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. 2002 Feb;39(2):81–90. doi: 10.1136/jmg.39.2.81

Current status of human chromosome 14

D Kamnasaran 1, D Cox 1
PMCID: PMC1735028  PMID: 11836355

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Selected References

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  1. Abujiang P., Mori T. J., Takahashi T., Tanaka F., Kasyu I., Hitomi S., Hiai H. Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers. Oncogene. 1998 Dec 10;17(23):3029–3033. doi: 10.1038/sj.onc.1202230. [DOI] [PubMed] [Google Scholar]
  2. Acebrón A., Aza-Blanc P., Rossi D. L., Lamas L., Santisteban P. Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1. J Clin Invest. 1995 Aug;96(2):781–785. doi: 10.1172/JCI118123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Attwood J., Kruse T., Vergnaud G., Malaspina P., Povey S. The EUROGEM map of human chromosome 14. Eur J Hum Genet. 1994;2(3):230–231. [PubMed] [Google Scholar]
  4. Bandera C. A., Takahashi H., Behbakht K., Liu P. C., LiVolsi V. A., Benjamin I., Morgan M. A., King S. A., Rubin S. C., Boyd J. Deletion mapping of two potential chromosome 14 tumor suppressor gene loci in ovarian carcinoma. Cancer Res. 1997 Feb 1;57(3):513–515. [PubMed] [Google Scholar]
  5. Bando T., Kato Y., Ihara Y., Yamagishi F., Tsukada K., Isobe M. Loss of heterozygosity of 14q32 in colorectal carcinoma. Cancer Genet Cytogenet. 1999 Jun;111(2):161–165. doi: 10.1016/s0165-4608(98)00242-8. [DOI] [PubMed] [Google Scholar]
  6. Barbi G., Steinbach P., Vogel W. Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites. Hum Genet. 1984;68(4):290–294. doi: 10.1007/BF00292586. [DOI] [PubMed] [Google Scholar]
  7. Berghmans S., Segers K., Shay T., Georges M., Cockett N., Charlier C. Breakpoint mapping positions the callipyge gene within a 450-kilobase chromosome segment containing the DLK1 and GTL2 genes. Mamm Genome. 2001 Feb;12(2):183–185. doi: 10.1007/s003350010246. [DOI] [PubMed] [Google Scholar]
  8. Bhugra B., Smolarek T. A., Lynch R. A., Meloni A. M., Sandberg A. A., Deaven L., Menon A. G. Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma. Cancer Lett. 1998 Apr 24;126(2):119–126. doi: 10.1016/s0304-3835(97)00478-3. [DOI] [PubMed] [Google Scholar]
  9. Billingsley G. D., Cox D. W., Duncan A. M., Goodfellow P. J., Grzeschik K. H. Regional localization of loci on chromosome 14 using somatic cell hybrids. Cytogenet Cell Genet. 1994;66(1):33–38. doi: 10.1159/000133659. [DOI] [PubMed] [Google Scholar]
  10. Billingsley G. D., Walter M. A., Hammond G. L., Cox D. W. Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1. Am J Hum Genet. 1993 Feb;52(2):343–353. [PMC free article] [PubMed] [Google Scholar]
  11. Bissbort S., Hitzeroth H. W., du Wentzel D. P., Van den Berg C. W., Senff H., Wienker T. F., Bender K. Linkage between the variegate porphyria (VP) and the alpha-1-antitrypsin (PI) genes on human chromosome 14. Hum Genet. 1988 Jul;79(3):289–290. doi: 10.1007/BF00366255. [DOI] [PubMed] [Google Scholar]
  12. Björkqvist A. M., Wolf M., Nordling S., Tammilehto L., Knuuttila A., Kere J., Mattson K., Knuutila S. Deletions at 14q in malignant mesothelioma detected by microsatellite marker analysis. Br J Cancer. 1999 Dec;81(7):1111–1115. doi: 10.1038/sj.bjc.6690816. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Blake J. A., Eppig J. T., Richardson J. E., Bult C. J., Kadin J. A. The Mouse Genome Database (MGD): integration nexus for the laboratory mouse. Nucleic Acids Res. 2001 Jan 1;29(1):91–94. doi: 10.1093/nar/29.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Boguski M. S., Schuler G. D. ESTablishing a human transcript map. Nat Genet. 1995 Aug;10(4):369–371. doi: 10.1038/ng0895-369. [DOI] [PubMed] [Google Scholar]
