Abstract
Aims—To determine whether the cause of death could be accurately predicted without the need for a necropsy, and thus to consider whether a "view and grant" system of issuing a cause of death could be introduced into England and Wales.
Method—A one year prospective necropsy study was performed incorporating 568 deaths. Before necropsy, in each case the cause of death was predicted from the available history without examination of the body, and this cause was then compared with the cause of death found at necropsy.
Results—The ability of the pathologist involved in the study to predict a cause of death before necropsy, either while in the mortuary or as a paper exercise, was shown to vary between 61% and 74% of cases. After the necropsy, the number of correct predicted causes of death ranged from 39% to 46%. Ischaemic heart disease was found to be the most common and most accurately predicted cause of death. Some natural diseases were frequently misdiagnosed, whereas certain types of unnatural disease were always identified correctly.
Conclusions—This study highlights the advantages and disadvantages of a view and grant system. Although it identifies a potential use of such a system, in some cases such as natural cardiac disease, because of the potentially high diagnostic error rate, the continuation of the present system of postmortem examination as part of the coroner's enquiry is recommended.
Key Words: necropsy • cause of death • coroner • view and grant
Full Text
The Full Text of this article is available as a PDF (144.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson R. E. The autopsy as an instrument of quality assessment. Classification of premortem and postmortem diagnostic discrepancies. Arch Pathol Lab Med. 1984 Jun;108(6):490–493. [PubMed] [Google Scholar]
- Asnaes S., Paaske F. The significance of medicolegal autopsy in determining mode and cause of death. Forensic Sci Int. 1979 Jul-Aug;14(1):23–40. doi: 10.1016/0379-0738(79)90152-x. [DOI] [PubMed] [Google Scholar]
- Asnaes S., Paaske F. Uncertainty of determining mode of death in medicolegal material without autopsy--a systematic autopsy study. Forensic Sci Int. 1980 Jan-Feb;15(1):3–17. doi: 10.1016/0379-0738(80)90190-5. [DOI] [PubMed] [Google Scholar]
- Asnaes S. Uncertainty of determining mode and cause of death without autopsy: an autopsy study of medically unattended non-medicolegal deaths. Forensic Sci Int. 1980 May-Jun;15(3):191–196. doi: 10.1016/0379-0738(80)90133-4. [DOI] [PubMed] [Google Scholar]
- BORRIS W. Die Bedeutung der Verwaltungssektion für die Morbititäts-und Mortalitätsstatistik. Z Arztl Fortbild (Jena) 1952 Aug 15;46(16):471–475. [PubMed] [Google Scholar]
- Battle R. M., Pathak D., Humble C. G., Key C. R., Vanatta P. R., Hill R. B., Anderson R. E. Factors influencing discrepancies between premortem and postmortem diagnoses. JAMA. 1987 Jul 17;258(3):339–344. [PubMed] [Google Scholar]
- Belzberg H., Rivkind A. I. It always pays to make a diagnosis: to autopsy or not to autopsy? Crit Care Med. 1998 Aug;26(8):1299–1300. doi: 10.1097/00003246-199808000-00002. [DOI] [PubMed] [Google Scholar]
- Blosser S. A., Zimmerman H. E., Stauffer J. L. Do autopsies of critically ill patients reveal important findings that were clinically undetected? Crit Care Med. 1998 Aug;26(8):1332–1336. doi: 10.1097/00003246-199808000-00015. [DOI] [PubMed] [Google Scholar]
- Britton M. Diagnostic errors discovered at autopsy. Acta Med Scand. 1974 Sep;196(3):203–210. doi: 10.1111/j.0954-6820.1974.tb00996.x. [DOI] [PubMed] [Google Scholar]
- Burrows S. The postmortem examination. Scientific necessity or folly? JAMA. 1975 Aug 4;233(5):441–443. [PubMed] [Google Scholar]
- Burton E. C., Troxclair D. A., Newman W. P., 3rd Autopsy diagnoses of malignant neoplasms: how often are clinical diagnoses incorrect? JAMA. 1998 Oct 14;280(14):1245–1248. doi: 10.1001/jama.280.14.1245. [DOI] [PubMed] [Google Scholar]
