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. 1995 Aug;63(8):3218–3221. doi: 10.1128/iai.63.8.3218-3221.1995

Characterization of recombinant tetanus toxin derivatives suitable for vaccine development.

D Figueiredo 1, C Turcotte 1, G Frankel 1, Y Li 1, O Dolly 1, G Wilkin 1, D Marriott 1, N Fairweather 1, G Dougan 1
PMCID: PMC173441  PMID: 7622252

Abstract

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

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Selected References

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