  15. Breiner J. A., Meis-Kindblom J., Kindblom L. G., McComb E., Liu J., Nelson M., Bridge J. A. Loss of 14q and 22q in gastrointestinal stromal tumors (pacemaker cell tumors). Cancer Genet Cytogenet. 2000 Jul 15;120(2):111–116. doi: 10.1016/s0165-4608(00)00212-0. [DOI] [PubMed] [Google Scholar]
  16. Brinkschmidt C., Christiansen H., Terpe H. J., Simon R., Boecker W., Lampert F., Stoerkel S. Comparative genomic hybridization (CGH) analysis of neuroblastomas--an important methodological approach in paediatric tumour pathology. J Pathol. 1997 Apr;181(4):394–400. doi: 10.1002/(SICI)1096-9896(199704)181:4<394::AID-PATH800>3.0.CO;2-1. [DOI] [PubMed] [Google Scholar]
  17. Brito-Babapulle V., Catovsky D. Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in patients with ataxia telangiectasia. Cancer Genet Cytogenet. 1991 Aug;55(1):1–9. doi: 10.1016/0165-4608(91)90228-m. [DOI] [PubMed] [Google Scholar]
  18. Brüls T., Gyapay G., Petit J. L., Artiguenave F., Vico V., Qin S., Tin-Wollam A. M., Da Silva C., Muselet D., Mavel D. A physical map of human chromosome 14. Nature. 2001 Feb 15;409(6822):947–948. doi: 10.1038/35057177. [DOI] [PubMed] [Google Scholar]
  19. Béroud C., Fournet J. C., Jeanpierre C., Droz D., Bouvier R., Froger D., Chrétien Y., Maréchal J. M., Weissenbach J., Junien C. Correlations of allelic imbalance of chromosome 14 with adverse prognostic parameters in 148 renal cell carcinomas. Genes Chromosomes Cancer. 1996 Dec;17(4):215–224. doi: 10.1002/(SICI)1098-2264(199612)17:4<215::AID-GCC3>3.0.CO;2-6. [DOI] [PubMed] [Google Scholar]
  20. Charlier C., Segers K., Karim L., Shay T., Gyapay G., Cockett N., Georges M. The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status. Nat Genet. 2001 Apr;27(4):367–369. doi: 10.1038/86856. [DOI] [PubMed] [Google Scholar]
  21. Charlier C., Segers K., Wagenaar D., Karim L., Berghmans S., Jaillon O., Shay T., Weissenbach J., Cockett N., Gyapay G. Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8. Genome Res. 2001 May;11(5):850–862. doi: 10.1101/gr.172701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Cox D. W., Billingsley G. D., Bale A. E., Donis-Keller H., Edwards J. H., Litt M., Mcbride W., Persichetti F., Spurr N. K., Weber J. L. CEPH consortium map of chromosome 14. Cytogenet Cell Genet. 1995;69(3-4):175–178. doi: 10.1159/000133955. [DOI] [PubMed] [Google Scholar]
  23. Cox D. W., Billingsley G., Nguyen V. T. A linkage map of human chromosome 14, including 13 gene loci. Genomics. 1994 Sep 15;23(2):331–337. doi: 10.1006/geno.1994.1508. [DOI] [PubMed] [Google Scholar]
  24. Cox D. W., Donlon T. A. Report of the committee on the genetic constitution of chromosomes 14 and 15. Cytogenet Cell Genet. 1989;51(1-4):280–298. doi: 10.1159/000132795. [DOI] [PubMed] [Google Scholar]
  25. Cox D. W., Gedde-Dahl T., Jr, Menon A. G., Nygaard T. G., Tomlinson I. M., Peters J., St George-Hyslop P. H., Walter M. A., Edwards J. H. Report of the second international workshop on human chromosome 14 mapping 1994. Cytogenet Cell Genet. 1995;69(3-4):159–174. doi: 10.1159/000133954. [DOI] [PubMed] [Google Scholar]
  26. Cox D. W. Report of the first international workshop on human chromosome 14 mapping 1993. Cytogenet Cell Genet. 1994;66(1):2–9. [PubMed] [Google Scholar]
  27. Creagan R. P., Tan Y. H., Chen S., Tischfield J. A., Ruddle F. H. Proceedings: Mouse-human somatic cell hybrids utilizing human parental cells containing a (14;22) translocation: assignment of the gene for nucleoside phosphorylase to chromosome 14. Cytogenet Cell Genet. 1974;13(1):83–85. doi: 10.1159/000130240. [DOI] [PubMed] [Google Scholar]
  28. Cruts M., Backhovens H., Theuns J., Clark R. F., Le Paslier D., Weissenbach J., Goate A. M., Martin J. J., Van Broeckhoven C. Genetic and physical characterization of the early-onset Alzheimer's disease AD3 locus on chromosome 14q24.3. Hum Mol Genet. 1995 Aug;4(8):1355–1364. doi: 10.1093/hmg/4.8.1355. [DOI] [PubMed] [Google Scholar]
