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. 1995 Mar;63(3):1134–1137. doi: 10.1128/iai.63.3.1134-1137.1995

Cholera toxin and Salmonella typhimurium induce different cytokine profiles in the gastrointestinal tract.

G R Klimpel 1, M Asuncion 1, J Haithcoat 1, D W Niesel 1
PMCID: PMC173123  PMID: 7868239

Abstract

Salmonella infection of the gastrointestinal tract (GT) results in fluid secretion and inflammation. In contrast, cholera toxin (CT) induces fluid secretion but no inflammation. Using a murine ligated intestinal loop model, we investigated cytokine production (interleukin-1 [IL-1], IL-2, IL-4, IL-6, IL-10, gamma interferon, and tumor necrosis factor alpha) in the GT following exposure to these agents. Salmonella typhimurium induced a Th1-like cytokine profile in loops obtained from either nonimmune mice or Salmonella-immunized mice. CT induced only IL-6 and IL-10 production in ligated loops from nonimmune mice but induced a Th2-like cytokine profile in ligated loops obtained from CT-immunized mice. These results show that CT and S. typhimurium induce very different cytokine profiles in the GT.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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