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. 1997 Oct;10(4):694–719. doi: 10.1128/cmr.10.4.694

Rickettsioses as paradigms of new or emerging infectious diseases.

D Raoult 1, V Roux 1
PMCID: PMC172941  PMID: 9336669

Abstract

Rickettsioses are caused by species of Rickettsia, a genus comprising organisms characterized by their strictly intracellular location and their association with arthropods. Rickettsia species are difficult to cultivate in vitro and exhibit strong serological cross-reactions with each other. These technical difficulties long prohibited a detailed study of the rickettsiae, and it is only following the recent introduction of novel laboratory methods that progress in this field has been possible. In this review, we discuss the impact that these practical innovations have had on the study of rickettsiae. Prior to 1986, only eight rickettsioses were clinically recognized; however, in the last 10 years, an additional six have been discovered. We describe the different steps that resulted in the description of each new rickettsiosis and discuss the influence of factors as diverse as physicians' curiosity and the adoption of molecular biology-based identification in helping to recognize these new infections. We also assess the pathogenic potential of rickettsial strains that to date have been associated only with arthropods, and we discuss diseases of unknown etiology that may be rickettsioses.

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Selected References

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  1. Ackley A. M., Peter W. J. Indigenous acquisition of epidemic typhus in the eastern United States. South Med J. 1981 Feb;74(2):245–247. doi: 10.1097/00007611-198102000-00034. [DOI] [PubMed] [Google Scholar]
  2. Adams J. R., Schmidtmann E. T., Azad A. F. Infection of colonized cat fleas, Ctenocephalides felis (Bouché), with a rickettsia-like microorganism. Am J Trop Med Hyg. 1990 Oct;43(4):400–409. doi: 10.4269/ajtmh.1990.43.400. [DOI] [PubMed] [Google Scholar]
  3. Adams W. H., Emmons R. W., Brooks J. E. The changing ecology of murine (endemic) typhus in Southern California. Am J Trop Med Hyg. 1970 Mar;19(2):311–318. doi: 10.4269/ajtmh.1970.19.311. [DOI] [PubMed] [Google Scholar]
  4. Aeschlimann A., Burgdorfer W., Matile H., Peter O., Wyler R. Aspects nouveaux du rôle de vecteur joué par Ixodes ricinus L. en Suisse. Note préliminaire. Acta Trop. 1979 Jun;36(2):181–191. [PubMed] [Google Scholar]
  5. Anacker R. L., List R. H., Mann R. E., Hayes S. F., Thomas L. A. Characterization of monoclonal antibodies protecting mice against Rickettsia rickettsii. J Infect Dis. 1985 Jun;151(6):1052–1060. doi: 10.1093/infdis/151.6.1052. [DOI] [PubMed] [Google Scholar]
  6. Anacker R. L., Mann R. E., Gonzales C. Reactivity of monoclonal antibodies to Rickettsia rickettsii with spotted fever and typhus group rickettsiae. J Clin Microbiol. 1987 Jan;25(1):167–171. doi: 10.1128/jcm.25.1.167-171.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Anacker R. L., McDonald G. A., List R. H., Mann R. E. Neutralizing activity of monoclonal antibodies to heat-sensitive and heat-resistant epitopes of Rickettsia rickettsii surface proteins. Infect Immun. 1987 Mar;55(3):825–827. doi: 10.1128/iai.55.3.825-827.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Anacker R. L., Philip R. N., Williams J. C., List R. H., Mann R. E. Biochemical and immunochemical analysis of Rickettsia rickettsii strains of various degrees of virulence. Infect Immun. 1984 Jun;44(3):559–564. doi: 10.1128/iai.44.3.559-564.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Anderson B. E., Tzianabos T. Comparative sequence analysis of a genus-common rickettsial antigen gene. J Bacteriol. 1989 Sep;171(9):5199–5201. doi: 10.1128/jb.171.9.5199-5201.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Anigstein L., Anigstein D. A review of the evidence in retrospect for a rickettsial etiology in Bullis fever. Tex Rep Biol Med. 1975;33(1):201–211. [PubMed] [Google Scholar]
  11. Arango-Jaramillo S., Farhang-Azad A., Wisseman C. L., Jr Experimental infection with Rickettsia mooseri and antibody response of adult and newborn laboratory rats. Am J Trop Med Hyg. 1984 Sep;33(5):1017–1025. doi: 10.4269/ajtmh.1984.33.1017. [DOI] [PubMed] [Google Scholar]
  12. Archibald L. K., Sexton D. J. Long-term sequelae of Rocky Mountain spotted fever. Clin Infect Dis. 1995 May;20(5):1122–1125. doi: 10.1093/clinids/20.5.1122. [DOI] [PubMed] [Google Scholar]
  13. Azad A. F. Epidemiology of murine typhus. Annu Rev Entomol. 1990;35:553–569. doi: 10.1146/annurev.en.35.010190.003005. [DOI] [PubMed] [Google Scholar]
  14. Azad A. F., Sacci J. B., Jr, Nelson W. M., Dasch G. A., Schmidtmann E. T., Carl M. Genetic characterization and transovarial transmission of a typhus-like rickettsia found in cat fleas. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):43–46. doi: 10.1073/pnas.89.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. BELL E. J., KOHLS G. M., STOENNER H. G., LACKMAN D. B. NONPATHOGENIC RICKETTSIAS RELATED TO THE SPOTTED FEVER GROUP ISOLATED FROM TICKS, DERMACENTOR VARIABILIS AND DERMACENTOR ANDERSONI FROM EASTERN MONTANA. J Immunol. 1963 May;90:770–781. [PubMed] [Google Scholar]
  16. BELL E. J., STOENNER H. G. Immunologic relationships among the spotted fever group of rickettsias determined by toxin neutralization tests in mice with convalescent animal serums. J Immunol. 1960 Feb;84:171–182. [PubMed] [Google Scholar]
  17. Babalis T., Tselentis Y., Roux V., Psaroulaki A., Raoult D. Isolation and identification of a rickettsial strain related to Rickettsia massiliae in Greek ticks. Am J Trop Med Hyg. 1994 Mar;50(3):365–372. doi: 10.4269/ajtmh.1994.50.365. [DOI] [PubMed] [Google Scholar]
  18. Bacellar F., Regnery R. L., Núncio M. S., Filipe A. R. Genotypic evaluation of rickettsial isolates recovered from various species of ticks in Portugal. Epidemiol Infect. 1995 Feb;114(1):169–178. doi: 10.1017/s095026880005202x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Baird R. W., Lloyd M., Stenos J., Ross B. C., Stewart R. S., Dwyer B. Characterization and comparison of Australian human spotted fever group rickettsiae. J Clin Microbiol. 1992 Nov;30(11):2896–2902. doi: 10.1128/jcm.30.11.2896-2902.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Baird R. W., Stenos J., Stewart R., Hudson B., Lloyd M., Aiuto S., Dwyer B. Genetic variation in Australian spotted fever group rickettsiae. J Clin Microbiol. 1996 Jun;34(6):1526–1530. doi: 10.1128/jcm.34.6.1526-1530.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Balayeva N. M., Demkin V. V., Rydkina E. B., Ignatovich V. F., Artemiev M. I., Lichoded LYa, Genig V. A. Genotypic and biological characteristics of non-identified strain of spotted fever group rickettsiae isolated in Crimea. Acta Virol. 1993 Dec;37(6):475–483. [PubMed] [Google Scholar]
  22. Balayeva N. M., Eremeeva M. E., Raoult D. Genomic identification of Rickettsia slovaca among spotted fever group rickettsia isolates from Dermacentor marginatus in Armenia. Acta Virol. 1994 Dec;38(6):321–325. [PubMed] [Google Scholar]