  29. De Rienzo A., Jhanwar S. C., Testa J. R. Loss of heterozygosity analysis of 13q and 14q in human malignant mesothelioma. Genes Chromosomes Cancer. 2000 Jul;28(3):337–341. [PubMed] [Google Scholar]
  30. Dear P. H., Bankier A. T., Piper M. B. A high-resolution metric HAPPY map of human chromosome 14. Genomics. 1998 Mar 1;48(2):232–241. doi: 10.1006/geno.1997.5140. [DOI] [PubMed] [Google Scholar]
  31. Deloukas P., Schuler G. D., Gyapay G., Beasley E. M., Soderlund C., Rodriguez-Tomé P., Hui L., Matise T. C., McKusick K. B., Beckmann J. S. A physical map of 30,000 human genes. Science. 1998 Oct 23;282(5389):744–746. doi: 10.1126/science.282.5389.744. [DOI] [PubMed] [Google Scholar]
  32. Doney M. K., Gerken S. C., Lynch R., Bhugra B., Hug K., White R., Weissenbach J., Menon A. G. Precise mapping of t(12;14) leiomyoma breakpoint on chromosome 14 between D14S298 and D14S540. Cancer Lett. 1995 Sep 25;96(2):245–252. doi: 10.1016/0304-3835(95)03938-s. [DOI] [PubMed] [Google Scholar]
  33. El-Rifai W., Sarlomo-Rikala M., Andersson L. C., Miettinen M., Knuutila S. High-resolution deletion mapping of chromosome 14 in stromal tumors of the gastrointestinal tract suggests two distinct tumor suppressor loci. Genes Chromosomes Cancer. 2000 Apr;27(4):387–391. [PubMed] [Google Scholar]
  34. Escary J. L., Bottius E., Prince N., Reyes C., Fiawoumo Y., Caloustian C., Bruls T., Fujiyama A., Cooper R. S., Adeyemo A. A. A first high-density map of 981 biallelic markers on human chromosome 14. Genomics. 2000 Dec 1;70(2):153–164. doi: 10.1006/geno.2000.6369. [DOI] [PubMed] [Google Scholar]
  35. Fernández-Cañn J. M., Peñalva M. A. Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue. J Biol Chem. 1998 Jan 2;273(1):329–337. doi: 10.1074/jbc.273.1.329. [DOI] [PubMed] [Google Scholar]
  36. Fisher E. M. The contribution of the mouse to advances in human genetics. Adv Genet. 1997;35:155–205. doi: 10.1016/s0065-2660(08)60450-2. [DOI] [PubMed] [Google Scholar]
  37. Fujimoto A., Allanson J., Crowe C. A., Lipson M. H., Johnson V. P. Natural history of mosaic trisomy 14 syndrome. Am J Med Genet. 1992 Sep 15;44(2):189–196. doi: 10.1002/ajmg.1320440214. [DOI] [PubMed] [Google Scholar]
  38. Fujino T., Risinger J. I., Collins N. K., Liu F. S., Nishii H., Takahashi H., Westphal E. M., Barrett J. C., Sasaki H., Kohler M. F. Allelotype of endometrial carcinoma. Cancer Res. 1994 Aug 15;54(16):4294–4298. [PubMed] [Google Scholar]
  39. Georgiades P., Chierakul C., Ferguson-Smith A. C. Parental origin effects in human trisomy for chromosome 14q: implications for genomic imprinting. J Med Genet. 1998 Oct;35(10):821–824. doi: 10.1136/jmg.35.10.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Georgiades P., Watkins M., Surani M. A., Ferguson-Smith A. C. Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12. Development. 2000 Nov;127(21):4719–4728. doi: 10.1242/dev.127.21.4719. [DOI] [PubMed] [Google Scholar]
  41. Gritti C., Dastot H., Soulier J., Janin A., Daniel M. T., Madani A., Grimber G., Briand P., Sigaux F., Stern M. H. Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. Blood. 1998 Jul 15;92(2):368–373. [PubMed] [Google Scholar]
  42. Hall J. G. Human diseases and genomic imprinting. Results Probl Cell Differ. 1999;25:119–132. doi: 10.1007/978-3-540-69111-2_6. [DOI] [PubMed] [Google Scholar]
  43. Herbers J., Schullerus D., Müller H., Kenck C., Chudek J., Weimer J., Bugert P., Kovacs G. Significance of chromosome arm 14q loss in nonpapillary renal cell carcinomas. Genes Chromosomes Cancer. 1997 May;19(1):29–35. [PubMed] [Google Scholar]
