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. 1995 Aug;63(8):3231–3234. doi: 10.1128/iai.63.8.3231-3234.1995

T-cell cytokine responses in human infection with Mycobacterium tuberculosis.

M Zhang 1, Y Lin 1, D V Iyer 1, J Gong 1, J S Abrams 1, P F Barnes 1
PMCID: PMC173444  PMID: 7622255

Abstract

Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.

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Selected References

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