  23. Balayeva N. M., Eremeeva M. E., Tissot-Dupont H., Zakharov I. A., Raoult D. Genotype characterization of the bacterium expressing the male-killing trait in the ladybird beetle Adalia bipunctata with specific rickettsial molecular tools. Appl Environ Microbiol. 1995 Apr;61(4):1431–1437. doi: 10.1128/aem.61.4.1431-1437.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Barbour A. G. Laboratory aspects of Lyme borreliosis. Clin Microbiol Rev. 1988 Oct;1(4):399–414. doi: 10.1128/cmr.1.4.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Beati L., Finidori J. P., Gilot B., Raoult D. Comparison of serologic typing, sodium dodecyl sulfate-polyacrylamide gel electrophoresis protein analysis, and genetic restriction fragment length polymorphism analysis for identification of rickettsiae: characterization of two new rickettsial strains. J Clin Microbiol. 1992 Aug;30(8):1922–1930. doi: 10.1128/jcm.30.8.1922-1930.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Beati L., Finidori J. P., Raoult D. First isolation of Rickettsia slovaca from Dermacentor marginatus in France. Am J Trop Med Hyg. 1993 Feb;48(2):257–268. doi: 10.4269/ajtmh.1993.48.257. [DOI] [PubMed] [Google Scholar]
  27. Beati L., Humair P. F., Aeschlimann A., Raoult D. Identification of spotted fever group rickettsiae isolated from Dermacentor marginatus and Ixodes ricinus ticks collected in Switzerland. Am J Trop Med Hyg. 1994 Aug;51(2):138–148. doi: 10.4269/ajtmh.1994.51.138. [DOI] [PubMed] [Google Scholar]
  28. Beati L., Kelly P. J., Mason P. R., Raoult D. Species-specific BALB/c mouse antibodies to rickettsiae studied by western blotting. FEMS Microbiol Lett. 1994 Jun 15;119(3):339–344. doi: 10.1111/j.1574-6968.1994.tb06910.x. [DOI] [PubMed] [Google Scholar]
  29. Beati L., Kelly P. J., Matthewman L. A., Mason P. R., Raoult D. Prevalence of rickettsia-like organisms and spotted fever group rickettsiae in ticks (Acari: Ixodidae) from Zimbabwe. J Med Entomol. 1995 Nov;32(6):787–792. doi: 10.1093/jmedent/32.6.787. [DOI] [PubMed] [Google Scholar]
  30. Beati L., Meskini M., Thiers B., Raoult D. Rickettsia aeschlimannii sp. nov., a new spotted fever group rickettsia associated with Hyalomma marginatum ticks. Int J Syst Bacteriol. 1997 Apr;47(2):548–554. doi: 10.1099/00207713-47-2-548. [DOI] [PubMed] [Google Scholar]
  31. Beati L., Raoult D. Rickettsia massiliae sp. nov., a new spotted fever group Rickettsia. Int J Syst Bacteriol. 1993 Oct;43(4):839–840. doi: 10.1099/00207713-43-4-839. [DOI] [PubMed] [Google Scholar]
  32. Beati L., Roux V., Ortuño A., Castella J., Porta F. S., Raoult D. Phenotypic and genotypic characterization of spotted fever group Rickettsiae isolated from Catalan Rhipicephalus sanguineus ticks. J Clin Microbiol. 1996 Nov;34(11):2688–2694. doi: 10.1128/jcm.34.11.2688-2694.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Bozeman F. M., Elisberg B. L., Humphries J. W., Runcik K., Palmer D. B., Jr Serologic evidence of Rickettsia canada infection of man. J Infect Dis. 1970 Apr;121(4):367–371. doi: 10.1093/infdis/121.4.367. [DOI] [PubMed] [Google Scholar]
  34. Bozeman F. M., Masiello S. A., Williams M. S., Elisberg B. L. Epidemic typhus rickettsiae isolated from flying squirrels. Nature. 1975 Jun 12;255(5509):545–547. doi: 10.1038/255545a0. [DOI] [PubMed] [Google Scholar]
  35. Bozeman F. M., Shiral A., Humphries J. W., Fuller H. S. Ecology of Rocky Mountain spotted fever. II. Natural infection of wild mammals and birds in Virginia and Maryland. Am J Trop Med Hyg. 1967 Jan;16(1):48–59. [PubMed] [Google Scholar]
  36. Brenner D. J., O'Connor S. P., Winkler H. H., Steigerwalt A. G. Proposals to unify the genera Bartonella and Rochalimaea, with descriptions of Bartonella quintana comb. nov., Bartonella vinsonii comb. nov., Bartonella henselae comb. nov., and Bartonella elizabethae comb. nov., and to remove the family Bartonellaceae from the order Rickettsiales. Int J Syst Bacteriol. 1993 Oct;43(4):777–786. doi: 10.1099/00207713-43-4-777. [DOI] [PubMed] [Google Scholar]
  37. Brettman L. R., Lewin S., Holzman R. S., Goldman W. D., Marr J. S., Kechijian P., Schinella R. Rickettsialpox: report of an outbreak and a contemporary review. Medicine (Baltimore) 1981 Sep;60(5):363–372. doi: 10.1097/00005792-198109000-00004. [DOI] [PubMed] [Google Scholar]
  38. Brezina R., Rehácek J., Ac P., Majerská M. Two strains of rickettsiae of Rocky Mountain spotted fever group recovered from Dermacentor marginatus ticks in Czechoslovakia. Results of preliminary serological identification. Acta Virol. 1969 Mar;13(2):142–145. [PubMed] [Google Scholar]
  39. Brouqui P., Dupont H. T., Drancourt M., Bourgeade A., Raoult D. Spotless boutonneuse fever. Clin Infect Dis. 1992 Jan;14(1):114–116. doi: 10.1093/clinids/14.1.114. [DOI] [PubMed] [Google Scholar]
  40. Brouqui P., Harle J. R., Delmont J., Frances C., Weiller P. J., Raoult D. African tick-bite fever. An imported spotless rickettsiosis. Arch Intern Med. 1997 Jan 13;157(1):119–124. [PubMed] [Google Scholar]
  41. Brown A. E., Meek S. R., Maneechai N., Lewis G. E. Murine typhus among Khmers living at an evacuation site on the Thai-Kampuchean border. Am J Trop Med Hyg. 1988 Jan;38(1):168–171. doi: 10.4269/ajtmh.1988.38.168. [DOI] [PubMed] [Google Scholar]
  42. Burgdorfer W., Aeschlimann A., Peter O., Hayes S. F., Philip R. N. Ixodes ricinus: vector of a hitherto undescribed spotted fever group agent in Switzerland. Acta Trop. 1979 Dec;36(4):357–367. [PubMed] [Google Scholar]
  43. Burgdorfer W., Anacker R. L., Bird R. G., Bertram D. S. Intranuclear growth of Rickettsia rickettsii. J Bacteriol. 1968 Oct;96(4):1415–1418. doi: 10.1128/jb.96.4.1415-1418.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Burgdorfer W., Barbour A. G., Hayes S. F., Benach J. L., Grunwaldt E., Davis J. P. Lyme disease-a tick-borne spirochetosis? Science. 1982 Jun 18;216(4552):1317–1319. doi: 10.1126/science.7043737. [DOI] [PubMed] [Google Scholar]
  45. Burgdorfer W., Brinton L. P. Mechanisms of transovarial infection of spotted fever Rickettsiae in ticks. Ann N Y Acad Sci. 1975;266:61–72. doi: 10.1111/j.1749-6632.1975.tb35088.x. [DOI] [PubMed] [Google Scholar]
  46. Burgdorfer W. Hemolymph test. A technique for detection of rickettsiae in ticks. Am J Trop Med Hyg. 1970 Nov;19(6):1010–1014. [PubMed] [Google Scholar]
  47. Burgdorfer W., Ormsbee R. A., Hoogstraal H. Ticks as vectors of Rickettsia prowazeki--a controversial issue. Am J Trop Med Hyg. 1972 Nov;21(6):989–998. doi: 10.4269/ajtmh.1972.21.989. [DOI] [PubMed] [Google Scholar]
  48. Burgdorfer W., Ormsbee R. A., Schmidt M. L., Hoogstraal H. A search for the epidemic typhus agent in Ethiopian ticks. Bull World Health Organ. 1973 May;48(5):563–569. [PMC free article] [PubMed] [Google Scholar]
  49. Burgdorfer W., Sexton D. J., Gerloff R. K., Anacker R. L., Philip R. N., Thomas L. A. Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States. Infect Immun. 1975 Jul;12(1):205–210. doi: 10.1128/iai.12.1.205-210.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Burgdorfer W., Varma M. G. Trans-stadial and transovarial development of disease agents in arthropods. Annu Rev Entomol. 1967;12:347–376. doi: 10.1146/annurev.en.12.010167.002023. [DOI] [PubMed] [Google Scholar]
  51. Campbell R. W., Domrow R. Rickettsioses in Australia: isolation of Rickettsia tsutsugamushi and R. australis from naturally infected arthropods. Trans R Soc Trop Med Hyg. 1974;68(5):397–402. doi: 10.1016/0035-9203(74)90156-4. [DOI] [PubMed] [Google Scholar]
  52. Capponi M., Floch H., Chambon L., Camicas J. L., Carteron B., Giroud P. Amblyomma variegatum d'origine africaine ou antillaise et rickettsies du genre Dermacentroxenus. Bull Soc Pathol Exot Filiales. 1969 Nov-Dec;62(6):1011–1017. [PubMed] [Google Scholar]
  53. Chen D. Q., Campbell B. C., Purcell A. H. A new rickettsia from a herbivorous insect, the pea aphid Acyrthosiphon pisum (Harris). Curr Microbiol. 1996 Aug;33(2):123–128. doi: 10.1007/s002849900086. [DOI] [PubMed] [Google Scholar]
  54. Dalton M. J., Clarke M. J., Holman R. C., Krebs J. W., Fishbein D. B., Olson J. G., Childs J. E. National surveillance for Rocky Mountain spotted fever, 1981-1992: epidemiologic summary and evaluation of risk factors for fatal outcome. Am J Trop Med Hyg. 1995 May;52(5):405–413. doi: 10.4269/ajtmh.1995.52.405. [DOI] [PubMed] [Google Scholar]