  44. Hoshi M., Otagiri N., Shiwaku H. O., Asakawa S., Shimizu N., Kaneko Y., Ohi R., Hayashi Y., Horii A. Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss. Br J Cancer. 2000 Jun;82(11):1801–1807. doi: 10.1054/bjoc.2000.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Hudson T. J., Stein L. D., Gerety S. S., Ma J., Castle A. B., Silva J., Slonim D. K., Baptista R., Kruglyak L., Xu S. H. An STS-based map of the human genome. Science. 1995 Dec 22;270(5244):1945–1954. doi: 10.1126/science.270.5244.1945. [DOI] [PubMed] [Google Scholar]
  46. Ingraham S. E., Lynch R. A., Kathiresan S., Buckler A. J., Menon A. G. hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma. Cancer Genet Cytogenet. 1999 Nov;115(1):56–61. doi: 10.1016/s0165-4608(99)00070-9. [DOI] [PubMed] [Google Scholar]
  47. Jarcho J. A., McKenna W., Pare J. A., Solomon S. D., Holcombe R. F., Dickie S., Levi T., Donis-Keller H., Seidman J. G., Seidman C. E. Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1. N Engl J Med. 1989 Nov 16;321(20):1372–1378. doi: 10.1056/NEJM198911163212005. [DOI] [PubMed] [Google Scholar]
  48. Kamnasaran D. Epigenetic inheritance associated with human chromosome 14. Clin Invest Med. 2001 Jun;24(3):138–146. [PubMed] [Google Scholar]
  49. Kamnasaran D., O'Brien P. C., Ferguson-Smith M. A., Cox D. W. Comparative mapping of human Chromosome 14q11.2-q13 genes with mouse homologous gene regions. Mamm Genome. 2000 Nov;11(11):993–999. doi: 10.1007/s003350010183. [DOI] [PubMed] [Google Scholar]
  50. Keats B., Ott J., Conneally M. Report of the committee on linkage and gene order. Cytogenet Cell Genet. 1989;51(1-4):459–502. doi: 10.1159/000132805. [DOI] [PubMed] [Google Scholar]
  51. Kobayashi S., Wagatsuma H., Ono R., Ichikawa H., Yamazaki M., Tashiro H., Aisaka K., Miyoshi N., Kohda T., Ogura A. Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse Meg3/Gtl2 and human MEG3. Genes Cells. 2000 Dec;5(12):1029–1037. doi: 10.1046/j.1365-2443.2000.00390.x. [DOI] [PubMed] [Google Scholar]
  52. Koike M., Chumakov A. M., Takeuchi S., Tasaka T., Yang R., Nakamaki T., Tsuruoka N., Koeffler H. P. C/EBP-epsilon: chromosomal mapping and mutational analysis of the gene in leukemia and preleukemia. Leuk Res. 1997 Sep;21(9):833–839. doi: 10.1016/s0145-2126(97)00072-6. [DOI] [PubMed] [Google Scholar]
  53. Korenberg J. R., Chen X. N., Sun Z., Shi Z. Y., Ma S., Vataru E., Yimlamai D., Weissenbach J. S., Shizuya H., Simon M. I. Human genome anatomy: BACs integrating the genetic and cytogenetic maps for bridging genome and biomedicine. Genome Res. 1999 Oct;9(10):994–1001. doi: 10.1101/gr.9.10.994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Laine J., Künstle G., Obata T., Sha M., Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395–407. doi: 10.1016/s1097-2765(00)00039-3. [DOI] [PubMed] [Google Scholar]
  55. Lander E. S., Linton L. M., Birren B., Nusbaum C., Zody M. C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15;409(6822):860–921. doi: 10.1038/35057062. [DOI] [PubMed] [Google Scholar]
  56. Lee D. J., Koch W. M., Yoo G., Lango M., Reed A., Califano J., Brennan J. A., Westra W. H., Zahurak M., Sidransky D. Impact of chromosome 14q loss on survival in primary head and neck squamous cell carcinoma. Clin Cancer Res. 1997 Apr;3(4):501–505. [PubMed] [Google Scholar]
  57. Lipson M. H. Trisomy 14 mosaicism syndrome. Am J Med Genet. 1987 Mar;26(3):541–544. doi: 10.1002/ajmg.1320260305. [DOI] [PubMed] [Google Scholar]
  58. Lynch R. A., Piper M., Bankier A., Bhugra B., Surti U., Liu J., Buckler A., Dear P. H., Menon A. G. Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. Genomics. 1998 Aug 15;52(1):17–26. doi: 10.1006/geno.1998.5406. [DOI] [PubMed] [Google Scholar]
  59. Mancini M., Cedrone M., Nanni M., Rondinelli M. B., Petti M. C., De Cuia M. R., Alimena G. Trisomy 14 in hematologic diseases. Another non-random abnormality within myeloid proliferative disorders. Cancer Genet Cytogenet. 1993 Mar;66(1):39–42. doi: 10.1016/0165-4608(93)90146-d. [DOI] [PubMed] [Google Scholar]
