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. 2003 Feb;57(2):89–95. doi: 10.1136/jech.57.2.89

An evolutionary paradigm for carcinogenesis?

P Vineis 1, G Matullo 1, M Manuguerra 1
PMCID: PMC1732384  PMID: 12540682

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Selected References

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  1. Airoldi Luisa, Orsi Federica, Magagnotti Cinzia, Coda Renato, Randone Donato, Casetta Giovanni, Peluso Marco, Hautefeuille Agnes, Malaveille Christian, Vineis Paolo. Determinants of 4-aminobiphenyl-DNA adducts in bladder cancer biopsies. Carcinogenesis. 2002 May;23(5):861–866. doi: 10.1093/carcin/23.5.861. [DOI] [PubMed] [Google Scholar]
  2. Bardelli A., Cahill D. P., Lederer G., Speicher M. R., Kinzler K. W., Vogelstein B., Lengauer C. Carcinogen-specific induction of genetic instability. Proc Natl Acad Sci U S A. 2001 Apr 10;98(10):5770–5775. doi: 10.1073/pnas.081082898. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Basu A., Mahata J., Gupta S., Giri A. K. Genetic toxicology of a paradoxical human carcinogen, arsenic: a review. Mutat Res. 2001 May;488(2):171–194. doi: 10.1016/s1383-5742(01)00056-4. [DOI] [PubMed] [Google Scholar]
  4. Brown C. C., Chu K. C. Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure. J Natl Cancer Inst. 1983 Mar;70(3):455–463. [PubMed] [Google Scholar]
  5. Choi S. W., Kim Y. I., Weitzel J. N., Mason J. B. Folate depletion impairs DNA excision repair in the colon of the rat. Gut. 1998 Jul;43(1):93–99. doi: 10.1136/gut.43.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Davidson L. A., Lupton J. R., Jiang Y. H., Chapkin R. S. Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. Carcinogenesis. 1999 May;20(5):785–791. doi: 10.1093/carcin/20.5.785. [DOI] [PubMed] [Google Scholar]
  7. Denissenko M. F., Koudriakova T. B., Smith L., O'Connor T. R., Riggs A. D., Pfeifer G. P. The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts. Oncogene. 1998 Dec 10;17(23):3007–3014. doi: 10.1038/sj.onc.1202214. [DOI] [PubMed] [Google Scholar]
  8. Denissenko M. F., Pao A., Tang M., Pfeifer G. P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science. 1996 Oct 18;274(5286):430–432. doi: 10.1126/science.274.5286.430. [DOI] [PubMed] [Google Scholar]
  9. Duthie S. J., Narayanan S., Blum S., Pirie L., Brand G. M. Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer. 2000;37(2):245–251. doi: 10.1207/S15327914NC372_18. [DOI] [PubMed] [Google Scholar]
  10. Gatenby R. A. Application of competition theory to tumour growth: implications for tumour biology and treatment. Eur J Cancer. 1996 Apr;32A(4):722–726. doi: 10.1016/0959-8049(95)00658-3. [DOI] [PubMed] [Google Scholar]
  11. Germolec D. R., Spalding J., Yu H. S., Chen G. S., Simeonova P. P., Humble M. C., Bruccoleri A., Boorman G. A., Foley J. F., Yoshida T. Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors. Am J Pathol. 1998 Dec;153(6):1775–1785. doi: 10.1016/S0002-9440(10)65692-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Haddow A. Sir Ernest Laurence Kennaway FRS, 1881-1958: chemical causation of cancer then and today. Perspect Biol Med. 1974 Summer;17(4):543–588. doi: 10.1353/pbm.1974.0049. [DOI] [PubMed] [Google Scholar]
  13. Hainaut P., Pfeifer G. P. Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. Carcinogenesis. 2001 Mar;22(3):367–374. doi: 10.1093/carcin/22.3.367. [DOI] [PubMed] [Google Scholar]
  14. Haraguchi Y., Sasaki A. Host-parasite arms race in mutation modifications: indefinite escalation despite a heavy load? J Theor Biol. 1996 Nov 21;183(2):121–137. doi: 10.1006/jtbi.1996.9999. [DOI] [PubMed] [Google Scholar]
  15. Hussain S. P., Hollstein M. H., Harris C. C. p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment. Ann N Y Acad Sci. 2000;919:79–85. doi: 10.1111/j.1749-6632.2000.tb06870.x. [DOI] [PubMed] [Google Scholar]
  16. Iversen O. H. The skin tumorigenic and carcinogenic effects of different doses, numbers of dose fractions and concentrations of 7,12-dimethylbenz[a]anthracene in acetone applied on hairless mouse epidermis. Possible implications for human carcinogenesis. Carcinogenesis. 1991 Mar;12(3):493–502. doi: 10.1093/carcin/12.3.493. [DOI] [PubMed] [Google Scholar]
  17. Jonason A. S., Kunala S., Price G. J., Restifo R. J., Spinelli H. M., Persing J. A., Leffell D. J., Tarone R. E., Brash D. E. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14025–14029. doi: 10.1073/pnas.93.24.14025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Karran P., Bignami M. DNA damage tolerance, mismatch repair and genome instability. Bioessays. 1994 Nov;16(11):833–839. doi: 10.1002/bies.950161110. [DOI] [PubMed] [Google Scholar]
  19. Ko Y. C. A critical review of epidemiologic studies on black-foot disease. J UOEH. 1986 Sep 1;8(3):339–353. doi: 10.7888/juoeh.8.339. [DOI] [PubMed] [Google Scholar]