  55. DiNubile M. J. Reliving a nightmare: a hard (and tragic) lesson in humility. Clin Infect Dis. 1996 Jul;23(1):160–165. doi: 10.1093/clinids/23.1.160. [DOI] [PubMed] [Google Scholar]
  56. Dobson M. E., Azad A. F., Dasch G. A., Webb L., Olson J. G. Detection of murine typhus infected fleas with an enzyme-linked immunosorbent assay. Am J Trop Med Hyg. 1989 May;40(5):521–528. doi: 10.4269/ajtmh.1989.40.521. [DOI] [PubMed] [Google Scholar]
  57. Drancourt M., Beati L., Tarasevich I., Raoult D. Astrakhan fever rickettsia is identical to Israel tick typhus rickettsia, a genotype of the Rickettsia conorii complex. J Infect Dis. 1992 Jun;165(6):1167–1168. doi: 10.1093/infdis/165.6.1167. [DOI] [PubMed] [Google Scholar]
  58. Drancourt M., Brouqui P., Chiche G., Raoult D. Acute pericarditis in Mediterranean spotted fever. Trans R Soc Trop Med Hyg. 1991 Nov-Dec;85(6):799–799. doi: 10.1016/0035-9203(91)90461-7. [DOI] [PubMed] [Google Scholar]
  59. Drancourt M., Kelly P. J., Regnery R., Raoult D. Identification of spotted fever group rickettsiae using polymerase chain reaction and restriction-endonuclease length polymorphism analysis. Acta Virol. 1992 Jan;36(1):1–6. [PubMed] [Google Scholar]
  60. Dumler J. S., Brouqui P., Aronson J., Taylor J. P., Walker D. H. Identification of Ehrlichia in human tissue. N Engl J Med. 1991 Oct 10;325(15):1109–1110. doi: 10.1056/NEJM199110103251517. [DOI] [PubMed] [Google Scholar]
  61. Dumler J. S., Gage W. R., Pettis G. L., Azad A. F., Kuhadja F. P. Rapid immunoperoxidase demonstration of Rickettsia rickettsii in fixed cutaneous specimens from patients with Rocky Mountain spotted fever. Am J Clin Pathol. 1990 Mar;93(3):410–414. doi: 10.1093/ajcp/93.3.410. [DOI] [PubMed] [Google Scholar]
  62. Dumler J. S., Taylor J. P., Walker D. H. Clinical and laboratory features of murine typhus in south Texas, 1980 through 1987. JAMA. 1991 Sep 11;266(10):1365–1370. [PubMed] [Google Scholar]
  63. Dupont H. T., Brouqui P., Faugere B., Raoult D. Prevalence of antibodies to Coxiella burnetti, Rickettsia conorii, and Rickettsia typhi in seven African countries. Clin Infect Dis. 1995 Nov;21(5):1126–1133. doi: 10.1093/clinids/21.5.1126. [DOI] [PubMed] [Google Scholar]
  64. Dupont H. T., Cornet J. P., Raoult D. Identification of rickettsiae from ticks collected in the Central African Republic using the polymerase chain reaction. Am J Trop Med Hyg. 1994 Mar;50(3):373–380. doi: 10.4269/ajtmh.1994.50.373. [DOI] [PubMed] [Google Scholar]
  65. Dwyer B. W., Graves S. R., McDonald M. I., Yung A. P., Doherty R. R., McDonald J. K. Spotted fever in East Gippsland, Victoria: a previously unrecognised focus of rickettsial infection. Med J Aust. 1991 Jan 21;154(2):121–125. doi: 10.5694/j.1326-5377.1991.tb120998.x. [DOI] [PubMed] [Google Scholar]
  66. Edlinger E., Navarro P. Les rickettsioses. Une morbidité du tourisme. Sem Hop. 1983 Jul 7;59(27-28):2053–2054. [PubMed] [Google Scholar]
  67. Elliott L. B., Fournier P. V., Teltow G. J. Rickettsia in Texas. Ann N Y Acad Sci. 1990;590:221–226. doi: 10.1111/j.1749-6632.1990.tb42223.x. [DOI] [PubMed] [Google Scholar]
  68. Eremeeva M. E., Balayeva N. M., Ignatovich V. F., Raoult D. Proteinic and genomic identification of spotted fever group rickettsiae isolated in the former USSR. J Clin Microbiol. 1993 Oct;31(10):2625–2633. doi: 10.1128/jcm.31.10.2625-2633.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Eremeeva M. E., Balayeva N. M., Ignatovich V. F., Raoult D. Serologic response to rickettsial antigens in patients with Astrakhan fever. Eur J Epidemiol. 1995 Aug;11(4):383–387. doi: 10.1007/BF01721221. [DOI] [PubMed] [Google Scholar]
  70. Eremeeva M. E., Balayeva N. M., Raoult D. Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting. Clin Diagn Lab Immunol. 1994 May;1(3):318–324. doi: 10.1128/cdli.1.3.318-324.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Eremeeva M. E., Beati L., Makarova V. A., Fetisova N. F., Tarasevich I. V., Balayeva N. M., Raoult D. Astrakhan fever rickettsiae: antigenic and genotypic analysis of isolates obtained from human and Rhipicephalus pumilio ticks. Am J Trop Med Hyg. 1994 Nov;51(5):697–706. doi: 10.4269/ajtmh.1994.51.697. [DOI] [PubMed] [Google Scholar]
  72. Eremeeva M. E., Roux V., Raoult D. Determination of genome size and restriction pattern polymorphism of Rickettsia prowazekii and Rickettsia typhi by pulsed field gel electrophoresis. FEMS Microbiol Lett. 1993 Aug 15;112(1):105–112. doi: 10.1111/j.1574-6968.1993.tb06431.x. [DOI] [PubMed] [Google Scholar]
  73. Eremeeva M., Balayeva N., Ignatovich V., Raoult D. Genomic study of Rickettsia akari by pulsed-field gel electrophoresis. J Clin Microbiol. 1995 Nov;33(11):3022–3024. doi: 10.1128/jcm.33.11.3022-3024.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Eremeeva M., Balayeva N., Roux V., Ignatovich V., Kotsinjan M., Raoult D. Genomic and proteinic characterization of strain S, a rickettsia isolated from Rhipicephalus sanguineus ticks in Armenia. J Clin Microbiol. 1995 Oct;33(10):2738–2744. doi: 10.1128/jcm.33.10.2738-2744.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Eremeeva M., Yu X., Raoult D. Differentiation among spotted fever group rickettsiae species by analysis of restriction fragment length polymorphism of PCR-amplified DNA. J Clin Microbiol. 1994 Mar;32(3):803–810. doi: 10.1128/jcm.32.3.803-810.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Espejo-Arenas E., Raoult D. First isolates of Rickettsia conorii in Spain using a centrifugation-shell vial assay. J Infect Dis. 1989 Jun;159(6):1158–1159. doi: 10.1093/infdis/159.6.1158. [DOI] [PubMed] [Google Scholar]
  77. Fan M. Y., Walker D. H., Yu S. R., Liu Q. H. Epidemiology and ecology of rickettsial diseases in the People's Republic of China. Rev Infect Dis. 1987 Jul-Aug;9(4):823–840. [PubMed] [Google Scholar]
  78. Fan M. Y., Walker D. H., Yu S. R., Liu Q. H. Epidemiology and ecology of rickettsial diseases in the People's Republic of China. Rev Infect Dis. 1987 Jul-Aug;9(4):823–840. [PubMed] [Google Scholar]
  79. Farhang-Azad A., Traub R., Baqar S. Transovarial transmission of murine typhus rickettsiae in Xenopsylla cheopis fleas. Science. 1985 Feb 1;227(4686):543–545. doi: 10.1126/science.3966162. [DOI] [PubMed] [Google Scholar]
  80. Font-Creus B., Bella-Cueto F., Espejo-Arenas E., Vidal-Sanahuja R., Muñoz-Espin T., Nolla-Salas M., Casagran-Borrell A., Mercade-Cuesta J., Segura-Porta F. Mediterranean spotted fever: a cooperative study of 227 cases. Rev Infect Dis. 1985 Sep-Oct;7(5):635–642. doi: 10.1093/clinids/7.5.635. [DOI] [PubMed] [Google Scholar]
  81. GIMENEZ D. F. STAINING RICKETTSIAE IN YOLK-SAC CULTURES. Stain Technol. 1964 May;39:135–140. doi: 10.3109/10520296409061219. [DOI] [PubMed] [Google Scholar]
  82. Gage K. L., Gilmore R. D., Karstens R. H., Schwan T. G. Detection of Rickettsia rickettsii in saliva, hemolymph and triturated tissues of infected Dermacentor andersoni ticks by polymerase chain reaction. Mol Cell Probes. 1992 Aug;6(4):333–341. doi: 10.1016/0890-8508(92)90010-u. [DOI] [PubMed] [Google Scholar]
  83. Gage K. L., Schrumpf M. E., Karstens R. H., Burgdorfer W., Schwan T. G. DNA typing of rickettsiae in naturally infected ticks using a polymerase chain reaction/restriction fragment length polymorphism system. Am J Trop Med Hyg. 1994 Feb;50(2):247–260. doi: 10.4269/ajtmh.1994.50.247. [DOI] [PubMed] [Google Scholar]