  60. Manolov G., Manolova Y. Marker band in one chromosome 14 from Burkitt lymphomas. Nature. 1972 May 5;237(5349):33–34. doi: 10.1038/237033a0. [DOI] [PubMed] [Google Scholar]
  61. Martin R. A., Sabol D. W., Rogan P. K. Maternal uniparental disomy of chromosome 14 confined to an interstitial segment (14q23-14q24.2). J Med Genet. 1999 Aug;36(8):633–636. [PMC free article] [PubMed] [Google Scholar]
  62. Matalon R., Supple P., Wyandt H., Rosenthal I. M. Transmission of ring 14 chromosome from mother to two sons. Am J Med Genet. 1990 Aug;36(4):381–385. doi: 10.1002/ajmg.1320360402. [DOI] [PubMed] [Google Scholar]
  63. Matolcsy A., Nádor R. G., Cesarman E., Knowles D. M. Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation. Am J Pathol. 1998 Nov;153(5):1609–1614. doi: 10.1016/S0002-9440(10)65749-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Matsumoto N., Soeda E., Ohashi H., Fujimoto M., Kato R., Tsujita T., Tomita H., Kondo S., Fukushima Y., Niikawa N. A 1.2-megabase BAC/PAC contig spanning the 14q13 breakpoint of t(2; 14) in a mirror-image polydactyly patient. Genomics. 1997 Oct 1;45(1):11–16. doi: 10.1006/geno.1997.4897. [DOI] [PubMed] [Google Scholar]
  65. Mertens F., Johansson B., Heim S., Kristoffersson U., Mandahl N., Turesson I., Malm C., Othzén A., Bartram C. R., Catovsky D. Trisomy 14 in atypical chronic myeloid leukemia. Leukemia. 1990 Feb;4(2):117–120. [PubMed] [Google Scholar]
  66. Miller B. A., Jaafar M. S., Capo H. Chromosome 14-terminal deletion and cataracts. Arch Ophthalmol. 1992 Aug;110(8):1053–1053. doi: 10.1001/archopht.1992.01080200033015. [DOI] [PubMed] [Google Scholar]
  67. Miyoshi N., Wagatsuma H., Wakana S., Shiroishi T., Nomura M., Aisaka K., Kohda T., Surani M. A., Kaneko-Ishino T., Ishino F. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cells. 2000 Mar;5(3):211–220. doi: 10.1046/j.1365-2443.2000.00320.x. [DOI] [PubMed] [Google Scholar]
  68. Moross T., Vaithilingam S. S., Styles S., Gardner H. A. Autosomal dominant anterior polar cataracts associated with a familial 2;14 translocation. J Med Genet. 1984 Feb;21(1):52–53. doi: 10.1136/jmg.21.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Murthy S. S., Testa J. R. Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma. J Cell Physiol. 1999 Aug;180(2):150–157. doi: 10.1002/(SICI)1097-4652(199908)180:2<150::AID-JCP2>3.0.CO;2-H. [DOI] [PubMed] [Google Scholar]
  70. Mutirangura A., Pornthanakasem W., Sriuranpong V., Supiyaphun P., Voravud N. Loss of heterozygosity on chromosome 14 in nasopharyngeal carcinoma. Int J Cancer. 1998 Oct 5;78(2):153–156. doi: 10.1002/(sici)1097-0215(19981005)78:2<153::aid-ijc5>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  71. Nakamura Y., Lathrop M., O'Connell P., Leppert M., Kamboh M. I., Lalouel J. M., White R. Frequent recombination is observed in the distal end of the long arm of chromosome 14. Genomics. 1989 Jan;4(1):76–81. doi: 10.1016/0888-7543(89)90317-0. [DOI] [PubMed] [Google Scholar]
  72. O'Connell P., Fischbach K., Hilsenbeck S., Mohsin S. K., Fuqua S. A., Clark G. M., Osborne C. K., Allred D. C. Loss of heterozygosity at D14S62 and metastatic potential of breast cancer. J Natl Cancer Inst. 1999 Aug 18;91(16):1391–1397. doi: 10.1093/jnci/91.16.1391. [DOI] [PubMed] [Google Scholar]
  73. Ono J., Nishiike K., Imai K., Otani K., Okada S. Ring chromosome 14 complicated with complex partial seizures and hypoplastic corpus callosum. Pediatr Neurol. 1999 Jan;20(1):70–72. doi: 10.1016/s0887-8994(98)00099-x. [DOI] [PubMed] [Google Scholar]