- Cameron H. M. Future of the hospital autopsy. Br J Hosp Med. 1988 Nov;40(5):335–335. [PubMed] [Google Scholar]
- Cameron H. M., McGoogan E. A prospective study of 1152 hospital autopsies: II. Analysis of inaccuracies in clinical diagnoses and their significance. J Pathol. 1981 Apr;133(4):285–300. doi: 10.1002/path.1711330403. [DOI] [PubMed] [Google Scholar]
- Cameron H. M., McGoogan E., Watson H. Necropsy: a yardstick for clinical diagnoses. Br Med J. 1980 Oct 11;281(6246):985–988. doi: 10.1136/bmj.281.6246.985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carvalho F. M., Widmer M. R., Cruz M., Palomo V., Cruz C. Clinical diagnosis versus autopsy. Bull Pan Am Health Organ. 1991;25(1):41–46. [PubMed] [Google Scholar]
- Charlton R. Autopsy and medical education: a review. J R Soc Med. 1994 Apr;87(4):232–236. [PMC free article] [PubMed] [Google Scholar]
- Clark M. A. The value of the hospital autopsy. Is it worth the cost? Am J Forensic Med Pathol. 1981 Sep;2(3):231–237. doi: 10.1097/00000433-198109000-00008. [DOI] [PubMed] [Google Scholar]
- Davison A. M., McFarlane J. H., Clark J. C. Differences in forensic pathology practice between Scotland and England. Med Sci Law. 1998 Oct;38(4):283–288. doi: 10.1177/002580249803800403. [DOI] [PubMed] [Google Scholar]
- Delendi M., Riboli E., Peruzzo P., Stanta G., Cocchi A., Gardiman D., Sasco A. J., Giarelli L. Comparison of diagnoses of cancers of the respiratory system on death certificates and at autopsy. IARC Sci Publ. 1991;(112):55–62. [PubMed] [Google Scholar]
- Di Bonito L., Stanta G., Delendi M., Peruzzo P., Gardiman D., Cocchi A., Patriarca S., Giarelli L. Comparison between diagnoses on death certificates and autopsy reports in Trieste: gynaecological cancers. IARC Sci Publ. 1991;(112):63–71. [PubMed] [Google Scholar]
- Dorzynski A. French doctors miss out on postmortem examinations. BMJ. 1997 Aug 30;315(7107):503–503. doi: 10.1136/bmj.315.7107.501e. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ermenc B. Minimizing mistakes in clinical diagnosis. J Forensic Sci. 1999 Jul;44(4):810–813. [PubMed] [Google Scholar]
- Fernandez-Segoviano P., Lázaro A., Esteban A., Rubio J. M., Iruretagoyena J. R. Autopsy as quality assurance in the intensive care unit. Crit Care Med. 1988 Jul;16(7):683–685. doi: 10.1097/00003246-198807000-00007. [DOI] [PubMed] [Google Scholar]
- GRUVER R. H., FREIS E. D. A study of diagnostic errors. Ann Intern Med. 1957 Jul;47(1):108–120. doi: 10.7326/0003-4819-47-1-108. [DOI] [PubMed] [Google Scholar]
- Gerdin B., Lindquist O. Comparison between predicted cause of death and cause of death found at autopsy in medicolegal autopsy material. Z Rechtsmed. 1980;85(3):181–187. doi: 10.1007/BF02116318. [DOI] [PubMed] [Google Scholar]
- Goldman L., Sayson R., Robbins S., Cohn L. H., Bettmann M., Weisberg M. The value of the autopsy in three medical eras. N Engl J Med. 1983 Apr 28;308(17):1000–1005. doi: 10.1056/NEJM198304283081704. [DOI] [PubMed] [Google Scholar]
- Goldstein B., Metlay L., Cox C., Rubenstein J. S. Association of pre mortem diagnosis and autopsy findings in pediatric intensive care unit versus emergency department versus ward patients. Crit Care Med. 1996 Apr;24(4):683–686. doi: 10.1097/00003246-199604000-00022. [DOI] [PubMed] [Google Scholar]
- Grundmann E., Menke G. G. Autopsy diagnosis versus clinical diagnosis, particularly in malignant disease. Comparison of two periods: 1961-70 and 1978-87. IARC Sci Publ. 1991;(112):81–90. [PubMed] [Google Scholar]
- Hartveit F. Clinical and post-mortem assessment of the cause of death. J Pathol. 1977 Dec;123(4):193–210. doi: 10.1002/path.1711230402. [DOI] [PubMed] [Google Scholar]
- Hasuo Y., Ueda K., Kiyohara Y., Wada J., Kawano H., Kato I., Yanai T., Fujii I., Omae T., Fujishima M. Accuracy of diagnosis on death certificates for underlying causes of death in a long-term autopsy-based population study in Hisayama, Japan; with special reference to cardiovascular diseases. J Clin Epidemiol. 1989;42(6):577–584. doi: 10.1016/0895-4356(89)90154-6. [DOI] [PubMed] [Google Scholar]
