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. 2000 Jul;84(1):83–87. doi: 10.1136/heart.84.1.83

Interleukin 6 expression in coronary circulation after coronary angioplasty as a risk factor for restenosis

Y Hojo 1, U Ikeda 1, T Katsuki 1, O Mizuno 1, H Fukazawa 1, K Kurosaki 1, H Fujikawa 1, K Shimada 1
PMCID: PMC1729404  PMID: 10862597

Abstract

OBJECTIVE—To investigate changes in cytokine expression in the coronary circulation induced by percutaneous transluminal coronary angioplasty (PTCA).
METHODS—The study involved 32 patients with ischaemic heart disease who underwent elective PTCA for isolated stenotic lesions of the left coronary artery. Ten patients had plain old balloon angioplasty, 10 had percutaneous transluminal rotational atherectomy, and 12 had stent implantation. Blood samples were drawn from the coronary sinus before and immediately after PTCA. Plasma concentrations of interleukin 6 (IL-6), platelet derived growth factor (PDGF), monocyte chemoattractant protein 1 (MCP-1), and macrophage coronary stimulating factor (M-CSF) were measured. The patients were scheduled for follow up angiography six months after PTCA. Late loss index was calculated using quantitative coronary angiography.
RESULTS—IL-6 concentrations in coronary sinus blood increased immediately after PTCA (p < 0.001), but there was no change in PDGF, MCP-1, or M-CSF. There was a positive correlation between changes in IL-6 concentrations immediately after PTCA and late loss index six months after PTCA (r = 0.73, p < 0.001). IL-6 concentrations in coronary sinus blood were higher in patients with late restenosis than in those without restenosis (p < 0.001).
CONCLUSIONS—PTCA induces IL-6 production in the coronary circulation. This may induce subsequent inflammatory responses in injured vessels and play an important role in late restenosis after PTCA.


Keywords: inflammation; cytokine; restenosis

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Figure 1  .

Figure 1  

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Correlation between changes in IL-6 concentrations in the coronary sinus induced by PTCA and late restenosis. (A) A significant positive correlation was found between relative changes in IL-6 concentrations immediately after PTCA and late loss index six months after PTCA (r = 0.73, p < 0.001). Circles, data from POBA (plain old balloon angioplasty) group; triangles, PTRA (percutaneous transluminal rotational coronary atherectomy) group; squares, stent group. (B) Patients were divided into two groups according to late restenosis. Patients with restenosis (n = 11) showed significantly higher IL-6 concentrations after PTCA than those without restenosis (n = 17). Data are means, error bars = SEM. *p < 0.001. 

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