  74. Ortigas A. P., Stein C. K., Thomson L. L., Hoo J. J. Delineation of 14q32.3 deletion syndrome. J Med Genet. 1997 Jun;34(6):515–517. doi: 10.1136/jmg.34.6.515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Pandit S. D., Wang J. C., Veile R. A., Mishra S. K., Warlick C. A., Donis-Keller H. Index, comprehensive microsatellite, and unified linkage maps of human chromosome 14 with cytogenetic tie points and a telomere microsatellite marker. Genomics. 1995 Oct 10;29(3):653–664. doi: 10.1006/geno.1995.9953. [DOI] [PubMed] [Google Scholar]
  76. Parente F., Grosgeorge J., Coindre J. M., Terrier P., Vilain O., Turc-Carel C. Comparative genomic hybridization reveals novel chromosome deletions in 90 primary soft tissue tumors. Cancer Genet Cytogenet. 1999 Dec;115(2):89–95. doi: 10.1016/s0165-4608(99)00082-5. [DOI] [PubMed] [Google Scholar]
  77. Paternotte C., Rudnicki D., Fizames C., Davoine C. S., Mavel D., Dürr A., Samson D., Marquette C., Muselet D., Vega-Czarny N. Quality assessment of whole genome mapping data in the refined familial spastic paraplegia interval on chromosome 14q. Genome Res. 1998 Nov;8(11):1216–1227. doi: 10.1101/gr.8.11.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Pekarsky Y., Hallas C., Isobe M., Russo G., Croce C. M. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2949–2951. doi: 10.1073/pnas.96.6.2949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Pentao L., Lewis R. A., Ledbetter D. H., Patel P. I., Lupski J. R. Maternal uniparental isodisomy of chromosome 14: association with autosomal recessive rod monochromacy. Am J Hum Genet. 1992 Apr;50(4):690–699. [PMC free article] [PubMed] [Google Scholar]
  80. Petersen M. B., Vejerslev L. O., Beck B. Trisomy 14 mosaicism in a 2 year old girl. J Med Genet. 1986 Feb;23(1):86–88. doi: 10.1136/jmg.23.1.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Petković I., Cepulić M. Cytogenetic analysis of primary neuroblastoma with del(1), del(14), hsr, and dmin chromosomes. Cancer Genet Cytogenet. 1991 Sep;55(2):231–234. doi: 10.1016/0165-4608(91)90082-6. [DOI] [PubMed] [Google Scholar]
  82. Polascik T. J., Cairns P., Epstein J. I., Fuzesi L., Ro J. Y., Marshall F. F., Sidransky D., Schoenberg M. Distal nephron renal tumors: microsatellite allelotype. Cancer Res. 1996 Apr 15;56(8):1892–1895. [PubMed] [Google Scholar]
  83. Rabin M., Watson M., Kidd V., Woo S. L., Breg W. R., Ruddle F. H. Regional location of alpha 1-antichymotrypsin and alpha 1-antitrypsin genes on human chromosome 14. Somat Cell Mol Genet. 1986 Mar;12(2):209–214. doi: 10.1007/BF01560668. [DOI] [PubMed] [Google Scholar]
  84. Robin N. H., Harari-Shacham A., Schwartz S., Wolff D. J. Duplication 14(q24.3q31) in a father and daughter: delineation of a possible imprinted region. Am J Med Genet. 1997 Aug 22;71(3):361–365. doi: 10.1002/(sici)1096-8628(19970822)71:3<361::aid-ajmg20>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  85. Rollini P., Fournier R. E. A 370-kb cosmid contig of the serpin gene cluster on human chromosome 14q32.1: molecular linkage of the genes encoding alpha 1-antichymotrypsin, protein C inhibitor, kallistatin, alpha 1-antitrypsin, and corticosteroid-binding globulin. Genomics. 1997 Dec 15;46(3):409–415. doi: 10.1006/geno.1997.5077. [DOI] [PubMed] [Google Scholar]
  86. Roux A. F., Rommens J. M., Read L., Duncan A. M., Cox D. W. Physical and transcription map in the region 14q24.3: identification of six novel transcripts. Genomics. 1997 Jul 15;43(2):130–140. doi: 10.1006/geno.1997.4786. [DOI] [PubMed] [Google Scholar]
  87. Saitou M., Sugimoto J., Hatakeyama T., Russo G., Isobe M. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. Oncogene. 2000 May 25;19(23):2796–2802. doi: 10.1038/sj.onc.1203604. [DOI] [PubMed] [Google Scholar]