  84. George F., Brisson C., Poncelet P., Laurent J. C., Massot O., Arnoux D., Ambrosi P., Klein-Soyer C., Cazenave J. P., Sampol J. Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled to immuno-magnetic beads: demonstration of endothelial injury after angioplasty. Thromb Haemost. 1992 Jan 23;67(1):147–153. [PubMed] [Google Scholar]
  85. George F., Brouqui P., Boffa M. C., Mutin M., Drancourt M., Brisson C., Raoult D., Sampol J. Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. Blood. 1993 Oct 1;82(7):2109–2116. [PubMed] [Google Scholar]
  86. Gilmore R. D., Jr, Cieplak W., Jr, Policastro P. F., Hackstadt T. The 120 kilodalton outer membrane protein (rOmp B) of Rickettsia rickettsii is encoded by an unusually long open reading frame: evidence for protein processing from a large precursor. Mol Microbiol. 1991 Oct;5(10):2361–2370. doi: 10.1111/j.1365-2958.1991.tb02082.x. [DOI] [PubMed] [Google Scholar]
  87. Gilot B., Laforge M. L., Pichot J., Raoult D. Relationships between the Rhipicephalus sanguineus complex ecology and Mediterranean spotted fever epidemiology in France. Eur J Epidemiol. 1990 Dec;6(4):357–362. doi: 10.1007/BF00151708. [DOI] [PubMed] [Google Scholar]
  88. Goddard J., Norment B. R. Spotted fever group rickettsiae in the lone star tick, Amblyomma americanum (Acari: Ixodidae). J Med Entomol. 1986 Sep 19;23(5):465–472. doi: 10.1093/jmedent/23.5.465. [DOI] [PubMed] [Google Scholar]
  89. Goldwasser R. A., Steiman Y., Klingberg W., Swartz T. A., Klingberg M. A. The isolation of strains of rickettsiae of the spotted fever group in Israel and their differentiation from other members of the group by immunofluorescence methods. Scand J Infect Dis. 1974;6(1):53–62. doi: 10.3109/inf.1974.6.issue-1.10. [DOI] [PubMed] [Google Scholar]
  90. Greenberg M., Pellitteri O. J., Jellison W. L. Rickettsialpox-A Newly Recognized Rickettsial Disease : III. Epidemiology. Am J Public Health Nations Health. 1947 Jul;37(7):860–868. [PMC free article] [PubMed] [Google Scholar]
  91. Gross E. M., Yagupsky P. Israeli rickettsial spotted fever in children. A review of 54 cases. Acta Trop. 1987 Mar;44(1):91–96. [PubMed] [Google Scholar]
  92. Gross L. How Charles Nicolle of the Pasteur Institute discovered that epidemic typhus is transmitted by lice: reminiscences from my years at the Pasteur Institute in Paris. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10539–10540. doi: 10.1073/pnas.93.20.10539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. HARRELL G. T. Rocky Mountain spotted fever. Medicine (Baltimore) 1949 Dec;28(4):333–370. doi: 10.1097/00005792-194912000-00001. [DOI] [PubMed] [Google Scholar]
  94. Hackstadt T. The biology of rickettsiae. Infect Agents Dis. 1996 Jun;5(3):127–143. [PubMed] [Google Scholar]
  95. Halle S., Dasch G. A., Weiss E. Sensitive enzyme-linked immunosorbent assay for detection of antibodies against typhus rickettsiae, Rickettsia prowazekii and Rickettsia typhi. J Clin Microbiol. 1977 Aug;6(2):101–110. doi: 10.1128/jcm.6.2.101-110.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Hamilton J. G. The role of pheromones in tick biology. Parasitol Today. 1992 Apr;8(4):130–133. doi: 10.1016/0169-4758(92)90284-9. [DOI] [PubMed] [Google Scholar]
  97. Hattwick M. A., O'Brien R. J., Hanson B. F. Rocky Mountain spotted fever: epidemiology of an increasing problem. Ann Intern Med. 1976 Jun;84(6):732–739. doi: 10.7326/0003-4819-84-6-732. [DOI] [PubMed] [Google Scholar]
  98. Hayes S. F., Burgdorfer W., Aeschlimann A. Sexual transmission of spotted fever group rickettsiae by infected male ticks: detection of rickettsiae in immature spermatozoa of Ixodes ricinus. Infect Immun. 1980 Feb;27(2):638–642. doi: 10.1128/iai.27.2.638-642.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  99. Hechemy K. E., Fox J. A., Gröschel D. H., Hayden F. G., Wenzel R. P. Immunoblot studies to analyze antibody to the Rickettsia typhi group antigen in sera from patients with acute febrile cerebrovasculitis. J Clin Microbiol. 1991 Nov;29(11):2559–2565. doi: 10.1128/jcm.29.11.2559-2565.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Hechemy K. E., Osterman J. V., Eisemann C. S., Elliott L. B., Sasowski S. J. Detection of typhus antibodies by latex agglutination. J Clin Microbiol. 1981 Jan;13(1):214–216. doi: 10.1128/jcm.13.1.214-216.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Hechemy K. E., Raoult D., Eisemann C., Han Y. S., Fox J. A. Detection of antibodies to Rickettsia conorii with a latex agglutination test in patients with Mediterranean spotted fever. J Infect Dis. 1986 Jan;153(1):132–135. doi: 10.1093/infdis/153.1.132. [DOI] [PubMed] [Google Scholar]
  102. Hechemy K. E., Raoult D., Fox J., Han Y., Elliott L. B., Rawlings J. Cross-reaction of immune sera from patients with rickettsial diseases. J Med Microbiol. 1989 Jul;29(3):199–202. doi: 10.1099/00222615-29-3-199. [DOI] [PubMed] [Google Scholar]
  103. Heinzen R. A., Hayes S. F., Peacock M. G., Hackstadt T. Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells. Infect Immun. 1993 May;61(5):1926–1935. doi: 10.1128/iai.61.5.1926-1935.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Higgins J. A., Azad A. F. Use of polymerase chain reaction to detect bacteria in arthropods: a review. J Med Entomol. 1995 May;32(3):213–222. doi: 10.1093/jmedent/32.3.213. [DOI] [PubMed] [Google Scholar]
  105. Higgins J. A., Radulovic S., Schriefer M. E., Azad A. F. Rickettsia felis: a new species of pathogenic rickettsia isolated from cat fleas. J Clin Microbiol. 1996 Mar;34(3):671–674. doi: 10.1128/jcm.34.3.671-674.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Hoogstraal H. Argasid and nuttalliellid ticks as parasites and vectors. Adv Parasitol. 1985;24:135–238. doi: 10.1016/s0065-308x(08)60563-1. [DOI] [PubMed] [Google Scholar]
  107. Hughes C. Rocky Mountain "spotless" fever with an erythema migrans-like skin lesion. Clin Infect Dis. 1995 Nov;21(5):1328–1329. doi: 10.1093/clinids/21.5.1328. [DOI] [PubMed] [Google Scholar]
  108. Hughes L. E., Clifford C. M., Gresbrink R., Thomas L. A., Keirans J. E. Isolation of a spotted fever group rickettsia from the Pacific Coast tick, Ixodes pacificus, in Oregon. Am J Trop Med Hyg. 1976 May;25(3):513–516. doi: 10.4269/ajtmh.1976.25.513. [DOI] [PubMed] [Google Scholar]
  109. Huys J., Kayhigi J., Freyens P., Berghe G. V. Single-dose treatment of epidemic typhus with doxycyline. Chemotherapy. 1973;18(5):314–317. doi: 10.1159/000221276. [DOI] [PubMed] [Google Scholar]
  110. Ignatovich V. F. Antigenic relations of Rickettsia prowazekii and Rickettsia canada, established in the study of sera of patients with Brill's disease. J Hyg Epidemiol Microbiol Immunol. 1977;21(1):55–60. [PubMed] [Google Scholar]
  111. JACKSON E. B., DANAUSKAS J. X., COALE M. C., SMADEL J. E. Recovery of Rickettsia akari from the Korean vole Microtus fortis pelliceus. Am J Hyg. 1957 Nov;66(3):301–308. doi: 10.1093/oxfordjournals.aje.a119903. [DOI] [PubMed] [Google Scholar]
  112. Kass E. M., Szaniawski W. K., Levy H., Leach J., Srinivasan K., Rives C. Rickettsialpox in a New York City hospital, 1980 to 1989. N Engl J Med. 1994 Dec 15;331(24):1612–1617. doi: 10.1056/NEJM199412153312403. [DOI] [PubMed] [Google Scholar]
  113. Katayama T., Furuya Y., Yoshida Y., Kaiho I. [Spotted fever group rickettsiosis and vectors in Kanagawa prefecture]. Kansenshogaku Zasshi. 1996 Jun;70(6):561–568. doi: 10.11150/kansenshogakuzasshi1970.70.561. [DOI] [PubMed] [Google Scholar]
  114. Kelly P. J., Beati L., Mason P. R., Matthewman L. A., Roux V., Raoult D. Rickettsia africae sp. nov., the etiological agent of African tick bite fever. Int J Syst Bacteriol. 1996 Apr;46(2):611–614. doi: 10.1099/00207713-46-2-611. [DOI] [PubMed] [Google Scholar]
