Abstract
Chronic granulocytic leukaemia (CGL) is a rare disease. For most patients the only curative treatment (an allogeneic stem cell transplant) is not available. Survival varies between a few months to many years from diagnosis, and an accurate prediction of the duration of survival could help patients and clinicians make informed decisions about the many treatment options. In 1984, the Sokal score was introduced to stratify patients into risk groups. Recently, a new prognostic scoring system was proposed by Hasford and co-workers for interferon treated patients. We have analysed survival on an unselected population based cohort of patients using both the Hasford and the Sokal scores. In the group overall, neither score was predictive of survival, but in younger patients (< 60 years) treated with interferon, the Hasford score was highly predictive of survival, dividing patients into groups with a five year survival of 77% (45 patients) v 33% (six patients) v 14% (31 patients) (p = 0.01).
Key Words: chronic granulocytic leukaemia • interferon α • prognosis • Hasford score • Sokal score
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Figure 1 How to calculate the Sokal and Hasford scores.
Figure 2 Actuarial overall survival in months by stratified Hasford score in patients < 60 years old treated with interferon: patients receiving allogeneic transplants were censored at the time of transplantation, in accordance with the methodology in the original paper.