  88. Sanlaville D., Aubry M. C., Dumez Y., Nolen M. C., Amiel J., Pinson M. P., Lyonnet S., Munnich A., Vekemans M., Morichon-Delvallez N. Maternal uniparental heterodisomy of chromosome 14: chromosomal mechanism and clinical follow up. J Med Genet. 2000 Jul;37(7):525–528. doi: 10.1136/jmg.37.7.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Sasaki M., Okamoto M., Sato C., Sugio K., Soejima J., Iwama T., Ikeuchi T., Tonomura A., Miyaki M., Sasazuki T. Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma. Cancer Res. 1989 Aug 15;49(16):4402–4406. [PubMed] [Google Scholar]
  90. Schmidt R., Eviatar L., Nitowsky H. M., Wong M., Miranda S. Ring chromosome 14: a distinct clinical entity. J Med Genet. 1981 Aug;18(4):304–307. doi: 10.1136/jmg.18.4.304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Schuler G. D., Boguski M. S., Stewart E. A., Stein L. D., Gyapay G., Rice K., White R. E., Rodriguez-Tomé P., Aggarwal A., Bajorek E. A gene map of the human genome. Science. 1996 Oct 25;274(5287):540–546. [PubMed] [Google Scholar]
  92. Schuster-Gossler K., Bilinski P., Sado T., Ferguson-Smith A., Gossler A. The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA. Dev Dyn. 1998 Jun;212(2):214–228. doi: 10.1002/(SICI)1097-0177(199806)212:2<214::AID-AJA6>3.0.CO;2-K. [DOI] [PubMed] [Google Scholar]
  93. Schwerdtle R. F., Winterpacht A., Störkel S., Brenner W., Hohenfellner R., Zabel B., Huber C., Decker H. J. Loss of heterozygosity studies and deletion mapping identify two putative chromosome 14q tumor suppressor loci in renal oncocytomas. Cancer Res. 1997 Nov 15;57(22):5009–5012. [PubMed] [Google Scholar]
  94. Shafritz A. B., Shore E. M., Gannon F. H., Zasloff M. A., Taub R., Muenke M., Kaplan F. S. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. N Engl J Med. 1996 Aug 22;335(8):555–561. doi: 10.1056/NEJM199608223350804. [DOI] [PubMed] [Google Scholar]
  95. Sharma V., Poorkaj P., Hisama F., Bonnycastle L., Yu C. E., Massa H., Trask B., Clancy K. P., Patterson D., Weissman S. M. An expression map from human chromosome 14q24.3. Genomics. 1998 Jan 15;47(2):314–318. doi: 10.1006/geno.1997.5106. [DOI] [PubMed] [Google Scholar]
  96. Srivatsan E. S., Murali V., Seeger R. C. Loss of heterozygosity for alleles on chromosomes 11q and 14q in neuroblastoma. Prog Clin Biol Res. 1991;366:91–98. [PubMed] [Google Scholar]
  97. Sutton V. R., Shaffer L. G. Search for imprinted regions on chromosome 14: comparison of maternal and paternal UPD cases with cases of chromosome 14 deletion. Am J Med Genet. 2000 Aug 28;93(5):381–387. doi: 10.1002/1096-8628(20000828)93:5<381::aid-ajmg7>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  98. Suzuki T., Mugishima H., Fujisawa T., Okuni M., Okabe I., Yokota J., Terada M. Loss of heterozygosity on chromosome 14 in neuroblastoma. Prog Clin Biol Res. 1991;366:135–145. [PubMed] [Google Scholar]
  99. Suzuki T., Yokota J., Mugishima H., Okabe I., Ookuni M., Sugimura T., Terada M. Frequent loss of heterozygosity on chromosome 14q in neuroblastoma. Cancer Res. 1989 Mar 1;49(5):1095–1098. [PubMed] [Google Scholar]
  100. Takayama H., Suzuki T., Mugishima H., Fujisawa T., Ookuni M., Schwab M., Gehring M., Nakamura Y., Sugimura T., Terada M. Deletion mapping of chromosomes 14q and 1p in human neuroblastoma. Oncogene. 1992 Jun;7(6):1185–1189. [PubMed] [Google Scholar]
  101. Tamura G., Sakata K., Nishizuka S., Maesawa C., Suzuki Y., Terashima M., Eda Y., Satodate R. Allelotype of adenoma and differentiated adenocarcinoma of the stomach. J Pathol. 1996 Dec;180(4):371–377. doi: 10.1002/(SICI)1096-9896(199612)180:4<371::AID-PATH704>3.0.CO;2-2. [DOI] [PubMed] [Google Scholar]
  102. Theobald M., Christiansen H., Schmidt A., Melekian B., Wolkewitz N., Christiansen N. M., Brinkschmidt C., Berthold F., Lampert F. Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma. Genes Chromosomes Cancer. 1999 Sep;26(1):40–46. [PubMed] [Google Scholar]