- Holler J. W., De Morgan N. P. A retrospective study of 200 post-mortem examinations. J Med Educ. 1970 Mar;45(3):168–170. doi: 10.1097/00001888-197003000-00007. [DOI] [PubMed] [Google Scholar]
- JAMES G., PATTON R. E., HESLIN A. S. Accuracy of cause-of-death statements on death certificates. Public Health Rep. 1955 Jan;70(1):39–51. [PMC free article] [PubMed] [Google Scholar]
- JUSTIN-BESANCON L., CHRETIEN J., DELAVIERRE P. [Appraisal of 1000 recent anatomo-clinical confrontations]. Bull Acad Natl Med. 1963 Apr 23;147:330–338. [PubMed] [Google Scholar]
- Karwinski B., Hartveit F. Death certification: increased clinical confidence in diagnosis and lack of interest in confirmation by necropsy is not justified. J Clin Pathol. 1989 Jan;42(1):13–17. doi: 10.1136/jcp.42.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kendrey G., Szende B., Lapis K., Marton T., Hargitai B., Roe F. J., Lee P. N. Misdiagnosis of lung cancer in a 2000 consecutive autopsy study in Budapest. Gen Diagn Pathol. 1996 Mar;141(3-4):169–178. [PubMed] [Google Scholar]
- Kingsford D. P. A review of diagnostic inaccuracy. Med Sci Law. 1995 Oct;35(4):347–351. doi: 10.1177/002580249503500413. [DOI] [PubMed] [Google Scholar]
- Kircher T., Nelson J., Burdo H. The autopsy as a measure of accuracy of the death certificate. N Engl J Med. 1985 Nov 14;313(20):1263–1269. doi: 10.1056/NEJM198511143132005. [DOI] [PubMed] [Google Scholar]
- Lowry F. Failure to perform autopsies means some MDs "walking in a fog of misplaced optimism". CMAJ. 1995 Sep 15;153(6):811–814. [PMC free article] [PubMed] [Google Scholar]
- MUNCK W. Autopsy finding and clinical diagnosis; a comparative study of 1000 cases. Acta Med Scand Suppl. 1952;266:775–781. doi: 10.1111/j.0954-6820.1952.tb13426.x. [DOI] [PubMed] [Google Scholar]
- McKelvie P. A. Medical certification of causes of death in an Australian metropolitan hospital. Comparison with autopsy findings and a critical review. Med J Aust. 1993 Jun 21;158(12):816-8, 820-1. [PubMed] [Google Scholar]
- McPhee S. J., Bottles K. Autopsy: moribund art or vital science? Am J Med. 1985 Jan;78(1):107–113. doi: 10.1016/0002-9343(85)90470-x. [DOI] [PubMed] [Google Scholar]
- Mollo F., Bertoldo E., Grandi G., Cavallo F. Reliability of death certifications for different types of cancer. An autopsy survey. Pathol Res Pract. 1986 Aug;181(4):442–447. doi: 10.1016/S0344-0338(86)80080-2. [DOI] [PubMed] [Google Scholar]
- Mort T. C., Yeston N. S. The relationship of pre mortem diagnoses and post mortem findings in a surgical intensive care unit. Crit Care Med. 1999 Feb;27(2):299–303. doi: 10.1097/00003246-199902000-00035. [DOI] [PubMed] [Google Scholar]
- O'Sullivan J. P. The coroner's necropsy in sudden death: an under-used source of epidemiological information. J Clin Pathol. 1996 Sep;49(9):737–740. doi: 10.1136/jcp.49.9.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OTTERLAND A., PIHL E. KLINISH, PATOLOGISK-ANATOMISK OCH OFFICIELL DOEDSORSAKSDIAGNOSTIK MED UTGANGSPUNKT FRAN 327 OBDUKTIONSFALL. Sven Lakartidn. 1964 Jan 8;61:68–86. [PubMed] [Google Scholar]
- Peacock S. J., Machin D., Duboulay C. E., Kirkham N. The autopsy: a useful tool or an old relic? J Pathol. 1988 Sep;156(1):9–14. doi: 10.1002/path.1711560105. [DOI] [PubMed] [Google Scholar]
- Pounder D. The coroner service. A relic in need of reform. BMJ. 1999 Jun 5;318(7197):1502–1503. doi: 10.1136/bmj.318.7197.1502. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prutting J. Lack of correlation between antemortem and postmortem diagnoses. N Y State J Med. 1967 Aug 1;67(15):2081–2084. [PubMed] [Google Scholar]
