Abstract
This case report describes a 75 year old man who had a renal papillary carcinoma associated with a low grade tumour of the collecting ducts. These tumours showed different immunohistochemical patterns for epithelial membrane antigen, cytokeratin 19, and Ulex europaeus lectin expression. In addition, cytogenetic findings were 47, XY, +7 <7> and 45, XY, -8, add(12)(q–ter)<10> for the papillary renal carcinoma and the low grade tumour of the collecting ducts, respectively. This is the first report where these two types of tumour are associated and cytogenetically distinguished.
Key Words: renal cell carcinoma • low grade tumour of the collecting ducts
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Figure 1 Computerised tomography with intravenous contrast showing two hypointense renal tumours.
Figure 2 Macroscopic examination: the two tumours show a grey heterogeneous cut surface (arrow) and a white homogeneous cut surface (asterisk).
Figure 3 (A, C) 2.5 cm diameter renal tumour: typical papillae with foamy cells (haematein-eosin-saffnou(HES) stain; original magnification, x250 and x400, respectively). (E) 2.5 cm diameter renal tumour: cells are immunoreactive with anti-epithelial membrane antigen (EMA) antibody. (B, D) 1.5 cm diameter renal tumour: hobnail cells line dilated tubules (HES; original magnification, x100 and x250, respectively). (F) 1.5 cm diameter renal tumour: cells were immunoreactive for the lectin Ulex europaeus (UEA-1).
Figure 4 Karyotype of the low grade tumour of the collecting ducts showing monosomy 8 and supplementary material on the long arm of chromosome 12: add(12)(q–ter). Other chromosomal losses are random.