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. 2004 Aug;30(4):337–340. doi: 10.1136/jme.2003.004739

Ethical issues in using a cocaine vaccine to treat and prevent cocaine abuse and dependence

W Hall 1, L Carter 1
PMCID: PMC1733917  PMID: 15289512

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carrera M. R., Ashley J. A., Parsons L. H., Wirsching P., Koob G. F., Janda K. D. Suppression of psychoactive effects of cocaine by active immunization. Nature. 1995 Dec 14;378(6558):727–730. doi: 10.1038/378727a0. [DOI] [PubMed] [Google Scholar]
  2. Carrera M. R., Ashley J. A., Wirsching P., Koob G. F., Janda K. D. A second-generation vaccine protects against the psychoactive effects of cocaine. Proc Natl Acad Sci U S A. 2001 Feb 6;98(4):1988–1992. doi: 10.1073/pnas.041610998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carrera M. R., Ashley J. A., Zhou B., Wirsching P., Koob G. F., Janda K. D. Cocaine vaccines: antibody protection against relapse in a rat model. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6202–6206. doi: 10.1073/pnas.97.11.6202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cohen P. J. Immunization for prevention and treatment of cocaine abuse: legal and ethical implications. Drug Alcohol Depend. 1997 Dec 15;48(3):167–174. doi: 10.1016/s0376-8716(97)00075-6. [DOI] [PubMed] [Google Scholar]
  5. Fox B. S. Development of a therapeutic vaccine for the treatment of cocaine addiction. Drug Alcohol Depend. 1997 Dec 15;48(3):153–158. doi: 10.1016/s0376-8716(97)00121-x. [DOI] [PubMed] [Google Scholar]
  6. Fox B. S., Kantak K. M., Edwards M. A., Black K. M., Bollinger B. K., Botka A. J., French T. L., Thompson T. L., Schad V. C., Greenstein J. L. Efficacy of a therapeutic cocaine vaccine in rodent models. Nat Med. 1996 Oct;2(10):1129–1132. doi: 10.1038/nm1096-1129. [DOI] [PubMed] [Google Scholar]
  7. Gawin F. H., Ellinwood E. H., Jr Cocaine and other stimulants. Actions, abuse, and treatment. N Engl J Med. 1988 May 5;318(18):1173–1182. doi: 10.1056/NEJM198805053181806. [DOI] [PubMed] [Google Scholar]
  8. Hall Wayne. The prospects for immunotherapy in smoking cessation. Lancet. 2002 Oct 5;360(9339):1089–1091. doi: 10.1016/S0140-6736(02)11134-2. [DOI] [PubMed] [Google Scholar]
  9. Johnson M. W., Ettinger R. H. Active cocaine immunization attenuates the discriminative properties of cocaine. Exp Clin Psychopharmacol. 2000 May;8(2):163–167. doi: 10.1037//1064-1297.8.2.163. [DOI] [PubMed] [Google Scholar]
  10. Kantak K. M., Collins S. L., Bond J., Fox B. S. Time course of changes in cocaine self-administration behavior in rats during immunization with the cocaine vaccine IPC-1010. Psychopharmacology (Berl) 2001 Jan;153(3):334–340. doi: 10.1007/s002130000555. [DOI] [PubMed] [Google Scholar]
  11. Kantak K. M., Collins S. L., Lipman E. G., Bond J., Giovanoni K., Fox B. S. Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration model. Psychopharmacology (Berl) 2000 Feb;148(3):251–262. doi: 10.1007/s002130050049. [DOI] [PubMed] [Google Scholar]
  12. Kosten Thomas R., Rosen Marc, Bond Julian, Settles Michael, Roberts John St Clair, Shields John, Jack Lindsay, Fox Barbara. Human therapeutic cocaine vaccine: safety and immunogenicity. Vaccine. 2002 Jan 15;20(7-8):1196–1204. doi: 10.1016/s0264-410x(01)00425-x. [DOI] [PubMed] [Google Scholar]
  13. Manschreck T. C., Laughery J. A., Weisstein C. C., Allen D., Humblestone B., Neville M., Podlewski H., Mitra N. Characteristics of freebase cocaine psychosis. Yale J Biol Med. 1988 Mar-Apr;61(2):115–122. [PMC free article] [PubMed] [Google Scholar]
  14. Simpson D. D., Joe G. W., Fletcher B. W., Hubbard R. L., Anglin M. D. A national evaluation of treatment outcomes for cocaine dependence. Arch Gen Psychiatry. 1999 Jun;56(6):507–514. doi: 10.1001/archpsyc.56.6.507. [DOI] [PubMed] [Google Scholar]
  15. Simpson D. Dwayne, Joe George W., Broome Kirk M. A national 5-year follow-up of treatment outcomes for cocaine dependence. Arch Gen Psychiatry. 2002 Jun;59(6):538–544. doi: 10.1001/archpsyc.59.6.538. [DOI] [PubMed] [Google Scholar]
  16. Sparenborg S., Vocci F., Zukin S. Peripheral cocaine-blocking agents: new medications for cocaine dependence. An introduction to immunological and enzymatic approaches to treating cocaine dependence reported by Fox, Gorelick and Cohen in the immediately succeeding articles (see pages 153-174). Drug Alcohol Depend. 1997 Dec 15;48(3):149–151. doi: 10.1016/s0376-8716(97)00072-0. [DOI] [PubMed] [Google Scholar]
  17. Torrens M., San L., Peri J. M., Olle J. M. Cocaine abuse among heroin addicts in Spain. Drug Alcohol Depend. 1991 Jan;27(1):29–34. doi: 10.1016/0376-8716(91)90083-b. [DOI] [PubMed] [Google Scholar]
  18. Vasica Gabriella, Tennant Christopher C. Cocaine use and cardiovascular complications. Med J Aust. 2002 Sep 2;177(5):260–262. doi: 10.5694/j.1326-5377.2002.tb04761.x. [DOI] [PubMed] [Google Scholar]
  19. Vocci F. J., Chiang C. N. Vaccines against nicotine: how effective are they likely to be in preventing smoking? CNS Drugs. 2001;15(7):505–514. doi: 10.2165/00023210-200115070-00001. [DOI] [PubMed] [Google Scholar]
  20. Wise R. A., Ranaldi R. Cocaine vaccines revisited. Nat Med. 1996 Oct;2(10):1073–1074. doi: 10.1038/nm1096-1073. [DOI] [PubMed] [Google Scholar]
  21. de Lima Maurício Silva, de Oliveira Soares Bernardo Garcia, Reisser Anelise Alves Pereira, Farrell Michael. Pharmacological treatment of cocaine dependence: a systematic review. Addiction. 2002 Aug;97(8):931–949. doi: 10.1046/j.1360-0443.2002.00209.x. [DOI] [PubMed] [Google Scholar]

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