Abstract
OBJECTIVE—To examine a general practice population to measure the prevalence of signs and symptoms of heart failure (SSHF) and left ventricular systolic dysfunction (LVSD). DESIGN—Cross sectional screening study in three general practices followed by echocardiography. SETTING AND PATIENTS—All patients ⩾ 50 years in two general practices and ⩾ 40 years in one general practice were screened by case record reviews and questionnaires (n = 2158), to identify subjects with some evidence of heart disease. Among these, subjects were sought who had SSHF (n = 115). Of 357 subjects with evidence of heart disease, 252 were eligible for examination, and 126 underwent further cardiological assessment, including 43 with SSHF. MAIN OUTCOME MEASURES—Prevalence of SSHF as defined by a modified Boston index, LVSD defined as an indirectly measured left ventricular ejection fraction ⩽ 0.45, and numbers of subjects needing an echocardiogram to detect one case with LVSD. RESULTS—SSHF afflicted 0.5% of quadragenarians and rose to 11.7% of octogenarians. Two thirds were handled in primary care only. At ⩾ 50 years of age 6.4% had SSHF, 2.9% had LVSD, and 1.9% (95% confidence interval 1.3% to 2.5%) had both. To detect one case with LVSD in primary care, 14 patients with evidence of heart disease without SSHF and 5.5 patients with SSHF had to be examined. CONCLUSION—SSHF is extremely prevalent in the community, especially in primary care, but more than two thirds do not have LVSD. The number of subjects with some evidence of heart disease needing an echocardiogram to detect one case of LVSD is 14. Keywords: heart failure; left ventricular systolic dysfunction
Full Text
The Full Text of this article is available as a PDF (136.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berning J., Rokkedal Nielsen J., Launbjerg J., Fogh J., Mickley H., Andersen P. E. Rapid estimation of left ventricular ejection fraction in acute myocardial infarction by echocardiographic wall motion analysis. Cardiology. 1992;80(3-4):257–266. doi: 10.1159/000175011. [DOI] [PubMed] [Google Scholar]
- Carlson K. J., Lee D. C., Goroll A. H., Leahy M., Johnson R. A. An analysis of physicians' reasons for prescribing long-term digitalis therapy in outpatients. J Chronic Dis. 1985;38(9):733–739. doi: 10.1016/0021-9681(85)90115-8. [DOI] [PubMed] [Google Scholar]
- Cowie M. R., Mosterd A., Wood D. A., Deckers J. W., Poole-Wilson P. A., Sutton G. C., Grobbee D. E. The epidemiology of heart failure. Eur Heart J. 1997 Feb;18(2):208–225. doi: 10.1093/oxfordjournals.eurheartj.a015223. [DOI] [PubMed] [Google Scholar]
- Cowie M. R., Struthers A. D., Wood D. A., Coats A. J., Thompson S. G., Poole-Wilson P. A., Sutton G. C. Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet. 1997 Nov 8;350(9088):1349–1353. doi: 10.1016/S0140-6736(97)06031-5. [DOI] [PubMed] [Google Scholar]
- Cowie M. R., Wood D. A., Coats A. J., Thompson S. G., Poole-Wilson P. A., Suresh V., Sutton G. C. Incidence and aetiology of heart failure; a population-based study. Eur Heart J. 1999 Mar;20(6):421–428. doi: 10.1053/euhj.1998.1280. [DOI] [PubMed] [Google Scholar]
- Dahlström U., Boman K., Edvardsson N., Pehrsson K., Persson S. Hjärtsvikt--en svårställd diagnos. Kan poängsystem identifiera patienterna? Lakartidningen. 1995 Mar 29;92(13):1360–1363. [PubMed] [Google Scholar]
- Davie A. P., Francis C. M., Love M. P., Caruana L., Starkey I. R., Shaw T. R., Sutherland G. R., McMurray J. J. Value of the electrocardiogram in identifying heart failure due to left ventricular systolic dysfunction. BMJ. 1996 Jan 27;312(7025):222–222. doi: 10.1136/bmj.312.7025.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eriksson H., Svärdsudd K., Caidahl K., Bjurö T., Larsson B., Welin L., Ohlson L. O., Wilhelmsen L. Early heart failure in the population. The study of men born in 1913. Acta Med Scand. 1988;223(3):197–209. doi: 10.1111/j.0954-6820.1988.tb15788.x. [DOI] [PubMed] [Google Scholar]
- Francis C. M., Caruana L., Kearney P., Love M., Sutherland G. R., Starkey I. R., Shaw T. R., McMurray J. J. Open access echocardiography in management of heart failure in the community. BMJ. 1995 Mar 11;310(6980):634–636. doi: 10.1136/bmj.310.6980.634. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kannel W. B., Belanger A. J. Epidemiology of heart failure. Am Heart J. 1991 Mar;121(3 Pt 1):951–957. doi: 10.1016/0002-8703(91)90225-7. [DOI] [PubMed] [Google Scholar]
- Kupari M., Lindroos M., Iivanainen A. M., Heikkilä J., Tilvis R. Congestive heart failure in old age: prevalence, mechanisms and 4-year prognosis in the Helsinki Ageing Study. J Intern Med. 1997 May;241(5):387–394. doi: 10.1046/j.1365-2796.1997.129150000.x. [DOI] [PubMed] [Google Scholar]