  115. Kelly P. J., Beati L., Matthewman L. A., Mason P. R., Dasch G. A., Raoult D. A new pathogenic spotted fever group rickettsia from Africa. J Trop Med Hyg. 1994 Jun;97(3):129–137. [PubMed] [Google Scholar]
  116. Kelly P. J., Mason P. R., Matthewman L. A., Raoult D. Seroepidemiology of spotted fever group rickettsial infections in humans in Zimbabwe. J Trop Med Hyg. 1991 Oct;94(5):304–309. [PubMed] [Google Scholar]
  117. Kelly P. J., Mason P. R. Serological typing of spotted fever group Rickettsia isolates from Zimbabwe. J Clin Microbiol. 1990 Oct;28(10):2302–2304. doi: 10.1128/jcm.28.10.2302-2304.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  118. Kelly P. J., Raoult D., Mason P. R. Isolation of spotted fever group rickettsias from triturated ticks using a modification of the centrifugation-shell vial technique. Trans R Soc Trop Med Hyg. 1991 May-Jun;85(3):397–398. doi: 10.1016/0035-9203(91)90303-g. [DOI] [PubMed] [Google Scholar]
  119. Kelly P., Matthewman L., Beati L., Raoult D., Mason P., Dreary M., Makombe R. African tick-bite fever: a new spotted fever group rickettsiosis under an old name. Lancet. 1992 Oct 17;340(8825):982–983. doi: 10.1016/0140-6736(92)92878-j. [DOI] [PubMed] [Google Scholar]
  120. Kirkland K. B., Wilkinson W. E., Sexton D. J. Therapeutic delay and mortality in cases of Rocky Mountain spotted fever. Clin Infect Dis. 1995 May;20(5):1118–1121. doi: 10.1093/clinids/20.5.1118. [DOI] [PubMed] [Google Scholar]
  121. La Scola B., Raoult D. Diagnosis of Mediterranean spotted fever by cultivation of Rickettsia conorii from blood and skin samples using the centrifugation-shell vial technique and by detection of R. conorii in circulating endothelial cells: a 6-year follow-up. J Clin Microbiol. 1996 Nov;34(11):2722–2727. doi: 10.1128/jcm.34.11.2722-2727.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Lambert M., Dugernier T., Bigaignon G., Rahier J., Piot P. Mediterranean spotted fever in Belgium. Lancet. 1984 Nov 3;2(8410):1038–1038. doi: 10.1016/s0140-6736(84)91133-4. [DOI] [PubMed] [Google Scholar]
  123. Landau Z., Feld S., Kunichezky S., Grinspan M., Gorbacz M. Thrombosis of the mesenteric vein as a complication of Mediterranean spotted fever. Clin Infect Dis. 1992 Dec;15(6):1070–1071. doi: 10.1093/clind/15.6.1070. [DOI] [PubMed] [Google Scholar]
  124. Lange J. V., Walker D. H., Wester T. B. Documented Rocky Mountain spotted fever in Wintertime. JAMA. 1982 May 7;247(17):2403–2404. [PubMed] [Google Scholar]
  125. Le Gac P. Sclérose en plaques et zoonoses. Importance du rôle du virus de l'avortement des bovins (pararickettsie X 14) dans l'étiopathogénie de la sclérose en plaques. C R Acad Sci Hebd Seances Acad Sci D. 1972 Jul 3;275(1):147–148. [PubMed] [Google Scholar]
  126. Linnemann C. C., Jr, Pretzman C. I., Peterson E. D. Acute febrile cerebrovasculitis. A non-spotted fever group rickettsial disease. Arch Intern Med. 1989 Jul;149(7):1682–1684. doi: 10.1001/archinte.149.7.1682. [DOI] [PubMed] [Google Scholar]
  127. Linnemann C. C., Jr, Schaeffer A. E., Burgdorfer W., Hutchinson L., Philip R. N. Rocky Mountain spotted fever in Clermont County, Ohio. II. Distribution of population and infected ticks in an endemic area. Am J Epidemiol. 1980 Jan;111(1):31–36. doi: 10.1093/oxfordjournals.aje.a112872. [DOI] [PubMed] [Google Scholar]
  128. Maeda K., Markowitz N., Hawley R. C., Ristic M., Cox D., McDade J. E. Human infection with Ehrlichia canis, a leukocytic rickettsia. N Engl J Med. 1987 Apr 2;316(14):853–856. doi: 10.1056/NEJM198704023161406. [DOI] [PubMed] [Google Scholar]
  129. Magnarelli L. A., Anderson J. F., Philip R. N., Burgdorfer W., Chappell W. A. Rickettsiae-infected ticks (acari: Ixodidae) and seropositive mammals at a focus for Rocky Mountain spotted fever in Connecticut, USA. J Med Entomol. 1983 Mar 30;20(2):151–156. doi: 10.1093/jmedent/20.2.151. [DOI] [PubMed] [Google Scholar]
  130. Mahara F., Koga K., Sawada S., Taniguchi T., Shigemi F., Suto T., Tsuboi Y., Ooya A., Koyama H., Uchiyama T. [The first report of the rickettsial infections of spotted fever group in Japan: three clinical cases]. Kansenshogaku Zasshi. 1985 Nov;59(11):1165–1171. doi: 10.11150/kansenshogakuzasshi1970.59.1165. [DOI] [PubMed] [Google Scholar]
  131. Manor E., Ighbarieh J., Sarov B., Kassis I., Regnery R. Human and tick spotted fever group Rickettsia isolates from Israel: a genotypic analysis. J Clin Microbiol. 1992 Oct;30(10):2653–2656. doi: 10.1128/jcm.30.10.2653-2656.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Mansueto S., Tringali G., Walker D. H. Widespread, simultaneous increase in the incidence of spotted fever group rickettsioses. J Infect Dis. 1986 Sep;154(3):539–540. doi: 10.1093/infdis/154.3.539-a. [DOI] [PubMed] [Google Scholar]
  133. Marrero M., Raoult D. Centrifugation-shell vial technique for rapid detection of Mediterranean spotted fever rickettsia in blood culture. Am J Trop Med Hyg. 1989 Feb;40(2):197–199. doi: 10.4269/ajtmh.1989.40.197. [DOI] [PubMed] [Google Scholar]
  134. Marrie T. J., Raoult D. Rickettsial infections of the central nervous system. Semin Neurol. 1992 Sep;12(3):213–224. doi: 10.1055/s-2008-1041178. [DOI] [PubMed] [Google Scholar]
  135. McDade J. E., Black C. M., Roumillat L. F., Redus M. A., Spruill C. L. Addition of monoclonal antibodies specific for Rickettsia akari to the rickettsial diagnostic panel. J Clin Microbiol. 1988 Oct;26(10):2221–2223. doi: 10.1128/jcm.26.10.2221-2223.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. McDade J. E., Brenner D. J., Bozeman F. M. Legionnaires' disease bacterium isolated in 1947. Ann Intern Med. 1979 Apr;90(4):659–661. doi: 10.7326/0003-4819-90-4-659. [DOI] [PubMed] [Google Scholar]
  137. McDade J. E. Evidence supporting the hypothesis that rickettsial virulence factors determine the severity of spotted fever and typhus group infections. Ann N Y Acad Sci. 1990;590:20–26. doi: 10.1111/j.1749-6632.1990.tb42202.x. [DOI] [PubMed] [Google Scholar]
  138. McDade J. E., Newhouse V. F. Natural history of Rickettsia rickettsii. Annu Rev Microbiol. 1986;40:287–309. doi: 10.1146/annurev.mi.40.100186.001443. [DOI] [PubMed] [Google Scholar]
  139. McDade J. E., Shepard C. C., Fraser D. W., Tsai T. R., Redus M. A., Dowdle W. R. Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med. 1977 Dec 1;297(22):1197–1203. doi: 10.1056/NEJM197712012972202. [DOI] [PubMed] [Google Scholar]
  140. McDade J. E., Shepard C. C., Redus M. A., Newhouse V. F., Smith J. D. Evidence of Rickettsia prowazekii infections in the United States. Am J Trop Med Hyg. 1980 Mar;29(2):277–284. doi: 10.4269/ajtmh.1980.29.277. [DOI] [PubMed] [Google Scholar]
  141. McKiel J. A., Bell E. J., Lackman D. B. Rickettsia canada: a new member of the typhus group of rickettsiae isolated from Haemaphysalis leporispalustris ticks in Canada. Can J Microbiol. 1967 May;13(5):503–510. doi: 10.1139/m67-065. [DOI] [PubMed] [Google Scholar]
  142. Montenegro M. R., Mansueto S., Hegarty B. C., Walker D. H. The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. Virchows Arch A Pathol Anat Histopathol. 1983;400(3):309–317. doi: 10.1007/BF00612192. [DOI] [PubMed] [Google Scholar]
  143. Niebylski M. L., Schrumpf M. E., Burgdorfer W., Fischer E. R., Gage K. L., Schwan T. G. Rickettsia peacockii sp. nov., a new species infecting wood ticks, Dermacentor andersoni, in western Montana. Int J Syst Bacteriol. 1997 Apr;47(2):446–452. doi: 10.1099/00207713-47-2-446. [DOI] [PubMed] [Google Scholar]
  144. Nilsson K., Jaenson T. G., Uhnoo I., Lindquist O., Pettersson B., Uhlén M., Friman G., Påhlson C. Characterization of a spotted fever group Rickettsia from Ixodes ricinus ticks in Sweden. J Clin Microbiol. 1997 Jan;35(1):243–247. doi: 10.1128/jcm.35.1.243-247.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. OLMER D., OLMER J. Epidémie des rickettsioses sur le littoral Méditerranéen; la fièvre boutonneuse. Rev Pathol Gen Physiol Clin. 1956 Jan;56(674):80–92. [PubMed] [Google Scholar]