  103. Tse J. Y., Ng H. K., Lau K. M., Lo K. W., Poon W. S., Huang D. P. Loss of heterozygosity of chromosome 14q in low- and high-grade meningiomas. Hum Pathol. 1997 Jul;28(7):779–785. doi: 10.1016/s0046-8177(97)90149-0. [DOI] [PubMed] [Google Scholar]
  104. Tumewu P., Royle G. Myelodysplastic syndrome and trisomy 14q. Cancer Genet Cytogenet. 1992 Nov;64(1):91–92. doi: 10.1016/0165-4608(92)90330-b. [DOI] [PubMed] [Google Scholar]
  105. Turleau C., de Grouchy J., Cornu A., Turquet M., Millet G. Trisomie 14 en mosaïque par isochromosome dicentrique. Ann Genet. 1980;23(4):238–240. [PubMed] [Google Scholar]
  106. Vasef M. A., Murata-Collins J. L., Alsabeh R., Medeiros L. J. Trisomy 14 in myelodysplastic syndromes: report of two cases and review of the literature. Arch Pathol Lab Med. 1998 Jan;122(1):77–83. [PubMed] [Google Scholar]
  107. Venter J. C., Adams M. D., Myers E. W., Li P. W., Mural R. J., Sutton G. G., Smith H. O., Yandell M., Evans C. A., Holt R. A. The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304–1351. doi: 10.1126/science.1058040. [DOI] [PubMed] [Google Scholar]
  108. Walter C. A., Shaffer L. G., Kaye C. I., Huff R. W., Ghidoni P. D., McCaskill C., McFarland M. B., Moore C. M. Short-limb dwarfism and hypertrophic cardiomyopathy in a patient with paternal isodisomy 14: 45,XY,idic(14)(p11). Am J Med Genet. 1996 Nov 11;65(4):259–265. doi: 10.1002/(SICI)1096-8628(19961111)65:4<259::AID-AJMG2>3.0.CO;2-K. [DOI] [PubMed] [Google Scholar]
  109. Wang Z., Weber J. L. Continuous linkage map of human chromosome 14 short tandem repeat polymorphisms. Genomics. 1992 Jul;13(3):532–536. doi: 10.1016/0888-7543(92)90121-8. [DOI] [PubMed] [Google Scholar]
  110. Weaver D. A., Hei T. K., Hukku B., Demuth J. P., Crawford E. L., McRaven J. A., Girgis S., Willey J. C. Localization of tumor suppressor gene candidates by cytogenetic and short tandem repeat analyses in tumorigenic human bronchial epithelial cells. Carcinogenesis. 2000 Feb;21(2):205–211. doi: 10.1093/carcin/21.2.205. [DOI] [PubMed] [Google Scholar]
  111. Weissenbach J. The Human Genome Project: from mapping to sequencing. Clin Chem Lab Med. 1998 Aug;36(8):511–514. doi: 10.1515/CCLM.1998.086. [DOI] [PubMed] [Google Scholar]
  112. Wu S. Q., Hafez G. R., Xing W., Newton M., Chen X. R., Messing E. The correlation between the loss of chromosome 14q with histologic tumor grade, pathologic stage, and outcome of patients with nonpapillary renal cell carcinoma. Cancer. 1996 Mar 15;77(6):1154–1160. doi: 10.1002/(sici)1097-0142(19960315)77:6<1154::aid-cncr23>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  113. Wylie A. A., Murphy S. K., Orton T. C., Jirtle R. L. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 2000 Nov;10(11):1711–1718. doi: 10.1101/gr.161600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  114. Xie Y. G., Rochefort D., Brais B., Howard H., Han F. Y., Gou L. P., Maciel P., The B. T., Larsson C., Rouleau G. A. Restriction map of a YAC and cosmid contig encompassing the oculopharyngeal muscular dystrophy candidate region on chromosome 14q11.2-q13. Genomics. 1998 Sep 1;52(2):201–204. doi: 10.1006/geno.1998.5421. [DOI] [PubMed] [Google Scholar]
  115. Yeatman G. W., Riccardi V. M. Partial trisomy of chromosome 14: (+14q-). Birth Defects Orig Artic Ser. 1976;12(5):119–124. [PubMed] [Google Scholar]
  116. Young J., Leggett B., Ward M., Thomas L., Buttenshaw R., Searle J., Chenevix-Trench G. Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas. Oncogene. 1993 Mar;8(3):671–675. [PubMed] [Google Scholar]
  117. Zlotogora J., Chakraborty S., Knowlton R. G., Wenger D. A. Krabbe disease locus mapped to chromosome 14 by genetic linkage. Am J Hum Genet. 1990 Jul;47(1):37–44. [PMC free article] [PubMed] [Google Scholar]

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