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. 2001 Apr;85(4):e7. doi: 10.1136/heart.85.4.e7

Behçet's disease with a large intracardiac thrombus: a case report

M Baykan, S Celik, C Erdol, E Baykan, I Durmus, S Bahadir, H Erdol, C Orem, H Cakirbay
PMCID: PMC1729672  PMID: 11250984

Abstract

Behçet's disease is recognised as a chronic multisystem disorder with vasculitis as its underlying pathological process. Cardiac involvement is rare and often associated with poor prognosis. A case of a 33 year old man with Behçet's disease, presenting with a large right ventricle and right atrial thrombus, is reported. Two dimensional (cross sectional), colour Doppler, and transoesophageal echocardiography, angiography, computed tomography, and magnetic resonance imaging were used to diagnose the disease. With cyclophosphamide and dexamethasone treatment, the cardiac lesions progressively resolved.


Keywords: Behçet's disease; intracardiac thrombus

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Figure 1  .

Figure 1  

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Transthoracic echocardiography on apical four chamber. (A) Before treatment. (B) After treatment. LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle.

Figure 2  .

Figure 2  

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Transthoracic echocardiography on parasternal short axes. (A) Before treatment. (B) After treatment. AO, aorta.

Figure 3  .

Figure 3  

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Transoesophageal echocardiographic image of the patient. (A) Before treatment. (B, C) After treatment.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bletry O., Mohattane A., Wechsler B., Beaufils P., Valère P., Petit J., Gourgon R., Grosgogeat Y., Godeau P. Atteinte cardiaque de la maladie de Behçet. Douze observations. Presse Med. 1988 Dec 17;17(45):2388–2391. [PubMed] [Google Scholar]
  2. Candan I., Erol C., Sonel A., Akalin H. Behçet's disease: cardiac and pulmonary involvement. Eur Heart J. 1986 Nov;7(11):999–1002. doi: 10.1093/oxfordjournals.eurheartj.a062006. [DOI] [PubMed] [Google Scholar]
  3. Chajek T., Aronowski E., Izak G. Decreased fibrinolysis in Behçet's disease. Thromb Diath Haemorrh. 1973 Jun 28;29(3):610–618. [PubMed] [Google Scholar]
  4. Hamzaoui K., Ayed K., Hamza M., Touraine J. L. Natural killer cells in Behçet's disease. Clin Exp Immunol. 1988 Jan;71(1):126–131. [PMC free article] [PubMed] [Google Scholar]
  5. Hull R. G., Harris E. N., Gharavi A. E., Tincani A., Asherson R. A., Valesini G., Denman A. M., Froude G., Hughes G. R. Anticardiolipin antibodies: occurrence in Behçet's syndrome. Ann Rheum Dis. 1984 Oct;43(5):746–748. doi: 10.1136/ard.43.5.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Huong D. L., Wechsler B., Papo T., de Zuttere D., Bletry O., Hernigou A., Delcourt A., Godeau P., Piette J. C. Endomyocardial fibrosis in Behçet's disease. Ann Rheum Dis. 1997 Mar;56(3):205–208. doi: 10.1136/ard.56.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jordan J. M., Allen N. B., Pizzo S. V. Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis. Am J Med. 1987 Mar;82(3):397–400. doi: 10.1016/0002-9343(87)90436-0. [DOI] [PubMed] [Google Scholar]
  8. Jorizzo J. L., Abernethy J. L., White W. L., Mangelsdorf H. C., Zouboulis C. C., Sarica R., Gaffney K., Mat C., Yazici H., al Ialaan A. Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers. J Am Acad Dermatol. 1995 Jun;32(6):968–976. doi: 10.1016/0190-9622(95)91333-5. [DOI] [PubMed] [Google Scholar]
  9. Kawakami Y., Nakayama Y., Nagao H., Hirota Y., Kawamura K. [A case of Behçet's disease complicated with acute myocardial infarction]. Kokyu To Junkan. 1991 Sep;39(9):935–938. [PubMed] [Google Scholar]
  10. Koç Y., Güllü I., Akpek G., Akpolat T., Kansu E., Kiraz S., Batman F., Kansu T., Balkanci F., Akkaya S. Vascular involvement in Behçet's disease. J Rheumatol. 1992 Mar;19(3):402–410. [PubMed] [Google Scholar]
  11. Lie J. T. Vascular involvement in Behçet's disease: arterial and venous and vessels of all sizes. J Rheumatol. 1992 Mar;19(3):341–343. [PubMed] [Google Scholar]
  12. Mendes L. A., Magraw L. L., Aldea G. S., Davidoff R. Right ventricular thrombus: an unusual manifestation of Behçet's disease. J Am Soc Echocardiogr. 1994 Jul-Aug;7(4):438–440. doi: 10.1016/s0894-7317(14)80208-3. [DOI] [PubMed] [Google Scholar]
  13. Schmitz-Huebner U., Knop J. Evidence for an endothelial cell dysfunction in association with Behçet's disease. Thromb Res. 1984 May 15;34(4):277–285. doi: 10.1016/0049-3848(84)90384-0. [DOI] [PubMed] [Google Scholar]
  14. Suzuki N., Sakane T., Ueda Y., Tsunematsu T. Abnormal B cell function in patients with Behçet's disease. Arthritis Rheum. 1986 Feb;29(2):212–219. doi: 10.1002/art.1780290209. [DOI] [PubMed] [Google Scholar]
  15. Valesini G., Pivetti-Pezzi P., Mastrandrea F., Moncada A., Cuomo M., Natali P. G. Evaluation of T cell subsets in Behçet's syndrome using anti-T cell monoclonal antibodies. Clin Exp Immunol. 1985 Apr;60(1):55–60. [PMC free article] [PubMed] [Google Scholar]
  16. Victorino R. M., Ryan P., Hughes G. R., Hodgson H. J. Cell-mediated immune functions and immunoregulatory cells in Behçet's syndrome. Clin Exp Immunol. 1982 Apr;48(1):121–128. [PMC free article] [PubMed] [Google Scholar]
  17. el-Ramahi K. M., Fawzy M. E., Sieck J. O., Vanhaleweyk G. Cardiac and pulmonary involvement in Behçet's disease. Scand J Rheumatol. 1991;20(5):373–376. doi: 10.3109/03009749109096815. [DOI] [PubMed] [Google Scholar]

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