  146. Oster C. N., Burke D. S., Kenyon R. H., Ascher M. S., Harber P., Pedersen C. E., Jr Laboratory-acquired Rocky Mountain spotted fever. The hazard of aerosol transmission. N Engl J Med. 1977 Oct 20;297(16):859–863. doi: 10.1056/NEJM197710202971604. [DOI] [PubMed] [Google Scholar]
  147. PHILIP C. B. Some epidemiological considerations in Rocky Mountain spotted fever. Public Health Rep. 1959 Jul;74(7):595–600. [PMC free article] [PubMed] [Google Scholar]
  148. Pavis C., Barré N. Kinetics of male pheromone production by Amblyomma variegatum (Acari: Ixodidae). J Med Entomol. 1993 Nov;30(6):961–965. doi: 10.1093/jmedent/30.6.961. [DOI] [PubMed] [Google Scholar]
  149. Pedersen C. E., Jr, Walters V. D. Comparative electrophoresis of spotted fever group rickettsial proteins. Life Sci. 1978 Feb;22(7):583–587. doi: 10.1016/0024-3205(78)90337-5. [DOI] [PubMed] [Google Scholar]
  150. Perine P. L., Krause D. W., Awoke S., McDade J. E. Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus. Lancet. 1974 Sep 28;2(7883):742–744. doi: 10.1016/s0140-6736(74)90940-4. [DOI] [PubMed] [Google Scholar]
  151. Philip C. B., Hoogstraal H., Reiss-Gutfreund R., Clifford C. M. Evidence of rickettsial disease agents in ticks from Ethiopian cattle. Bull World Health Organ. 1966;35(2):127–131. [PMC free article] [PubMed] [Google Scholar]
  152. Philip R. N., Casper E. A., Burgdorfer W., Gerloff R. K., Hughes L. E., Bell E. J. Serologic typing of rickettsiae of the spotted fever group by microimmunofluorescence. J Immunol. 1978 Nov;121(5):1961–1968. [PubMed] [Google Scholar]
  153. Philip R. N., Casper E. A. Serotypes of spotted fever group rickettsiae isolated from Dermacentor andersoni (Stiles) ticks in western Montana. Am J Trop Med Hyg. 1981 Jan;30(1):230–238. doi: 10.4269/ajtmh.1981.30.230. [DOI] [PubMed] [Google Scholar]
  154. Pretzman C., Daugherty N., Poetter K., Ralph D. The distribution and dynamics of Rickettsia in the tick population of Ohio. Ann N Y Acad Sci. 1990;590:227–236. doi: 10.1111/j.1749-6632.1990.tb42224.x. [DOI] [PubMed] [Google Scholar]
  155. Public Health Weekly Reports for FEBRUARY 23, 1923. Public Health Rep. 1923 Feb 23;38(8):333–381. [PMC free article] [PubMed] [Google Scholar]
  156. Public Health Weekly Reports for MAY 30, 1947. Public Health Rep. 1947 May 30;62(22):777–823. [PMC free article] [PubMed] [Google Scholar]
  157. Public Health Weekly Reports for NOVEMBER 22, 1946. Public Health Rep. 1946 Nov 22;61(47):1677–1712. [PMC free article] [PubMed] [Google Scholar]
  158. Public Health Weekly Reports for NOVEMBER 8, 1946. Public Health Rep. 1946 Nov 8;61(45):1605–1640. [PMC free article] [PubMed] [Google Scholar]
  159. Péter O., Raoult D., Gilot B. Isolation by a sensitive centrifugation cell culture system of 52 strains of spotted fever group rickettsiae from ticks collected in France. J Clin Microbiol. 1990 Jul;28(7):1597–1599. doi: 10.1128/jcm.28.7.1597-1599.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  160. ROSE H. M. The clinical manifestations and laboratory diagnosis of rickettsialpox. Ann Intern Med. 1949 Nov;31(5):871-83, illust. doi: 10.7326/0003-4819-31-5-871. [DOI] [PubMed] [Google Scholar]
  161. Radulovic S., Feng H. M., Morovic M., Djelalija B., Popov V., Crocquet-Valdes P., Walker D. H. Isolation of Rickettsia akari from a patient in a region where Mediterranean spotted fever is endemic. Clin Infect Dis. 1996 Feb;22(2):216–220. doi: 10.1093/clinids/22.2.216. [DOI] [PubMed] [Google Scholar]
  162. Radulovic S., Higgins J. A., Jaworski D. C., Dasch G. A., Azad A. F. Isolation, cultivation, and partial characterization of the ELB agent associated with cat fleas. Infect Immun. 1995 Dec;63(12):4826–4829. doi: 10.1128/iai.63.12.4826-4829.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  163. Radulovic S., Speed R., Feng H. M., Taylor C., Walker D. H. EIA with species-specific monoclonal antibodies: a novel seroepidemiologic tool for determination of the etiologic agent of spotted fever rickettsiosis. J Infect Dis. 1993 Nov;168(5):1292–1295. doi: 10.1093/infdis/168.5.1292. [DOI] [PubMed] [Google Scholar]
  164. Raoult D., Arzouni J. P., Jambon M. C., Beytout J., Ramousse O. Western blot as a seroepidemiologic tool for detecting foci of Mediterranean spotted fever (MSF). Eur J Epidemiol. 1994 Feb;10(1):37–40. doi: 10.1007/BF01717449. [DOI] [PubMed] [Google Scholar]
  165. Raoult D., Brouqui P., Roux V. A new spotted-fever-group rickettsiosis. Lancet. 1996 Aug 10;348(9024):412–412. doi: 10.1016/s0140-6736(05)65037-4. [DOI] [PubMed] [Google Scholar]
  166. Raoult D., Dasch G. A. Immunoblot cross-reactions among Rickettsia, Proteus spp. and Legionella spp. in patients with Mediterranean spotted fever. FEMS Immunol Med Microbiol. 1995 Mar;11(1):13–18. doi: 10.1111/j.1574-695X.1995.tb00073.x. [DOI] [PubMed] [Google Scholar]
  167. Raoult D., Dasch G. A. Line blot and western blot immunoassays for diagnosis of Mediterranean spotted fever. J Clin Microbiol. 1989 Sep;27(9):2073–2079. doi: 10.1128/jcm.27.9.2073-2079.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  168. Raoult D., Dupont H. T., Chicheportiche C., Peter O., Gilot B., Drancourt M. Mediterranean spotted fever in Marseille, France: correlation between prevalence of hospitalized patients, seroepidemiology, and prevalence of infected ticks in three different areas. Am J Trop Med Hyg. 1993 Feb;48(2):249–256. doi: 10.4269/ajtmh.1993.48.249. [DOI] [PubMed] [Google Scholar]
  169. Raoult D., Roux V., Ndihokubwayo J. B., Bise G., Baudon D., Marte G., Birtles R. Jail fever (epidemic typhus) outbreak in Burundi. Emerg Infect Dis. 1997 Jul-Sep;3(3):357–360. doi: 10.3201/eid0303.970313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Raoult D., Tissot Dupont H., Caraco P., Brouqui P., Drancourt M., Charrel C. Mediterranean spotted fever in Marseille: descriptive epidemiology and the influence of climatic factors. Eur J Epidemiol. 1992 Mar;8(2):192–197. doi: 10.1007/BF00144799. [DOI] [PubMed] [Google Scholar]
  171. Raoult D., Weiller P. J., Chagnon A., Chaudet H., Gallais H., Casanova P. Mediterranean spotted fever: clinical, laboratory and epidemiological features of 199 cases. Am J Trop Med Hyg. 1986 Jul;35(4):845–850. doi: 10.4269/ajtmh.1986.35.845. [DOI] [PubMed] [Google Scholar]
  172. Raoult D., Zuchelli P., Weiller P. J., Charrel C., San Marco J. L., Gallais H., Casanova P. Incidence, clinical observations and risk factors in the severe form of Mediterranean spotted fever among patients admitted to hospital in Marseilles 1983-1984. J Infect. 1986 Mar;12(2):111–116. doi: 10.1016/s0163-4453(86)93508-5. [DOI] [PubMed] [Google Scholar]
  173. Regnery R. L., Fu Z. Y., Spruill C. L. Flying squirrel-associated Rickettsia prowazekii (epidemic typhus rickettsiae) characterized by a specific DNA fragment produced by restriction endonuclease digestion. J Clin Microbiol. 1986 Jan;23(1):189–191. doi: 10.1128/jcm.23.1.189-191.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  174. Regnery R. L., Spruill C. L., Plikaytis B. D. Genotypic identification of rickettsiae and estimation of intraspecies sequence divergence for portions of two rickettsial genes. J Bacteriol. 1991 Mar;173(5):1576–1589. doi: 10.1128/jb.173.5.1576-1589.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  175. Regnery R., Martin M., Olson J. Naturally occurring "Rochalimaea henselae" infection in domestic cat. Lancet. 1992 Aug 29;340(8818):557–558. doi: 10.1016/0140-6736(92)91760-6. [DOI] [PubMed] [Google Scholar]
