Full Text
The Full Text of this article is available as a PDF (158.1 KB).
Figure 1 .
Pathways for the metabolism of homocysteine. Normal transsulfuration requires cystathionine β synthase with vitamin B6 as cofactor. Remethylation requires 5, 10-methylenetetrahydrofolate reductase and methionine synthase. The latter requires folate as cosubstrate and vitamin B12 (cobalamin) as cofactor. An alternative remethylation pathway also exists using the cobalamin independent betaine-homocysteine methyltransferase.