Change in heart rate (ANOVA p = 0.004). In this and figs 2-6, Insulin 40 and Insulin 100 refer to measurements taken during insulin infusions of 40 and 100 mU/m2/min, respectively, after (A) 30 minutes and (B) 60 minutes. ANOVA refers to analysis of variance for repeated measures that was used to compare the effect of insulin doses with placebo. Symbols refer to post hoc t tests comparing each dose of insulin infusion with placebo at each time point. *p < 0.05, **p < 0.01,***p < 0.005.