- Riboli E., Stanta G., Delendi M., Gardiman D., Peruzzo P., Sasco A. J., Giarelli L. Comparison between diagnoses of cancers of the stomach, colon, rectum, gall-bladder, liver and pancreas on death certificates and at autopsy in Trieste, 1970-84. IARC Sci Publ. 1991;(112):45–54. [PubMed] [Google Scholar]
- Robinson I. A., Marley N. J. Factors predicting cases with unexpected clinical findings at necropsy. J Clin Pathol. 1996 Nov;49(11):909–912. doi: 10.1136/jcp.49.11.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rossi S., Reale D., Grandi E. Correlation of clinical diagnosis with autopsy findings. IARC Sci Publ. 1991;(112):99–108. [PubMed] [Google Scholar]
- Segerberg-Konttinen M. Determination of cause and mode of death before and after medicolegal autopsy: a comparative study. J Forensic Sci. 1988 Mar;33(2):441–447. [PubMed] [Google Scholar]
- Smith C. J., Scott S. M., Wagner B. M. The necessary role of the autopsy in cardiovascular epidemiology. Hum Pathol. 1998 Dec;29(12):1469–1479. doi: 10.1016/s0046-8177(98)90018-1. [DOI] [PubMed] [Google Scholar]
- Stambouly J. J., Kahn E., Boxer R. A. Correlation between clinical diagnoses and autopsy findings in critically ill children. Pediatrics. 1993 Aug;92(2):248–251. [PubMed] [Google Scholar]
- Stevanovic G., Tucakovic G., Dotlic R., Kanjuh V. Correlation of clinical diagnoses with autopsy findings: a retrospective study of 2,145 consecutive autopsies. Hum Pathol. 1986 Dec;17(12):1225–1230. doi: 10.1016/s0046-8177(86)80564-0. [DOI] [PubMed] [Google Scholar]
- Swartout H. O., Webster R. G. To What Degree Are Mortality Statistics Dependable? Am J Public Health Nations Health. 1940 Jul;30(7):811–815. doi: 10.2105/ajph.30.7.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Szende B., Kendrey G., Lapis K., Lee P. N., Roe F. J. Accuracy of admission and pre-autopsy clinical diagnoses in the light of autopsy findings: a study conducted in Budapest. Hum Exp Toxicol. 1994 Oct;13(10):671–680. doi: 10.1177/096032719401301004. [DOI] [PubMed] [Google Scholar]
- Teo C. E. A study of coroner's cases from hospitals: a comparison of autopsy and clinical diagnosis. Ann Acad Med Singapore. 1993 Jan;22(1):3–7. [PubMed] [Google Scholar]
- Tsujimura T., Yamada Y., Kubo M., Fushimi H., Kameyama M. Why couldn't an accurate diagnosis be made? An analysis of 1044 consecutive autopsy cases. Pathol Int. 1999 May;49(5):408–410. doi: 10.1046/j.1440-1827.1999.00879.x. [DOI] [PubMed] [Google Scholar]
- Vanatta P. R., Petty C. S. Limitations of the forensic external examination in determining the cause and manner of death. Hum Pathol. 1987 Feb;18(2):170–174. doi: 10.1016/s0046-8177(87)80335-0. [DOI] [PubMed] [Google Scholar]
- Veress B., Alafuzoff I. A retrospective analysis of clinical diagnoses and autopsy findings in 3,042 cases during two different time periods. Hum Pathol. 1994 Feb;25(2):140–145. doi: 10.1016/0046-8177(94)90269-0. [DOI] [PubMed] [Google Scholar]
- Veress B., Alafuzoff I. Clinical diagnostic accuracy audited by autopsy in a university hospital in two eras. Qual Assur Health Care. 1993 Dec;5(4):281–286. doi: 10.1093/intqhc/5.4.281. [DOI] [PubMed] [Google Scholar]
- Wilson R. R. In defense of the autopsy. JAMA. 1966 Jun 13;196(11):1011–1012. [PubMed] [Google Scholar]
- Yukawa N., Carter N., Rutty G., Green M. A. Intra-alveolar haemorrhage in sudden infant death syndrome: a cause for concern? J Clin Pathol. 1999 Aug;52(8):581–587. doi: 10.1136/jcp.52.8.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zehr K. J., Liddicoat J. R., Salazar J. D., Gillinov A. M., Hruban R. H., Hutchins G. M., Cameron D. E. The autopsy: still important in cardiac surgery. Ann Thorac Surg. 1997 Aug;64(2):380–383. doi: 10.1016/S0003-4975(97)00551-1. [DOI] [PubMed] [Google Scholar]
- de Pangher Manzini V., Revignas M. G., Brollo A. Diagnosis of malignant tumor: comparison between clinical and autopsy diagnoses. Hum Pathol. 1995 Mar;26(3):280–283. doi: 10.1016/0046-8177(95)90058-6. [DOI] [PubMed] [Google Scholar]