grimes D. S., Hindle E., Dyer T. Sunlight, cholesterol and coronary heart disease. QJM. 1996 Aug;89(8):579–589. doi: 10.1093/qjmed/89.8.579. [DOI] [PubMed] [Google Scholar]
- Hayward J. M., Holmes W. F., Gooden B. A. Cardiovascular responses in man to a stream of cold air. Cardiovasc Res. 1976 Nov;10(6):691–696. doi: 10.1093/cvr/10.6.691. [DOI] [PubMed] [Google Scholar]
- Heunis J. C., Olivier J., Bourne D. E. Short-term relationships between winter temperatures and cardiac disease mortality in Cape Town. S Afr Med J. 1995 Oct;85(10):1016–1019. [PubMed] [Google Scholar]
- Keatinge W. R., Coleshaw S. R., Cotter F., Mattock M., Murphy M., Chelliah R. Increases in platelet and red cell counts, blood viscosity, and arterial pressure during mild surface cooling: factors in mortality from coronary and cerebral thrombosis in winter. Br Med J (Clin Res Ed) 1984 Nov 24;289(6456):1405–1408. doi: 10.1136/bmj.289.6456.1405. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuller L., Lilienfeld A., Fisher R. An epidemiological study of sudden and unexpected deaths in adults. Medicine (Baltimore) 1967 Jul;46(4):341–361. doi: 10.1097/00005792-196707000-00003. [DOI] [PubMed] [Google Scholar]
- Lam S. K. Aetiological factors of peptic ulcer: perspectives of epidemiological observations this century. J Gastroenterol Hepatol. 1994;9 (Suppl 1):S93–S98. doi: 10.1111/j.1440-1746.1994.tb01310.x. [DOI] [PubMed] [Google Scholar]
- Lassvik C. T., Areskog N. H. Angina in cold environment. Reactions to exercise. Br Heart J. 1979 Oct;42(4):396–401. doi: 10.1136/hrt.42.4.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marshall R. J., Scragg R., Bourke P. An analysis of the seasonal variation of coronary heart disease and respiratory disease mortality in New Zealand. Int J Epidemiol. 1988 Jun;17(2):325–331. doi: 10.1093/ije/17.2.325. [DOI] [PubMed] [Google Scholar]
- McDonagh T. A., Woodward M., Morrison C. E., McMurray J. J., Tunstall-Pedoe H., Lowe G. D., McColl K. E., Dargie H. J. Helicobacter pylori infection and coronary heart disease in the North Glasgow MONICA population. Eur Heart J. 1997 Aug;18(8):1257–1260. doi: 10.1093/oxfordjournals.eurheartj.a015436. [DOI] [PubMed] [Google Scholar]
- McKee C. M. Deaths in winter: can Britain learn from Europe? Eur J Epidemiol. 1989 Jun;5(2):178–182. doi: 10.1007/BF00156826. [DOI] [PubMed] [Google Scholar]
- Mendall M. A., Goggin P. M., Molineaux N., Levy J., Toosy T., Strachan D., Camm A. J., Northfield T. C. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J. 1994 May;71(5):437–439. doi: 10.1136/hrt.71.5.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moshkowitz M., Konikoff F. M., Arber N., Peled Y., Santo M., Bujanover Y., Gilat T. Seasonal variation in the frequency of Helicobacter pylori infection: a possible cause of the seasonal occurrence of peptic ulcer disease. Am J Gastroenterol. 1994 May;89(5):731–733. [PubMed] [Google Scholar]
- Patel P., Mendall M. A., Carrington D., Strachan D. P., Leatham E., Molineaux N., Levy J., Blakeston C., Seymour C. A., Camm A. J. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ. 1995 Sep 16;311(7007):711–714. doi: 10.1136/bmj.311.7007.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raven P. B., Wilkerson J. E., Horvath S. M., Bolduan N. W. Thermal, metabolic, and cardiovascular responses to various degrees of cold stress. Can J Physiol Pharmacol. 1975 Apr;53(2):293–298. doi: 10.1139/y75-041. [DOI] [PubMed] [Google Scholar]
- Rose G. Cold weather and ischaemic heart disease. Br J Prev Soc Med. 1966 Apr;20(2):97–100. doi: 10.1136/jech.20.2.97. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Savarino V., Mela G. S., Zentilin P., Lapertosa G., Cutela P., Mele M. R., Mansi C., Dallorto E., Vassallo A., Celle G. Are duodenal ulcer seasonal fluctuations paralleled by seasonal changes in 24-hour gastric acidity and Helicobacter pylori infection? J Clin Gastroenterol. 1996 Apr;22(3):178–181. doi: 10.1097/00004836-199604000-00005. [DOI] [PubMed] [Google Scholar]
- Seretakis D., Lagiou P., Lipworth L., Signorello L. B., Rothman K. J., Trichopoulos D. Changing seasonality of mortality from coronary heart disease. JAMA. 1997 Sep 24;278(12):1012–1014. [PubMed] [Google Scholar]
- Van Gent C. M., Van der Voort H., Hessel L. W. High-density lipoprotein cholesterol, monthly variation and association with cardiovascular risk factors in 1000 forty-year-old Dutch citizens. Clin Chim Acta. 1978 Aug 15;88(1):155–162. doi: 10.1016/0009-8981(78)90163-8. [DOI] [PubMed] [Google Scholar]
- Van Staveren W. A., Deurenberg P., Burema J., De Groot L. C., Hautvast J. G. Seasonal variation in food intake, pattern of physical activity and change in body weight in a group of young adult Dutch women consuming self-selected diets. Int J Obes. 1986;10(2):133–145. [PubMed] [Google Scholar]
- Vik B., Try K., Thelle D. S., Førde O. H. Tromsø Heart Study: vitamin D metabolism and myocardial infarction. Br Med J. 1979 Jul 21;2(6183):176–176. doi: 10.1136/bmj.2.6183.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilmshurst P. Temperature and cardiovascular mortality. BMJ. 1994 Oct 22;309(6961):1029–1030. doi: 10.1136/bmj.309.6961.1029. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodhouse P. R., Khaw K. T., Plummer M., Foley A., Meade T. W. Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet. 1994 Feb 19;343(8895):435–439. doi: 10.1016/s0140-6736(94)92689-1. [DOI] [PubMed] [Google Scholar]