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. 1995 Mar;63(3):1142–1144. doi: 10.1128/iai.63.3.1142-1144.1995

Nitric oxide production does not directly increase macrophage candidacidal activity.

A Vazquez-Torres 1, J Jones-Carson 1, E Balish 1
PMCID: PMC173125  PMID: 7868241

Abstract

Some activated murine macrophages produced nitrite but were unable to kill Candida albicans. Furthermore, a nitric oxide (NO) generator inhibited C. albicans growth but was not candidacidal. Our results suggest that NO is candidastatic and that No is not directly involved but is associated with or induces other macrophage candidacidal mechanisms.

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Selected References

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