  20. Lawley P. D., Brookes P. Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action. Nature. 1965 May 1;206(983):480–483. doi: 10.1038/206480a0. [DOI] [PubMed] [Google Scholar]
  21. LeClerc J. E., Li B., Payne W. L., Cebula T. A. High mutation frequencies among Escherichia coli and Salmonella pathogens. Science. 1996 Nov 15;274(5290):1208–1211. doi: 10.1126/science.274.5290.1208. [DOI] [PubMed] [Google Scholar]
  22. Leigh E. G., Jr The evolution of mutation rates. Genetics. 1973 Apr;73(Suppl):1–18. [PubMed] [Google Scholar]
  23. McCully K. S. The significance of wheat in the Dakota Territory, human evolution, civilization, and degenerative diseases. Perspect Biol Med. 2001 Winter;44(1):52–61. doi: 10.1353/pbm.2001.0012. [DOI] [PubMed] [Google Scholar]
  24. Neel J. V., Weder A. B., Julius S. Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": the "thrifty genotype" hypothesis enters the 21st century. Perspect Biol Med. 1998 Autumn;42(1):44–74. doi: 10.1353/pbm.1998.0060. [DOI] [PubMed] [Google Scholar]
  25. Nilsen T. I., Vatten L. J. Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis. Br J Cancer. 2001 Feb 2;84(3):417–422. doi: 10.1054/bjoc.2000.1582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Peluso M., Airoldi L., Magagnotti C., Fiorini L., Munnia A., Hautefeuille A., Malaveille C., Vineis P. White blood cell DNA adducts and fruit and vegetable consumption in bladder cancer. Carcinogenesis. 2000 Feb;21(2):183–187. doi: 10.1093/carcin/21.2.183. [DOI] [PubMed] [Google Scholar]
  27. Porta M., Malats N., Alguacil J., Ruiz L., Jariod M., Carrato A., Rifá J., Guarner L. Coffee, pancreatic cancer, and K-ras mutations: updating the research agenda. J Epidemiol Community Health. 2000 Sep;54(9):656–659. doi: 10.1136/jech.54.9.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rodin S. N., Rodin A. S. Human lung cancer and p53: the interplay between mutagenesis and selection. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12244–12249. doi: 10.1073/pnas.180320897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Rosse W. F. New insights into paroxysmal nocturnal hemoglobinuria. Curr Opin Hematol. 2001 Mar;8(2):61–67. doi: 10.1097/00062752-200103000-00001. [DOI] [PubMed] [Google Scholar]
  30. Rowan A. J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D., Bodmer W. F., Tomlinson I. P. APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3352–3357. doi: 10.1073/pnas.97.7.3352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Smith A. H., Goycolea M., Haque R., Biggs M. L. Marked increase in bladder and lung cancer mortality in a region of Northern Chile due to arsenic in drinking water. Am J Epidemiol. 1998 Apr 1;147(7):660–669. doi: 10.1093/oxfordjournals.aje.a009507. [DOI] [PubMed] [Google Scholar]
  32. Steen H. B. The origin of oncogenic mutations: where is the primary damage? Carcinogenesis. 2000 Oct;21(10):1773–1776. doi: 10.1093/carcin/21.10.1773. [DOI] [PubMed] [Google Scholar]
  33. Strohman R. C. The coming Kuhnian revolution in biology. Nat Biotechnol. 1997 Mar;15(3):194–200. doi: 10.1038/nbt0397-194. [DOI] [PubMed] [Google Scholar]
  34. Taddei F., Radman M., Maynard-Smith J., Toupance B., Gouyon P. H., Godelle B. Role of mutator alleles in adaptive evolution. Nature. 1997 Jun 12;387(6634):700–702. doi: 10.1038/42696. [DOI] [PubMed] [Google Scholar]
  35. Tomlinson I., Bodmer W. Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog. Nat Med. 1999 Jan;5(1):11–12. doi: 10.1038/4687. [DOI] [PubMed] [Google Scholar]
  36. Vineis P., Malats N., Porta M., Real F. X. Human cancer, carcinogenic exposures and mutation spectra. Mutat Res. 1999 Mar;436(2):185–194. [PubMed] [Google Scholar]
  37. Vineis P., Perera F. DNA adducts as markers of exposure to carcinogens and risk of cancer. Int J Cancer. 2000 Nov 1;88(3):325–328. [PubMed] [Google Scholar]
  38. Vineis P., Schulte P., McMichael A. J. Misconceptions about the use of genetic tests in populations. Lancet. 2001 Mar 3;357(9257):709–712. doi: 10.1016/S0140-6736(00)04136-2. [DOI] [PubMed] [Google Scholar]
  39. Vulimiri SV, Wu X, Baer-Dubowska W, Andrade Md, Detry M, Spitz MR, DiGiovanni J. Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo-2' deoxyguanosine in lymphocyte DNA from a case-control study of lung cancer involving minority populations. Mol Carcinog. 2000 Apr;27(4):330–330. doi: 10.1002/(sici)1098-2744(200004)27:4<330::aid-mc11>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  40. Wiencke J. K., Thurston S. W., Kelsey K. T., Varkonyi A., Wain J. C., Mark E. J., Christiani D. C. Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. J Natl Cancer Inst. 1999 Apr 7;91(7):614–619. doi: 10.1093/jnci/91.7.614. [DOI] [PubMed] [Google Scholar]
  41. van Tongeren J. H., Kunst A., Majoor C. L., Schillings P. H. Folic-acid deficiency in chronic arsenic poisoning. Lancet. 1965 Apr 10;1(7389):784–786. doi: 10.1016/s0140-6736(65)92956-9. [DOI] [PubMed] [Google Scholar]

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