Abstract
ReoPro (abciximab) is an extremely potent inhibitor of the glycoprotein IIb/IIIa receptor, the final common pathway of platelet activation and aggregation. Its main role is the maintenance of coronary patency after suboptimal results with coronary intervention. However, one of the complications of this treatment is excessive bleeding, a problem which may be compounded by a rare idiosyncratic thrombocytopenic reaction. A severe episode of thrombocytopenia in a 64 year old man is described; he was treated with ReoPro for a right coronary stenosis which had not been resolved by angioplasty. His platelet level dropped quickly and only improved after 20 units of platelets were given. Keywords: ReoPro; abciximab; platelets; thrombocytopenia; interventional cardiology
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- Berkowitz S. D., Sane D. C., Sigmon K. N., Shavender J. H., Harrington R. A., Tcheng J. E., Topol E. J., Califf R. M. Occurrence and clinical significance of thrombocytopenia in a population undergoing high-risk percutaneous coronary revascularization. Evaluation of c7E3 for the Prevention of Ischemic Complications (EPIC) Study Group. J Am Coll Cardiol. 1998 Aug;32(2):311–319. doi: 10.1016/s0735-1097(98)00252-6. [DOI] [PubMed] [Google Scholar]
- Ferguson J. J., Kereiakes D. J., Adgey A. A., Fox K. A., Hillegass W. B., Jr, Pfisterer M., Vassanelli C. Safe use of platelet GP IIb/IIIa inhibitors. Am Heart J. 1998 Apr;135(4):S77–S89. doi: 10.1016/s0002-8703(98)70300-x. [DOI] [PubMed] [Google Scholar]
- Ferrari E., Thiry M., Touati C., Gibelin P., Baudouy M. Acute profound thrombocytopenia after c7E3 Fab therapy. Circulation. 1997 Nov 18;96(10):3809–3810. [PubMed] [Google Scholar]
- Mendes V., Resende M., Santos J. M., Mourão L., Santos A. L., Luís A. S. Trombocitopénia grave associada à terapêutica com Abciximab--a propósito de um caso clínico. Rev Port Cardiol. 1998 Jul-Aug;17(7-8):609–613. [PubMed] [Google Scholar]