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. 1995 Jul;63(7):2770–2772. doi: 10.1128/iai.63.7.2770-2772.1995

Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors.

A McNeil 1, S J Dunstan 1, S Clark 1, R A Strugnell 1
PMCID: PMC173371  PMID: 7790097

Abstract

The role of the epidermal growth factor (EGF) receptor in cell invasion by Salmonella typhimurium was examined in vitro and in vivo by using waved-2 mice which express an EGF receptor with reduced kinase activity. S. typhimurium invaded fibroblasts from waved-2 mice as efficiently as fibroblasts from wild-type control animals. In vivo, S. typhimurium both invaded the gastrointestinal tract and penetrated through to the spleen of waved-2 mice. Our studies suggest that the EGF receptor has only a limited role, if any, in cell invasion by S. typhimurium.

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Selected References

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