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Infection and Immunity logoLink to Infection and Immunity
. 1995 Aug;63(8):3209–3212. doi: 10.1128/iai.63.8.3209-3212.1995

Hemolytic activity of the Pasteurella haemolytica leukotoxin.

G L Murphy 1, L C Whitworth 1, K D Clinkenbeard 1, P A Clinkenbeard 1
PMCID: PMC173439  PMID: 7622250

Abstract

A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demonstrated the typical beta-hemolytic phenotype on sheep and rabbit blood agar, whereas the mutant did not.

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Selected References

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