  176. Reiss-Gutfreund R. J. The isolation of Rickettsia prowazeki and mooseri from unusual sources. Am J Trop Med Hyg. 1966 Nov;15(6):943–949. doi: 10.4269/ajtmh.1966.15.943. [DOI] [PubMed] [Google Scholar]
  177. Robertson R. G., Wiseman C. L., Jr, Traub R. Tick-borne rickttsiae of the spotted fever group in West Pakistan. I. Isolation of strains from ticks in different habitats. Am J Epidemiol. 1970 Dec;92(6):382–394. doi: 10.1093/oxfordjournals.aje.a121221. [DOI] [PubMed] [Google Scholar]
  178. Robertson R. G., Wisseman C. L., Jr Tick-borne rickettsiae of the spotted fever group in West Pakistan. II. Serological classification of isolates from West Pakistan and Thailand: evidence for two new species. Am J Epidemiol. 1973 Jan;97(1):55–64. doi: 10.1093/oxfordjournals.aje.a121485. [DOI] [PubMed] [Google Scholar]
  179. Romero A., Zeissig O., España D., Rizzo L. Tifus exantemático en Guatemala. Bol Oficina Sanit Panam. 1977 Sep;83(3):223–236. [PubMed] [Google Scholar]
  180. Roux V., Drancourt M., Raoult D. Determination of genome sizes of Rickettsia spp. within the spotted fever group, using pulsed-field gel electrophoresis. J Bacteriol. 1992 Nov;174(22):7455–7457. doi: 10.1128/jb.174.22.7455-7457.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  181. Roux V., Fournier P. E., Raoult D. Differentiation of spotted fever group rickettsiae by sequencing and analysis of restriction fragment length polymorphism of PCR-amplified DNA of the gene encoding the protein rOmpA. J Clin Microbiol. 1996 Sep;34(9):2058–2065. doi: 10.1128/jcm.34.9.2058-2065.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  182. Roux V., Raoult D. Genotypic identification and phylogenetic analysis of the spotted fever group rickettsiae by pulsed-field gel electrophoresis. J Bacteriol. 1993 Aug;175(15):4895–4904. doi: 10.1128/jb.175.15.4895-4904.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  183. Roux V., Raoult D. Phylogenetic analysis of the genus Rickettsia by 16S rDNA sequencing. Res Microbiol. 1995 Jun;146(5):385–396. doi: 10.1016/0923-2508(96)80284-1. [DOI] [PubMed] [Google Scholar]
  184. Roux V., Rydkina E., Eremeeva M., Raoult D. Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae. Int J Syst Bacteriol. 1997 Apr;47(2):252–261. doi: 10.1099/00207713-47-2-252. [DOI] [PubMed] [Google Scholar]
  185. Ruiz-Beltrán R., Herrero-Herrero J. I., Martín-Sánchez A. M., Martín-González J. A. Prevalence of antibodies to Rickettsia conorii Coxiella burnetii and Rickettsia typhi in Salamanca Province (Spain). Serosurvey in the human population. Eur J Epidemiol. 1990 Sep;6(3):293–299. doi: 10.1007/BF00150435. [DOI] [PubMed] [Google Scholar]
  186. Ruiz R., Herrero J. I., Martin A. M., Sanz F., Mateos A., Hernandez A., Querol R., Portugal J. Vascular permeability in boutonneuse fever. J Infect Dis. 1984 Jun;149(6):1036–1036. doi: 10.1093/infdis/149.6.1036. [DOI] [PubMed] [Google Scholar]
  187. Russo P. K., Mendelson D. C., Etkind P. H., Garber M., Berardi V. P., Gilfillan R. F. Epidemic typhus (Rickettsia prowazekii) in Massachusetts: evidence of infection. N Engl J Med. 1981 May 7;304(19):1166–1168. doi: 10.1056/NEJM198105073041911. [DOI] [PubMed] [Google Scholar]
  188. Salgo M. P., Telzak E. E., Currie B., Perlman D. C., Litman N., Levi M., Nathenson G., Benach J. L., Al-Hafidh R., Casey J. A focus of Rocky Mountain spotted fever within New York City. N Engl J Med. 1988 May 26;318(21):1345–1348. doi: 10.1056/NEJM198805263182101. [DOI] [PubMed] [Google Scholar]
  189. Sarov B., Galil A., Sikuler E., Yagupsky P., Saah A., Gilad A., Naggan L., Sarov I. Prospective study on symptomatic versus asymptomatic infections and serological response to spotted fever group rickettsiae in two rural sites in the Negev (southern Israel). Ann N Y Acad Sci. 1990;590:243–245. doi: 10.1111/j.1749-6632.1990.tb42226.x. [DOI] [PubMed] [Google Scholar]
  190. Schriefer M. E., Sacci J. B., Jr, Dumler J. S., Bullen M. G., Azad A. F. Identification of a novel rickettsial infection in a patient diagnosed with murine typhus. J Clin Microbiol. 1994 Apr;32(4):949–954. doi: 10.1128/jcm.32.4.949-954.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  191. Sexton D. J., Banks J., Graves S., Hughes K., Dwyer B. Prevalence of antibodies to spotted fever group rickettsiae in dogs from southeastern Australia. Am J Trop Med Hyg. 1991 Aug;45(2):243–248. doi: 10.4269/ajtmh.1991.45.243. [DOI] [PubMed] [Google Scholar]
  192. Sexton D. J., Corey G. R. Rocky Mountain "spotless" and "almost spotless" fever: a wolf in sheep's clothing. Clin Infect Dis. 1992 Sep;15(3):439–448. doi: 10.1093/clind/15.3.439. [DOI] [PubMed] [Google Scholar]
  193. Sexton D. J., Dwyer B., Kemp R., Graves S. Spotted fever group rickettsial infections in Australia. Rev Infect Dis. 1991 Sep-Oct;13(5):876–886. doi: 10.1093/clinids/13.5.876. [DOI] [PubMed] [Google Scholar]
  194. Sexton D. J., King G., Dwyer B. Fatal Queensland tick typhus. J Infect Dis. 1990 Sep;162(3):779–780. doi: 10.1093/infdis/162.3.779. [DOI] [PubMed] [Google Scholar]
  195. Silpapojakul K., Pradutkanchana J., Pradutkanchana S., Kelly D. J. Rapid, simple serodiagnosis of murine typhus. Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):625–628. doi: 10.1016/0035-9203(95)90417-4. [DOI] [PubMed] [Google Scholar]
  196. Sirisanthana T., Pinyopornpanit V., Sirisanthana V., Strickman D., Kelly D. J., Dasch G. A. First cases of spotted fever group rickettsiosis in Thailand. Am J Trop Med Hyg. 1994 Jun;50(6):682–686. doi: 10.4269/ajtmh.1994.50.682. [DOI] [PubMed] [Google Scholar]
  197. Sompolinsky D., Boldur I., Goldwasser R. A., Kahana H., Kazak R., Keysary A., Pik A. Serological cross-reactions between Rickettsia typhi, Proteus vulgaris OX19, and Legionella bozemanii in a series of febrile patients. Isr J Med Sci. 1986 Oct;22(10):745–752. [PubMed] [Google Scholar]
  198. Sonenshine D. E., Bozeman F. M., Williams M. S., Masiello S. A., Chadwick D. P., Stocks N. I., Lauer D. M., Elisberg B. L. Epizootiology of epidemic typhus (Rickettsia prowazekii) in flying squirrels. Am J Trop Med Hyg. 1978 Mar;27(2 Pt 1):339–349. doi: 10.4269/ajtmh.1978.27.339. [DOI] [PubMed] [Google Scholar]
  199. Stein A., Raoult D. A simple method for amplification of DNA from paraffin-embedded tissues. Nucleic Acids Res. 1992 Oct 11;20(19):5237–5238. doi: 10.1093/nar/20.19.5237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  200. Stewart R. S. Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 1. Clinical and epidemiological features. Med J Aust. 1991 Jan 21;154(2):94–99. doi: 10.5694/j.1326-5377.1991.tb120993.x. [DOI] [PubMed] [Google Scholar]
  201. TAYLOR R. M., KINGSTON J. R., RIZK F. A note on typhus in Egypt and the Sudan. Am J Trop Med Hyg. 1957 Sep;6(5):863–870. doi: 10.4269/ajtmh.1957.6.863. [DOI] [PubMed] [Google Scholar]
  202. Takada N., Fujita H., Yano Y., Tsuboi Y., Mahara F. First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. J Med Entomol. 1994 Mar;31(2):183–185. doi: 10.1093/jmedent/31.2.183. [DOI] [PubMed] [Google Scholar]
  203. Tamura A., Ohashi N., Urakami H., Miyamura S. Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov. Int J Syst Bacteriol. 1995 Jul;45(3):589–591. doi: 10.1099/00207713-45-3-589. [DOI] [PubMed] [Google Scholar]
  204. Tarasevich I. V., Makarova V. A., Fetisova N. F., Stepanov A. V., Miskarova E. D., Balayeva N., Raoult D. Astrakhan fever, a spotted-fever rickettsiosis. Lancet. 1991 Jan 19;337(8734):172–173. doi: 10.1016/0140-6736(91)90833-b. [DOI] [PubMed] [Google Scholar]