- Køber L., Torp-Pedersen C., Carlsen J., Videbaek R., Egeblad H. An echocardiographic method for selecting high risk patients shortly after acute myocardial infarction, for inclusion in multi-centre studies (as used in the TRACE study). TRAndolapril Cardiac Evaluation. Eur Heart J. 1994 Dec;15(12):1616–1620. doi: 10.1093/oxfordjournals.eurheartj.a060443. [DOI] [PubMed] [Google Scholar]
- Levy D., Savage D. D., Garrison R. J., Anderson K. M., Kannel W. B., Castelli W. P. Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study. Am J Cardiol. 1987 Apr 15;59(9):956–960. doi: 10.1016/0002-9149(87)91133-7. [DOI] [PubMed] [Google Scholar]
- Madsen B. K., Hansen J. F., Stokholm K. H., Brøns J., Husum D., Mortensen L. S. Chronic congestive heart failure. Description and survival of 190 consecutive patients with a diagnosis of chronic congestive heart failure based on clinical signs and symptoms. Eur Heart J. 1994 Mar;15(3):303–310. doi: 10.1093/oxfordjournals.eurheartj.a060495. [DOI] [PubMed] [Google Scholar]
- Mair F. S., Crowley T. S., Bundred P. E. Prevalence, aetiology and management of heart failure in general practice. Br J Gen Pract. 1996 Feb;46(403):77–79. [PMC free article] [PubMed] [Google Scholar]
- McDonagh T. A., Morrison C. E., Lawrence A., Ford I., Tunstall-Pedoe H., McMurray J. J., Dargie H. J. Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population. Lancet. 1997 Sep 20;350(9081):829–833. doi: 10.1016/S0140-6736(97)03033-X. [DOI] [PubMed] [Google Scholar]
- McDonagh T. A., Robb S. D., Murdoch D. R., Morton J. J., Ford I., Morrison C. E., Tunstall-Pedoe H., McMurray J. J., Dargie H. J. Biochemical detection of left-ventricular systolic dysfunction. Lancet. 1998 Jan 3;351(9095):9–13. doi: 10.1016/s0140-6736(97)03034-1. [DOI] [PubMed] [Google Scholar]
- Morgan S., Smith H., Simpson I., Liddiard G. S., Raphael H., Pickering R. M., Mant D. Prevalence and clinical characteristics of left ventricular dysfunction among elderly patients in general practice setting: cross sectional survey. BMJ. 1999 Feb 6;318(7180):368–372. doi: 10.1136/bmj.318.7180.368. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mosterd A., Hoes A. W., de Bruyne M. C., Deckers J. W., Linker D. T., Hofman A., Grobbee D. E. Prevalence of heart failure and left ventricular dysfunction in the general population; The Rotterdam Study. Eur Heart J. 1999 Mar;20(6):447–455. [PubMed] [Google Scholar]
- Nielsen O. W., Hansen J. F., Hilden J., Larsen C. T., Svanegaard J. Risk assessment of left ventricular systolic dysfunction in primary care: cross sectional study evaluating a range of diagnostic tests. BMJ. 2000 Jan 22;320(7229):220–224. doi: 10.1136/bmj.320.7229.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parameshwar J., Shackell M. M., Richardson A., Poole-Wilson P. A., Sutton G. C. Prevalence of heart failure in three general practices in north west London. Br J Gen Pract. 1992 Jul;42(360):287–289. [PMC free article] [PubMed] [Google Scholar]
- Quinones M. A., Waggoner A. D., Reduto L. A., Nelson J. G., Young J. B., Winters W. L., Jr, Ribeiro L. G., Miller R. R. A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography. Circulation. 1981 Oct;64(4):744–753. doi: 10.1161/01.cir.64.4.744. [DOI] [PubMed] [Google Scholar]
- Remes J., Miettinen H., Reunanen A., Pyörälä K. Validity of clinical diagnosis of heart failure in primary health care. Eur Heart J. 1991 Mar;12(3):315–321. doi: 10.1093/oxfordjournals.eurheartj.a059896. [DOI] [PubMed] [Google Scholar]
- Rose G. A., Blackburn H. Cardiovascular survey methods. Monogr Ser World Health Organ. 1968;56:1–188. [PubMed] [Google Scholar]
- Sahn D. J., DeMaria A., Kisslo J., Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978 Dec;58(6):1072–1083. doi: 10.1161/01.cir.58.6.1072. [DOI] [PubMed] [Google Scholar]
- Schocken D. D., Arrieta M. I., Leaverton P. E., Ross E. A. Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol. 1992 Aug;20(2):301–306. doi: 10.1016/0735-1097(92)90094-4. [DOI] [PubMed] [Google Scholar]
- Troy B. L., Pombo J., Rackley C. E. Measurement of left ventricular wall thickness and mass by echocardiography. Circulation. 1972 Mar;45(3):602–611. doi: 10.1161/01.cir.45.3.602. [DOI] [PubMed] [Google Scholar]
- Vasan R. S., Larson M. G., Benjamin E. J., Evans J. C., Reiss C. K., Levy D. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol. 1999 Jun;33(7):1948–1955. doi: 10.1016/s0735-1097(99)00118-7. [DOI] [PubMed] [Google Scholar]
- Wheeldon N. M., MacDonald T. M., Flucker C. J., McKendrick A. D., McDevitt D. G., Struthers A. D. Echocardiography in chronic heart failure in the community. Q J Med. 1993 Jan;86(1):17–23. [PubMed] [Google Scholar]
- Willenheimer R. B., Israelsson B. A., Cline C. M., Erhardt L. R. Simplified echocardiography in the diagnosis of heart failure. Scand Cardiovasc J. 1997;31(1):9–16. doi: 10.3109/14017439709058063. [DOI] [PubMed] [Google Scholar]
- Yusuf S., Sleight P., Pogue J., Bosch J., Davies R., Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000 Jan 20;342(3):145–153. doi: 10.1056/NEJM200001203420301. [DOI] [PubMed] [Google Scholar]