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Journal of Epidemiology and Community Health logoLink to Journal of Epidemiology and Community Health
. 2000 May;54(5):355–360. doi: 10.1136/jech.54.5.355

Plasma vitamin C and food choice in the third Glasgow MONICA population survey

W Wrieden 1, M Hannah 1, C Bolton-Smith 1, R Tavendale 1, C Morrison 1, H Tunstall-Pedoe 1
PMCID: PMC1731679  PMID: 10814656

Abstract

STUDY OBJECTIVE—To determine the contribution of different foods to the estimated intakes of vitamin C among those differing in plasma vitamin C levels, and thereby inform dietary strategies for correcting possible deficiency.
DESIGN—Cross sectional random population survey.
SETTING—North Glasgow, Scotland, 1992.
PARTICIPANTS—632 men and 635 women, aged 25 to 74 years, not taking vitamin supplements, who participated in the third MONICA study (population survey monitoring trends and determinants of cardiovascular disease).
MEASUREMENTS AND MAIN RESULTS—Dietary and sociodemographic information was collected using a food frequency and lifestyle questionnaire. Plasma vitamin C was measured in non-fasted venous blood samples and subjects categorised by cut points of 11.4 and 22.7 µmol/l as being of low, marginal or optimal vitamin C status. Food sources of dietary vitamin C were identified for subjects in these categories. Plasma vitamin C concentrations were compared among groups classified according to intake of key foods. More men (26%) than women (14%) were in the low category for vitamin C status; as were a higher percentage of smokers and of those in the older age groups. Intake of vitamin C from potatoes and chips (fried potatoes) was uniform across categories; while the determinants of optimal versus low status were the intakes of citrus fruit, non-citrus fruit and fruit juice. Optimal status was achieved by a combined frequency of fruit, vegetables and/or fruit juice of three times a day or more except in older male smokers where a frequency greater than this was required even to reach a marginal plasma vitamin C level.
CONCLUSION—Fruit, vegetables and/or fruit juice three or more times a day increases plasma vitamin C concentrations above the threshold for risk of deficiency.


Keywords: vitamin C; food frequency; fruit; vegetables

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Selected References

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  1. Bolton-Smith C. Antioxidant vitamin intakes in Scottish smokers and nonsmokers. Dose effects and biochemical correlates. Ann N Y Acad Sci. 1993 May 28;686:347–360. doi: 10.1111/j.1749-6632.1993.tb39199.x. [DOI] [PubMed] [Google Scholar]
  2. Bolton-Smith C., Casey C. E., Gey K. F., Smith W. C., Tunstall-Pedoe H. Antioxidant vitamin intakes assessed using a food-frequency questionnaire: correlation with biochemical status in smokers and non-smokers. Br J Nutr. 1991 May;65(3):337–346. doi: 10.1079/bjn19910094. [DOI] [PubMed] [Google Scholar]
  3. Bolton-Smith C., Smith W. C., Woodward M., Tunstall-Pedoe H. Nutrient intakes of different social-class groups: results from the Scottish Heart Health Study (SHHS). Br J Nutr. 1991 May;65(3):321–335. doi: 10.1079/bjn19910093. [DOI] [PubMed] [Google Scholar]
  4. Brook M., Grimshaw J. J. Vitamin C concentration of plasma and leukocytes as related to smoking habit, age, and sex of humans. Am J Clin Nutr. 1968 Nov;21(11):1254–1258. doi: 10.1093/ajcn/21.11.1254. [DOI] [PubMed] [Google Scholar]
  5. CALDER J. H., CURTIS R. C., FORE H. Comparison of vitamin C in plasma and leucocytes of smokers and non-smokers. Lancet. 1963 Mar 9;1(7280):556–556. doi: 10.1016/s0140-6736(63)91360-6. [DOI] [PubMed] [Google Scholar]
  6. Garry P. J., Goodwin J. S., Hunt W. C., Gilbert B. A. Nutritional status in a healthy elderly population: vitamin C. Am J Clin Nutr. 1982 Aug;36(2):332–339. doi: 10.1093/ajcn/36.2.332. [DOI] [PubMed] [Google Scholar]
  7. Gey K. F., Stähelin H. B., Eichholzer M. Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: Basel Prospective Study. Clin Investig. 1993 Jan;71(1):3–6. doi: 10.1007/BF00210955. [DOI] [PubMed] [Google Scholar]
  8. Kallner A. B., Hartmann D., Hornig D. H. On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers. Am J Clin Nutr. 1981 Jul;34(7):1347–1355. doi: 10.1093/ajcn/34.7.1347. [DOI] [PubMed] [Google Scholar]
  9. Matilainen T., Vartiainen E., Puska P., Alfthan G., Pokusajeva S., Moisejeva N., Uhanov M. Plasma ascorbic acid concentrations in the Republic of Karelia, Russia and in North Karelia, Finland. Eur J Clin Nutr. 1996 Feb;50(2):115–120. [PubMed] [Google Scholar]
  10. Morrison C., Woodward M., Leslie W., Tunstall-Pedoe H. Effect of socioeconomic group on incidence of, management of, and survival after myocardial infarction and coronary death: analysis of community coronary event register. BMJ. 1997 Feb 22;314(7080):541–546. doi: 10.1136/bmj.314.7080.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Riemersma R. A., Wood D. A., Macintyre C. C., Elton R. A., Gey K. F., Oliver M. F. Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene. Lancet. 1991 Jan 5;337(8732):1–5. doi: 10.1016/0140-6736(91)93327-6. [DOI] [PubMed] [Google Scholar]
  12. Sauberlich H. E. Human requirements and needs. Vitamin C status: methods and findings. Ann N Y Acad Sci. 1975 Sep 30;258:438–450. doi: 10.1111/j.1749-6632.1975.tb29302.x. [DOI] [PubMed] [Google Scholar]
  13. Smith W. C., Crombie I. K., Tavendale R., Irving J. M., Kenicer M. B., Tunstall Pedoe H. The Scottish Heart Health Study: objectives and development of methods. Health Bull (Edinb) 1987 Jul;45(4):211–217. [PubMed] [Google Scholar]
  14. Tunstall-Pedoe H., Kuulasmaa K., Amouyel P., Arveiler D., Rajakangas A. M., Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation. 1994 Jul;90(1):583–612. doi: 10.1161/01.cir.90.1.583. [DOI] [PubMed] [Google Scholar]
  15. Tunstall-Pedoe H., Smith W. C., Crombie I. K., Tavendale R. Coronary risk factor and lifestyle variation across Scotland: results from the Scottish Heart Health Study. Scott Med J. 1989 Dec;34(6):556–560. doi: 10.1177/003693308903400604. [DOI] [PubMed] [Google Scholar]
  16. Tunstall-Pedoe H., Woodward M., Tavendale R., A'Brook R., McCluskey M. K. Comparison of the prediction by 27 different factors of coronary heart disease and death in men and women of the Scottish Heart Health Study: cohort study. BMJ. 1997 Sep 20;315(7110):722–729. doi: 10.1136/bmj.315.7110.722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Williams C. Healthy eating: clarifying advice about fruit and vegetables. BMJ. 1995 Jun 3;310(6992):1453–1455. doi: 10.1136/bmj.310.6992.1453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yarnell J. W., Fehily A. M., Milbank J. E., Sweetnam P. M., Walker C. L. A short dietary questionnaire for use in an epidemiological survey: comparison with weighed dietary records. Hum Nutr Appl Nutr. 1983 Apr;37(2):103–112. [PubMed] [Google Scholar]

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