  205. Tarasevich I. V., Makarova V. A., Fetisova N. F., Stepanov A. V., Miskarova E. D., Raoult D. Studies of a "new" rickettsiosis "Astrakhan" spotted fever. Eur J Epidemiol. 1991 May;7(3):294–298. doi: 10.1007/BF00145681. [DOI] [PubMed] [Google Scholar]
  206. Taylor J. P., Betz T. G., Rawlings J. A. Epidemiology of murine typhus in Texas. 1980 through 1984. JAMA. 1986 Apr 25;255(16):2173–2176. [PubMed] [Google Scholar]
  207. Taylor J. P., Istre G. R., McChesney T. C. The epidemiology of Rocky Mountain spotted fever in Arkansas, Oklahoma, and Texas, 1981 through 1985. Am J Epidemiol. 1988 Jun;127(6):1295–1301. doi: 10.1093/oxfordjournals.aje.a114922. [DOI] [PubMed] [Google Scholar]
  208. Teysseire N., Boudier J. A., Raoult D. Rickettsia conorii entry into Vero cells. Infect Immun. 1995 Jan;63(1):366–374. doi: 10.1128/iai.63.1.366-374.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  209. Teysseire N., Chiche-Portiche C., Raoult D. Intracellular movements of Rickettsia conorii and R. typhi based on actin polymerization. Res Microbiol. 1992 Nov-Dec;143(9):821–829. doi: 10.1016/0923-2508(92)90069-z. [DOI] [PubMed] [Google Scholar]
  210. Traub R., Wisseman C. L. The ecology of murine typhus-a critical review. Trop Dis Bull. 1978 Apr;75(4):237–317. [PubMed] [Google Scholar]
  211. Tselentis Y., Babalis T. L., Chrysanthis D., Gikas A., Chaliotis G., Raoult D. Clinicoepidemiological study of murine typhus on the Greek island of Evia. Eur J Epidemiol. 1992 Mar;8(2):268–272. doi: 10.1007/BF00144812. [DOI] [PubMed] [Google Scholar]
  212. Uchida T. Rickettsia japonica, the etiologic agent of Oriental spotted fever. Microbiol Immunol. 1993;37(2):91–102. doi: 10.1111/j.1348-0421.1993.tb03185.x. [DOI] [PubMed] [Google Scholar]
  213. Uchida T., Tashiro F., Funato T., Kitamura Y. Immunofluorescence test with Rickettsia montana for serologic diagnosis of rickettsial infection of the spotted fever group in Shikoku, Japan. Microbiol Immunol. 1986;30(10):1061–1066. doi: 10.1111/j.1348-0421.1986.tb03035.x. [DOI] [PubMed] [Google Scholar]
  214. Uchida T., Yan Y., Kitaoka S. Detection of Rickettsia japonica in Haemaphysalis longicornis ticks by restriction fragment length polymorphism of PCR product. J Clin Microbiol. 1995 Apr;33(4):824–828. doi: 10.1128/jcm.33.4.824-828.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  215. Uchida T., Yu X. J., Uchiyama T., Walker D. H. Identification of a unique spotted fever group rickettsia from humans in Japan. J Infect Dis. 1989 Jun;159(6):1122–1126. doi: 10.1093/infdis/159.6.1122. [DOI] [PubMed] [Google Scholar]
  216. Walker D. H., Cain B. G., Olmstead P. M. Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. Am J Clin Pathol. 1978 Jun;69(6):619–623. doi: 10.1093/ajcp/69.6.619. [DOI] [PubMed] [Google Scholar]
  217. Walker D. H., Fishbein D. B. Epidemiology of rickettsial diseases. Eur J Epidemiol. 1991 May;7(3):237–245. doi: 10.1007/BF00145672. [DOI] [PubMed] [Google Scholar]
  218. Walker D. H., Gay R. M., Valdes-Dapena M. The occurrence of eschars in Rocky Mountain spotted fever. J Am Acad Dermatol. 1981 May;4(5):571–576. doi: 10.1016/s0190-9622(81)70059-8. [DOI] [PubMed] [Google Scholar]
  219. Walker D. H., Liu Q. H., Yu X. J., Li H., Taylor C., Feng H. M. Antigenic diversity of Rickettsia conorii. Am J Trop Med Hyg. 1992 Jul;47(1):78–86. doi: 10.4269/ajtmh.1992.47.78. [DOI] [PubMed] [Google Scholar]
  220. Walker D. H. Rocky Mountain spotted fever: a disease in need of microbiological concern. Clin Microbiol Rev. 1989 Jul;2(3):227–240. doi: 10.1128/cmr.2.3.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  221. Walker D. H. Rocky Mountain spotted fever: a seasonal alert. Clin Infect Dis. 1995 May;20(5):1111–1117. doi: 10.1093/clinids/20.5.1111. [DOI] [PubMed] [Google Scholar]
  222. Weisburg W. G., Dobson M. E., Samuel J. E., Dasch G. A., Mallavia L. P., Baca O., Mandelco L., Sechrest J. E., Weiss E., Woese C. R. Phylogenetic diversity of the Rickettsiae. J Bacteriol. 1989 Aug;171(8):4202–4206. doi: 10.1128/jb.171.8.4202-4206.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  223. Weiss E., Coolbaugh J. C., Williams J. C. Separation of viable Rickettsia typhi from yolk sac and L cell host components by renografin density gradient centrifugation. Appl Microbiol. 1975 Sep;30(3):456–463. doi: 10.1128/am.30.3.456-463.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  224. Wells G. M., Woodward T. E., Fiset P., Hornick R. B. Rocky mountain spotted fever caused by blood transfusion. JAMA. 1978 Jun 30;239(26):2763–2765. doi: 10.1001/jama.239.26.2763. [DOI] [PubMed] [Google Scholar]
  225. Wenzel R. P., Hayden F. G., Gröschel D. H., Salata R. A., Young W. S., Greenlee J. E., Newman S., Miller P. J., Hechemy K. E., Burgdorfer W. Acute febrile cerebrovasculitis: a syndrome of unknown, perhaps rickettsial, cause. Ann Intern Med. 1986 May;104(5):606–615. doi: 10.7326/0003-4819-104-5-606. [DOI] [PubMed] [Google Scholar]
  226. Werren J. H., Hurst G. D., Zhang W., Breeuwer J. A., Stouthamer R., Majerus M. E. Rickettsial relative associated with male killing in the ladybird beetle (Adalia bipunctata). J Bacteriol. 1994 Jan;176(2):388–394. doi: 10.1128/jb.176.2.388-394.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  227. Wilde H., Pornsilapatip J., Sokly T., Thee S. Murine and scrub typhus at Thai-Kampuchean border displaced persons camps. Trop Geogr Med. 1991 Oct;43(4):363–369. [PubMed] [Google Scholar]
  228. Williams S. G., Sacci J. B., Jr, Schriefer M. E., Andersen E. M., Fujioka K. K., Sorvillo F. J., Barr A. R., Azad A. F. Typhus and typhuslike rickettsiae associated with opossums and their fleas in Los Angeles County, California. J Clin Microbiol. 1992 Jul;30(7):1758–1762. doi: 10.1128/jcm.30.7.1758-1762.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  229. Williams W. J., Radulovic S., Dasch G. A., Lindstrom J., Kelly D. J., Oster C. N., Walker D. H. Identification of Rickettsia conorii infection by polymerase chain reaction in a soldier returning from Somalia. Clin Infect Dis. 1994 Jul;19(1):93–99. doi: 10.1093/clinids/19.1.93. [DOI] [PubMed] [Google Scholar]
  230. Wood D. O., Williamson L. R., Winkler H. H., Krause D. C. Nucleotide sequence of the Rickettsia prowazekii citrate synthase gene. J Bacteriol. 1987 Aug;169(8):3564–3572. doi: 10.1128/jb.169.8.3564-3572.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  231. Xu W., Beati L., Raoult D. Characterization of and application of monoclonal antibodies against Rickettsia africae, a newly recognized species of spotted fever group rickettsia. J Clin Microbiol. 1997 Jan;35(1):64–70. doi: 10.1128/jcm.35.1.64-70.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  232. Yagupsky P., Wolach B. Fatal Israeli spotted fever in children. Clin Infect Dis. 1993 Nov;17(5):850–853. doi: 10.1093/clinids/17.5.850. [DOI] [PubMed] [Google Scholar]
  233. Yan Y., Uchiyama T., Uchida T. Nucleotide sequence of polymerase chain reaction product amplified from Rickettsia japonica DNA using Rickettsia rickettsii 190-kilodalton surface antigen gene primers. Microbiol Immunol. 1994;38(11):865–869. doi: 10.1111/j.1348-0421.1994.tb02139.x. [DOI] [PubMed] [Google Scholar]
  234. Yu X., Jin Y., Fan M., Xu G., Liu Q., Raoult D. Genotypic and antigenic identification of two new strains of spotted fever group rickettsiae isolated from China. J Clin Microbiol. 1993 Jan;31(1):83–88. doi: 10.1128/jcm.31.1.83-88.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  235. Zhang J. Z., Fan M. Y., Bi D. Z., Cui W. F., Han Y. F. Genotypic identification of three new strains of spotted fever group rickettsiae isolated in China. Acta Virol. 1996 Sep;40(4):215–219. [PubMed] [Google Scholar]

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